TY - CHAP A1 - Schulze, Thomas A1 - Sarradj, Ennes A1 - Geyer, Thomas T1 - Windgeräuschreduktion am Ohr T2 - Fortschritte der Akustik, DAGA 2016, Aachen, 14.-17. März 2016, 42. Jahrestagung für Akustik Y1 - 2016 SN - 978-3-939296-10-2 PB - DAGA CY - Berlin ER - TY - GEN A1 - Berger, Birk A1 - Steinberger, Thomas A1 - Schüngel, Edmund A1 - Koepke, Mark A1 - Mussenbrock, Thomas A1 - Awakowicz, Peter A1 - Schulze, Julian T1 - Enhanced power coupling efficiency in inductive discharges with RF substrate bias driven at consecutive harmonics with adjustable phase T2 - Applied Physics Letters Y1 - 2017 U6 - https://doi.org/10.1063/1.5000144 SN - 1077-3118 VL - 111 IS - 20 ER - TY - CHAP A1 - Bauer, Monika A1 - Dreyer, Christian A1 - Kahle, Olaf A1 - Schuldt, U. A1 - Uhlig, C. A1 - Schulze, K. A1 - Schulz, Stefan E. A1 - Uhlig, M. A1 - Geßner, Thomas T1 - Comparison of Fluorinated and Non-Fluorinated Novel Low-k Polycyanurates for Integrated Circuit (IC) Metallization Y1 - 2006 ER - TY - GEN A1 - Wilczek, Sebastian A1 - Trieschmann, Jan A1 - Eremin, Denis A1 - Brinkmann, Ralf Peter A1 - Schulze, Julian A1 - Schuengel, Edmund A1 - Derzsi, Aranka A1 - Korolov, Ihor A1 - Hartmann, Peter A1 - Donkó, Zoltán A1 - Mussenbrock, Thomas T1 - Kinetic Interpretation of Resonance Phenomena in Low Pressure Capacitively Coupled Radio Frequency Plasmas T2 - Physics of Plasmas Y1 - 2016 U6 - https://doi.org/10.1063/1.4953432 SN - 1070-664X SN - 1089-7674 VL - 23 IS - 6 SP - 063514 ER - TY - GEN A1 - Schulze, Julian A1 - Schüngel, Edmund A1 - Derzsi, Aranka A1 - Korolov, Ihor A1 - Mussenbrock, Thomas T1 - Complex Electron Heating in Capacitive Multi-Frequency Plasmas T2 - IEEE Transactions on Plasma Science Y1 - 2014 U6 - https://doi.org/10.1109/TPS.2014.2306265 SN - 0093-3813 VL - 42 IS - 10 SP - 2780 EP - 2781 ER - TY - GEN A1 - Wilczek, Sebastian A1 - Trieschmann, Jan A1 - Schulze, Julian A1 - Schüngel, Edmund A1 - Brinkmann, Ralf Peter A1 - Derzsi, Aranka A1 - Korolov, Ihor A1 - Donkó, Zoltán A1 - Mussenbrock, Thomas T1 - The Effect of the Driving Frequency on the Confinement of Beam Electrons and Plasma Density in Low Pressure Capacitive Discharges T2 - Plasma Sources Science and Technology Y1 - 2015 U6 - https://doi.org/10.1088/0963-0252/24/2/024002 SN - 0963-0252 SN - 1361-6595 VL - 24 IS - 2 SP - 024002 ER - TY - GEN A1 - Berger, Birk A1 - Brandt, Steven A1 - Franek, James A1 - Schüngel, Edmund A1 - Koepke, Mark A1 - Mussenbrock, Thomas A1 - Schulze, Julian T1 - Experimental Investigations of Electron Heating Dynamics and Ion Energy Distributions in Capacitive Discharges Driven by Customized Voltage Waveforms T2 - Journal of Applied Physics Y1 - 2015 U6 - https://doi.org/10.1063/1.4937403 SN - 1089-7550 SN - 0021-8979 VL - 118 IS - 22 SP - 223302 ER - TY - GEN A1 - Schulze, Julian A1 - Mussenbrock, Thomas T1 - Electron Heating in Technological Plasmas T2 - Plasma Sources Science and Technology Y1 - 2016 U6 - https://doi.org/10.1088/0963-0252/25/2/020401 SN - 0963-0252 