TY - GEN A1 - Wetter, Oliver A1 - Pfister, Christian A1 - Werner, Johannes P. A1 - Zorita, Eduardo A1 - Wagner, Sebastian A1 - Seneviratne, Sonia I. A1 - Herget, Jürgen A1 - Grünewald, Uwe A1 - Luterbacher, Jürg A1 - Alcoforado, Maria João A1 - Barriendos, Mariano A1 - Bieber, Ursula A1 - Brázdil, Rudolf A1 - Burmeister, Karl H. A1 - Camenisch, Chantal A1 - Contino, Antonio A1 - Dobrovolný, Petr A1 - Glaser, Rüdiger A1 - Himmelsbach, Iso A1 - Kiss, Andrea A1 - Kotyza, Oldřich A1 - Labbé, Thomas A1 - Limanówka, Danuta A1 - Litzenburger, Laurent A1 - Nordl, Øyvind A1 - Pribyl, Kathleen A1 - Retsö, Dag A1 - Riemann, Dirk A1 - Rohr, Christian A1 - Siegfried, Werner A1 - Söderberg, Johan A1 - Spring, Jean-Laurent T1 - The year-long unprecedented European heat and drought of 1540 – a worst case T2 - Climatic change N2 - The heat waves of 2003 in Western Europe and 2010 in Russia, commonly labelled as rare climatic anomalies outside of previous experience, are often taken as harbingers of more frequent ex-tremes in the global warming-influenced future. However, a recent reconstruction of spring–summer temperatures for WE resulted in the likelihood of significantly higher temperatures in 1540. In order to check the plausibility of this result we investigated the severity of the 1540 drought by putting forward the argument of the known soil desiccation-temperature feedback. Based on more than 300 first-hand documentary weather report sources originating from an area of 2 to 3 million km2, we show that Europe was affected by an unprecedented 11-month-long Megadrought. The estimated number of precipitation days and precipitation amount for Central and Western Europe in 1540 is significantly lower than the 100-year minima of the in-strumental measurement period for spring, summer and autumn. This result is supported by independent documentary evidence about extremely low river flows and Europe-wide wild-, forestand settlement fires. We found that an event of this severity cannot be simulated by state-of-the-art climate models. Y1 - 2014 UR - http://link.springer.com/article/10.1007%2Fs10584-014-1184-2#page-1 U6 - https://doi.org/10.1007/s10584-014-1184-2 SN - 1573-1480 SN - 0165-0009 VL - 125 IS - 3-4 SP - 349 EP - 363 ER - TY - GEN A1 - Pfister, Christian A1 - Wetter, Oliver A1 - Brázdil, Rudolf A1 - Dobrovolný, Petr A1 - Glaser, Rüdiger A1 - Luterbacher, Jürg A1 - Seneviratne, Sonia I. A1 - Zorita, Eduardo A1 - Alcoforado, Maria João A1 - Barriendos, Mariano A1 - Bieber, Ursula A1 - Burmeister, Karl H. A1 - Camenisch, Chantal A1 - Contino, Antonio A1 - Grünewald, Uwe A1 - Herget, Jürgen A1 - Himmelsbach, Iso A1 - Labbé, Thomas A1 - Limanówka, Danuta A1 - Litzenburger, Laurent A1 - Kiss, Andrea A1 - Kotyza, Oldřich A1 - Nordl, Øyvind A1 - Pribyl, Kathleen A1 - Retsö, Dag A1 - Riemann, Dirk A1 - Rohr, Christian A1 - Siegfried, Werner A1 - Spring, Jean-Laurent A1 - Söderberg, Johan A1 - Wagner, Sebastian A1 - Werner, Johannes P. T1 - Tree-rings and people – different views on the 1540 Megadrought. Reply to Büntgen et al. 2015 T2 - Climatic change Y1 - 2015 U6 - https://doi.org/10.1007/s10584-015-1429-8 SN - 0165-0009 SN - 1573-1480 VL - 131 IS - 2 SP - 191 EP - 198 ER - TY - GEN A1 - Bredies, Kristian A1 - Wagner, Marcus A1 - Schubert, Christian A1 - Ahnelt, Peter T1 - Computer-assisted counting of retinal cells by automatic segmentation after TV denoising T2 - BMC ophthalmology KW - Mammalian photoreceptor cells KW - Automatical counting