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Oxyfunctionalization of Pharmaceuticals by Fungal Peroxygenases

  • Throughout drug discovery and development, metabolic studies are driven by an increased interest to understand the potential for side effects and drug-drug interactions. Peroxygenases are a subclass of peroxide-dependent enzymes that catalyze the transfer of a peroxide-borne oxygen to diverse substrates. The selective oxyfunctionalization of organic molecules is one of the major challenges for the chemical community. Benzylic hydroxylation is one of the most frequently observed reactions of unspecific peroxygenases due to the activated nature of benzylic C–H bonds. The hydroxylation of aromatic rings is a common reaction in the formation of drug metabolites by P450s in mammals including humans. In the liver, P450s facilely metabolize secondary and tertiary amines as well as ethers to the corresponding dealkylated metabolites. The regio- and stereoselective direct introduction of oxygen functionalities into complex pharmaceuticals is a great challenge for organic chemists.

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Metadaten
Author: Jan Kiebist, Martin HofrichterORCiD, Ralf Zuhse, Katrin Scheibner
ISBN:978-981-4800-80-8
ISBN:978-1-00-070757-1
Title of the source (English):Pharmaceutical biocatalysis : chemoenzymatic synthesis of active pharmaceutical ingredients
Publisher:Jenny Stanford Publishing Pte. Ltd.
Place of publication:Singapore
Editor: Peter Grunwald
Document Type:Part of a book (chapter)
Language:English
Year of publication:2019
Tag:Peroxygenase
Edition:1. Auflage
First Page:643
Last Page:673
Series ; volume number:Jenny Stanford series on biocatalysis ; Vol. 5
Faculty/Chair:Fakultät 2 Umwelt und Naturwissenschaften / FG Enzymtechnologie
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