TY - CHAP A1 - Villgrattner, Thomas A1 - Schneider, Erich A1 - Andersch, Philipp A1 - Ulbrich, Heinz ED - Suda, Yoshihiro T1 - Compact high dynamic 3 dof camera orientation system, development and control T2 - The 10th International Conference on Motion and Vibration Control MOVIC, proceedings, 17 - 20 August 2010, Tokyo, Japan Y1 - 2010 PB - Institute of Industrial Science, the University of Tokyo CY - Tokyo ER - TY - CHAP A1 - Wright, W. Geoffrey A1 - Schneider, Erich T1 - Manual motor control during "virtual" self-motion: Implications for vr rehabilitation T2 - 2009 Virtual Rehabilitation International Conference, Haifa, Israel, 29 June - 2 July 2009 Y1 - 2009 UR - http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=5174226 SN - 978-1-4244-4188-4 SN - 978-1-4244-4189-1 SP - 166 EP - 172 PB - IEEE CY - Piscataway, NJ ER - TY - GEN A1 - Aubele, Maria A1 - Grill, Eva A1 - Eggert, Thomas A1 - Schneider, Erich A1 - Strobl, Ralf A1 - Jahn, Klaus A1 - Müller, Martin A1 - Holle, Rolf A1 - Linkohr, Birgit A1 - Heier, Margit A1 - Ladwig, Karl-Heinz A1 - Lehnen, Nadine T1 - Symptoms in unilatral vestibular hypofunction are associated with number of catch-up saccades and retinal errors: results from the population-based KORA FF4study T2 - Frontiers in Neurology N2 - Objective: The presence and intensity of symptoms vary in patients with unilateral vestibular hypofunction. We aimed to determine which saccadic and vestibulo-ocular reflex parameters best predict the presence of symptoms in unilateral vestibular hypofunction in order to better understand vestibular compensation and its implications for rehabilitation therapy. Methods: Video head impulse test data were analyzed from a subpopulation of 23 symptomatic and 10 currently symptom-free participants with unilateral vestibular hypofunction, embedded in the KORA (Cooperative Health Research in the Region of Augsburg) FF4 study, the second follow-up of the KORA S4 population-based health survey (2,279 participants). Results: A higher number of catch-up saccades, a higher percentage of covert saccades, and a larger retinal error at 200 ms after the onset of the head impulse were associated with relevant symptoms in participants with unilateral vestibular hypofunction (p = 0.028, p = 0.046, and p = 0.038, respectively). After stepwise selection, the number of catch-up saccades and retinal error at 200 ms remained in the final logistic regression model, which was significantly better than a null model (p = 0.014). Age, gender, saccade amplitude, saccade latency, and VOR gain were not predictive of the presence of symptoms. Conclusion: The accuracy of saccadic compensation seems to be crucial for the presence of symptoms in unilateral vestibular hypofunction, highlighting the role of specific gaze stabilization exercises in rehabilitation. Early saccades, mainly triggered by the vestibular system, do not seem to compensate accurately enough, resulting in a relevant retinal error and the need for more as well as more accurate catch-up saccades, probably triggered by the visual system. KW - video head impulse test, vHIT, catch-up saccades, unilateral vestibular hypofunction, retinal error, vestibulo-ocular reflex, VOR, population-based survey Y1 - 2023 UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715252/ SN - 1664-2295 VL - 2023 IS - 14 ER - TY - GEN A1 - Michailidou, Efterpi A1 - Korda, Athanasia A1 - Wyss, Thomas A1 - Bardins, Stanislav