SN - 1361-6595 VL - 25 IS - 2 SP - 020401 ER - TY - CHAP A1 - Berger, Birk A1 - Brandt, Steven A1 - Franek, James A1 - Schüngel, Edmund A1 - Koepke, Mark A1 - Schulze, Julian A1 - Mussenbrock, Thomas A1 - Bruneau, Bastien A1 - Johnson, Erik A1 - Lafleur, Trevor A1 - Booth, Jean-Paul A1 - O'Connell, Deborah A1 - Gans, Timo A1 - Korolov, Ihor A1 - Derzsi, Aranka A1 - Donkó, Zoltán T1 - Electron power absorption dynamics and ion energy distributions in capacitive discharges driven by customized voltage waveforms in argon and CF4 T2 - 2016 IEEE International Conference on Plasma Science (ICOPS), Banff, Canada, June 19-23, 2016 Y1 - 2016 SN - 978-1-4673-9601-1 U6 - https://doi.org/10.1109/PLASMA.2016.7534353 PB - IEEE CY - Piscataway, NJ ER - TY - CHAP A1 - Wilczek, Sebastian A1 - Trieschmann, Jan A1 - Schulze, Julian A1 - Schüngel, Edmund A1 - Brinkmann, Ralf Peter A1 - Derzsi, Aranka A1 - Korolov, Ihor A1 - Donkó, Zoltán A1 - Mussenbrock, Thomas T1 - Confinement of highly energetic electron beams in low pressure capacitive discharges T2 - Plasma Sciences (ICOPS), 2015 IEEE International Conference on, May 24-28, 2015, Antalya, Turkey Y1 - 2015 SN - 978-1-4799-6974-6 U6 - https://doi.org/10.1109/PLASMA.2015.7179545 PB - IEEE CY - Piscataway, NJ ER - TY - CHAP A1 - Wilczek, Sebastian A1 - Trieschmann, Jan A1 - Brinkmann, Ralf Peter A1 - Mussenbrock, Thomas A1 - Schulze, Julian A1 - Schüngel, Edmund A1 - Derzsi, Aranka A1 - Korolov, Ihor A1 - Hartmann, Paul A1 - Donkó, Zoltán T1 - Hysteresis effects and confinement of beam electrons in capacitive discharges T2 - 2016 IEEE International Conference on Plasma Science (ICOPS), Banff, Canada, June 19-23, 2016 Y1 - 2016 SN - 978-1-4673-9601-1 U6 - https://doi.org/10.1109/PLASMA.2016.7534342 PB - IEEE CY - Piscataway, NJ ER - TY - GEN A1 - Lukosius, Mindaugas A1 - Dabrowski, Jarek Marek A1 - Lisker, Marco A1 - Kitzmann, Julia A1 - Schulze, Sebastian A1 - Lippert, Gunther A1 - Fursenko, Oksana A1 - Yamamoto, Yuji A1 - Schubert, Markus Andreas A1 - Krause, Hans-Michael A1 - Wolff, Andre A1 - Mai, A. A1 - Schröder, Thomas A1 - Lupina, Grzegorz T1 - Metal-free, CVD Graphene synthesis on 200 mm Ge / Si(001) substrates T2 - ACS Applied Materials and Interfaces Y1 - 2016 U6 - https://doi.org/10.1021/acsami.6b11397 SN - 1944-8244 SN - 1944-8252 VL - 8 IS - 49 SP - 33786 EP - 33793 ER - TY - GEN A1 - Daksha, Manaswi A1 - Derzsi, Aranka A1 - Wilczek, Sebastian A1 - Trieschmann, Jan A1 - Mussenbrock, Thomas A1 - Awakowicz, Peter A1 - Donkó, Zoltán A1 - Schulze, Julian T1 - The Effect of Realistic Heavy Particle Induced Secondary Electron Emission Coefficients on the Electron Power Absorption Dynamics in Single- and Dual-Frequency CCPs T2 - Plasma Sources Science and Technology Y1 - 2017 U6 - https://doi.org/10.1088/1361-6595/aa7c88 SN - 1361-6595 SN - 0963-0252 VL - 26 IS - 8 SP - 085006 ER - TY - GEN A1 - Schmidt, Frederik A1 - Schulze, Julian A1 - Johnson, Erik A1 - Booth, Jean-Paul A1 - Keil, Douglas A1 - French, David