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Effects of gut microbial metabolite trimethylamine N-oxide (TMAO) on platelets and endothelial cells

  • Thrombotic events result from different pathologies and are the underlying causes of severe diseases like stroke or myocardial infarction. Recent basic research now revealed a link between food uptake, food conversion and gut metabolism. Gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin and L-carnitine was associated with the development of cardiovascular diseases. Within this review we give a systematic overview about the influence of TMAO on blood components like platelets and endothelial cells which both are involved as key players in thrombotic processes. In summary, a mechanistic correlation between the gut microbiome, TMAO and cardiovascular diseases becomes obvious and emphasizes to the significance of the intestinal microbiome.

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Author: Anne Krüger-Genge, Friedrich Jung, Frank Hufert, Ernst Michael Jung, Jan-Heiner KüpperGND, J. Storsberg
URL:https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch209206
DOI:https://doi.org/10.3233/CH-209206
ISSN:1875-8622
ISSN:1386-0291
Title of the source (English):Clinical Hemorheology and Microcirculation
Document Type:Scientific journal article peer-reviewed
Language:English
Year of publication:2020
Tag:Microbiome; atherosclerosis; endothelial cells; platelets; trimethylamin-N-oxide
Volume/Year:76
Issue number:2
First Page:309
Last Page:316
Faculty/Chair:Fakultät 2 Umwelt und Naturwissenschaften / FG Molekulare Zellbiologie
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