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Detection and quantification of single engineered nanoparticles in complex samples using template matching in wide-field surface plasmon microscopy

  • An ultrasensitive analytical method for direct detection of single nanoparticles in complex environment is described. The method relies on the wide-field surface plasmon microscopy (SPM). The suppression of matrix effects is achieved by image analysis based on the template matching. First, characteristic SPM images of nanoparticles are collected in aqueous suspensions. Then the detection of nanoparticles in complex environment is performed using template matching. Quantification and characterization of nanoparticles size was demonstrated at subppb level (∼ 100 pg/mL) in such complex media as wines, fruit juices, or cosmetic formulation. Visualization of the nanoparticles is performed in real time. The method does not require any sample pretreatment. If the minimally acceptable adsorption rate is defined as one nanoparticle to the whole sensor surface per few seconds, the working range of the method is ∼ 10 6 to 10 10 nanoparticles per mL.

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Metadaten
Author: Shavkat NizamovORCiD, Vitali ScherbahnORCiD, Vladimir M. MirskyORCiDGND
DOI:https://doi.org/10.1021/acs.analchem.6b02878
ISSN:1520-6882
Title of the source (English):Analytical Chemistry
Document Type:Scientific journal article peer-reviewed
Language:English
Year of publication:2016
Volume/Year:88
Issue number:20
First Page:10206
Last Page:10214
Faculty/Chair:Fakultät 2 Umwelt und Naturwissenschaften / FG Nanobiotechnologie
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