M. A1 - Trieschmann, Jan A1 - Mussenbrock, Thomas T1 - Multi Frequency Matching for Voltage Waveform Tailoring T2 - Plasma Sources Science and Technology Y1 - 2018 U6 - https://doi.org/10.1088/1361-6595/aad2cd SN - 0963-0252 SN - 1361-6595 VL - 27 IS - 9 ER - TY - GEN A1 - Wilczek, Sebastian A1 - Trieschmann, Jan A1 - Schulze, Julian A1 - Donko, Zoltan A1 - Brinkmann, Ralf Peter A1 - Mussenbrock, Thomas T1 - Disparity between current and voltage driven capacitively coupled radio frequency discharges T2 - Plasma Sources Science and Technology Y1 - 2018 U6 - https://doi.org/10.1088/1361-6595/aae5c1 SN - 1361-6595 SN - 0963-0252 VL - 27 IS - 12 ER - TY - GEN A1 - Berger, Birk A1 - You, Kwangho A1 - Lee, Hyo-Chang A1 - Mussenbrock, Thomas A1 - Awakowicz, Peter A1 - Schulze, Julian T1 - Observation of the generation of multiple electron beams during a single sheath expansion phase in capacitive RF plasmas T2 - Plasma Sources Science and Technology Y1 - 2018 U6 - https://doi.org/10.1088/1361-6595/aaefc7 SN - 1361-6595 SN - 0963-0252 VL - 27 IS - 12 ER - TY - GEN A1 - Gibson, Andrew R. A1 - Donkó, Zoltán A1 - Alelyani, Layla A1 - Bischoff, Lena A1 - Hübner, Gerrit A1 - Bredin, Jérôme A1 - Doyle, Scott A1 - Korolov, Ihor A1 - Niemi, Kari A1 - Mussenbrock, Thomas A1 - Hartmann, Peter A1 - Dedrick, James P. A1 - Schulze, Julian A1 - Gans, Timo A1 - O'Connell, Deborah T1 - Disrupting the spatio-temporal symmetry of the electron dynamics in atmospheric pressure plasmas by voltage waveform tailoring T2 - Plasma Sources Science and Technology Y1 - 2019 U6 - https://doi.org/10.1088/1361-6595/aaf535 SN - 1361-6595 SN - 0963-0252 VL - 28 IS - 1 ER - TY - GEN A1 - Bischoff, Lena A1 - Hübner, Gerrit A1 - Korolov, Ihor A1 - Donkó, Zoltán A1 - Hartmann, Peter A1 - Gans, Timo A1 - Held, Julian A1 - Schulz-von der Gathen, Volker A1 - Liu, Yue A1 - Mussenbrock, Thomas A1 - Schulze, Julian T1 - Experimental and computational investigations of electron dynamics in micro atmospheric pressure radio-frequency plasma jets operated in He/N2 mixtures T2 - Plasma Sources Science and Technology Y1 - 2018 U6 - https://doi.org/10.1088/1361-6595/aaf35d SN - 1361-6595 SN - 0963-0252 VL - 27 IS - 12 ER - TY - GEN A1 - Korolov, Ihor A1 - Donko, Zoltan A1 - Hübner, Gerrit A1 - Bischoff, Lena A1 - Hartmann, Peter A1 - Gans, Timo A1 - Liu, Yue A1 - Mussenbrock, Thomas A1 - Schulze, Julian T1 - Control of electron dynamics, radical and metastable species generation in atmospheric pressure RF plasma jets by Voltage Waveform Tailoring T2 - Plasma Sources Science and Technology Y1 - 2019 U6 - https://doi.org/10.1088/1361-6595/ab38ea SN - 0963-0252 SN - 1361-6595 VL - 28 IS - 9 ER - TY - GEN A1 - Krüger, Florian A1 - Wilczek, Sebastian A1 - Mussenbrock, Thomas A1 - Schulze, Julian T1 - Voltage waveform tailoring in radio frequency plasmas for surface charge neutralization inside etch trenches T2 - Plasma Sources Science and Technology Y1 - 2019 U6 - https://doi.org/10.1088/1361-6595/ab2c72 