TY - GEN A1 - Lehnen, Nadine A1 - Radziej, Katharina A1 - Weigel, Angelika A1 - Känel, Roland von A1 - Glasauer, Stefan A1 - Pietron, Victor A1 - Van den Bergh, Omer A1 - Löwe, Bernd A1 - Lehmann, Marco A1 - Henningsen, Peter T1 - Complementing conceptual models of persistent somatic symptoms with mathematical formalization T2 - Psychosomatic Medicine Y1 - 2020 U6 - https://doi.org/10.1097/PSY.0000000000000801 SN - 1534-7796 VL - 82 IS - 5 SP - 527 EP - 528 ER - TY - GEN A1 - Schaefer, Daniel A1 - Jörres, Rudolf A1 - Nowak, Dennis A1 - Van Den Bergh, Omer A1 - Bogaerts, Katleen A1 - Glasauer, Stefan A1 - Lehnen, Nadine A1 - Von Werder, Dina T1 - Late breaking abstract : replication and validation of a rebreathing experiment to investigate post-COVID symptoms T2 - European Respiratory Journal Y1 - 2023 U6 - https://doi.org/10.1183/13993003.congress-2023.PA5072 VL - 62 IS - Suppl. 67 PB - European Respiratory Society ER - TY - GEN A1 - von Werder, Dina A1 - Aubele, Maria A1 - Regnath, Franziska A1 - Tebbe, Elisabeth A1 - Mladenov, Dejan A1 - von Rheinbaben, Victoria A1 - Hahn, Elisabeth A1 - Schäfer, Daniel A1 - Biersack, Katharina A1 - Adorjan, Kristina A1 - Stubbe, Hans C. A1 - Bogaerts, Katleen A1 - Jörres, Rudolf A. A1 - Nowak, Dennis A1 - Van den Bergh, Omer A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Increased breathlessness in post-COVID syndrome despite normal breathing patterns in a rebreathing challenge T2 - Scientific reports N2 - Severe symptoms in the absence of measurable body pathology are a frequent hallmark of post-COVID syndrome. From a Bayesian Brain perspective, such symptoms can be explained by incorrect internal models that the brain uses to interpret sensory signals. In this pre-registered study, we investigate whether induced breathlessness perception during a controlled CO2rebreathing challenge is reflected by altered respiratory measures (physiology and breathing patterns), and propose different computational mechanisms that could explain our findings in a Bayesian Brain framework. We analysed data from 40 patients with post-COVID syndrome and 40 healthy participants. Results from lung function, neurological and neurocognitive examination of all participants were within normal limits on the day of the experiment. Using a Bayesian repeated-measures ANOVA, we found that patients’ breathlessness was strongly increased (BF10,baseline =8.029, BF10,rebreathing =11636, BF10,recovery =43662) compared to controls. When excluding patients who hyperventilated (N = 8, 20%) during the experiment from the analysis, differences in breathlessness remained (BF10,baseline =1.283, BF10,rebreathing =126.812, BF10,recovery =751.282). For physiology and breathing patterns, all evidence pointed towards no difference between the two groups (0.307  BF10 < 0.704). In summary, we found intact breathing patterns and physiology but increased symptom perception in patients with post-COVID syndrome. Y1 - 2025 U6 - https://doi.org/10.1038/s41598-025-11728-x SN - 2045-2322 VL - 15 IS - 1 SP - 1 EP - 15 PB - Springer Nature CY - [London] ER -