KW - Adaptive algorithm Y1 - 2013 U6 - https://doi.org/10.1186/1471-2415-13-59 SN - 1471-2415 VL - 13 ER - TY - GEN A1 - Lehnen, Nadine A1 - Heuser, Fabian A1 - Sağlam, Murat A1 - Schulz, Christian M. A1 - Wagner, Klaus J. A1 - Taki, Masakatsu A1 - Kochs, Eberhard F. A1 - Jahn, Klaus A1 - Schneider, Erich T1 - Opioid-induced nausea involves a vestibular problem preventable by head-rest T2 - PLoS one Y1 - 2015 U6 - https://doi.org/10.1371/journal.pone.0135263 SN - 1932-6203 VL - 10 IS - 8 SP - e0135263 ER - TY - GEN A1 - Heuser, Fabian A1 - Schulz, Christian A1 - Sağlam, Murat A1 - Ramaioli, Cecilia A1 - Heuberger, Maria A1 - Wagner, Klaus J. A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Brandt, Thomas A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Preventing opioid-induced nausea and vomiting: Rest your head and close your eyes? T2 - PloS one Y1 - 2017 U6 - https://doi.org/10.1371/journal.pone.0173925 SN - 1932-6203 VL - 12 IS - 3 SP - e0173925 ER - TY - GEN A1 - Averkov, Gennadiy A1 - Wagner, Christian T1 - Inequalities for the lattice width of lattice-free convex sets in the plane T2 - Beiträge zur Algebra und Geometrie N2 - A closed, convex set K in R2 with non-empty interior is called lattice-free if the interior of K is disjoint with Z2. In this paper we study the relation between the area and the lattice width of a planar lattice-free convex set in the general and centrally symmetric case. A correspondence between lattice width on the one hand and covering minima on the other, allows us to reformulate our results in terms of covering minima introduced by Kannan and Lovász (Ann Math (2) 128(3):577–602, 1988). We obtain a sharp upper bound for the area for any given value of the lattice width. The lattice-free convex sets satisfying the upper bound are characterized. Lower bounds are studied as well. Parts of our results are applied in Averkov et al. (Maximal lattice-free polyhedra: finiteness and an explicit description in dimension three, http://arxiv.org/abs/1010.1077, 2010) for cutting plane generation in mixed integer linear optimization, which was the original inducement for this paper. We further rectify a result of Kannan and Lovász (Ann Math (2) 128(3):577–602, 1988) with a new proof. KW - Area Convex set KW - Covering minimum KW - Inhomogeneous minimum KW - Lattice-free body KW - Lattice width Y1 - 2012 UR - https://link.springer.com/article/10.1007%2Fs13366-011-0028-8 U6 - https://doi.org/10.1007/s13366-011-0028-8 SN - 2191-0383 SN - 0138-4821 VL - 53 IS - 1 SP - 1 EP - 23 ER - TY - GEN A1 - Dropco, Ivor A1 - Kaiser, Ulrich A1 - Wagner, Lola A1 - Brunner, Stefan M. A1 - Schlitt, Hans Jürgen A1 - Stroszczynski, Christian A1 - Jung, Friedrich A1 - Yi, Dong A1 - Herr, Wolfgang A1 - Jung, Ernst Michael T1 - Color mapping using ultrasound system-integrated perfusion software for evaluation of focal liver lesions: a possible first step for more independent reading T2 - Journal of Gastrointestinal and Liver Diseases N2 - Aims To assess the value of using integrated parametric ultrasound software for contrast-enhanced ultrasonography (CEUS) of liver tumors. Methods 107 patients with liver tumors were studied. CEUS were performed to detect focal lesions. Parametric images were based on continuous CINE LOOPs, from the early-arterial phase (15 s) to the portal-venous phase (1 min) generated by perfusion software. The evaluations of the parametric images and their dignity for liver lesions were performed