SN - 963-0252 SN - 1361-6595 VL - 28 IS - 7 ER - TY - GEN A1 - Korolov, Ihor A1 - Leimkühler, Marc A1 - Boeke, Marc A1 - Donkó, Zoltan A1 - Schulz-von der Gathen, Volker A1 - Bischoff, Lena A1 - Hübner, Gerrit A1 - Hartmann, Peter A1 - Gans, Timo A1 - Liu, Yue A1 - Mussenbrock, Thomas A1 - Schulze, Julian T1 - Helium metastable species generation in atmospheric pressure RF plasma jets driven by tailored voltage waveforms in mixtures of He and N 2 T2 - Journal of Physics D: Applied Physics Y1 - 2020 U6 - https://doi.org/10.1088/1361-6463/ab6d97 SN - 1361-6463 VL - 53 ER - TY - GEN A1 - Schlykow, Viktoria A1 - Manganelli, Constanza Lucia A1 - Römer, Friedhard A1 - Clausen, Caterina J. A1 - Augel, Lion A1 - Schulze, Jörg A1 - Katzer, Jens A1 - Schubert, Michael Andreas A1 - Witzigmann, Bernd A1 - Schroeder, Thomas A1 - Capellini, Giovanni A1 - Fischer, Inga Anita T1 - Ge(Sn) nano-island/Si heterostructure photodetectors with plasmonic antennas T2 - Nanotechnology Y1 - 2020 U6 - https://doi.org/10.1088/1361-6528/ab91ef SN - 1361-6528 VL - 31 IS - 34 ER - TY - GEN A1 - Wilczek, Sebastian A1 - Schulze, Julian A1 - Brinkmann, Ralf Peter A1 - Donkó, Zoltan A1 - Trieschmann, Jan A1 - Mussenbrock, Thomas T1 - Electron dynamics in low pressure capacitively coupled radio frequency discharges T2 - Journal of Applied Physics Y1 - 2020 U6 - https://doi.org/10.1063/5.0003114.1 VL - 127 IS - 18 ER - TY - GEN A1 - Liu, Yue A1 - Korolov, Ihor A1 - Trieschmann, Jan A1 - Steuer, David A1 - Schulz-von der Gathen, Volker A1 - Böke, Marc A1 - Bischoff, Lena A1 - Hübner, Gerrit A1 - Schulze, Julian A1 - Mussenbrock, Thomas T1 - Micro Atmospheric Pressure Plasma Jets Excited in He/O2 by Voltage Waveform Tailoring: A Study Based on a Numerical Hybrid Model and Experiments T2 - Plasma Sources Science and Technology Y1 - 2021 U6 - https://doi.org/10.1088/1361-6595/abd0e0 SN - 1361-6595 VL - 30 IS - 6 SP - 1 EP - 30 ER - TY - GEN A1 - Liu, Yue A1 - Trieschmann, Jan A1 - Berger, Birk A1 - Schulze, Julian A1 - Mussenbrock, Thomas T1 - Non-Linear Effects and Electron Heating Dynamics in Radio-Frequency Capacitively Coupled Plasmas with a Non-Uniform Transverse Magnetic Field T2 - Physics of Plasmas Y1 - 2021 U6 - https://doi.org/10.1063/5.0045947 SN - 1089-7674 VL - 28 IS - 5 ER - TY - GEN A1 - Rosellini, Matteo A1 - Schulze, Alicia A1 - Omer, Ejlal A. A1 - Ali, Nadeen T. A1 - Marini, Federico A1 - Küpper, Jan-Heiner A1 - Efferth, Thomas T1 - The effect of plastic-related compounds on transcriptome-wide gene expression on CYP2C19-overexpressing HepG2 cells T2 - Molecules N2 - In recent years, plastic and especially microplastic in the oceans have caused huge problems to marine flora and fauna. Recently, such particles have also been detected in blood, breast milk, and placenta, underlining their ability to enter the human body, presumably via the food chain and other yet-unknown mechanisms. In addition, plastic contains plasticizers, antioxidants, or lubricants, whose impact