TY - GEN A1 - Heuser, Fabian A1 - Schulz, Christian A1 - Sağlam, Murat A1 - Ramaioli, Cecilia A1 - Heuberger, Maria A1 - Wagner, Klaus J. A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Brandt, Thomas A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Preventing opioid-induced nausea and vomiting: Rest your head and close your eyes? T2 - PloS one Y1 - 2017 U6 - https://doi.org/10.1371/journal.pone.0173925 SN - 1932-6203 VL - 12 IS - 3 SP - e0173925 ER - TY - GEN A1 - Chun, K. R. Julian A1 - Schmidt, Boris A1 - Kuck, Karl-Heinz A1 - Andresen, Dietrich A1 - Willems, Stefan A1 - Spitzer, Stefan G. A1 - Hoffmann, Ellen A1 - Schumacher, Burghard A1 - Eckardt, Lars A1 - Seidl, Karlheinz A1 - Jünger, Claus A1 - Horack, Martin A1 - Brachmann, Johannes A1 - Senges, Jochen T1 - Catheter ablation of atrial fibrillation in the young T2 - Clinical Research in Cardiology Y1 - 2013 U6 - https://doi.org/10.1007/s00392-013-0553-6 SN - 1861-0684 SN - 1861-0692 VL - 102 IS - 6 SP - 459 EP - 468 ER - TY - GEN A1 - Wasmer, Kristina A1 - Köbe, Julia A1 - Andresen, Dietrich A1 - Zahn, Ralf A1 - Spitzer, Stefan G. A1 - Jehle, Joachim A1 - Brachmann, Johannes A1 - Stellbrink, Christoph A1 - Martens, Eimo A1 - Hochadel, Matthias A1 - Senges, Jochen A1 - Klein, Helmut A1 - Eckhardt, Lars T1 - Comparing outcome of patients with coronary artery disease and dilated cardiomyopathy in ICD and CRT recipients: data from the German DEVICE—registry T2 - Clinical Research in Cardiology Y1 - 2013 U6 - https://doi.org/10.1007/s00392-013-0559-0 SN - 1861-0684 SN - 1861-0692 VL - 102 IS - 7 SP - 513 EP - 521 ER - TY - GEN A1 - Ghanbari, Aline Azizi A1 - Dörr, Rolf A1 - Spitzer, Stefan G. A1 - Stumpf, Jürgen A1 - Britz, Andreas A1 - Amann-Zalan, Ildiko A1 - Lodwig, Volker A1 - Ulm, Bernhard A1 - Schnell, Oliver A1 - Lohmann, Tobias T1 - Adiponectin in coronary heart disease and newly diagnosed impaired glucose tolerance T2 - Diabetes and Vascular Disease Research Y1 - 2013 U6 - https://doi.org/10.1177/1479164113490179 SN - 1752-8984 SN - 1479-1641 VL - 10 IS - 5 SP - 452 EP - 458 ER - TY - GEN A1 - Verma, Atul A1 - Debruyne, Philippe A1 - Nardi, Stefano A1 - Deneke, Thomas A1 - DeGreef, Yves A1 - Spitzer, Stefan G. A1 - Balzer, Jörn O. A1 - Börsma, Lucas T1 - Evaluation and Reduction fo Asymptomatic Cerebral Embolism in Ablation of Atrial Fibrillation, but High Prevalence of Chronic Silent Infarction T2 - Circulation: Arrhythmia and Electrophysiology Y1 - 2013 U6 - https://doi.org/10.1161/CIRCEP.113.000612 SN - 1941-3149 SN - 1941-3084 VL - 6 IS - 5 SP - 835 EP - 842 ER - TY - GEN A1 - Steinmetzer, Tobias A1 - Bönninger, Ingrid A1 - Priwitzer, Barbara A1 - Reinhardt, Fritjof A1 - Reckhardt, Markus Christoph A1 - Erk, Dorela A1 - Travieso-González, Carlos M. T1 - Clustering of Human Gait with Parkinson's Disease by Using Dynamic Time Warping T2 - IEEE International Work Conference on Bioinspired Intelligence (IWOBI) N2 - We present a new method for detecting gait disorders according to their stadium using cluster methods for sensor data. 21 healthy and 18 Parkinson subjects performed the Time Up and Go test. The time series were segmented into separate steps. For the analysis the horizontal acceleration measured by a mobile sensor system was considered. We used Dynamic Time Warping and Hierarchical Custering to distinguish the stadiums. A specificity of 92% was achieved. KW - DTW KW - clustering KW - parkinson disease KW - time series Y1 - 2018 U6 - https://doi.org/10.1109/IWOBI.2018.8464203 VL - 2018 SP - 1 EP - 6 ER - TY - GEN A1 - Spitzer, Stefan G. A1 - Spitzer, H. H. A1 - Scholz, P. T1 - Die Verteilung atrialer Arrhythmien in Abhängigkeit von der Dokumentation einer schmalen Kammerkomplextachykardie bei Patienten mit typischer Tachykardieanamnese und unauffälligem Ruhe-EKG T2 - Herzschrittmacher Y1 - 1998 IS - 18 SP - 243 EP - 247 ER - TY - GEN A1 - Brachmann, Johannes A1 - Lewalter, Thorsten A1 - Kuck, Karl-Heinz A1 - Andresen, Dietrich A1 - Willems, Stephan A1 - Spitzer, Stefan G. A1 - Straube, Florian A1 - Schumacher, Burghard A1 - Eckardt, Lars A1 - Danilovic, Dejan A1 - Dierk, Thomas A1 - Hochadel, Matthias A1 - Senges, Jochen T1 - Long-term symptom improvement and patient satisfaction following catheter ablation of supraventricular tachycardia: insights from the German ablation registry T2 - European Heart Journal Y1 - 2017 UR - https://academic.oup.com/eurheartj/article/38/17/1317/3074208 U6 - https://doi.org/10.1093/eurheartj/ehx101 SN - 1522-9645 VL - 38 IS - 17 SP - 1317 EP - 1326 ER - TY - GEN A1 - Schöberl, Florian A1 - Irving, Stephanie A1 - Pradhan, Cauchy A1 - Bardins, Stanislav A1 - Trapp, Christoph A1 - Schneider, Erich A1 - Kugler, Günter A1 - Bartenstein, Peter A1 - Dietrich, Marianne A1 - Brandt, Thomas A1 - Zwergal, Andreas T1 - Prolonged allocentric navigation deficits indicate hippocampal damage in TGA T2 - Neurology : official journal of the American Academy of Neurology N2 - Objective To investigate long-term recovery of allocentric and egocentric spatial orientation as a sensitive marker for hippocampal and extrahippocampal network function in transient global amnesia (TGA). Methods A group of 18 patients with TGA performed an established real-space navigation paradigm, requiring allo- and egocentric spatial orientation abilities, 3 days (postacute stage) and 3 months (follow-up) after symptom onset. Visual exploration behavior and navigation strategy were documented by a gaze-controlled, head-fixed camera. Allo- and egocentric spatial orientation performance was compared to that of 12 age-matched healthy controls. Navigation-induced brain activations were measured using [18F]-fluorodeoxyglucose-PET in a subgroup of 8 patients in the postacute stage and compared to those of the controls. Results In the postacute stage, the patients navigated worse and had higher error rates than controls in allocentric (p = 0.002), but not in egocentric, route planning (p = 0.30), despite complete recovery of verbal (p = 0.58) and figural memory (p = 0.11). Until follow-up, allocentric navigation deficits improved, but higher error rates and reduced use of shortcuts persisted (p < 0.0001). Patients still exhibited relatively more fixations of unique landmarks during follow-up (p = 0.05). PET measurements during the postacute stage showed increased navigation-induced brain activations in the right hippocampus, bilateral retrosplenial, parietal, and mesiofrontal cortices, and cerebellar dentate nucleus in patients compared to controls (p < 0.005). Conclusions Patients with TGA show selective and prolonged deficits of allocentric spatial orientation. Activations in right hippocampal and extrahippocampal hubs of the cerebral navigation network functionally substitute for the deficit in creating and updating the internal cognitive map in TGA. Y1 - 2019 UR - https://n.neurology.org/content/92/3/e234/tab-article-info U6 - https://doi.org/10.1212/WNL.0000000000006779 SN - 0028-3878 SN - 1526-632X VL - 92 IS - 3 SP - e234 EP - e243 ER - TY - GEN A1 - Grill, Eva A1 - Heuberger, Maria A1 - Strobl, Ralf A1 - Saglam, Murat A1 - Holle, Rolf A1 - Linkohr, Birgit A1 - Ladwig, Karl-Heinz A1 - Peters, Annette A1 - Schneider, Erich A1 - Jahn, Klaus A1 - Lehnen, Nadine T1 - Prevalence, determinants, and consequences of vestibular hypofunction. results from the kora-ff4 survey T2 - Frontiers in Neurology N2 - Objective: Uni- or bilateral vestibular hypofunction (VH) impairs balance and mobility, and may specifically lead to injury from falls and to disability. The extent of this problem in the general population is still unknown and most likely to be underestimated. Objective of this study was to determine the prevalence, determinants, and consequences of VH in the general population. Methods: Data originates from the cross-sectional second follow-up (FF4) in 2013/14 of the KORA (Cooperative Health Research in the Region of Augsburg)-S4 study (1999–2001) from Southern Germany. This was a random sample of the target population consisting of all residents of the region aged 25–74 years in 1999. We included all participants who reported moderate or severe vertigo or dizziness during the last 12 months and a random sub-sample of participants representative for the general population