TY - BOOK A1 - Grünewald, Uwe A1 - Chmielewski, Robert A1 - Kaltofen, Michael A1 - Rolland, Wolfgang A1 - Schümberg, Sabine A1 - Ahlheim, Michael A1 - Sauer, Thoma A1 - Wagner, Ralf A1 - Schluchter, Wolfgang T1 - Ursachen, Verlauf und Folgen des Sommer-Hochwassers 1997 an der Oder sowie Aussagen zu bestehenden Risikopotentialen : eine interdisziplinäre Studie KW - Hochwasser Y1 - 1998 SN - 3-933181-03-8 N1 - Langfassung PB - IDNDR CY - Bonn ER - TY - GEN A1 - Wälder, Konrad A1 - Frischbier, Nico A1 - Bredemeier, Michael A1 - Näther, Wolfgang A1 - Wagner, Sven T1 - Analysis of OF – layer humus mass variation in a mixed stand of European beech and Norway spruce: An application of structural equation modelling T2 - Ecological Modelling Y1 - 2008 SN - 0304-3800 VL - 213 IS - 3-4 SP - 319 EP - 330 ER - TY - CHAP A1 - Boley, Harold A1 - Dean, Mike A1 - Kifer, Michael A1 - Tabet, Said A1 - Wagner, Gerd T1 - RuleML Position Statement Y1 - 2005 UR - http://www.w3.org/2004/12/rules-ws/paper/96/ ER - TY - GEN A1 - Dropco, Ivor A1 - Kaiser, Ulrich A1 - Wagner, Lola A1 - Brunner, Stefan M. A1 - Schlitt, Hans Jürgen A1 - Stroszcynski, Christian A1 - Jung, Friedrich A1 - Yi, Dong A1 - Herr, Wolfgang A1 - Jung, Ernst Michael T1 - Color mapping using ultrasound system-integrated perfusion software for evaluation of focal liver lesions: a possible first step for more independent reading T2 - Journal of Gastrointestinal and Liver Diseases N2 - Aims To assess the value of using integrated parametric ultrasound software for contrast-enhanced ultrasonography (CEUS) of liver tumors. Methods 107 patients with liver tumors were studied. CEUS were performed to detect focal lesions. Parametric images were based on continuous CINE LOOPs, from the early-arterial phase (15 s) to the portal-venous phase (1 min) generated by perfusion software. The evaluations of the parametric images and their dignity for liver lesions were performed independently by an experienced and a less-experienced investigator. Computed tomography, magnetic resonance imaging scans or histological analysis were used as references. Results High parametric image quality were obtained in all patients. Among the patients, 44% lesions were benign, 56% were malignant. The experienced investigator correctly classified 46 of 47 (98%) as benign, and 60 of 60 (100%) as malignant tumors based on the parametric images. The less-experienced investigator correctly classified 39 of 47 (83%) as benign, and 49 of 60 (82%) malignant tumors, acheaving a high statistical accuracy of 98% with this type of diagnostic. Conclusion Parametric imaging for grading the malignant degree of tumor may be a good complement to existing ultrasound techniques and was particularly helpful for improving the assessments of the less-experienced examiner. KW - CEUS KW - parametric imaging KW - dynamic vascularization KW - liver malignancies Y1 - 2023 UR - https://europepmc.org/article/med/38147619 U6 - https://doi.org/10.15403/jgld-4997 SN - 1842-1121 VL - 32 IS - 4 SP - 479 EP - 487 ER - TY - GEN A1 - Künzel, Stephan R. A1 - Hoffmann, Maximilian A1 - Weber, Silvio A1 - Künzel, Karolina A1 - Kämmerer, Susanne A1 - Günscht, Mario A1 - Klapproth, Erik A1 - Rausch, Johanna S. E. A1 - Sadek, Mirna S. A1 - Kolanowski, Tomasz A1 - Meyer-Roxlau, Stefanie A1 - Piorkowski, Christopher A1 - Tugtekin, Sems M. A1 - Rose-John, Stefan A1 - Yin, Xiaoke A1 - Mayr, Manuel A1 - Kuhlmann, Jan Dominik A1 - Wimberger, Pauline A1 - Grützmann, Konrad A1 - Herzog, Natalie A1 - Küpper, Jan-Heiner A1 - O’Reilly, Molly A1 - Kabir, S. Nashitha A1 - Sommerfeld, Laura C. A1 - Guan, Kaomei A1 - Wielockx, Ben A1 - Fabritz, Larissa A1 - Nattel, Stanley A1 - Ravens, Ursula A1 - Dobrev, Dobromir A1 - Wagner, Michael A1 - El-Armouche, Ali T1 - Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation T2 - Circulation Research N2 - Rationale: Fibrosis promotes the maintenance of atrial fibrillation (AF), making it resistant to therapy. Improved understanding of the molecular mechanisms leading to atrial fibrosis will open new pathways toward effective antifibrotic therapies. Objective: This study aims to decipher the mechanistic interplay between PLK2 (polo-like kinase 2) and the profibrotic cytokine OPN (osteopontin) in the pathogenesis of atrial fibrosis and AF. Methods and Results: Atrial PLK2 mRNA expression was 10-fold higher in human fibroblasts than in cardiomyocytes. Compared with sinus rhythm, right atrial