A1 - Schneider, Erich A1 - Morrison, Miranda A1 - Wagner, Franca A1 - Caversaccio, Marco A1 - Mantokoudis, Georgios T1 - The value of saccade metrics and VOR gain in detecting a vestibular stroke T2 - Journal of Vestibular Research N2 - Objective: A normal video Head Impulse Test is the gold standard in the emergency department to rule-in patients with an acute vestibular syndrome and a stroke. We aimed to compare the diagnostic accuracy of vHIT metrics regarding the vestibulo-ocular reflex gain and the corrective saccades in detecting vestibular strokes. Methods: Prospective cross-sectional study (convenience sample) of patients presenting with acute vestibular syndrome in the emergency department of a tertiary referral centre between February 2015 and May 2020. We screened 1677 patients and enrolled 76 patients fulfilling the inclusion criteria of acute vestibular syndrome. All patients underwent video head impulse test with automated and manual data analysis. A delayed MRI served as a gold standard for vestibular stroke confirmation. Results: Out of 76 patients, 52 were diagnosed with acute unilateral vestibulopathy and 24 with vestibular strokes. The overall accuracy of detecting stroke with an automated vestibulo-ocular reflex gain was 86.8%, compared to 77.6% for cumulative saccade amplitude and automatic saccade mean peak velocity measured by an expert and 71% for cumulative saccade amplitude and saccade mean peak velocity measured automatically. Gain misclassified 13.1% of the patients as false positive or false negative, manual cumulative saccade amplitude and saccade mean peak velocity 22.3%, and automated cumulative saccade amplitude and saccade mean peak velocity 28.9% respectively. Conclusions: We found a better accuracy of video head impulse test for the diagnosis of vestibular strokes when using the vestibulo-ocular reflex gain than using saccade metrics. Nevertheless, saccades provide an additional and important information for video head impulse test evaluation. The automated saccade detection algorithm is not yet perfect compared to expert analysis, but it may become a valuable tool for future non-expert video head impulse test evaluations. KW - Head impulse test saccades KW - vestibular stroke KW - saccades Y1 - 2024 U6 - https://doi.org/10.3233/VES-230083 SN - 1878-6464 VL - 34 IS - 1 SP - 49 EP - 61 ER - TY - GEN A1 - Lehnen, Nadine A1 - Ramaioli, Cecilia A1 - Todd, Nicholas Sean A1 - Bartl, Klaus A1 - Kohlbecher, Stefan A1 - Jahn, Klaus A1 - Schneider, Erich T1 - Clinical and video head impulses: a simple bedside test in children T2 - Journal of Neurology KW - Head Velocity KW - Head Impulse KW - Head Impulse Testing KW - Rotational Chair KW - Vestibular Function Test Y1 - 2017 U6 - https://doi.org/10.1007/s00415-017-8450-y SN - 1432-1459 VL - 264 IS - 5 SP - 1002 EP - 1004 ER - TY - GEN A1 - Nanning, Felix A1 - Braune, Katharina A1 - Uttner, Ingo A1 - Ludolph, Albert Christian A1 - Gorges, Martin A1 - Lulé, Dorothée T1 - Altered Gaze Control During Emotional Face Exploration in Patients With Amyotrophic Lateral Sclerosis T2 - Neurology N2 - Objectives Up to 50% of patients with amyotrophic lateral sclerosis (ALS) present with cognitive problems and behavioral dysfunctions including recognition of human faces presenting different emotions. We investigated whether impaired processing of emotional faces is associated with abnormal scan paths during visual