without vertigo or dizziness during the last 12 months were tested. VH was assessed with the Video-Head Impulse Test (vHIT). Trained examiners applied high-acceleration, small-amplitude passive head rotations (“head impulses”) to the left and right in the plane of the horizontal semicircular canals while participants fixated a target straight ahead. During head impulses, head movements were measured with inertial sensors, eye movements with video-oculography (EyeSeeCam vHIT). Results: A total of 2,279 participants were included (mean age 60.8 years, 51.6% female), 570 (25.0%) with moderate or severe vertigo or dizziness during the last 12 months. Of these, 450 were assessed with vHIT where 26 (5.8%) had unilateral VH, and 16 (3.6%) had bilateral VH. Likewise, 190 asymptomatic participants were tested. Of these 5 (2.6%) had unilateral VH, and 2 (1.1%) had bilateral VH. Prevalence of uni- or bilateral VH among tested symptomatic participants was 2.4% in those < 48 years, and 32.1% in individuals aged 79 and over. Age-adjusted prevalence was 6.7% (95% CI 4.8%; 8.6%). VH was associated with worse health, falls, hearing loss, hearing impairment, and ear pressure. Conclusion: VH may affect between 53 and 95 million adults in Europe and the US. While not all affected persons will experience the full spectrum of symptoms and consequences, adequate diagnostic and therapeutic measures should become standard of care to decrease the burden of disease. Y1 - 2018 U6 - https://doi.org/10.3389/fneur.2018.01076 SN - 1664-2295 VL - 9 ER - TY - GEN A1 - Glasauer, Stefan T1 - Sensorimotor control of smooth pursuit T2 - Neuroscience 2018 Home N2 - Interaction with the visual world critically depends on when and how we move our eyes. Eye movements, in turn, alter our experience of the world by selecting objects to foveate and tracking objects over time. The interaction between vision and eye movements continues indefinitely, one process modulating the strength and timing of the other. Despite this tight linkage, vision is often studied outside the context of eye movements, during stable fixation. Likewise, eye movements are often studied with sparse visual stimuli and under ideal viewing conditions. A more accurate understanding of vision requires studying perception in the context of eye movements. Different types of eye movements reveal different aspects of how the brain works. The continuous nature of tracking smooth pursuit eye movements, combined with its ubiquitous presence in natural vision, makes it an excellent system in which to analyze perception at fine spatial and temporal resolutions. For example, how does vision change during the transition from fixation to pursuit, and when does the brain allocate resources to account for these changes? In contrast, the ballistic nature of saccades requires analysis divided into discrete epochs, including well before the saccade during the planning stage, during saccade execution, and after the movement. At the neuronal level, how do heterogeneous populations of visual- and saccade-related cells come to represent a single saccade vector during these different epochs? What are the effects on visual perception when saccades and pursuit interact? This symposium will reveal how research incorporating both types of eye movements and visual perception can provide a more ecologically valid account of visual-motor integration and the intervening cognitive processes. This symposium will review innovative approaches and recent advances in understanding the interplay of eye movements and vision. We will take a multifaceted approach to understanding the effects of both exploratory (saccades) and tracking (smooth pursuit) eye movements on vision by using a range of methodologies and animal models (data-driven modeling, clinical populations, and simultaneous recordings of neuronal populations; humans, macaques, and marmosets). This symposium will appeal to vision scientists interested in selective attention, motion processing, neuronal modeling, motor control, neural circuits, and related topics. Our collective goal is to uncover the dynamics of visual perception and the candidate neuronal mechanisms that support eye movements. Y1 - 2018 UR - https://www.abstractsonline.com/pp8/#!