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From Alkanes to Carboxylic Acids: Terminal Oxygenation by a Fungal Peroxygenase

  • A new heme–thiolate peroxidase catalyzes the hydroxylation of n-alkanes at the terminal position—a challenging reaction in organic chemistry—with H2O2 as the only cosubstrate. Besides the primary product, 1-dodecanol, the conversion of dodecane yielded dodecanoic, 12-hydroxydodecanoic, and 1,12-dodecanedioic acids, as identified by GC–MS. Dodecanal could be detected only in trace amounts, and 1,12-dodecanediol was not observed, thus suggesting that dodecanoic acid is the branch point between mono- and diterminal hydroxylation. Simultaneously, oxygenation was observed at other hydrocarbon chain positions (preferentially C2 and C11). Similar results were observed in reactions of tetradecane. The pattern of products formed, together with data on the incorporation of 18O from the cosubstrate H218O2, demonstrate that the enzyme acts as a peroxygenase that is able to catalyze a cascade of mono- and diterminal oxidation reactions of long-chain n-alkanes to give carboxylic acids.

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Author: Andrés Olmedo, Carmen Aranda, José C. del Rio, Jan Kiebist, Katrin Scheibner, Angel T. Martínez, Ana Gutiérrez
URL:http://onlinelibrary.wiley.com/doi/10.1002/anie.201605430/abstract
DOI:https://doi.org/10.1002/anie.201605430
ISSN:1521-3773
Title of the source (English):Angewandte Chemie International Edition
Document Type:Scientific journal article peer-reviewed
Language:English
Year of publication:2016
Tag:Peroxyenase
Volume/Year:55
Issue number:40
First Page:12248
Last Page:12251
Faculty/Chair:Fakultät 2 Umwelt und Naturwissenschaften / FG Enzymtechnologie
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