TY - CHAP A1 - Mai, Andreas A1 - Dauderstädt, Ulrike A1 - Pahner, D. A1 - Krellmann, M. A1 - Schmeißer, Dieter A1 - Wagner, M. T1 - In situ determination of laser induced degradation of micro-mirror arrays T2 - International Students and Young Scientists Workshop Photonics and Microsystems, Cottbus, Germany, 8 - 10 June 2011 N2 - The Fraunhofer Institute for Photonic Microsystems (Fraunhofer IPMS) develops spatial light modulators (SLMs) based on arrays of tiltable micro mirrors on a semiconductor chip. Typical applications are pattern generation for deepUV-laser mask writing or structured illumination in microscopy. Development and optimization of such SLMs requires detailed knowledge of the device behaviour under operating conditions. Here, the flatness of each single mirror effects the image resolution and contrast of the generated pattern and is amongst others a characteristic property of SLMs. In this context a surface topography measurement under laser exposure (in situ) was designed. The interferometric setup uses the phase-shift principle and allows a resolution in z-direction in the single-digit nanometer range. During irradiation with UV-laser light at 248 nm (KrF) and energy densities of up to 20 mJ/cm2 the change in single micro-mirrors topography was detected in situ. Measurementswith varying pulse energies were carried out to identify an impacton the device performance. In general, the setup is neither limited to a specific illumination wavelength nor to micro-mirrors as structures under test. KW - micro-mirror arrays KW - laser induced degradation Y1 - 2011 SN - 978-1-4577-1651-5 U6 - https://doi.org/10.1109/STYSW.2011.6155850 SP - 84 EP - 88 PB - IEEE CY - Piscataway, NJ ER - TY - RPRT A1 - Müller, Jörg A1 - Dieter, M. A1 - Bauhus, J. A1 - Spellmann, H. A1 - Möhring, B. A1 - Wagner, S. A1 - Wolf, Heino A1 - Niekisch, M. A1 - Weiger, H. A1 - Feindt, Peter H. A1 - Hamm, Ulrich A1 - Wätzold, Frank A1 - Wolters, Volkmar A1 - Engels, Eve-Marie A1 - Schraml, U. A1 - Lang, F. A1 - Pröbstl-Haider, U. A1 - Richter, K. T1 - Wege zu einem effizienten Waldnaturschutz in Deutschland. Stellungnahme Y1 - 2020 UR - http://www.fnr.de/fileadmin/allgemein/pdf/Effizienter_Waldnaturschutz_in_Deutschland.pdf PB - Wissenschaftlicher Beirat Waldpolitik und Wissenschaftlicher Beirat Biodiversität und Genetische Ressourcen beim BMEL ER - TY - CHAP A1 - Pickenhain, Sabine A1 - Wagner, M. ED - Grötschel, Martin T1 - Optimal Control Problems with a First Order PDE System - Necessary and Sufficient Optimality Conditions T2 - Online optimization of large scale systems Y1 - 2001 SN - 3-540-42459-8 SP - 159 EP - 172 PB - Springer CY - Berlin [u.a.] ER - TY - CHAP A1 - Henkel, Karsten A1 - Schwiertz, Carola A1 - Wagner, S. A1 - Valdeig, A. A1 - List, M. A1 - Schmeißer, Dieter T1 - Partikel- und Tropfendetektion im Mikrometerbereich mittels Schwingquarzen Y1 - 2003 SN - 3-935712-92-8 SP - 291 EP - 294 PB - w.e.b.-Univ.