/4649/presentation/40985 ER - TY - GEN A1 - Salmasi, Mehrdad A1 - Glasauer, Stefan A1 - Stemmler, Martin T1 - Neurotransmitter spillover redresses the information loss caused by synaptic depression T2 - Lisboa 2019, Conference Lisbon, Portugal, 28 feb - 3 mar Y1 - 2019 UR - http://cosyne.org/cosyne19/Cosyne2019_program_book.pdf SP - 154 ER - TY - GEN A1 - Kostorz, Kathrin A1 - Flanagin, Virginia A1 - Glasauer, Stefan T1 - Instructor-observer synchronization of BOLD activity mediated by instructive origami videos T2 - Neuroscience 2018 Y1 - 2018 UR - https://www.abstractsonline.com/pp8/#!/4649/presentation/5751 ER - TY - GEN A1 - Glasauer, Stefan A1 - Shi, Z. T1 - 150 years of Vierordt’s law: The role of experimental protocol T2 - CA: Society for Neuroscience, 2018 Y1 - 2018 UR - https://www.abstractsonline.com/pp8/#!/4649/presentation/4957 UR - https://www.sfn.org/-/media/SfN/Documents/NEW-SfN/Meetings/Neuroscience-2018/Abstracts/Neuroscience-2018-Abstracts/SFN18_Abstract-PDFs---Theme-J.pdf CY - San Diego ER - TY - GEN A1 - Korda, Athanasia A1 - Zamaro, Ewa A1 - Wagner, Franca A1 - Morrison, Miranda A1 - Schneider, Erich A1 - Caversaccio, Marco Domenico A1 - Sauter, Thomas C. A1 - Mantokoudis, Georgios T1 - Acute vestibular syndrome: is skew deviation a central sign? T2 - Journal of Neurology N2 - Objective Skew deviation results from a dysfunction of the graviceptive pathways in patients with an acute vestibular syndrome (AVS) leading to vertical diplopia due to vertical ocular misalignment. It is considered as a central sign, however, the prevalence of skew and the accuracy of its test is not well known . Methods We performed a prospective study from February 2015 until September 2020 of all patients presenting at our emergency department (ED) with signs of AVS. All patients underwent clinical HINTS and video test of skew (vTS) followed by a delayed MRI, which served as a gold standard for vestibular stroke confirmation. Results We assessed 58 healthy subjects, 53 acute unilateral vestibulopathy patients (AUVP) and 24 stroke patients. Skew deviation prevalence was 24% in AUVP and 29% in strokes. For a positive clinical test of skew, the cut-off of vertical misalignment was 3 deg with a very low sensitivity of 15% and specificity of 98.2%. The sensitivity of vTS was 29.2% with a specificity of 75.5%. Conclusions Contrary to prior knowledge, skew deviation proved to be more prevalent in patients with AVS and occurred in every forth patient with AUVP. Large skew deviations (> 3.3 deg), were pointing toward a central lesion. Clinical and video test of skew offered little additional diagnostic value compared to other diagnostic tests such as the head impulse test and nystagmus test. Video test of skew could aid to quantify skew in the ED setting in which neurotological expertise is not always readily available. KW - Acute stroke KW - Acute unilateral vestibulopathy KW - Test of skew KW - VOG KW - Vertigo KW - Video-oculography Y1 - 2021 U6 - https://doi.org/10.1007/s00415-021-10692-6 SN - 1432-1459 SN - 0340-5354 VL - 269 IS - 3 SP - 1396 EP - 1403 ER - TY - GEN A1 - Spiegel, Rainer A1 - Claassen, Jens A1 - Teufel, Julian A1 - Bardins, Stanislav A1 - Schneider, Erich A1 - Lehrer, Nicole A1 - Jahn, Klaus A1 - Anciaes da Silva, Fábio A1 - Hahn, Ales A1 - Farahmand, Parvis A1 - Brandt, Thomas A1 - Strupp, Michael A1 - Kalla, Roger T1 - Resting in darkness improves downbeat nystagmus: evidence from an observational study T2 - Annals of the New York Academy of Sciences N2 - Resting in an upright position during daytime decreases downbeat nystagmus (DBN). When measured in brightness only, that is, without intermitting exposure to darkness, it does not make a significant difference whether patients have previously rested in brightness or in darkness. In real-world scenarios, people are often exposed to brightness and darkness intermittently. The aim of this study was to analyze whether resting in brightness or resting in darkness was associated with