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Optimization of a biocatalytic process to gain (R)-1-phenylethanol by applying the software tool Sabento for ecological assessment during the early stages of development

  • Ecological assessment using the software tool Sabento was conducted to compare different processes to gain the fine chemical (R)-1-phenylethanol from ethylbenzene. The software was applied during the biocatalytic process development using the unspecific peroxygenase (EC .11.2.1) of the fungus Agrocybe aegerita. The process could be systematically improved with respect to the ecological performance during process development. Compared to a modern chemical process and a further biotechnological process, it now reaches the best environmental key indicator. The software tool Sabento proved to be well suited to work out the most important factors determining the ecological burdens in the early stages of process development.

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Author: Stephanie Friedrich, Glenn Gröbe, Martin Kluge, Tobias Brinkmann, Martin HofrichterORCiD, Katrin Scheibner
URL:http://www.sciencedirect.com/science/article/pii/S1381117713002774
DOI:https://doi.org/10.1016/j.molcatb.2013.10.002
ISSN:1381-1177
Title of the source (English):Journal of Molecular Catalysis : B, Enzymatic
Document Type:Scientific journal article peer-reviewed
Language:English
Year of publication:2014
Tag:Agrocybe aegerita; Biocatalytic process for (R)-1-phenylethanol; Ecological assessment; Unspecific peroxygenase (EC 1.11.2.1)
Issue number:103
First Page:36
Last Page:40
Faculty/Chair:Fakultät 2 Umwelt und Naturwissenschaften / FG Enzymtechnologie
Institution name at the time of publication:Fakultät für Naturwissenschaften (eHL) / Prof. Enzymtechnologie
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