TY - GEN A1 - Salmasi, Mehrdad A1 - Glasauer, Stefan A1 - Stemmler, Martin T1 - Neurotransmitter spillover redresses the information loss caused by synaptic depression T2 - Lisboa 2019, Conference Lisbon, Portugal, 28 feb - 3 mar Y1 - 2019 UR - http://cosyne.org/cosyne19/Cosyne2019_program_book.pdf SP - 154 ER - TY - GEN A1 - Kostorz, Kathrin A1 - Flanagin, Virginia A1 - Glasauer, Stefan T1 - Instructor-observer synchronization of BOLD activity mediated by instructive origami videos T2 - Neuroscience 2018 Y1 - 2018 UR - https://www.abstractsonline.com/pp8/#!/4649/presentation/5751 ER - TY - GEN A1 - Glasauer, Stefan A1 - Shi, Z. T1 - 150 years of Vierordt’s law: The role of experimental protocol T2 - CA: Society for Neuroscience, 2018 Y1 - 2018 UR - https://www.abstractsonline.com/pp8/#!/4649/presentation/4957 UR - https://www.sfn.org/-/media/SfN/Documents/NEW-SfN/Meetings/Neuroscience-2018/Abstracts/Neuroscience-2018-Abstracts/SFN18_Abstract-PDFs---Theme-J.pdf CY - San Diego ER - TY - GEN A1 - Costalago Meruelo, Alicia A1 - Fleuriet, Jérome A1 - Bakst, Leah A1 - Mustari, Michael J. A1 - Glasauer, Stefan T1 - Modeling and Prediction of Sinusoidal Smooth Pursuit using Artificial Neural Networks T2 - 40th Annual International Conference of the IEEE, Engineering in Medicine and Biology Society, 2018 Y1 - 2018 UR - http://embc.embs.org/2018/wp-content/uploads/sites/35/2018/08/99118-EMBC-Final-Program.pdf UR - https://embs.papercept.net/conferences/conferences/EMBC18/program/EMBC18_ContentListWeb_3.html#thpos-23_09 PB - IEEE EMBC Hawaii ER - TY - GEN A1 - Glasauer, Stefan T1 - Sensorimotor control of smooth pursuit T2 - Neuroscience 2018 Home N2 - Interaction with the visual world critically depends on when and how we move our eyes. Eye movements, in turn, alter our experience of the world by selecting objects to foveate and tracking objects over time. The interaction between vision and eye movements continues indefinitely, one process modulating the strength and timing of the other. Despite this tight linkage, vision is often studied outside the context of eye movements, during stable fixation. Likewise, eye movements are often studied with sparse visual stimuli and under ideal viewing conditions. A more accurate understanding of vision requires studying perception in the context of eye movements. Different types of eye movements reveal different aspects of how the brain works. The continuous nature of tracking smooth pursuit eye movements, combined with its ubiquitous presence in natural vision, makes it an excellent system in which to analyze perception at fine spatial and temporal resolutions. For example, how does vision change during the transition from fixation to pursuit, and when does the brain allocate resources to account for these changes? In contrast, the ballistic nature of saccades requires analysis divided into discrete epochs, including well before the saccade during the planning stage, during saccade execution, and after the movement. At the neuronal level, how do heterogeneous populations of visual- and saccade-related cells come to represent a single saccade vector during these different epochs? What are the effects on visual perception when saccades and pursuit interact? This symposium will reveal how research incorporating both types of eye movements and visual perception can provide a more ecologically valid account of visual-motor integration and the intervening cognitive processes. This symposium will review innovative approaches and recent advances in understanding the interplay of eye movements and vision. We will take a multifaceted approach to understanding the effects of both exploratory (saccades) and tracking (smooth pursuit) eye movements on vision by using a range of methodologies and animal models (data-driven modeling, clinical populations, and simultaneous recordings of neuronal populations; humans, macaques, and marmosets). This symposium will appeal to vision scientists interested in selective attention, motion processing, neuronal modeling, motor control, neural circuits, and related topics. Our collective goal is to uncover the dynamics of visual perception and the candidate neuronal mechanisms that support eye movements. Y1 - 2018 UR - https://www.abstractsonline.com/pp8/#!