a lower post-resting DBN after intermitting exposures to brightness and darkness. Eight patients were recorded with three-dimensional video-oculography in brightness and darkness conditions, each following two 2-h resting intervals under either brightness or darkness resting conditions. The dependent variable was DBN intensity, measured in mean slow phase velocity. A repeated measures ANOVA with the factors measurement condition (brightness vs. darkness), resting condition (brightness vs. darkness), and time (after first vs. second resting interval) showed a significant effect for the factor resting condition, where previous resting in darkness was associated with a significantly lower DBN relative to previous resting in brightness (P < 0.01). The clinical relevance is to advise patients with DBN to rest in darkness. KW - downbeat nystagmus KW - symptom relief KW - resting KW - oscillopsia KW - video-oculographic measurement (VOG) Y1 - 2016 U6 - https://doi.org/10.1111/nyas.13172 SN - 1749-6632 SN - 0077-8923 VL - 1375 IS - 1 SP - 66 EP - 73 ER - TY - CHAP A1 - Kutzner, Tobias A1 - Steinert, Christian A1 - Weigert, Martin A1 - Wälder, Olga A1 - Robel, Karsten A1 - Yan, Alan T1 - Complex Assessments in Mathematics and Computer Science with STACK and VPL T2 - InnoEducaTIC, Las Palmas, Gran Canaria, 2018 N2 - Programming is not complicated and yet many students do not pass the first hurdles. Software is logical, follows clear rules and mathematical laws. Any healthy person with basic literacy, numeracy and writing skills can learn it. Writing a book, painting pictures or other creative challenges are much harder. And yet many fail at comparable competences. Teaching programming skills by listening and reading is not enough. Students need the process of trial and error in order to acquire the skills needed and should be able to learn by them. However, students should be able to work independently on a computer. The problem that the beginners are overwhelmed and the advanced are bored. This is the case especially in computer science. Despite the use of a comfortable Learning Management System (LMS), many tasks have been submitted to paper and PDF at our university so far. Since the available question-types could not cover all possible complex tasks, it was difficult to inspire the lecturers for a complete digitization of their tasks. To be able to automatically evaluate even tasks in mathematics, computer science and related scientific disciplines two modules have been successfully evaluated at our university. This paper presents the use of these Moodle modules STACK and VPL in selected courses in mathematics and computer science and how to randomize tasks. In these modules complex tasks are prepared in such a way that they are still solvable for the students and automatically evaluated by the system, thus could considerably facilitate the work of the lecturers and academic staff. On concrete examples possible solutions are shown. KW - LMS assessment KW - automatic formative assessment KW - education KW - mathematics KW - computer science Y1 - 2018 UR - https://accedacris.ulpgc.es/bitstream/10553/52713/2/49.Complex_assessments_mathematics.pdf SN - 978-84-09-02374-5 SP - 375 EP - 381 PB - Universidad de Las Palmas de Gran Canaria CY - Las Palmas ER - TY - CHAP A1 - Bönninger, Ingrid A1 - Steinmetzer, Tobias T1 - Therapierfolgsmessung bei Parkinson-Patienten T2 - 7. Lausitzer Schlaganfalltag, 23. Senftenberger Gespräche zum Schlaganfall : Klinische Praxis und neurowissenschaftliche Aspekte, Senftenberg 10. März 2018 KW - Parkinson Y1 - 2018 SP - 65 EP - 66 PB - Klinikum Niederlausitz [u.a.] CY - Senftenberg ER - TY - GEN A1 - Spitzer, Stefan G. T1 - Möglichkeiten und Grenzen der klinischen Elektrophysiologie T2 - Wissenschaftliche Zeitschrift der Technischen Universität Dresden Y1 - 1999 SN - 0043-6925 VL - 48 IS - 1 SP - 30 EP - 35 ER - TY - GEN A1 - Glasauer, Stefan A1 - Straka, Hans T1 - Optimality of the vestibulo-ocular reflex T2 - Abstracts NWG Meeting Göttingen 2021 Y1 - 2021 UR - https://www.nwg-goettingen.de/2021/module/posterliste/supMat.asp?nr=T17-11 VL - 2021 ER -