appendages and isolated right atrial fibroblasts from patients with AF showed downregulation of PLK2 mRNA and protein, along with increased PLK2 promotor methylation. Genetic deletion as well as pharmacological inhibition of PLK2 induced profibrotic phenotype conversion in cardiac fibroblasts and led to a striking de novo secretion of OPN. Accordingly, PLK2-deficient (PLK2 knockout) mice showed cardiac fibrosis and were prone to experimentally induced AF. In line with these findings, OPN plasma levels were significantly higher only in patients with AF with atrial low-voltage zones (surrogates of fibrosis) compared with sinus rhythm controls. Mechanistically, we identified ERK1/2 as the relevant downstream mediator of PLK2 leading to increased OPN expression. Finally, oral treatment with the clinically available drug mesalazine, known to inhibit ERK1/2, prevented cardiac OPN overexpression and reversed the pathological PLK2 knockout phenotype in PLK2 knockout mice. Conclusions: Abnormal PLK2/ERK1/2/OPN axis function critically contributes to AF-related atrial fibrosis, suggesting reinforcing PLK2 activity and/or OPN inhibition as innovative targets to prevent fibrosis progression in AF. Mesalazine derivatives may be used as lead compounds for the development of novel anti-AF agents targeting fibrosis. KW - atrial fibrillation KW - fibroblasts KW - fibrosis KW - mesalamine KW - osteopontin Y1 - 2021 UR - https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.121.319425 U6 - https://doi.org/10.1161/CIRCRESAHA.121.319425 SN - 1524-4571 SN - 0009-7330 VL - 129 IS - 8 SP - 804 EP - 820 ER - TY - GEN A1 - Ehrling, Sebastian A1 - Senkovska, Irena A1 - Efimova, Anastasia A1 - Bon, Volodymyr A1 - Abylgazina, Leila A1 - Petkov, Petko A1 - Evans, Jack D. A1 - Attallah, Ahmed Gamal A1 - Wharmby, Michael Thomas A1 - Roslova, Maria A1 - Huang, Zhehao A1 - Tanaka, Hideki A1 - Wagner, Andreas A1 - Schmidt, Peer A1 - Kaskel, Stefan T1 - Temperature Driven Transformation of the Flexible Metal-Organic Framework DUT-8(Ni) T2 - Chemistry - a European journal N2 - DUT-8(Ni) metal-organic framework belongs to the family of flexible pillared layer materials. The desolvated framework can be obtained in the open pore form (op) or in the closed pore form (cp), depending on the crystal size regime. In the present work, we report on the behaviour of desolvated DUT-8(Ni) at elevated temperatures. For both, op and cp variants, heating causes a structural transition, leading to an new, crystalline compound, containing two interpenetrated networks. The state of the framework before transition (op vs. cp) influences the transition temperature: the small particles of the op phase transform at significantly lower temperature in comparison to the macroparticles of the cp phase, transforming close to the decomposition temperature. The new compound, confined closed pore phase (ccp), was characterized by powder X-ray diffraction and spectroscopic techniques, such as IR, EXAFS, and positron annihilation lifetime spectroscopy (PALS). Thermal effects of structural cp to ccp transitions were studied using differential scanning calorimetry (DSC), showing an overall exothermic effect of the process, involving bond breaking and reformation. Theoretical calculations reveal the energetics, driving the observed temperature induced phase transition. KW - Metal organic framework (MOF) KW - Thermal analysis KW - Crystal structure KW - Phase transition Y1 - 2022 UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202201281 U6 - https://doi.org/10.1002/chem.202201281 SN - 1521-3765 VL - 28 IS - 55 SP - 1 EP - 10 ER - TY - GEN A1 - Jahnke, Sonja A1 - Cruysen, Caren A1 - Prill, Robert A1 - Kittmann, Fabian A1 - Pflug, Nicola A1 - Albert, Justin Amadeus A1 - Camargo, Tibor de A1 - Arnrich, Bert A1 - Krolikowska, Aleksandra A1 - Kolcz, Anna A1 - Reichert, Pawel A1 - Oleksy, Lukasz A1 - Michel, Sven A1 - Kopf, Sebastian A1 - Wagner, Michael A1 - Scheffler, Sven A1 - Becker, Roland T1 - Protocol for a Randomized Crossover Trial to Evaluate the Effect of Soft Brace and Rigid Orthosis on Performance and Readiness to Return to Sport Six Months Post‑ACL‑Reconstruction T2 - Healthcare N2 - A randomized crossover trial was designed to investigate the influence of muscle activation and strength on functional stability/control of the knee joint, to determine whether bilateral imbalances still occur six months after successful anterior