/4649/presentation/40985 ER - TY - GEN A1 - Kutzner, Tobias A1 - Kostova, Eleonora A1 - Bothe, Jacqueline A1 - Freytag, Andreas T1 - Portal for generating cross university didactic self-assessment apps without programming skills T2 - VIII Jornadas Iberoamericanas de Innovación Educativa en el Ámbito de las TIC y las TAC (InnoEducaTIC 2021) N2 - Based on the didactic concept of a school mathematics app, a portal for the automatic creation of interdisciplinary learning apps without programming knowledge is being developed at the Brandenburg University of Technology Cottbus – Senftenberg (BTU). The aim was to develop the conception and implementation of a portal for the creation of universal learning apps as a mobile (online) assessment for the study entry phase on the one hand and the publication of the apps on the other. This article presents the basic concept of the app portal, the structure of the app portal, and initial tests of the prototype with faculty and students at BTU. KW - Mobile-assessment KW - Educational technology KW - Distant learning KW - Html5 app development Y1 - 2021 UR - https://accedacris.ulpgc.es/handle/10553/11321717 SN - 978-84-09-35708-6 SP - 149 EP - 156 ER - TY - GEN A1 - Kutzner, Tobias A1 - Nesterow, Igor A1 - Freytag, Andreas T1 - New Moodle plugin for IMS Question and Test Interoperability specification (QTI) T2 - VIII Jornadas Iberoamericanas de Innovación Educativa en el Ámbito de las TIC y las TAC, Las Palmas de Gran Canaria, 18 y 19 de noviembre de 20 N2 - In the ESF project "StudiPortal Brandenburg", eight Brandenburg universities, colleges and the Brandenburg Study Orientation Network are working together on the development of a portal for study orientation, preparation and support. An important part of the project is to store questions from different systems in a question exchange database and make it accessible for all project partners. Since there is currently no well-functioning option for this, we decided to develop an extension for integration into our question exchange platform. For this purpose, a new Moodle plugin was developed at BTU Cottbus - Senftenberg that converts questions from the QTI 2.1 standard into Moodle XML and vice versa. The aim was to convert as many question types as possible free of loss. For this purpose, questions from various systems that work with the QTI standard were made available and tested for the possibility of lossless conversion. The result is the prototype of a plugin that can convert eight different question types. In this article we present the first prototype of the plugin. KW - Question Exchange KW - Online Self-Assessment Tools KW - IMS QTI transformation KW - Moodle Plugin KW - Interface Y1 - 2021 UR - https://accedacris.ulpgc.es/bitstream/10553/113223/1/New_moodle_plugin.pdf SN - 978-84-09-35708-6 ER - TY - GEN A1 - Andreessen, Lena M. A1 - Gerjets, Peter A1 - Meurers, Detmar A1 - Zander, Thorsten O. T1 - Toward neuroadaptive support technologies for improving digital reading: a passive BCI-based assessment of mental workload imposed by text difficulty and presentation speed during reading T2 - User Modeling and User-Adapted Interaction N2 - We investigated whether a passive brain–computer interface that was trained to distinguish low and high mental workload in the electroencephalogram (EEG) can be used to identify (1) texts of different readability difficulties and (2) texts read at different presentation speeds. For twelve subjects we calibrated a subject-dependent, but task-independent predictive model classifying mental workload. We then recorded EEG data from each subject, while twelve texts in blocks of three were presented to them word by word. Half of the texts were easy, and the other half were difficult texts according to classic reading formulas. From each text category three texts were read at a self-adjusted comfortable presentation speed and the other three at an increased speed. For each subject we applied the predictive model to EEG data of each word of the twelve texts. We found that the resulting predictive values for mental workload were higher for difficult texts than for easy texts. Predictive values from texts presented at an increased speed were also higher than for those presented at a normal self-adjusted speed. The results suggest that the task-independent predictive model can be used on single-subject level to build a highly predictive user model of the reader over time. Such a model could be employed in a system which continuously monitors brain activity related to mental workload and adapts to specific reader’s abilities and characteristics by adjusting the difficulty of text materials and the way it is presented to the reader in real time. A neuroadaptive system like this could foster efficient reading and text-based learning by keeping readers’ mental workload levels at an individually optimal level. KW - Computer Science Applications KW - Human-Computer Interaction KW - Education Y1 - 2020 U6 - https://doi.org/10.1007/s11257-020-09273-5 SN - 0924-1868 VL - 31 IS - 1 SP - 75 EP - 104 ER - TY - GEN A1 - Korda, Athanasia A1 - Zamaro, Ewa A1 - Wagner, Franca A1 - Morrison, Miranda A1 - Schneider, Erich