TY - GEN A1 - Kolkovsky, Vladimir A1 - Stübner, R. A1 - Langa, Sergiu A1 - Wende, U. A1 - Kaiser, Bert A1 - Conrad, Holger A1 - Schenk, Harald T1 - Influence of annealing in H atmosphere on the electrical properties of Al₃O₃ layers grown on p-type Si by the atomic layer deposition technique T2 - Solid-State Electronics Y1 - 2016 U6 - https://doi.org/10.1016/j.sse.2016.06.005 SN - 0038-1101 VL - 123 SP - 89 EP - 95 ER - TY - GEN A1 - Jung, E.M. A1 - Kaiser, U. A1 - Herr, W. A1 - Stroszczynski, C. A1 - Jung, F. T1 - Novel high-resolution contrast agent ultrasound techniques HiFR CEUS and SR CEUSin combination with shear wave elastography, fat assessment and viscosity of liver parenchymal changes and tumors T2 - Clinical Hemorheology and Microcirculation N2 - Abstract. BACKGROUND: The continuous development of ultrasound techniques increasingly enables better description and visu alization of unclear lesions. New ultrasound systems must be evaluated with regard to all these diagnostic possibilities. METHODS:Amultifrequency C1-7 convex probe (SC7-1M) with the new high-end system Resona A20 Series was used moderntechnologies, includingHiFRCEUS, SRCEUSandmultimodaltissueimaging withs hearwaveelastography(SWE), fat evaluation and viscosity measurements (M-Ref) were applied. RESULTS:Ofn=70(meanvalue 48,3 years±20,3 years, range 18–84 years) cases examined, a definitive diagnosis could be made in n=67 cases, confirmed by reference imaging and/or follow-up. Of these, n=22 cases were malignant changes (HCC (hepatocellular carcinoma) n=9, CCC (cholangiocellular carcinoma) n=3, metastases of colorectal carcinomas or recurrences of HCC n=10). In all 12 cases of HCC or CCC, the elastography measurements using the shear wave technique (with values >2m/s to 3.7m/s) showed mean values of 2.3±0.31m/s and a degree of fibrosis of F2 to F4. In n=14 cases, changes in the fat measurement (range 0.51 to 0.72dB/cm/MHz, mean values 0.58±0.12dB/cm/MHz) in the sense of proportional fatty changes in the liver were detected. In the 4 cases of localized fat distribution disorders, the values were >0.7dB/cm/MHz in the sense of significant fatty deposits in the remaining liver tissue. Relevant changes in the viscosity measurements with values >1.8kPa were found in n=31 cases, in n=5 cases of cystic lesions with partially sclerosing cholangitis, in n=13 cases of malignant lesions and in n=9 cases post-interventionally, but also in n=4 cases of benign foci with additional systemic inflammation. CONCLUSIONS:The results are promising and show a new quality of ultrasound-based liver diagnostics. However, there is a need for further investigations with regard to the individual aspects, preferably on a multi-center basis. KW - Multimodal liver tissue imaging (M-Ref) KW - UMA KW - HiFR CEUS KW - SR CEUS KW - Elastography KW - Fat evaluation KW - Viscosity Y1 - 2024 UR - https://content.iospress.com/download/clinical-hemorheology-and-microcirculation/ch249103?id=clinical-hemorheology-and-microcirculation%2Fch249103 U6 - https://doi.org/10.3233/CH-249103 VL - 86 (2024) SP - 263 EP - 273 ER - TY - GEN A1 - Jung, EM A1 - Pleyer, L A1 - Dropco, I A1 - Kaiser, U A1 - Yi, D A1 - Stroszczynski, C A1 - Jung, F T1 - Dynamic Contrast Ultrasound Diagnostics (CEUS) of Liver Lesions and Post-treatment Control with A New High-resolution Examination Technique (HiFR) and Perfusion T2 - Journal of Gastrointestinal & Liver Diseases N2 - Background & Aims: To evaluate, if high frame rate (HiFR) contrast-enhanced ultrasound (CEUS) and external perfusion analysis (VueBox®)can give answers on liver tumour diagnostics. Methods: A multifrequency probe (C1-6 /Resona R9) and 1-2.4 ml ultrasound contrast medium were used for CEUS up to 5-6 min. Independent analysis of DICOM-CINE files was performed, correlated to follow-up, computed tomography, magnetic resonance imaging, or histopathology. Results: In 110 patients the difference between marginal peak enhancement (PE) of malignant and benign leasions was significant. In the peripheral area, the AUCs were lower in malignant lesions (144.8±139.3) than in benign lesions (123.6±119.8). The mean transit time (mTT) was shorter in malignant lesions in the center. In the liver parenchyma, however, the mTT was significantly longer in malignant lesions (141.6±107.9s) than in benign lesions (128.8±138.6 s). The rise time (RT) was significantly shorter central (66.5±30.9s) and peripheral (72.8±35.1s) in malignant lesions than in benign lesions (114.33±159.58s). The wash in rate (WiR) in benign lesions was 848.3±2,563.7 rU in the center. Wash-out rate (WoR) in the center, peripheral and in the liver parenchyma showed a significantly lower wash-out in the malignant lesions. Conclusions: HiFR CEUS with perfusion analysis enables the assessment of focal, diffuse and postinterventional liver changes. KW - Ultrasound contrast media KW - Magnetic resonance imaging KW - Contrast-enhanced ultrasound KW - Liver analysis KW - Perfusion Y1 - 2024 U6 - https://doi.org/10.15403/jgld-5589 VL - 33 IS - 3 SP - 362 EP - 371 ER - TY - GEN