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Actin type and distribution in erythrocytes

  • Erythrocytes transport oxygen from the lungs to the tissues. The excess surface area together with the elasticity of the erythrocyte cell membrane provides the flexibility needed to pass through the microvasculature where the oxygen exchange occurs. Although the architecture of the red cell and its membrane-associated cytoskeletal network is known in general, the factors that control the characteristic shape change during echinocyte formation are poorly understood. In this short report we show that in echinocytes a completely reorganized membrane cytoskeleton with a box-like structure of actin filaments prevailed indicating the importance of the actin cytoskeleton during echinocyte formation.

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Author: Anne Krüger-Genge, Friedrich Jung, Jan-Heiner KüpperGND, Christian Lehmann, Ralf-Peter Franke
URL:https://content.iospress.com/articles/journal-of-cellular-biotechnology/jcb179014
DOI:https://doi.org/10.3233/JCB-179014
ISSN:2352-3697
ISSN:2352-3689
Title of the source (English):Journal of Cellular Biotechnology
Document Type:Scientific journal article peer-reviewed
Language:English
Year of publication:2018
Tag:Erythrocytes; actin; echinocytes; submembraneous cytoskeleton
Volume/Year:3
Issue number:2
First Page:81
Last Page:83
Faculty/Chair:Fakultät 2 Umwelt und Naturwissenschaften / FG Molekulare Zellbiologie
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