A1 - Caversaccio, Marco Domenico A1 - Sauter, Thomas C. A1 - Mantokoudis, Georgios T1 - Acute vestibular syndrome: is skew deviation a central sign? T2 - Journal of Neurology N2 - Objective Skew deviation results from a dysfunction of the graviceptive pathways in patients with an acute vestibular syndrome (AVS) leading to vertical diplopia due to vertical ocular misalignment. It is considered as a central sign, however, the prevalence of skew and the accuracy of its test is not well known . Methods We performed a prospective study from February 2015 until September 2020 of all patients presenting at our emergency department (ED) with signs of AVS. All patients underwent clinical HINTS and video test of skew (vTS) followed by a delayed MRI, which served as a gold standard for vestibular stroke confirmation. Results We assessed 58 healthy subjects, 53 acute unilateral vestibulopathy patients (AUVP) and 24 stroke patients. Skew deviation prevalence was 24% in AUVP and 29% in strokes. For a positive clinical test of skew, the cut-off of vertical misalignment was 3 deg with a very low sensitivity of 15% and specificity of 98.2%. The sensitivity of vTS was 29.2% with a specificity of 75.5%. Conclusions Contrary to prior knowledge, skew deviation proved to be more prevalent in patients with AVS and occurred in every forth patient with AUVP. Large skew deviations (> 3.3 deg), were pointing toward a central lesion. Clinical and video test of skew offered little additional diagnostic value compared to other diagnostic tests such as the head impulse test and nystagmus test. Video test of skew could aid to quantify skew in the ED setting in which neurotological expertise is not always readily available. KW - Acute stroke KW - Acute unilateral vestibulopathy KW - Test of skew KW - VOG KW - Vertigo KW - Video-oculography Y1 - 2021 U6 - https://doi.org/10.1007/s00415-021-10692-6 SN - 1432-1459 SN - 0340-5354 VL - 269 IS - 3 SP - 1396 EP - 1403 ER - TY - GEN A1 - Spiegel, Rainer A1 - Claassen, Jens A1 - Teufel, Julian A1 - Bardins, Stanislav A1 - Schneider, Erich A1 - Lehrer, Nicole A1 - Jahn, Klaus A1 - Anciaes da Silva, Fábio A1 - Hahn, Ales A1 - Farahmand, Parvis A1 - Brandt, Thomas A1 - Strupp, Michael A1 - Kalla, Roger T1 - Resting in darkness improves downbeat nystagmus: evidence from an observational study T2 - Annals of the New York Academy of Sciences N2 - Resting in an upright position during daytime decreases downbeat nystagmus (DBN). When measured in brightness only, that is, without intermitting exposure to darkness, it does not make a significant difference whether patients have previously rested in brightness or in darkness. In real-world scenarios, people are often exposed to brightness and darkness intermittently. The aim of this study was to analyze whether resting in brightness or resting in darkness was associated with a lower post-resting DBN after intermitting exposures to brightness and darkness. Eight patients were recorded with three-dimensional video-oculography in brightness and darkness conditions, each following two 2-h resting intervals under either brightness or darkness resting conditions. The dependent variable was DBN intensity, measured in mean slow phase velocity. A repeated measures ANOVA with the factors measurement condition (brightness vs. darkness), resting condition (brightness vs. darkness), and time (after first vs. second resting interval) showed a significant effect for the factor resting condition, where previous resting in darkness was associated with a significantly lower DBN relative to previous resting in brightness (P < 0.01). The clinical relevance is to advise patients with DBN to rest in darkness. KW - downbeat nystagmus KW - symptom relief KW - resting KW - oscillopsia KW - video-oculographic measurement (VOG) Y1 - 2016 U6 - https://doi.org/10.1111/nyas.13172 SN - 1749-6632 SN - 0077-8923 VL - 1375 IS - 1 SP - 66 EP - 73 ER - TY - GEN A1 - Striteska, Maja A1 - Chovanec, Martin A1 - Steinmetzer, Tobias A1 - Chrobok, Viktor A1 - Profant, Oliver A1 - Schneider, Erich A1 - Kremlacek, Jan A1 - Valis, Martin T1 - Binocular video head impulse test: Normative data study T2 - Frontiers in Neurology N2 - Introduction The video head impulse test (vHIT) evaluates the vestibulo-ocular reflex (VOR). It’s usually recorded from only one eye. Newer vHIT devices allow a binocular quantification of the VOR. Purpose (Aim) To investigate the advantages of simultaneously recorded binocular vHIT (bvHIT) to detect the differences between the VOR gains of the adducting and the abducting eye, to define the most precise VOR measure, and to assess gaze dys/conjugacy. We aimed to establish normative values for bvHIT adducting/abducting eye