exploration. Methods Cognitively unimpaired patients with ALS (n = 45) and matched healthy controls (n = 37) underwent neuropsychological assessment and video-based eye tracking. Eye movements were recorded while participants visually explored faces expressing different emotions (neutral, disgusted, happy, fearful, and sad) and houses mimicking faces. Results Compared with controls, patients with ALS fixated significantly longer to regions which are not relevant for emotional information when faces expressed fear (p = 0.007) and disgust (p = 0.006), whereas the eyes received less attention in faces expressing disgust (p = 0.041). Fixation duration in any area of interest was not significantly associated with the cognitive state or clinical symptoms of disease severity. Discussion In cognitively unimpaired patients with ALS, altered gaze patterns while visually exploring faces expressing different emotions might derive from impaired top-down attentional control with possible involvement of subliminal frontotemporal areas. This may account for indistinctness in emotion recognition reported in previous studies because nonsalient features retrieve more attention compared with salient areas. Current findings may indicate distinct emotion processing dysfunction of ALS pathology, which may be different from, for example, executive dysfunction. KW - Amyotrophic lateral sclerosis KW - Clinical Neurology KW - Clinical neurology examination KW - Neuro-ophthalmology KW - Neuromuscular Disease KW - Visual processing Y1 - 2023 U6 - https://doi.org/10.1212/WNL.0000000000207214 SN - 0028-3878 VL - 101 IS - 6 SP - 264 EP - 269 ER - TY - GEN A1 - Lehnen, Nadine A1 - Schneider, Erich A1 - Jahn, Klaus T1 - Do neurologists need the head impulse test? T1 - Braucht der Neurologe den Kopfimpulstest? T2 - Nervenarzt Y1 - 2013 U6 - https://doi.org/10.1007/s00115-013-3822-8 SN - 0028-2804 SN - 1433-0407 VL - 84 IS - 8 SP - 973 EP - 974 ER - TY - PAT A1 - Brandt, Thomas A1 - Glasauer, Stefan A1 - Schneider, Erich T1 - Aufnahmevorrichtung für die kopfgestützte Bilderfassung und Verfahren zur Steuerung der Aufnahmevorrichtung Y1 - 2004 UR - http://google.com/patents/DE10251933A1?cl=no. ER - TY - GEN A1 - Jahn, Klaus A1 - Schneider, Erich T1 - Untersuchung der vestibulären Funktion bei Schwindelpatienten T2 - Nervenheilkunde Y1 - 2012 SN - 0722-1541 VL - 31 IS - 5 SP - 370 EP - 377 ER - TY - GEN A1 - Feil, Katharina A1 - Claassen, Jens A1 - Brandins, Stanislavs A1 - Teufel, Julian A1 - Krafczyk, Siegbert A1 - Schneider, Erich T1 - Effect of chlorzoxazone in patients with downbeat nystagmus: a pilot trial T2 - Neurology Y1 - 2013 U6 - https://doi.org/10.1212/WNL.0b013e3182a55f6d SN - 0028-3878 SN - 1526-632X VL - 81 IS - 13 SP - 1152 EP - 1158 ER - TY - GEN A1 - Kalla, Roger A1 - Spiegel, Rainer A1 - Claassen, Jens A1 - Bardins, Stanislav A1 - Hahn, Ales A1 - Schneider, Erich A1 - Lehrer, Nicole A1 - Glasauer, Stefan A1 - Brandt, Thomas A1 - Strupp, Michael T1 - Comparison of 10-mg doses of 4-aminopyridine and 3,4-diaminopyridine for the treatment of downbeat nystagmus T2 - Journal of neuro-ophthalmology Y1 - 2011 U6 - https://doi.org/10.1097/WNO.0b013e3182258086 SN - 1536-5166 SN - 1070-8022 VL - 32 IS - 2 SP - 320 EP - 325 ER - TY - GEN A1 - Schulz, Christian M. A1 - Schneider, Erich A1 - Fritz, L. A1 - Vockeroth, Johannes A1 - Hapfelmeier, Alexander A1 - Wasmaier, M. T1 - Eye tracking for assessment of workload: a pilot