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Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease

  • Recently, it was shown that patients with Parkinson's disease (PD) who exhibit an “Alzheimer's disease (AD)-like” pattern of brain atrophy are at greater risk for future cognitive decline. This study aimed to investigate whether this association is domain-specific and whether atrophy associated with brain aging also relates to cognitive impairment in PD. SPARE-AD, an MRI index capturing AD-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort. All patients underwent an extensive neuropsychological test battery. Patients diagnosed with mild cognitive impairment or dementia were found to have higher SPARE-AD scores as compared to patients with normal cognition and healthy controls. All patient groups showed increased brain age. SPARE-AD predicted impairment in memory, language and executive functions, whereas advanced brain age was associated with deficits in attention and working memory. Data suggest thatRecently, it was shown that patients with Parkinson's disease (PD) who exhibit an “Alzheimer's disease (AD)-like” pattern of brain atrophy are at greater risk for future cognitive decline. This study aimed to investigate whether this association is domain-specific and whether atrophy associated with brain aging also relates to cognitive impairment in PD. SPARE-AD, an MRI index capturing AD-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort. All patients underwent an extensive neuropsychological test battery. Patients diagnosed with mild cognitive impairment or dementia were found to have higher SPARE-AD scores as compared to patients with normal cognition and healthy controls. All patient groups showed increased brain age. SPARE-AD predicted impairment in memory, language and executive functions, whereas advanced brain age was associated with deficits in attention and working memory. Data suggest that SPARE-AD and brain age are differentially related to domain-specific cognitive decline in PD. The underlying pathomechanisms remain to be determined.show moreshow less

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Author: Daniel Charissé, Guray Erus, Raymond Pomponio, Martin Gorges, Nele Schmidt, Christine Schneider, Inga Liepelt-Scarfone, Oliver Riedel, Kathrin Reetz, Jörg B. Schulz, Daniela Berg, Alexander Storch, Karsten Witt, Richard Dodel, Elke Kalbe, Jan Kassubek, Rüdiger Hilker-Roggendorf, Simon Baudrexel
URL:https://www.sciencedirect.com/science/article/pii/S0197458021002748?via%3Dihub
DOI:https://doi.org/10.1016/j.neurobiolaging.2021.08.020
ISSN:0197-4580
Title of the source (English):Neurobiology of Aging
Document Type:Scientific journal article peer-reviewed
Language:English
Year of publication:2022
Tag:Alzheimer's disease; Brain Age; MRI; Parkinson's disease; Pattern classification
Volume/Year:109
First Page:31
Last Page:42
Way of publication:Open Access
Faculty/Chair:Fakultät 1 MINT - Mathematik, Informatik, Physik, Elektro- und Informationstechnik / FG Medizinische Informationssysteme
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