TY - GEN A1 - Heuser, Fabian A1 - Schulz, Christian A1 - Sağlam, Murat A1 - Ramaioli, Cecilia A1 - Heuberger, Maria A1 - Wagner, Klaus J. A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Brandt, Thomas A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Preventing opioid-induced nausea and vomiting: Rest your head and close your eyes? T2 - PloS one Y1 - 2017 U6 - https://doi.org/10.1371/journal.pone.0173925 SN - 1932-6203 VL - 12 IS - 3 SP - e0173925 ER - TY - GEN A1 - Chun, K. R. Julian A1 - Schmidt, Boris A1 - Kuck, Karl-Heinz A1 - Andresen, Dietrich A1 - Willems, Stefan A1 - Spitzer, Stefan G. A1 - Hoffmann, Ellen A1 - Schumacher, Burghard A1 - Eckardt, Lars A1 - Seidl, Karlheinz A1 - Jünger, Claus A1 - Horack, Martin A1 - Brachmann, Johannes A1 - Senges, Jochen T1 - Catheter ablation of atrial fibrillation in the young T2 - Clinical Research in Cardiology Y1 - 2013 U6 - https://doi.org/10.1007/s00392-013-0553-6 SN - 1861-0684 SN - 1861-0692 VL - 102 IS - 6 SP - 459 EP - 468 ER - TY - GEN A1 - Wasmer, Kristina A1 - Köbe, Julia A1 - Andresen, Dietrich A1 - Zahn, Ralf A1 - Spitzer, Stefan G. A1 - Jehle, Joachim A1 - Brachmann, Johannes A1 - Stellbrink, Christoph A1 - Martens, Eimo A1 - Hochadel, Matthias A1 - Senges, Jochen A1 - Klein, Helmut A1 - Eckhardt, Lars T1 - Comparing outcome of patients with coronary artery disease and dilated cardiomyopathy in ICD and CRT recipients: data from the German DEVICE—registry T2 - Clinical Research in Cardiology Y1 - 2013 U6 - https://doi.org/10.1007/s00392-013-0559-0 SN - 1861-0684 SN - 1861-0692 VL - 102 IS - 7 SP - 513 EP - 521 ER - TY - GEN A1 - Ghanbari, Aline Azizi A1 - Dörr, Rolf A1 - Spitzer, Stefan G. A1 - Stumpf, Jürgen A1 - Britz, Andreas A1 - Amann-Zalan, Ildiko A1 - Lodwig, Volker A1 - Ulm, Bernhard A1 - Schnell, Oliver A1 - Lohmann, Tobias T1 - Adiponectin in coronary heart disease and newly diagnosed impaired glucose tolerance T2 - Diabetes and Vascular Disease Research Y1 - 2013 U6 - https://doi.org/10.1177/1479164113490179 SN - 1752-8984 SN - 1479-1641 VL - 10 IS - 5 SP - 452 EP - 458 ER - TY - GEN A1 - Verma, Atul A1 - Debruyne, Philippe A1 - Nardi, Stefano A1 - Deneke, Thomas A1 - DeGreef, Yves A1 - Spitzer, Stefan G. A1 - Balzer, Jörn O. A1 - Börsma, Lucas T1 - Evaluation and Reduction fo Asymptomatic Cerebral Embolism in Ablation of Atrial Fibrillation, but High Prevalence of Chronic Silent Infarction T2 - Circulation: Arrhythmia and Electrophysiology Y1 - 2013 U6 - https://doi.org/10.1161/CIRCEP.113.000612 SN - 1941-3149 SN - 1941-3084 VL - 6 IS - 5 SP - 835 EP - 842 ER - TY - GEN A1 - Steinmetzer, Tobias A1 - Bönninger, Ingrid A1 - Priwitzer, Barbara A1 - Reinhardt, Fritjof A1 - Reckhardt, Markus Christoph A1 - Erk, Dorela A1 - Travieso-González, Carlos M. T1 - Clustering of Human Gait with Parkinson's Disease by Using Dynamic Time Warping T2 - IEEE International Work Conference on Bioinspired Intelligence (IWOBI) N2 - We present a new method for detecting gait disorders according to their stadium using cluster methods for sensor data. 21 healthy and 18 Parkinson subjects performed the Time Up and Go test. The time series were segmented into separate steps. For the analysis the horizontal acceleration measured by a mobile sensor system was considered. We used Dynamic Time Warping and Hierarchical Custering to distinguish the stadiums. A specificity of 92% was achieved. KW - DTW KW - clustering KW - parkinson disease KW - time series Y1 - 2018 U6 - https://doi.org/10.1109/IWOBI.2018.8464203 VL - 2018 SP - 1 EP - 6 ER - TY - GEN A1 - Spitzer, Stefan G. A1 - Spitzer, H. H. A1 - Scholz, P. T1 - Die Verteilung atrialer Arrhythmien in Abhängigkeit von der Dokumentation einer schmalen Kammerkomplextachykardie bei Patienten mit typischer Tachykardieanamnese und unauffälligem Ruhe-EKG T2 - Herzschrittmacher Y1 - 1998 IS - 18 SP - 243 EP - 247 ER - TY - GEN A1 - Brachmann, Johannes A1 - Lewalter, Thorsten A1 - Kuck, Karl-Heinz A1 - Andresen, Dietrich A1 - Willems, Stephan A1 - Spitzer, Stefan G. A1 - Straube, Florian A1 - Schumacher, Burghard A1 - Eckardt, Lars A1 - Danilovic, Dejan A1 - Dierk, Thomas A1 - Hochadel, Matthias A1 - Senges, Jochen T1 - Long-term symptom improvement and patient satisfaction following catheter ablation of supraventricular tachycardia: insights from the German ablation registry T2 - European Heart Journal Y1 - 2017 UR - https://academic.oup.com/eurheartj/article/38/17/1317/3074208 U6 - https://doi.org/10.1093/eurheartj/ehx101 SN - 1522-9645 VL - 38 IS - 17 SP - 1317 EP - 1326 ER - TY - GEN A1 - Schöberl, Florian A1 - Irving, Stephanie A1 - Pradhan, Cauchy A1 - Bardins, Stanislav A1 - Trapp, Christoph A1 - Schneider, Erich A1 - Kugler, Günter A1 - Bartenstein, Peter A1 - Dietrich, Marianne A1 - Brandt, Thomas A1 - Zwergal, Andreas T1 - Prolonged allocentric navigation deficits indicate hippocampal damage in TGA T2 - Neurology : official journal