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Self-referencing SPR-sensor based on integral measurements of light intensity reflected by arbitrarily distributed sensing and referencing spots

  • A new approach for self-referencing in SPR biosensors is reported. The method is technologically simple and applicable for a wide range of existing SPR instrumentation with Kretschmann configuration. It is based on the micropatterning of the sensor area with sensing and referencing areas whose shape and distribution can be chosen arbitrarily and their characteristic sizes are larger than the plasmons propagation length. Provided that roughly a half of the area is used as the sensing area while its optical thickness is different from that of the referencing area, an integral measurement of the intensity of the reflected light over such a patterned surface near the summary resonance conditions exhibits self-referencing properties. An over ten-fold suppression of the effect caused by the variation of the bulk refractive index was observed.

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Metadaten
Author: Shavkat NizamovORCiD, Vitali ScherbahnORCiD, Vladimir M. MirskyORCiDGND
DOI:https://doi.org/10.1016/j.snb.2014.10.022
ISSN:0925-4005
Title of the source (English):Sensors and Actuators B: Chemical
Document Type:Scientific journal article peer-reviewed
Language:English
Year of publication:2015
Volume/Year:207
Issue number:A
First Page:740
Last Page:747
Faculty/Chair:Fakultät 2 Umwelt und Naturwissenschaften / FG Nanobiotechnologie
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