independently by an experienced and a less-experienced investigator. Computed tomography, magnetic resonance imaging scans or histological analysis were used as references. Results High parametric image quality were obtained in all patients. Among the patients, 44% lesions were benign, 56% were malignant. The experienced investigator correctly classified 46 of 47 (98%) as benign, and 60 of 60 (100%) as malignant tumors based on the parametric images. The less-experienced investigator correctly classified 39 of 47 (83%) as benign, and 49 of 60 (82%) malignant tumors, acheaving a high statistical accuracy of 98% with this type of diagnostic. Conclusion Parametric imaging for grading the malignant degree of tumor may be a good complement to existing ultrasound techniques and was particularly helpful for improving the assessments of the less-experienced examiner. KW - CEUS KW - parametric imaging KW - dynamic vascularization KW - liver malignancies Y1 - 2023 UR - https://europepmc.org/article/med/38147619 U6 - https://doi.org/10.15403/jgld-4997 SN - 1842-1121 VL - 32 IS - 4 SP - 479 EP - 487 ER - TY - GEN A1 - Lützner, Jörg A1 - Lange, Toni A1 - Schmitt, Jochen A1 - Kopkow, Christian A1 - Dreinhöfer, Karsten E A1 - Friederich, Niklaus F. A1 - Gravius, Sascha A1 - Heller, Karl-Dieter A1 - Hube, Robert A1 - Gromnica-Ihle, Erika A1 - Kirschner, Stephan A1 - Kladny, Bernd A1 - Kremer, Michael A1 - Linke, Maike A1 - Malzahn, Jürgen A1 - Sabatowski, Rainer A1 - Scharf, Hanns-Peter A1 - Stöve, Johannes A1 - Wagner, Richard A1 - Günther, Klaus-Peter T1 - [The S2k guideline: Indications for knee endoprosthesis : Evidence and consent-based indications for total knee arthroplasty] T2 - Der Orthopäde Y1 - 2018 U6 - https://doi.org/10.1007/s00132-018-3612-x SN - 1433-0431 SN - 0085-4530 VL - 47 IS - 9 SP - 777 EP - 781 ER - TY - GEN A1 - Lange, Toni A1 - Kopkow, Christian A1 - Lützner, Jörg A1 - Günther, Klaus-Peter A1 - Gravius, Sascha A1 - Scharf, Hanns-Peter A1 - Stöve, Johannes A1 - Wagner, Richard A1 - Schmitt, Jochen T1 - Comparison of different rating scales for the use in Delphi studies: different scales lead to different consensus and show different test-retest reliability T2 - BMC Medical Research Methodology Y1 - 2020 U6 - https://doi.org/10.1186/s12874-020-0912-8 SN - 1471-2288 VL - 20 IS - 1 ER - TY - GEN A1 - Lützner, Jörg A1 - Deckert, Stefanie A1 - Lange, Toni A1 - Postler, Anne Elisabeth A1 - Aringer, Martin A1 - Berth, Hendrik A1 - Bork, Hartmut A1 - Dreinhöfer, Karsten E A1 - Günther, Klaus-Peter A1 - Heller, Karl-Dieter A1 - Hube, Robert A1 - Kirschner, Stephan A1 - Kladny, Bernd A1 - Kopkow, Christian A1 - Sabatowski, Rainer A1 - Stoeve, Johannes A1 - Wagner, Richard A1 - Lützner, Cornelia T1 - Evidenzbasierte und patientenorientierte Indikationsstellung zur Knieendoprothese – Update der Leitlinie T2 - Zeitschrift für Orthopädie und Unfallchirurgie N2 - ZusammenfassungDie Implantation einer Knieendoprothese zählt mit ca. 170000 Eingriffen pro Jahr zu den am häufigsten stationär durchgeführten Operationen in Deutschland. Eine einheitliche, angemessene und patientenorientierte ärztliche Indikationsstellung ist bei einem solchen Eingriff unerlässlich. Das Update der S2k-Leitlinie „Indikation Knieendoprothese“ beinhaltet auf aktueller Evidenz basierende und im breiten Konsens abgestimmte Empfehlungen und eine Checkliste im praxistauglichen Format.Für dieses Leitlinien-Update wurde eine systematische Literaturrecherche nach (inter-)nationalen Leitlinien und systematischen Übersichtsarbeiten zur Gonarthrose und Knieendoprothetik durchgeführt, um klinisch relevante Fragestellungen zu Diagnostik, Prädiktoren für das Outcome, Risikofaktoren und Kontraindikatoren zu beantworten.Eine Knieendoprothese soll nur bei radiologisch nachgewiesener fortgeschrittener Gonarthrose (Kellgren-Lawrence-Grad 3 oder 4), nach vorangegangener konservativer Therapie über mindestens 3 Monate sowie bei hohem subjektivem Leidensdruck hinsichtlich der kniebezogenen Beschwerden und nach Ausschluss möglicher Kontraindikationen (Infektionen, Begleiterkrankungen, BMI ≥ 40 kg/m2) erfolgen. Modifizierbare Risikofaktoren (wie Rauchen, Diabetes mellitus, Anämie) sollen zuvor adressiert und ggf. optimiert werden. Die Ziele der Patient*innen sollen erfragt und deren Eintrittswahrscheinlichkeit gemeinsam besprochen werden. Schließlich ist die Entscheidung zur Knieendoprothese von Patient*in und Operateur*in gemeinsam zu treffen, wenn der zu erwartende Nutzen die möglichen Risiken überwiegt.Das Update der S2k-Leitlinie wurde um die unikondyläre Knieendoprothese erweitert, die präoperative Optimierung modifizierbarer Risikofaktoren ergänzt sowie Konkretisierungen der Hauptindikationskriterien vorgenommen. Y1 - 2024 U6 - https://doi.org/10.1055/a-2288-7254 SN - 1864-6697 PB - Georg Thieme Verlag KG ER - TY - GEN A1 - Zanoun, El-Sayed A1 - Bauer, Christian A1 - Wagner, Claus A1 - Durst, Franz A1 - Egbers, Christoph A1 - Bellani, Gabriele A1 - Talamelli, Alessandro T1 - Cross-validation of numerical and experimental data in turbulent pipe flow with new scaling correlations T2 - Journal of turbulence N2 - The dependence of turbulence statistics and wall friction on Reynolds number in fully developed turbulent pipe flow remains a fundamental subject in fluid mechanics. This paper cross-validates experimental and numerical results, focusing on the scaling of turbulence statistics at the pipe centerline and across the inner-outer flow region. Pipe flow experiments were reviewed for friction Reynolds numbers 810≤Re𝜏≤55×103, where Re𝜏=𝑢𝜏⁢𝑅/𝜈, 𝑢𝜏 is the wall friction velocity, 𝑅 the pipe radius, and 𝜈 the kinematic viscosity. Complementary DNS data for 180≤Re𝜏≤2880 provide detailed insight into near-wall turbulence. A novel friction correlation, Re𝜏=0.048Re0.923 c is introduced, predicting pipe-wall friction across a wide range of Re𝑐 with accuracy better than ±2.06%, where Re𝑐 is the Reynolds number based on the centerline streamwise mean velocity component 𝑈zc. This correlation enables reliable friction estimates from centerline single-point measurements or DNS data without requiring near-wall or streamwise pressure-gradient information and is validated by consistent agreement with both experiments and DNS. The monotonic decrease in centerline turbulence intensity ⟨𝑢′𝑧2⟩1/2/𝑈zc with increasing Re𝑐 is explained using the streamwise mean momentum equation. Finally, azimuthal spatial filtering of DNS data highlights the limitations of hot-wire resolution near the wall. For Re𝜏≥2880, higher-order experimental statistics agree well with DNS for 𝑦+≥30 and into the logarithmic region, with both datasets equally well described by logarithmic or power-law correlations, while near-wall discrepancies remain due to resolution limits. KW - Pipe flow KW - Turbulence statistics KW - DNS KW - Experiments Y1 - 2025 U6 - https://doi.org/10.1080/14685248.2025.2560314 SP - 1 EP - 22 PB - Taylor & Francis CY - London ER -