of the American Academy of Neurology N2 - Objective To investigate long-term recovery of allocentric and egocentric spatial orientation as a sensitive marker for hippocampal and extrahippocampal network function in transient global amnesia (TGA). Methods A group of 18 patients with TGA performed an established real-space navigation paradigm, requiring allo- and egocentric spatial orientation abilities, 3 days (postacute stage) and 3 months (follow-up) after symptom onset. Visual exploration behavior and navigation strategy were documented by a gaze-controlled, head-fixed camera. Allo- and egocentric spatial orientation performance was compared to that of 12 age-matched healthy controls. Navigation-induced brain activations were measured using [18F]-fluorodeoxyglucose-PET in a subgroup of 8 patients in the postacute stage and compared to those of the controls. Results In the postacute stage, the patients navigated worse and had higher error rates than controls in allocentric (p = 0.002), but not in egocentric, route planning (p = 0.30), despite complete recovery of verbal (p = 0.58) and figural memory (p = 0.11). Until follow-up, allocentric navigation deficits improved, but higher error rates and reduced use of shortcuts persisted (p < 0.0001). Patients still exhibited relatively more fixations of unique landmarks during follow-up (p = 0.05). PET measurements during the postacute stage showed increased navigation-induced brain activations in the right hippocampus, bilateral retrosplenial, parietal, and mesiofrontal cortices, and cerebellar dentate nucleus in patients compared to controls (p < 0.005). Conclusions Patients with TGA show selective and prolonged deficits of allocentric spatial orientation. Activations in right hippocampal and extrahippocampal hubs of the cerebral navigation network functionally substitute for the deficit in creating and updating the internal cognitive map in TGA. Y1 - 2019 UR - https://n.neurology.org/content/92/3/e234/tab-article-info U6 - https://doi.org/10.1212/WNL.0000000000006779 SN - 0028-3878 SN - 1526-632X VL - 92 IS - 3 SP - e234 EP - e243 ER - TY - GEN A1 - Grill, Eva A1 - Heuberger, Maria A1 - Strobl, Ralf A1 - Saglam, Murat A1 - Holle, Rolf A1 - Linkohr, Birgit A1 - Ladwig, Karl-Heinz A1 - Peters, Annette A1 - Schneider, Erich A1 - Jahn, Klaus A1 - Lehnen, Nadine T1 - Prevalence, determinants, and consequences of vestibular hypofunction. results from the kora-ff4 survey T2 - Frontiers in Neurology N2 - Objective: Uni- or bilateral vestibular hypofunction (VH) impairs balance and mobility, and may specifically lead to injury from falls and to disability. The extent of this problem in the general population is still unknown and most likely to be underestimated. Objective of this study was to determine the prevalence, determinants, and consequences of VH in the general population. Methods: Data originates from the cross-sectional second follow-up (FF4) in 2013/14 of the KORA (Cooperative Health Research in the Region of Augsburg)-S4 study (1999–2001) from Southern Germany. This was a random sample of the target population consisting of all residents of the region aged 25–74 years in 1999. We included all participants who reported moderate or severe vertigo or dizziness during the last 12 months and a random sub-sample of participants representative for the general population without vertigo or dizziness during the last 12 months were tested. VH was assessed with the Video-Head Impulse Test (vHIT). Trained examiners applied high-acceleration, small-amplitude passive head rotations (“head impulses”) to the left and right in the plane of the horizontal semicircular canals while participants fixated a target straight ahead. During head impulses, head movements were measured with inertial sensors, eye movements with video-oculography (EyeSeeCam vHIT). Results: A total of 2,279 participants were included (mean age 60.8 years, 51.6% female), 570 (25.0%) with moderate or severe vertigo or dizziness during the last 12 months. Of these, 450 were assessed with vHIT where 26 (5.8%) had unilateral VH, and 16 (3.6%) had bilateral VH. Likewise, 190 asymptomatic participants were tested. Of these 5 (2.6%) had unilateral VH, and 2 (1.1%) had bilateral VH. Prevalence of uni- or bilateral VH among tested symptomatic participants was 2.4% in those < 48 years, and 32.1% in individuals aged 79 and over. Age-adjusted prevalence was 6.7% (95% CI 4.8%; 8.6%). VH was associated with worse health, falls, hearing loss, hearing impairment, and ear pressure. Conclusion: VH may affect between 53 and 95 million adults in Europe and the US. While not all affected persons will experience the full spectrum of symptoms and consequences, adequate diagnostic and therapeutic measures should become standard of care to decrease the burden of disease. Y1 - 2018 U6 - https://doi.org/10.3389/fneur.2018.01076 SN - 1664-2295 VL - 9 ER -