study in an anaesthesia simulator environment T2 - British journal of anaesthesia Y1 - 2011 U6 - https://doi.org/10.1093/bja/aeq307 SN - 1471-6771 SN - 0007-0912 VL - 106 IS - 1 SP - 44 EP - 50 ER - TY - GEN A1 - Schulz, Christian M. A1 - Schneider, Erich A1 - Fritz, L. A1 - Vockeroth, Johannes A1 - Hapfelmeier, Alexander A1 - Brandt, Thomas T1 - Visual attention of anaesthetists during simulated critical incidents T2 - British Journal of Anaesthesia Y1 - 2011 U6 - https://doi.org/10.1093/bja/aer087 SN - 1471-6771 SN - 0007-0912 VL - 106 IS - 6 SP - 807 EP - 813 ER - TY - GEN A1 - Morrison, Miranda A1 - Kerkeni, Hassen A1 - Korda, Athanasia A1 - Räss, Simone A1 - Caversaccio, Marco Domenico A1 - Abegg, Mathias A1 - Schneider, Erich A1 - Mantokoudis, Georgios T1 - Automated alternate cover test for 'HINTS' assessment: a validation study T2 - European archives of oto-rhino-laryngology and head & neck N2 - Objective The alternate cover test (ACT) in patients with acute vestibular syndrome is part of the ‘HINTS’ battery test. Although quantitative, the ACT is highly dependent on the examiner’s experience and could theoretically vary greatly between examiners. In this study, we sought to validate an automated video-oculography (VOG) system based on eye tracking and dedicated glasses. Methods We artificially induced a vertical strabismus to simulate a skew deviation on ten healthy subjects, aged from 26 to 66, using different press-on Fresnel prisms on one eye while recording eye position with VOG of the contralateral eye. We then compared the system’s performance to that of a blinded trained orthoptist using conventional, semi-quantitative method of skew measurement known as the alternate prism cover test (APCT) as a gold standard. Results We found a significant correlation between the reference APCT and the Skew VOG (Pearson’s R2 = 0.606, p < 0.05). There was a good agreement between the two tests (intraclass correlation coefficient 0.852, 95 CI 0.728–0.917, p < 0.001). The overall accuracy of the VOG was estimated at 80.53% with an error rate of 19.46%. There was no significant difference in VOG skew estimations compared with the gold standard except for very small skews. Conclusions VOG offers an objective and quantitative skew measurement and proved to be accurate in measuring vertical eye misalignment compared to the ACT with prisms. Precision was moderate, which mandates a sufficient number of tests per subject. KW - Skew deviation KW - Validation KW - Test of skew KW - Alternate cover test KW - Video-oculography Y1 - 2022 U6 - https://doi.org/10.1007/s00405-021-06998-w SN - 1434-4726 SP - 2873 EP - 2879 ER - TY - GEN A1 - Kugler, Günter A1 - Huppert, Doreen A1 - Schneider, Erich A1 - Brandt, Thomas T1 - Wie Höhenschwindel die visuelle Exploration und den Gang beeinträchtigt T1 - How acrophobia impairs visual exploration and gait T2 - Nervenarzt Y1 - 2013 U6 - https://doi.org/10.1007/s00115-013-3905-6 SN - 0028-2804 SN - 1433-0407 VL - 84 IS - 10 SP - 1233 EP - 1237 ER - TY - GEN A1 - Lehnen, Nadine A1 - Schneider, Erich A1 - Jahn, Klaus T1 - Klinische Untersuchungen bei Schwindel: Kopfimpulstest und dynamische Sehschärfe T2 - Neurotransmitter Y1 - 2013 SN - 2196-6397 SN - 1436-123X VL - 24 IS - 4 SP - 39 EP - 43 ER - TY - GEN A1 - Teufel, Julian A1 - Bardins, Stanislav A1 - Spiegel, Rainer A1 - Kremmyda, O. A1 - Schneider, Erich A1 - Strupp, Michael A1 - Kalla, R. T1 - Real time