VOR gains and to introduce the VOR dysconjugacy ratio (vorDR) between adducting and abducting eyes for bvHIT. Methods We enrolled 44 healthy adult participants in a cross-sectional, prospective study using a repeated-measures design to assess test–retest reliability. A binocular EyeSeeCam Sci 2 device was used to simultaneously record bvHIT from both eyes during impulsive head stimulation in the horizontal plane. Results Pooled bvHIT retest gains of the adducting eye significantly exceeded those of the abducting eye (mean (SD): 1.08 (SD = 0.06), 0.95 (SD = 0.06), respectively). Both adduction and abduction gains showed similar variability, suggesting comparable precision and therefore equal suitability for VOR asymmetry assessment. The pooled vorDR here introduced to bvHIT was 1.13 (SD = 0.05). The test–retest repeatability coefficient was 0.06. Conclusion Our study provides normative values reflecting the conjugacy of eye movement responses to horizontal bvHIT in healthy participants. The results were similar to a previous study using the gold-standard scleral search coil, which also reported greater VOR gains in the adducting than in the abducting eye. In analogy to the analysis of saccade conjugacy, we propose the use of a novel bvHIT dysconjugacy ratio to assess dys/conjugacy of VOR-induced eye movements. In addition, to accurately assess VOR asymmetry, and to avoid directional gain preponderance between adduction and abduction VOR-induced eye movements leading to monocular vHIT bias, we recommend using a binocular ductional VOR asymmetry index that compares the VOR gains of only the abduction or only the adduction movements of both eyes. KW - binocular video head impulse test KW - conjugate gaze KW - adduction KW - abduction KW - ductional VOR asymmetry index KW - dysconjugacy ratio KW - monocular VOR asymmetry index KW - vestibuloocular reflex Y1 - 2023 U6 - https://doi.org/10.3389/fneur.2023.1153102 SN - 1664-2295 VL - 14 ER - TY - GEN A1 - Friedrich, Maximilian U. A1 - Schneider, Erich A1 - Buerklein, Miriam A1 - Taeger, Johannes A1 - Hartig, Johannes A1 - Volkmann, Jens A1 - Peach, Robert A1 - Zeller, Daniel T1 - Smartphone video nystagmography using convolutional neural networks: ConVNG T2 - Journal of Neurology N2 - Eye movement abnormalities are commonplace in neurological disorders. However, unaided eye movement assessments lack granularity. Although videooculography (VOG) improves diagnostic accuracy, resource intensiveness precludes its broad use. To bridge this care gap, we here validate a framework for smartphone video-based nystagmography capitalizing on recent computer vision advances. Methods A convolutional neural network was fine-tuned for pupil tracking using > 550 annotated frames: ConVNG. In a cross-sectional approach, slow-phase velocity of optokinetic nystagmus was calculated in 10 subjects using ConVNG and VOG. Equivalence of accuracy and precision was assessed using the “two one-sample t-test” (TOST) and Bayesian interval-null approaches. ConVNG was systematically compared to OpenFace and MediaPipe as computer vision (CV) benchmarks for gaze estimation. Results ConVNG tracking accuracy reached 9–15% of an average pupil diameter. In a fully independent clinical video dataset, ConVNG robustly detected pupil keypoints (median prediction confidence 0.85). SPV measurement accuracy was equivalent to VOG (TOST p < 0.017; Bayes factors (BF) > 24). ConVNG, but not MediaPipe, achieved equivalence to VOG in all SPV calculations. Median precision was 0.30°/s for ConVNG, 0.7°/s for MediaPipe and 0.12°/s for VOG. ConVNG precision was significantly higher than MediaPipe in vertical planes, but both algorithms’ precision was inferior to VOG. Conclusions ConVNG enables offline smartphone video nystagmography with an accuracy comparable to VOG and significantly higher precision than MediaPipe, a benchmark computer vision application for gaze estimation. This serves as a blueprint for highly accessible tools with potential to accelerate progress toward precise and personalized Medicine. KW - Digital medicine KW - Nystagmus KW - Eye movement disorders KW - Videooculography KW - Computer vision KW - Telemedicine KW - Precision medicine Y1 - 2022 U6 - https://doi.org/10.1007/s00415-022-11493-1 SN - 1432-1459 VL - 270 SP - 2518 EP - 2530 ER - TY - GEN A1 - Ramaioli, Cecilia A1 - Steinmetzer, Tobias A1 - Brietzke, Adrian A1 - Meyer, Paul A1 - Pham Xuan, Rebecca A1 - Schneider, Erich A1 - Gorges, Martin T1 - Assessment of vestibulo-ocular reflex and its adaptation during stop-and-go car rides in motion sickness susceptible passengers T2 - Experimental Brain Research N2 - Motion sickness is a physiological condition that negatively impacts a person's comfort