TY - CHAP A1 - Grünewald, Uwe A1 - Biemelt, Detlef A1 - Bekurts, Volker A1 - Schreiter, Marco A1 - Tahl, Sigrun T1 - Standortuntersuchungen zur besseren Quantifizierung von Elementen des regionalen Wasserhaushaltes KW - Wasserhaushalt Y1 - 1999 SN - 3-11-016308-X PB - Berlin ; New York : de Gruyter ER - TY - CHAP A1 - Biemelt, Detlef A1 - Bekurts, Volker A1 - Grünewald, Uwe T1 - Ermittlung der Verdunstung und der Grundwasserneubildung an Tagebau-Restseen und auf Kippenstandorten der Lausitz Y1 - 1995 SN - 1430-0176 PB - Dresden : Dresdner Grundwasserforschungszentrum (DGFZ) ER - TY - GEN A1 - Mönks, Uwe A1 - Dörksen, Helene A1 - Lohweg, Volker A1 - Hübner, Michael T1 - Information Fusion of Conflicting Input Data T2 - Sensors Y1 - 2016 SN - 1424-8220 VL - 16 IS - 11 ER - TY - GEN A1 - Michalik, Stephan A1 - Reder, Alexander A1 - Richts, Björn A1 - Faßhauer, Patrick A1 - Mäder, Ulrike A1 - Pedreira, Tiago A1 - Poehlein, Anja A1 - Heel, Auke van A1 - Tilburg, Amanda van A1 - Altenbuchner, Josef A1 - Klewing, Anika A1 - Reuß, Daniel A1 - Daniel, Rolf A1 - Commichau, Fabian M. A1 - Kuipers, Oscar A1 - Hamoen, Leendert A1 - Völker, Uwe A1 - Stülke, Jörg T1 - The Bacillus subtilis Minimal Genome Compendium T2 - ACS Synthetic Biology N2 - To better understand cellular life, it is essential to decipher the contribution of individual components and their interactions. Minimal genomes are an important tool to investigate these interactions. Here, we provide a database of 105 fully annotated genomes of a series of strains with sequential deletion steps of the industrially relevant model bacterium Bacillus subtilis starting with the laboratory wild type strain B. subtilis 168 and ending with B. subtilis PG38, which lacks approximately 40% of the original genome. The annotation is supported by sequencing of key intermediate strains as well as integration of literature knowledge for the annotation of the deletion scars and their potential effects. The strain compendium presented here represents a comprehensive genome library of the entire MiniBacillus project. This resource will facilitate the more effective application of the different strains in basic science as well as in biotechnology. Y1 - 2021 UR - https://pubs.acs.org/doi/10.1021/acssynbio.1c00339 U6 - https://doi.org/10.1021/acssynbio.1c00339 SN - 2161-5063 VL - 10 IS - 10 SP - 2767 EP - 2771 ER - TY - GEN A1 - Frost, Fabian A1 - Weiss, Stefan A1 - Hertel, Johannes A1 - Rühlemann, Malte A1 - Bang, Corinna A1 - Franke, Andre A1 - Nauck, Matthias A1 - Dörr, Marcus A1 - Völzke, Henry A1 - Roggenbuck, Dirk A1 - Schierack, Peter A1 - Völker, Uwe A1 - Homuth, Georg A1 - Aghdassi, Ali A. A1 - Sendler, Matthias A1 - Lerch, Markus M. A1 - Weiss, Frank U. T1 - Fecal glycoprotein 2 is a marker of gut microbiota dysbiosis and systemic inflammation T2 - Gut Pathogens N2 - Background autoantigenic glycoprotein 2 (GP2) is an important component of the innate immune system which originates from the exocrine pancreas as well as from the small intestines. The relationship of GP2 with the intestinal microbiome as well as the systemic implications of increased fecal GP2 levels are, however, still unclear. Therefore, fecal samples from 2,812 individuals of the Study of Health in Pomerania (SHIP) were collected to determine GP2 levels (enzyme-linked immunosorbent assay) and gut microbiota profiles (16 S rRNA gene sequencing). These data were correlated and associated with highly standardised and comprehensive phenotypic data of the study participants. Results Fecal GP2 levels were increased in individuals with higher body mass index and smokers, whereas lower levels were found in case of preserved exocrine pancreatic function, female sex or a healthier diet. Moreover, higher GP2 levels were associated with increased serum levels of high-sensitivity C-reactive protein, loss of gut microbial diversity and an increase of potentially detrimental bacteria (Streptococcus, Haemophilus, Clostridium XIVa, or Collinsella). At the same time, predicted microbial pathways for the biosynthesis of beneficial short-chain fatty acids or lactic acid were depleted in individuals with high fecal GP2. Of note, GP2 exhibited a stronger association to overall microbiome variation than calprotectin. Conclusion Fecal GP2 is a biomarker of gut microbiota dysbiosis and associated with increased systemic inflammation. The intestines may be more important as origin for GP2 than pancreatic acinar cells. Future studies need to investigate the potential clinical value in disease specific patient cohorts. Y1 - 2024 U6 - https://doi.org/10.1186/s13099-024-00657-1 SN - 1757-4749 VL - 16 IS - 1 SP - 1 EP - 11 PB - Springer Science and Business Media LLC ER -