computerbased visual feedback improves visual acuity in downbeat nystagmus, a pilot study T2 - Journal of NeuroEngineering and Rehabilitation Y1 - 2016 SN - 1743-0003 VL - 13 IS - 1 ER - TY - GEN A1 - Guinand, Nils A1 - Van de Berg, Raymond A1 - Cavuscens, Samuel A1 - Ranieri, Maurizio A1 - Schneider, Erich A1 - Lucieer, Floor A1 - Kingma, Hermann A1 - Guyot, Jean-Philippe A1 - Perez Fornos, Angelica T1 - The Video Head Impulse Test to Assess the Efficacy of Vestibular Implants in Humans T2 - Frontiers in neurology Y1 - 2017 U6 - https://doi.org/10.3389/fneur.2017.00600 SN - 1664-2295 VL - 8 SP - 13 ER - TY - GEN A1 - Luis, L. A1 - Costa, João A1 - Muñoz, E. A1 - Carvalho, M. de A1 - Carmona, S. A1 - Schneider, Erich T1 - Vestibulo-ocular reflex dynamics with head-impulses discriminates spinocerebellar ataxias types 1, 2 and 3 and Friedreich ataxia. T2 - Journal of Vestibular Research Y1 - 2016 U6 - https://doi.org/10.3233/VES-160579 SN - 0957-4271 SN - 1878-6464 VL - 26 IS - 3 SP - 327 EP - 334 ER - TY - GEN A1 - Keller, Jürgen A1 - Gorges, Martin A1 - Aho-Özhan, Helena Eira Anneli A1 - Carmona, S. A1 - Schneider, Erich T1 - Eye-tracking control to assess cognitive functions in patients with amyotrophic lateral sclerosis T2 - JoVE Y1 - 2016 U6 - https://doi.org/10.3791/54634 SN - 1940-087X VL - 116 SP - e54634 ER - TY - GEN A1 - Luis, L. A1 - Lehnen, Nadine A1 - Muñoz, E. A1 - Carvalho, M. de A1 - Schneider, Erich T1 - Anticompensatory quick eye movements after head impulses: A peripheral vestibular sign in spontaneous nystagmus T2 - Journal of Vestibular Research Y1 - 2016 U6 - https://doi.org/10.3233/VES-160566 SN - 0957-4271 SN - 1878-6464 VL - 25 IS - 5-6 SP - 267 EP - 271 ER - TY - GEN A1 - Mossman, Benjamin A1 - Mossman, Stuart A1 - Purdie, Gordon A1 - Schneider, Erich T1 - Age dependent normal horizontal vor gain of head impulse test as measured with video-oculography T2 - Journal of Otolaryngology - Head & Neck Surgery Y1 - 2015 U6 - https://doi.org/10.1186/s40463-015-0081-7 SN - 1916-0216 VL - 44 SP - 29 ER - TY - GEN A1 - Spiegel, Rainer A1 - Kalla, R. A1 - Rettinger, N. A1 - Schneider, Erich A1 - Straumann, D. A1 - Marti, S. A1 - Glasauer, Stefan T1 - Head position during resting modifies spontaneous daytime decrease of downbeat nystagmus T2 - Neurology Y1 - 2010 U6 - https://doi.org/10.1212/WNL.0b013e3181feb22f SN - 0028-3878 SN - 1526-632X VL - 75 IS - 21 SP - 1928 EP - 1932 ER - TY - GEN A1 - Wright, W. Geoffrey A1 - Schneider, Erich A1 - Glasauer, Stefan T1 - Compensatory manual motor responses while object wielding during combined linear visual and physical roll tilt stimulation T2 - Experimental Brain Research Y1 - 2009 U6 - https://doi.org/10.1007/s00221-008-1581-8 SN - 0014-4819 SN - 1432-1106 VL - 192 IS - 4 SP - 683 EP - 694 ER - TY - GEN A1 - Guenther, Anna L. A1 - Bartl, Klaus A1 - Nauderer, Josef A1 - Schneider, Erich A1 - Huesmann, Alexander A1 - Brandt, Thomas A1 - Glasauer, Stefan T1 - Modalitydependent indication of the subjective vertical during combined linear and rotational movements T2 - Annals of the New York Academy of Sciences Y1 - 2009 U6 - https://doi.org/10.1111/j.1749-6632.2009.03849.x SN - 1749-6632 VL - 1164 SP - 376 EP - 379 ER - TY - GEN A1 - Einhäuser, Wolfgang A1 - Schumann, Frank A1 - Vockeroth, Johannes A1 - Bartl, Klaus A1 - Cerf, Moran A1 - Harel, Jonathan A1 - Schneider, Erich A1 - König, Peter T1 - Distinct roles for eye and head movements