and will be an emerging condition in autonomous vehicles without proper countermeasures. The vestibular system plays a key role in the origin of motion sickness. Understanding the susceptibility and (mal) adaptive mechanisms of the highly integrated vestibular system is a prerequisite for the development of countermeasures. We hypothesize a differential association between motion sickness and vestibular function in healthy individuals with and without susceptibility for motion sickness. We quantified vestibular function by measuring the high-frequency vestibulo-ocular reflex (VOR) using video head impulse testing (vHIT) in 17 healthy volunteers before and after a 11 min motion sickness-inducing naturalistic stop-and-go car ride on a test track (Dekra Test Oval, Klettwitz, Germany). The cohort was classified as motion sickness susceptible (n = 11) and non-susceptible (n = 6). Six (out of 11) susceptible participants developed nausea symptoms, while a total of nine participants were free of these symptoms. The VOR gain (1) did not differ significantly between participant groups with (n = 8) and without motion sickness symptoms (n = 9), (2) did not differ significantly in the factor time before and after the car ride, and showed no interaction between symptom groups and time, as indicated by a repeated measures ANOVA (F(1,15) = 2.19, p = 0.16. Bayesian inference confirmed that there was “anecdotal evidence” for equality of gain rather than difference across groups and time (BF10 < 0.77). Our results suggest that individual differences in VOR measures or adaptation to motion sickness provocative stimuli during naturalistic stop-and-go driving cannot predict motion sickness susceptibility or the likelihood of developing motion sickness. KW - Video head impulse test KW - Vestibulo-ocular reflex KW - Adaptation KW - Motion sickness KW - Stop-and-go car ride Y1 - 2023 U6 - https://doi.org/10.1007/s00221-023-06619-4 SN - 1432-1106 SN - 0014-4819 VL - 241 IS - 6 SP - 1523 EP - 1531 ER - TY - GEN A1 - Dong-Han, Lee A1 - Schneider, Erich A1 - Sang-Yeon, Lee A1 - Kim, Ji-Soo A1 - Koo, Ja-Won T1 - Objective measurement of HINTS (Head Impulse, Nystagmus, Test of Skew) in peripheral vestibulopathy T2 - Auris Nasus Larynx N2 - ABSTRACT Objective To evaluate how often the positive sign of HINTS (Head-Impulse, Gaze Evoked Nystagmus, Test of Skew) appears in patients with acute peripheral vestibular lesion, HINTS findings were quantitatively measured and analyzed in patients with peripheral vestibulopathy accompanying spontaneous nystagmus. Methods HINTS was evaluated in 14 vertigo patients with spontaneous nystagmus. Horizontal vestibulo-ocular reflex (VOR) gain was measured using the video head impulse test (vHIT). To evaluate gaze-evoked nystagmus (GEN), slow-phase velocities at different points of lateral gaze were measured and plotted, then the slope and its inverse value, the neural integrator time constant, were calculated. Skew deviation was tested using anaglyph filters to simulate the alternate cover test, and the degree and latency of vertical eyeball deviation were measured. The ABCD2 score was calculated to evaluate the risk of stroke. Results Among 13 patients of peripheral vestibulopathy, 7 showed positive signs in HINTS (normal vHIT: 5, direction-changing GEN: 0, skew deviation: 3). One patient with a cerebellopontine angle tumor presented with both a peripheral and central pattern and showed positive HINTS findings (presence of direction-changing GEN). The mean VOR gain of patients with abnormal vHIT was 0.58±0.29 and 1.10±0.11 in the affected and contralateral side, respectively, while those in patients with normal vHIT were 1.04±0.21 and 1.13±0.12, respectively. The neural integrator time constant calculated from the mean slope of horizontal slow-phase velocity according to horizontal eye position was 42.9 s. The mean vertical eyeball deviation of patients with positive skew was 2.14±1.18° while uncovering the eye on the affected side, and -1.97±1.59° while uncovering the eye on the unaffected side. The median ABCD2 score of 14 patients was 2 (range, 1-3). Conclusions HINTS findings were objectively measured in vertigo patients with spontaneous nystagmus. Although positive findings of HINTS have been recognized as a central sign, 54% (7/13) of cases with peripheral vestibulopathy showed positive HINTS signs. HINTS results should be interpreted carefully considering that a substantial proportion of peripheral vestibulopathy shows a positive HINTS sign. KW - Dizziness KW - Vertigo KW - Head impulse test KW - Nystagmus KW - Skew deviation Y1 - 2022 U6 - https://doi.org/10.1016/j.anl.2022.03.003 SN - 1879-1476 SN - 0385-8146 VL - 49 IS - 6 SP - 938 EP - 949 ER -