cruciate ligament reconstruction (ACLR), and to analyze whether the use of orthotic devices changes the activity onset of these muscles. Furthermore, conclusions on the feedforward and feedback mechanisms are highlighted. Therefore, twenty‑eight patients will take part in a modified Back in Action (BIA) test battery at an average of six months after a primary unilateral ACLR, which used an autologous ipsilateral semitendinosus tendon graft. This includes double‑leg and single‑leg stability tests, double‑leg and single‑leg countermovement jumps, double‑leg and single‑leg drop jumps, a speedy jump test, and a quick feet test. During the tests, gluteus medius and semitendinosus muscle activity are analyzed using surface electromyography (sEMG). Motion analysis is conducted using Microsoft Azure DK and 3D force plates. The tests are performed while wearing knee rigid orthosis, soft brace, and with no aid, in random order. Additionally, the range of hip and knee motion and hip abductor muscle strength under isometric conditions are measured. Furthermore, patient‑rated outcomes will be assessed. Y1 - 2023 U6 - https://doi.org/10.3390/healthcare11040513 SN - 2227-9032 VL - 11 IS - 4 ER - TY - CHAP A1 - Eickhoff, Ralf A1 - Tittelbach-Helmrich, Klaus A1 - Wickert, Michael A1 - Wagner, Jens A1 - Mayer, Uwe A1 - Elvira, Victor A1 - Ibáñez, Jesús A1 - Stamenković, Zoran A1 - Ellinger, Frank T1 - Physical Layer Amendments for MIMO Features in 802.11a Y1 - 2011 ER - TY - GEN A1 - Lützner, Jörg A1 - Lange, Toni A1 - Schmitt, Jochen A1 - Kopkow, Christian A1 - Dreinhöfer, Karsten E A1 - Friederich, Niklaus F. A1 - Gravius, Sascha A1 - Heller, Karl-Dieter A1 - Hube, Robert A1 - Gromnica-Ihle, Erika A1 - Kirschner, Stephan A1 - Kladny, Bernd A1 - Kremer, Michael A1 - Linke, Maike A1 - Malzahn, Jürgen A1 - Sabatowski, Rainer A1 - Scharf, Hanns-Peter A1 - Stöve, Johannes A1 - Wagner, Richard A1 - Günther, Klaus-Peter T1 - [The S2k guideline: Indications for knee endoprosthesis : Evidence and consent-based indications for total knee arthroplasty] T2 - Der Orthopäde Y1 - 2018 U6 - https://doi.org/10.1007/s00132-018-3612-x SN - 1433-0431 SN - 0085-4530 VL - 47 IS - 9 SP - 777 EP - 781 ER - TY - GEN A1 - Schenk, Harald A1 - Grahmann, Jan A1 - Sandner, Thilo A1 - Wagner, Michael A1 - Dauderstädt, Ulrike A1 - Schmidt, Jan-Uwe T1 - Micro mirrors for high-speed laser deflections and patterning T2 - Physics Procedia Y1 - 2014 U6 - https://doi.org/10.1016/j.phpro.2014.08.090 SN - 1875-3892 VL - 56 SP - 7 EP - 18 ER - TY - GEN A1 - Dauderstädt, Ulrike A1 - Dürr, Peter A1 - Gehner, Andreas A1 - Wagner, Michael A1 - Schenk, Harald T1 - Analog Spatial Light Modulators based on Micromirror Arrays T2 - Micromachines, Special Issue "Beam Steering via Arrayed Micromachines" Y1 - 2021 U6 - https://doi.org/10.3390/mi12050483 SN - 2072-666X VL - 12 IS - 5 ER - TY - CHAP A1 - Schenk, Harald A1 - Wagner, Michael A1 - Grahmann, Jan A1 - Merten, André ED - Kye, Jongwook ED - Owa, Soichi T1 - Advances in MOEMS technologies for high quality imaging systems T2 - Optical Microlithography XXXI, 27 February-1 March 2018, San Jose, California, Unites States N2 - An overview of advances in MOEMS devices and technologies for high quality imaging systems is provided. A particular focus is laid on recent technological further developments possibly opening gateways to unprecedented device and system functionality by e. g.: increase of pixel count towards higher parallel operation, decrease of the mirror pitch in large arrays towards applications like high-performance holography, novel technologies for higher operation bandwidth, increase of aperture size for scanning applications like LIDAR, integration of high reflection coatings for processing of multi Watt laser radiation for marking and engraving, and phased arrays for high speed laser beam steering. Y1 - 2018 SN - 978-1-5106-1666-0 SN - 978-1-5106-1667-7 U6 - https://doi.org/10.1117/12.2297399 PB - SPIE CY - Bellingham, Washington ER - TY - GEN A1 - Sicker, Cornelius A1 - Heber, Jörg A1 - Berndt, Dirk A1 - Rückerl, Florian A1 - Tinevez, Jean-Yves A1 - Shorte, Spencer A1 - Wagner, Michael A1 - Schenk, Harald T1 - Spatially resolved contrast measurement of diffractive micromirror arrays T2 - MOEMS and miniaturized systems XIV, 9 - 12 February 2015, San Francisco, California, United States Y1 - 2015 SN - 978-1-62841-465-3 SP - 93750D-1 EP - 93750D-10 PB - SPIE CY - Bellingham, Wash. ER -