in selecting salient image parts during natural exploration T2 - Annals of the New York Academy of Sciences Y1 - 2009 U6 - https://doi.org/10.1111/j.1749-6632.2008.03714.x SN - 1749-6632 VL - 1164 SP - 188 EP - 193 ER - TY - GEN A1 - Glasauer, Stefan A1 - Schneider, Erich A1 - Grasso, Renato A1 - Ivanenko, Yuri P. T1 - Space-time relativity in self-motion reproduction T2 - Journal of Neurophysiology Y1 - 2007 U6 - https://doi.org/10.1152/jn.01243.2005 SN - 0022-3077 SN - 1522-1598 VL - 97 IS - 1 SP - 451 EP - 461 ER - TY - GEN A1 - Einhäuser, Wolfgang A1 - Schumann, Frank A1 - Bardins, Stanislav A1 - Bartl, Klaus A1 - Böning, Guido A1 - Schneider, Erich A1 - König, Peter T1 - Human eyehead co-ordination in natural exploration T2 - Network Y1 - 2007 U6 - https://doi.org/10.1080/09548980701671094 SN - 0954-898X SN - 1361-6536 VL - 18 IS - 3 SP - 267 EP - 297 ER - TY - GEN A1 - Zingler, Vera C. A1 - Kryvoshey, Dmytro A1 - Schneider, Erich A1 - Glasauer, Stefan A1 - Brandt, Thomas A1 - Strupp, Michael T1 - A clinical test of otolith function: static ocular counterroll with passive head tilt. T2 - Neuroreport Y1 - 2006 SN - 0959-4965 VL - 17 IS - 6 SP - 611 EP - 615 ER - TY - GEN A1 - Nowak, Dennis A. A1 - Hermsdörfer, Joachim A1 - Schneider, Erich A1 - Glasauer, Stefan T1 - Moving objects in a rotating environment rapid prediction of coriolis and centrifugal force perturbations T2 - Experimental Brain Research Y1 - 2004 U6 - https://doi.org/10.1007/s00221-004-1839-8 SN - 0014-4819 SN - 1432-1106 VL - 157 IS - 2 SP - 241 EP - 254 ER - TY - GEN A1 - Schneider, Erich A1 - Glasauer, Stefan A1 - Dieterich, Marianne A1 - Kalla, Roger A1 - Brandt, Thomas T1 - Diagnosis of vestibular imbalance in the blink of an eye T2 - Neurology Y1 - 2004 SN - 0028-3878 SN - 1526-632X VL - 63 IS - 7 SP - 1209 EP - 1216 ER - TY - GEN A1 - Hayashi, Yujiro A1 - Kanzaki, Jin A1 - Etho, Norihito A1 - Higashino, Kazutaka A1 - Goto, Fumiyuki A1 - Schneider, Erich A1 - Kunihiro, Takanobu T1 - Three-dimensional analysis of nystagmus in benign paroxysmal positional vertigo. new insights into its pathophysiology T2 - Journal of Neurology Y1 - 2002 U6 - https://doi.org/10.1007/s00415-002-0905-z SN - 0340-5354 SN - 1432-1459 VL - 249 IS - 12 SP - 1683 EP - 1688 ER - TY - GEN A1 - Schneider, Erich A1 - Glasauer, Stefan A1 - Dieterich, Marianne T1 - Comparison of human ocular torsion patterns during natural and galvanic vestibular stimulation T2 - Journal of Neurophysiology Y1 - 2002 U6 - https://doi.org/10.1152/jn.00558.2001 SN - 0022-3077 SN - 1522-1598 VL - 87 IS - 4 SP - 2064 EP - 2073 ER - TY - GEN A1 - Ramaioli, Cecilia A1 - Steinmetzer, Tobias A1 - Brietzke, Adrian A1 - Meyer, Paul A1 - Pham Xuan, Rebecca A1 - Schneider, Erich A1 - Gorges, Martin T1 - Assessment of vestibulo-ocular reflex and its adaptation during stop-and-go car rides in motion sickness susceptible passengers T2 - Experimental Brain Research N2 - Motion sickness is a physiological condition that negatively impacts a person's comfort and will be an emerging condition in autonomous vehicles without proper countermeasures. The vestibular system plays a key role in the origin of motion sickness. Understanding the susceptibility and (mal) adaptive mechanisms of the highly integrated vestibular system is a prerequisite for the development of countermeasures. We hypothesize a differential association between motion sickness and vestibular function in