-Verl. CY - Dresden ER - TY - JOUR A1 - Pickenhain, Sabine A1 - Wagner, M. T1 - Pontryagin principle for state-constrained control problems governed by a first-order PDE system Y1 - 2000 ER - TY - JOUR A1 - Wagner, M. T1 - Transportation flow problems with Radon measure variables Y1 - 2000 ER - TY - CHAP A1 - Pickenhain, Sabine A1 - Wagner, M. ED - Ioffe, Alexander T1 - Critical points in relaxed deposit problems T2 - Calculus of variations and optimal control, Technion 1998, proceedings of the International Conference on the Calculus of Variations and Related Topics, 25 - 31 March, 1998 Y1 - 2000 SN - 0-8493-0605-1 SP - 217 EP - 236 PB - Chapman & Hall/CRC CY - Boca Raton, Fla. [u.a.] ER - TY - JOUR A1 - Wagner, M. T1 - Pontryagin's maximum principle for Dieudonne-Rashevsky type problems involving Lipschitz functions Y1 - 1999 ER - TY - JOUR A1 - Lykina, Valeriya A1 - Pickenhain, Sabine A1 - Wagner, M. T1 - Different interpretations of the improper integral objective in an infinite horizon control problem Y1 - 2008 ER - TY - JOUR A1 - Lykina, Valeriya A1 - Pickenhain, Sabine A1 - Wagner, M. T1 - On a resource allocation model with inifinite horizon Y1 - 2008 ER - TY - CHAP A1 - Herre, Heinrich A1 - Jaspars, Jan O. M. A1 - Wagner, Gerd T1 - What is Negation? Y1 - 1999 ER - TY - GEN A1 - Schwarzkopf, Jutta A1 - Dirsyte, R. A1 - Devi, A. A1 - Kwasniewski, A. A1 - Schmidbauer, M. A1 - Wagner, Gerd A1 - Michling, Marcel A1 - Schmeißer, Dieter A1 - Fornari, Robert T1 - Influence of Na on the structure of Bi4Ti3O12 films deposited by liquid-delivery spin MOCVD T2 - Thin solid films Y1 - 2011 SN - 0040-6090 VL - 519 IS - 17 SP - 5754 EP - 5759 ER - TY - GEN A1 - Grahmann, Jan A1 - Merten, André A1 - Ostendorf, Ralf A1 - Fontenot, M. A1 - Bleh, Daniela A1 - Schenk, Harald A1 - Wagner, Hans-Joachim T1 - Tunable external cavity quantum cascade lasers (EC-QCL): an application field for MOEMS based scanning gratings T2 - SPIE Conference: MOEMS and Miniaturized Systems XIII, San Francisco, 2014 Y1 - 2014 SN - 978-0-8194-9890-8 SP - 897708-1 EP - 897708-11 PB - SPIE Press CY - Bellingham ER - TY - CHAP A1 - Bleh, D. A1 - Ostendorf, Ralf A1 - Merten, A. A1 - Grahmann, Jan A1 - Schenk, Harald A1 - Kunzer, M. A1 - Schmidt, R. A1 - Wagner, J. T1 - Miniaturization of a fast tunable external cavity QCL with customized gratings and MOEMS components T2 - International Quantum Cascade Lasers School & Workshop (IQCLSW), Policoro, Italy Y1 - 2014 UR - http://www.iqclsw2014.cnr.it/wp-content/uploads/2014/03/Bleh-IQCLSW2014.pdf?0f100a SP - 1 EP - 2 ER - TY - GEN A1 - Lehnen, Nadine A1 - Heuser, Fabian A1 - Sağlam, Murat A1 - Schulz, Christian M. A1 - Wagner, Klaus J. A1 - Taki, Masakatsu A1 - Kochs, Eberhard F. A1 - Jahn, Klaus A1 - Schneider, Erich T1 - Opioid-induced nausea involves a vestibular problem preventable by head-rest T2 - PLoS one Y1 - 2015 U6 - https://doi.org/10.1371/journal.pone.0135263 SN - 1932-6203 VL - 10 IS - 8 SP - e0135263 ER - TY - GEN A1 - Künzel, Stephan R. A1 - Hoffmann, Maximilian A1 - Weber, Silvio A1 - Künzel, Karolina A1 - Kämmerer, Susanne A1 - Günscht, Mario A1 - Klapproth, Erik A1 - Rausch, Johanna S. E. A1 - Sadek, Mirna S. A1 - Kolanowski, Tomasz A1 - Meyer-Roxlau, Stefanie A1 - Piorkowski, Christopher A1 - Tugtekin, Sems M. A1 - Rose-John, Stefan A1 - Yin, Xiaoke A1 - Mayr, Manuel A1 - Kuhlmann, Jan Dominik A1 - Wimberger, Pauline A1 - Grützmann, Konrad A1 - Herzog, Natalie A1 - Küpper, Jan-Heiner A1 - O’Reilly, Molly A1 - Kabir, S. Nashitha A1 - Sommerfeld, Laura C. A1 - Guan, Kaomei A1 - Wielockx, Ben A1 - Fabritz, Larissa A1 - Nattel, Stanley A1 - Ravens, Ursula A1 - Dobrev, Dobromir A1 - Wagner, Michael A1 - El-Armouche, Ali T1 - Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation T2 - Circulation Research N2 - Rationale: Fibrosis promotes the maintenance of atrial fibrillation (AF), making it resistant to therapy. Improved understanding of the molecular mechanisms leading to atrial fibrosis will open new pathways toward effective antifibrotic therapies. Objective: This study aims to decipher the mechanistic interplay between PLK2 (polo-like kinase 2) and the profibrotic cytokine OPN (osteopontin) in the pathogenesis of atrial fibrosis and AF. Methods and Results: Atrial PLK2 mRNA expression was 10-fold higher in human fibroblasts than in cardiomyocytes. Compared with sinus rhythm, right atrial appendages and isolated right atrial fibroblasts from patients with AF showed downregulation of PLK2 mRNA and protein, along with increased PLK2 promotor methylation. Genetic deletion as well as pharmacological inhibition of PLK2 induced profibrotic phenotype conversion in cardiac fibroblasts and led to a striking de novo secretion of OPN. Accordingly, PLK2-deficient (PLK2 knockout) mice showed cardiac fibrosis and were prone to experimentally induced AF. In line with these findings, OPN plasma levels were significantly higher only in patients with AF with atrial low-voltage zones (surrogates of fibrosis) compared with sinus rhythm controls. Mechanistically, we identified ERK1/2 as the relevant downstream mediator of PLK2 leading to increased OPN expression. Finally, oral treatment with the clinically available drug mesalazine, known to inhibit ERK1/2, prevented cardiac OPN overexpression and reversed the pathological PLK2 knockout phenotype in PLK2 knockout mice. Conclusions: Abnormal PLK2/ERK1/2/OPN axis function critically contributes to AF-related atrial fibrosis, suggesting reinforcing PLK2 activity and/or OPN inhibition as innovative targets to prevent fibrosis progression in AF. Mesalazine derivatives may be used as lead compounds for the development of novel anti-AF agents targeting fibrosis. KW - atrial fibrillation KW - fibroblasts KW - fibrosis KW - mesalamine KW - osteopontin Y1 - 2021 UR - https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.121.319425 U6 - https://doi.org/10.1161/CIRCRESAHA.121.319425 SN - 1524-4571 SN - 0009-7330 VL - 129 IS - 8 SP - 804 EP - 820 ER - TY - GEN A1 - Steuer, O. A1 - Liedke, Maciej O. A1 - Butterling, M. A1 - Schwarz, D. A1 - Schulze, J. A1 - Li, Z. A1 - Wagner, A. A1 - Fischer, Inga Anita A1 - Hübner, R. A1 - Zhou, S. T1 - Evolution of point defects in pulsed-laser-melted Ge1-xSnx probed by positron annihilation lifetime spectroscopy T2 - Journal of Physics: Condensed Matter N2 - Direct-band-gap Germanium-Tin alloys (Ge1-xSnx) with high carrier mobilities are promising materials for nano- and optoelectronics. The concentration of open volume defects in the alloy, such as Sn and Ge vacancies, influences the final device performance. In this article, we present an evaluation of the point defects in molecular-beam-epitaxy grown Ge1-xSnx films treated by post-growth nanosecond-range pulsed laser melting (PLM). Doppler broadening – variable energy positron annihilation spectroscopy and variable energy positron annihilation lifetime spectroscopy are used to investigate the defect nanostructure in the Ge1-xSnx films exposed to increasing laser energy density. The