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Modeling atrial fibrosis in vitro - Generation and characterization of a novel human atrial fibroblast cell line

  • Atrial fibrillation (AF) is regularly accompanied by cardiac fibrosis and concomitant heart failure. Due to the heterogeneous nature and complexity of fibrosis, the knowledge about the underlying mechanisms is limited, which prevents effective pharmacotherapy. A deeper understanding of cardiac fibroblasts is essential to meet this need. We previously described phenotypic and functional differences between atrial fibroblasts from patients in sinus rhythm and with AF. Herein, we established and characterized a novel human atrial fibroblast line, which displays typical fibroblast morphology and function comparable to primary cells but with improved proliferation capacity and low spontaneous myofibroblast differentiation. These traits make our model suitable for the study of fibrosis mechanisms and for drug screening aimed at developing effective antifibrotic pharmacotherapy.

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Author: Stephan R. Künzel, Johanna S. E. Rausch, Charlotte Schäffer, Maximilian Hoffmann, Karolina Künzel, Erik Klapproth, Theresa Kant, Natalie Herzog, Jan-Heiner KüpperGND, Kristina Lorenz, Svenja Dudek, Ramona Emig, Ursula Ravens, Eva A. Rog‐Zielinska, Rémi Peyronnet, Ali El‐Armouche
DOI:https://doi.org/10.1002/2211-5463.12896
ISSN:2211-5463
Title of the source (English):FEBS Open Bio
Document Type:Scientific journal article peer-reviewed
Language:English
Year of publication:2020
Tag:cardiovascular disease; cell culture; cell lines; fibroblasts; fibrosis; heart
Volume/Year:10
Issue number:7
First Page:1210
Last Page:1218
Faculty/Chair:Fakultät 2 Umwelt und Naturwissenschaften / FG Molekulare Zellbiologie
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