healthy individuals with and without susceptibility for motion sickness. We quantified vestibular function by measuring the high-frequency vestibulo-ocular reflex (VOR) using video head impulse testing (vHIT) in 17 healthy volunteers before and after a 11 min motion sickness-inducing naturalistic stop-and-go car ride on a test track (Dekra Test Oval, Klettwitz, Germany). The cohort was classified as motion sickness susceptible (n = 11) and non-susceptible (n = 6). Six (out of 11) susceptible participants developed nausea symptoms, while a total of nine participants were free of these symptoms. The VOR gain (1) did not differ significantly between participant groups with (n = 8) and without motion sickness symptoms (n = 9), (2) did not differ significantly in the factor time before and after the car ride, and showed no interaction between symptom groups and time, as indicated by a repeated measures ANOVA (F(1,15) = 2.19, p = 0.16. Bayesian inference confirmed that there was “anecdotal evidence” for equality of gain rather than difference across groups and time (BF10 < 0.77). Our results suggest that individual differences in VOR measures or adaptation to motion sickness provocative stimuli during naturalistic stop-and-go driving cannot predict motion sickness susceptibility or the likelihood of developing motion sickness. KW - Video head impulse test KW - Vestibulo-ocular reflex KW - Adaptation KW - Motion sickness KW - Stop-and-go car ride Y1 - 2023 U6 - https://doi.org/10.1007/s00221-023-06619-4 SN - 1432-1106 SN - 0014-4819 VL - 241 IS - 6 SP - 1523 EP - 1531 ER - TY - GEN A1 - Charissé, Daniel A1 - Erus, Guray A1 - Pomponio, Raymond A1 - Gorges, Martin A1 - Schmidt, Nele A1 - Schneider, Christine A1 - Liepelt-Scarfone, Inga A1 - Riedel, Oliver A1 - Reetz, Kathrin A1 - Schulz, Jörg B. A1 - Berg, Daniela A1 - Storch, Alexander A1 - Witt, Karsten A1 - Dodel, Richard A1 - Kalbe, Elke A1 - Kassubek, Jan A1 - Hilker-Roggendorf, Rüdiger A1 - Baudrexel, Simon T1 - Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease T2 - Neurobiology of Aging N2 - Recently, it was shown that patients with Parkinson's disease (PD) who exhibit an “Alzheimer's disease (AD)-like” pattern of brain atrophy are at greater risk for future cognitive decline. This study aimed to investigate whether this association is domain-specific and whether atrophy associated with brain aging also relates to cognitive impairment in PD. SPARE-AD, an MRI index capturing AD-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort. All patients underwent an extensive neuropsychological test battery. Patients diagnosed with mild cognitive impairment or dementia were found to have higher SPARE-AD scores as compared to patients with normal cognition and healthy controls. All patient groups showed increased brain age. SPARE-AD predicted impairment in memory, language and executive functions, whereas advanced brain age was associated with deficits in attention and working memory. Data suggest that SPARE-AD and brain age are differentially related to domain-specific cognitive decline in PD. The underlying pathomechanisms remain to be determined. KW - Alzheimer's disease KW - Brain Age KW - MRI KW - Parkinson's disease KW - Pattern classification Y1 - 2022 UR - https://www.sciencedirect.com/science/article/pii/S0197458021002748?via%3Dihub U6 - https://doi.org/10.1016/j.neurobiolaging.2021.08.020 SN - 0197-4580 VL - 109 SP - 31 EP - 42 ER -