A1 - Jung, EM A1 - Wiesinger, I A1 - Kaiser, U A1 - Jung, F T1 - Initial experiences with dynamic, quality indicator-based multimodal tissue analysis (M-Ref) with parallel assessment of viscosity and shear wave elastography in liver parenchyma alterations T2 - Clinical Hemorheology and Microcirculation N2 - BACKGROUND AND OBJECTIVE: Modern ultrasound technology enables detailed tissue morphology analysis. A novel approach involves measuring viscoelasticity or viscosity. This pilot study investigates the potential of a novel high-end ultrasound system with dynamic quality indicators and the M-Ref tool. METHODS: Using a novel premium high-end ultrasound system (Resona A20/Mindray), comparative investigations were conducted on 52 patients, evaluating B-mode morphology, shear wave tissue elastography (STE), and viscosity (STVi) of the liver parenchyma. The study utilized a cohort of 25 healthy volunteers as a control group. The examinations were performed intercostally using a multifrequency convex probe SC7-1U (1–7 MHz) and breath-hold technique, ensuring that at least the highest or second-highest score in the dynamic quality control (5 stars) was achieved. Measurements were made in a color-coded region with a maximum 2 cm diameter and a depth of no more than 2 cm, avoiding bile ducts or blood vessels, at a depth up 2 cm from the liver capsule. RESULTS: A minimum of 10 measurements were taken for each parameter: liver steatosis (based on acoustic attenuation coefficient, USAT), viscosity (STVi), and shear wave elastography (STE) with correlation to fibrosis grade. Reference values for the control group were <1.4 m/s and <5 kPa for STE, with cirrhosis criteria defined as values >2.6 m/s and >15 kPa. For steatosis, values up to 0.5 dB/cm/MHz were considered normal, while values >0.8 dB/cm/MHz indicated fatty liver. Viscosity values <1.7 Pa.s were deemed normal, with >3.6 Pa.s indicating significant abnormality. Major causes of increased viscosity included severe steatosis, active hepatitis, hepatic tumors, or post-ablative states. In all cases, a high-quality indicator score (>93%) was achieved with at least 4/5 top reference markers in green. CONCLUSIONS: This pilot study confirms the comprehensive capabilities of multimodal imaging for tissue characterization using B-mode, elastography, and new techniques for assessing viscoelasticity. However, extensive multicenter evaluations will be needed to definitively establish reference values specific to the type of transducer and equipment used. Y1 - 2024 UR - https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch248111 U6 - https://doi.org/10.3233/CH-248111 VL - 88 IS - 4 SP - 419 EP - 427 ER - TY - GEN A1 - Kopkow, Christian A1 - Konrad, B. A1 - Prate, K. A1 - Sommerfeld, T. A1 - Kaiser, U. T1 - Physiotherapeutische Behandlung im tagesstationären multimodalen interdisziplinären Setting bei Patienten mit chronischen Spannungskofschmerz T2 - Praxis Pysiotherapie Y1 - 2010 IS - 3 SP - 13 EP - 17 ER - TY - GEN A1 - Kaiser, U. A1 - Deckert, Stefanie A1 - Kopkow, Christian A1 - Trautmann, F. A1 - Schmitt, Jochen A1 - Sabatowski, Rainer T1 - Response to Ruan et al. T2 - European Journal of Pain Y1 - 2016 U6 - https://doi.org/10.1002/ejp.900 SN - 1532-2149 SN - 1090-3801 VL - 20 IS - 9 SP - 1545 EP - 1546 ER - TY - GEN A1 - Neustadt, Katrin A1 - Deckert, Stefanie A1 - Kopkow, Christian A1 - Preißler, A. A1 - Bosse, B. A1 - Funke, C. A1 - Jacobi, Lena A1 - Mattenklodt, P. A1 - Nagel, B. A1 - Seidel, P. A1 - Sittl, R. A1 - Steffen, E. A1 - Sabatowski, Rainer A1 - Schmitt, Jochen A1 - Kaiser, U. T1 - What does pain intensity mean from the patient perspective? A qualitative study on the patient perspective of pain intensity as an outcome parameter in treatment evaluation and on the interpretability of pain intensity measurements T1 - Was bedeutet Schmerzintensität aus Sicht der Patienten? Eine qualitative Studie zur Patientenperspektive auf Schmerzstärke als Konstrukt in der Therapieevaluation und die Interpretierbarkeit der Schmerzstärkemessung T2 - Der Schmerz Y1 - 2017 U6 - https://doi.org/10.1007/s00482-017-0234-x SN - 1432-2129 SN - 0932-433X VL - 31 IS - 12 SP - 580 EP - 593 ER - TY - GEN A1 - Deckert, Stefanie A1 - Kaiser, U. A1 - Kopkow, Christian A1 - Trautmann, F. A1 - Sabatowski, Rainer A1 - Schmitt, Jochen T1 - A systematic review of the outcomes reported in multimodal pain therapy for chronic pain T2 - European Journal of Pain Y1 - 2015 U6 - https://doi.org/10.1002/ejp.721 SN - 1532-2149 SN - 1090-3801 VL - 20 IS - 1 SP - 51 EP - 63 ER - TY - GEN A1 - Neustadt, Katrin A1 - Deckert, Stefanie A1 - Heineck, R. A1 - Kopkow, Christian A1 - Preissler, A. A1 - Sabatowski, Rainer A1 - Schmitt, Jochen A1 - Kaiser, U. T1 - Patient perspectives in outcome research : Development of a focus group concept for collating patient perspectives on determination of effectiveness of multimodal pain therapy - A pilot study T2 - Der Schmerz Y1 - 2017 U6 - https://doi.org/10.1007/s00482-016-0171-0 SN - 1432-2129 SN - 0932-433X VL - 31 IS - 2 SP - 139 EP - 148 ER -