experimental results, supported with ATomic SUPerposition calculations, evidence that after PLM, the average size of the open volume defects increases, which represents a raise in concentration of vacancy agglomerations, but the overall defect density is reduced as a function of the PLM fluence. At the same time, the positron annihilation spectroscopy analysis provides information about dislocations and Ge vacancies decorated by Sn atoms. Moreover, it is shown that the PLM reduces the strain in the layer, while dislocations are responsible for trapping of Sn and formation of small Sn-rich-clusters. KW - GeSn KW - laser annealing KW - positron annihilation KW - PLM KW - point defects Y1 - 2023 UR - https://iopscience.iop.org/article/10.1088/1361-648X/ad0a10/meta U6 - https://doi.org/10.1088/1361-648X/ad0a10 SN - 0953-8984 VL - 36 IS - 8 SP - 1 EP - 11 ER - TY - GEN A1 - Dropco, Ivor A1 - Kaiser, Ulrich A1 - Wagner, Lola A1 - Brunner, Stefan M. A1 - Schlitt, Hans Jürgen A1 - Stroszczynski, Christian A1 - Jung, Friedrich A1 - Yi, Dong A1 - Herr, Wolfgang A1 - Jung, Ernst Michael T1 - Color mapping using ultrasound system-integrated perfusion software for evaluation of focal liver lesions: a possible first step for more independent reading T2 - Journal of Gastrointestinal and Liver Diseases N2 - Aims To assess the value of using integrated parametric ultrasound software for contrast-enhanced ultrasonography (CEUS) of liver tumors. Methods 107 patients with liver tumors were studied. CEUS were performed to detect focal lesions. Parametric images were based on continuous CINE LOOPs, from the early-arterial phase (15 s) to the portal-venous phase (1 min) generated by perfusion software. The evaluations of the parametric images and their dignity for liver lesions were performed independently by an experienced and a less-experienced investigator. Computed tomography, magnetic resonance imaging scans or histological analysis were used as references. Results High parametric image quality were obtained in all patients. Among the patients, 44% lesions were benign, 56% were malignant. The experienced investigator correctly classified 46 of 47 (98%) as benign, and 60 of 60 (100%) as malignant tumors based on the parametric images. The less-experienced investigator correctly classified 39 of 47 (83%) as benign, and 49 of 60 (82%) malignant tumors, acheaving a high statistical accuracy of 98% with this type of diagnostic. Conclusion Parametric imaging for grading the malignant degree of tumor may be a good complement to existing ultrasound techniques and was particularly helpful for improving the assessments of the less-experienced examiner. KW - CEUS KW - parametric imaging KW - dynamic vascularization KW - liver malignancies Y1 - 2023 UR - https://europepmc.org/article/med/38147619 U6 - https://doi.org/10.15403/jgld-4997 SN - 1842-1121 VL - 32 IS - 4 SP - 479 EP - 487 ER - TY - JOUR A1 - Shi, Zhuanghua A1 - Allenmark, Fredrik A1 - Theisinger, Laura A. A1 - Pistorius, Rasmus L. A1 - Glasauer, Stefan A1 - Müller, Hermann J. A1 - Falter-Wagner, Christine M. T1 - Predictive Processing in ASD: The Atypical Iterative Prior Updating Account JF - Biological Psychiatry Global Open Science Y1 - 2025 U6 - https://doi.org/10.1016/j.bpsgos.2025.100468 SN - 2667-1743 VL - 5 IS - 3 PB - Elsevier BV ER -