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Toward ultrasensitive surface plasmon resonance sensors

  • Despite the history of application of surface plasmon resonance (SPR) for chemo- and biosensing being over 30 years long, the development of this technique is still in progress. This review is focused on the technological aspects of further improvement of analytical performance of SPR transducers based on Kretschmann configuration. We describe basic measurement configurations, their improvements and optimizations, and their drawbacks and limitations. An importance of referencing in SPR sensors is highlighted. The referencing approaches are classified into the following domains: (1) macroscopic spatially separated referencing, (2) self-referencing based on micro-patterning, (3) in-place referencing, (4) spatiotemporal referencing, and (5) electrochemically assisted referencing. The underlying principles of these approaches, examples of their implementation, and resulting improvements of sensor performance are described. Finally, an analysis of SPR data and an extraction of affinity properties are discussed.

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Metadaten
Author: Vitali ScherbahnORCiD, Shavkat NizamovORCiD, Vladimir M. MirskyORCiDGND
DOI:https://doi.org/https://doi.org/10.1007/5346_2017_21
ISBN:978-3-319-75220-4
ISBN:978-3-319-75219-8
Title of the source (English):Label-free biosensing : advanced materials, devices and applications
Publisher:Springer
Place of publication:Cham
Editor: Michael J. Schöning, Arshak Poghossian
Document Type:Part of a book (chapter)
Language:English
Year of publication:2018
Tag:Self-referencing; Surface plasmon resonance; Surface plasmon resonance microscopy
First Page:409
Last Page:448
Series ; volume number:Springer series on chemical sensors and biosensors ; 16
Faculty/Chair:Fakultät 2 Umwelt und Naturwissenschaften / FG Nanobiotechnologie
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