TY - CHAP A1 - Bölte, Jens-Henning Ingo Holger A1 - Utgenannt, Stephan A1 - Klepel, Olaf A1 - Erler, Thomas A1 - Rümmler, Stephan A1 - Bron, Michael T1 - Heteroatom doped porous carbon catalysts with systematically varied properties obtained by template assisted synthesis T2 - Book of abstracts, 8th International Symposium on Carbon for Catalysis, CarboCat–VIII, 26. – 29.06. 2018, Porto Y1 - 2018 UR - http://carbocatviii.eventos.chemistry.pt/images/abstract_book.pdf SN - 978-989-8124-22-7 SP - S. 69 PB - Sociedade Portuguesa de Química CY - Porto ER - TY - CHAP A1 - Utgenannt, Stephan A1 - Vormelchert, Carolin A1 - Klepel, Olaf A1 - Jarczewski, Sebastian A1 - Drozdek, Michal A1 - Kustrowski, Piotr A1 - Erler, Thomas A1 - Rümmler, Stephan A1 - Bron, Michael T1 - Template assisted synthesis of porous carbon catalysts with systematically varied properties T2 - The zeolites : materials with engineered properties : book of abstracts / 7th FEZA Conference, July 3-7, 2017, Sofia, Bulgaria Y1 - 2017 SP - S. 199 CY - Sofia ER - TY - GEN A1 - Stephan, Thomas A1 - Deutschländer, Angela A1 - Nolte, Annina A1 - Schneider, Erich A1 - Wiesmann, Martin A1 - Brandt, Thomas A1 - Dieterich, Marianne T1 - Functional mri of galvanic vestibular stimulation with alternating currents at different frequencies T2 - Neuroimage Y1 - 2005 U6 - https://doi.org/10.1016/j.neuroimage.2005.02.049 SN - 1053-8119 VL - 26 IS - 3 SP - 721 EP - 732 ER - TY - GEN A1 - Li, Chouyang A1 - Rezania, Simin A1 - Kammerer, Sarah A1 - Sokolowski, Armin Andreas A1 - Devaney, Trevor Thomas Joseph A1 - Gorischek, Astrid A1 - Jahn, Stephan Wenzel A1 - Hackl, Hubert A1 - Groschner, Klaus A1 - Windpassinger, Christian A1 - Malle, Ernst A1 - Bauernhofer, Thomas A1 - Schreibmayer, Wolfgang T1 - Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line T2 - Scientific Reports N2 - Mechanical interaction between cells - specifically distortion of tensional homeostasis-emerged as an important aspect of breast cancer genesis and progression. We investigated the biophysical characteristics of mechanosensitive ion channels (MSCs) in the malignant MCF-7 breast cancer cell line. MSCs turned out to be the most abundant ion channel species and could be activated by negative pressure at the outer side of the cell membrane in a saturable manner. Assessing single channel conductance (GΛ) for different monovalent cations revealed an increase in the succession: Li⁺ < Na⁺ < K⁺ ≈Rb⁺ ≈ Cs⁺. Divalent cations permeated also with the order: Ca²⁺ < Ba²⁺. Comparison of biophysical properties enabled us to identify MSCs in MCF-7 as ion channels formed by the Piezo1 protein. Using patch clamp technique no functional MSCs were observed in the benign MCF-10A mammary epithelial cell line. Blocking of MSCs by GsMTx-4 resulted in decreased motility of MCF-7, but not of MCF-10A cells, underscoring a possible role of Piezo1 in invasion and metastatic propagation. The role of Piezo1 in biology and progression of breast cancer is further substantiated by markedly reduced overall survival in patients with increased Piezo1 mRNA levels in the primary tumor. Y1 - 2015 U6 - https://doi.org/10.1038/srep08364 SN - 2045-2322 VL - 5 ER - TY - GEN A1 - Rezania, Simin A1 - Kammerer, Sarah A1 - Li, Chouyang A1 - Steinecker-Frohnwieser, Bibiane A1 - Gorischek, Astrid A1 - Devaney, Trevor Thomas Joseph A1 - Verheyen, Sarah A1 - Passegger, Christina A1 - Ghaffari Tabrizi-Wizsy, Nassim A1 - Hackl, Hubert A1 - Platzer, Dieter A1 - Zarnani, A.H. A1 - Malle, Ernst A1 - Jahn, Stephan Wenzel A1 - Bauernhofer, Thomas A1 - Schreibmayer, Wolfgang T1 - Overexpression of KCNJ3 gene splice variants affects vital parameters of the malignant breast cancer cell line MCF-7 in an opposing manner T2 - BMC Cancer N2 - Background Overexpression the KCNJ3, a gene that encodes subunit 1 of G-protein activated inwardly rectifying K+ channel (GIRK1) in the primary tumor has been found to be associated with reduced survival times and increased lymph node metastasis in breast cancer patients. Methods In order to survey possible tumorigenic properties of GIRK1 overexpression, a range of malignant mammary epithelial cells, based on the MCF-7 cell line that permanently overexpress different splice variants of the KCNJ3 gene (GIRK1a, GIRK1c, GIRK1d and as a control, eYFP) were produced. Subsequently, selected cardinal neoplasia associated cellular parameters were assessed and compared. ResultsAdhesion to fibronectin coated surface as well as cell proliferation remained unaffected. Other vital parameters intimately linked to malignancy, i.e. wound healing, chemoinvasion, cellular velocities / motilities and angiogenesis were massively affected by GIRK1 overexpression. Overexpression of different GIRK1 splice variants exerted differential actions. While GIRK1a and GIRK1c overexpression reinforced the affected parameters towards malignancy, overexpression of GIRK1d resulted in the opposite. Single channel recording using the patch clamp technique revealed functional GIRK channels in the plasma membrane of MCF-7 cells albeit at very low frequency. DiscussionWe conclude that GIRK1d acts as a dominant negative constituent of functional GIRK complexes present in the plasma membrane of MCF-7 cells, while overexpression of GIRK1a and GIRK1c augmented their activity. The core component responsible for the cancerogenic action of GIRK1 is apparently presented by a segment comprising aminoacids 235–402, that is present exclusively in GIRK1a and GIRK1c, but not GIRK1d (positions according to GIRK1a primary structure). Conclusions The current study provides insight into the cellular and molecular consequences of KCNJ3 overexpression in breast cancer cells and the mechanism upon clinical outcome in patients suffering from breast cancer. Y1 - 2016 U6 - https://doi.org/10.1186/s12885-016-2664-8 SN - 1471-2407 VL - 16 ER - TY - GEN A1 - Fink, Thomas A1 - Metzner, Andreas A1 - Willems, Stephan A1 - Eckardt, Lars A1 - Ince, Hüseyin A1 - Brachmann, Johannes A1 - Spitzer, Stefan G. A1 - Deneke, Thomas A1 - Schmitt, Claus A1 - Hochadel, Matthias A1 - Senges, Jochen A1 - Rillig, Andreas T1 - Procedural success, safety and patients satisfaction after second ablation of atrial fibrillation in the elderly: results from the German Ablation Registry T2 - Clinical Research in Cardiology volume KW - Catheter ablation, Atrial fibrillation, Elderly, Repeat ablation Y1 - 2019 U6 - https://doi.org/https://doi.org/10.1007/s00392-019-01471-5 SN - 1861-0692 SN - 1861-0684 VL - 108 SP - 1354 EP - 1363 CY - Springer Nature ER - TY - RPRT A1 - Mettke, Angelika A1 - Alvaro-Gonzales, Jorge A1 - Malys, Ewa A1 - Marks, Stephan A1 - Thomas, Cynthia A1 - Weber, Thomas A1 - Weigelt, Alexander T1 - Rückbau industrieller Bausubstanz - Großformatige Betonelemente im ökologischen Kreislauf KW - Betonelemente KW - Staubmessung KW - Rückbau Y1 - 2001 PB - BTU, Lehrstuhl Altlasten, Fachgruppe Bauliches Recycling CY - Cottbus ER - TY - GEN A1 - Jahn, Stephan F. A1 - Blaudeck, Thomas A1 - Baumann, Reinhard R. A1 - Jakob, Alexander A1 - Ecorchard, Petra A1 - Rüffer, Tobias A1 - Lang, Heinrich A1 - Schmidt, Peer T1 - Inkjet Printing of Conductive Silver Patterns by Using the First Aqueous Particle-Free MOD Ink without Additional Stabilizing Ligands T2 - Chemistry of Materials N2 - The chemical and physical properties of [AgO2C(CH2OCH2)3H] (3) and its use as an aqueous, ligand-free MOD ink (MOD = metal−organic decomposition) for piezo inkjet printing is discussed. The printed, thermal, or photochemical sintered silver features are electrically conductive on glass (2.7 × 107 S m−1) and PET (PET = polyethylene terephthalate) substrates (1.1 × 107 S m−1) corresponding to 43% and 18% of the bulk silver conductivity. Conducted tape tests show the suitability of the ink for particularly polymer substrates. TG-MS studies demonstrate a two-step decomposition for the conversion of 3 to elemental silver. The structure of 3 in the solid state was determined by single X-ray structure determination. Y1 - 2010 UR - http://pubs.acs.org/doi/abs/10.1021/cm9036428 U6 - https://doi.org/10.1021/cm9036428 SN - 1520-5002 VL - 22 IS - 10 SP - 3067 EP - 3071 ER - TY - GEN A1 - Jahn, Stephan F. A1 - Jakob, Alexander A1 - Blaudeck, Thomas A1 - Schmidt, Peer A1 - Lang, Heinrich A1 - Baumann, Reinhard R. T1 - Inkjet printing of conductive patterns with an aqueous solution of [AgO2C(CH2OCH2)3H] without any additional stabilizing ligands T2 - Thin Solid Films N2 - The use of silver(I)-2-[2-(2-methoxyethoxy)ethoxy]acetate, [AgO2C(CH2OCH2)3H], and its application as an aqueous metal-organic decomposition (MOD) inkjet ink is reported. The chemical and physical properties of the silver carboxylate and the ink formulated thereof are discussed. The ink meets all requirements of piezo driven inkjet printing. The printed features were converted into electrically conducting silver patterns by thermal or photo-thermal treatment. The conversion of [AgO2C(CH2OCH2)3H] to elemental silver follows a two-step decomposition as demonstrated by thermogravimetry–mass spectrometry (TG–MS) measurements. The measured conductivities of the printed features on glass and polyethylene-terephthalate (PET) are 2.7 × 107 S m−1 and 1.1 × 107 S m−1, respectively, which correspond to 43% (glass) and 18% (PET) of the bulk silver conductivity. KW - Inkjet printing KW - Silver KW - Carboxylate KW - Ethyleneglycol KW - Flexible electronics Y1 - 2010 UR - http://www.sciencedirect.com/science/article/pii/S0040609010000866 U6 - https://doi.org/10.1016/j.tsf.2010.01.030 SN - 0040-6090 VL - 518 IS - 12 SP - 3218 EP - 3222 ER - TY - GEN A1 - Siepa, Sarah A1 - Danko, Stephan A1 - Tsankov, Tsanko V. A1 - Mussenbrock, Thomas A1 - Czarnetzki, Uwe T1 - On the OES Line-Ratio Technique in Argon and Argon Containing Plasmas T2 - Journal of Physics D: Applied Physics Y1 - 2014 U6 - https://doi.org/10.1088/0022-3727/47/44/445201 SN - 1361-6463 VL - 47 IS - 44 SP - 445201 ER -