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Arthrospira platensis accelerates the formation of an endothelial cell monolayer and protects against endothelial cell detachment after bacterial contamination

  • Within the last years a comprehensive number of scientific studies demonstrated beneficial effect of Arthropira platensis (AP) as dietary supplement due to a high content of proteins, minerals and vitamins. Positive effects like promoting the immune system, reducing inflammation and an anti-oxidant capacity are reported. In this study, the effect of an aqueous AP extract on primary human venous endothelial cells (HUVEC) was investigated. In addition, the effect of AP on HUVEC treated with a bacterial toxin (lipopolysaccharide, LPA), inducing an activation of HUVEC and cellular detachment, was analyzed. Depending on the concentration of AP extract a significantly accelerated formation of an endothelial cell monolayer was observed. Furthermore, the detachment of HUVEC after LPA addition was dramatically reduced by AP. In conclusion, the data are promising and indicatory for an application of Arthrospira platensis in the clinical field.

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Author: Anne Krüger-Genge, Susanne Steinbrecht, Conrad H. G. Jung, Sophia Westphal, Stefanie Klöpzig, Peter Waldeck, Jan-Heiner KüpperGND, J. Storsberg, Friedrich Jung
URL:https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch201096
DOI:https://doi.org/10.3233/CH-201096
ISSN:1386-0291
Title of the source (English):Clinical Hemorheology and Microcirculation
Document Type:Scientific journal article peer-reviewed
Language:English
Year of publication:2021
Tag:Arthrospira platensis; endothelial cells; xCELLigence system
Volume/Year:78
Issue number:2
First Page:151
Last Page:161
Faculty/Chair:Fakultät 2 Umwelt und Naturwissenschaften / FG Thermodynamik
Fakultät 2 Umwelt und Naturwissenschaften / FG Molekulare Zellbiologie
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