on human health is also under investigation. At the cellular level, the most important enzymes involved in the metabolism of xenobiotic compounds are the cytochrome P450 monooxygenases (CYPs). Despite their extensive characterization in the maintenance of cellular balance, their interactions with plastic and related products are unexplored. In this study, the possible interactions between several plastic-related compounds and one of the most important cytochromes, CYP2C19, were analyzed. By applying virtual compound screening and molecular docking to more than 1000 commercially available plastic-related compounds, we identified candidates that are likely to interact with this protein. A growth inhibition assay confirmed their cytotoxic activity on a CYP2C19-transfected hepatic cell line. Subsequently, we studied the effect of the selected compounds on the transcriptome-wide gene expression level by conducting RNA sequencing. Three candidate molecules were identified, i.e., 2,2′-methylene bis(6-tert-butyl-4-methylphenol), 1,1-bis(3,5-di-tert-butyl-2-hydroxyphenyl) ethane, and 2,2′-methylene bis(6-cyclohexyl-4-methylphenol)), which bound with a high affinity to CYP2C19 in silico. They exerted a profound cytotoxicity in vitro and interacted with several metabolic pathways, of which the ‘cholesterol biosynthesis process’ was the most affected. In addition, other affected pathways involved mitosis, DNA replication, and inflammation, suggesting an increase in hepatotoxicity. These results indicate that plastic-related compounds could damage the liver by affecting several molecular pathways. KW - cytotoxicity KW - ecotoxicity KW - hepatotoxicity KW - microplastic KW - RNA sequencing Y1 - 2023 UR - https://www.mdpi.com/1420-3049/28/16/5952 U6 - https://doi.org/10.3390/molecules28165952 SN - 1420-3049 VL - 28 IS - 16 ER - TY - GEN A1 - Rosellini, Matteo A1 - Omer, Ejlal A. A1 - Schulze, Alicia A1 - Ali, Nadeen T. A1 - Boulos, Joelle C. A1 - Marini, Federico A1 - Küpper, Jan-Heiner A1 - Efferth, Thomas T1 - Impact of plastic-related compounds on the gene expression signature of HepG2 cells transfected with CYP3A4 T2 - Archives of Toxicology N2 - The presence of plastic and microplastic within the oceans as well as in marine flora and fauna have caused a multitude of problems that have been the topic of numerous investigations for many years. However, their impact on human health remains largely unknown. Such plastic and microplastic particles have been detected in blood and placenta, underlining their ability to enter the human body. Plastics also contain other compounds, such as plasticizers, antioxidants, or dyes, whose impact on human health is currently being studied. Critical enzymes within the metabolism of endogenous molecules, especially of xenobiotics, are the cytochrome P450 monooxygenases (CYPs). Although their importance in maintaining cellular balance has been confirmed, their interactions with plastics and related products are poorly understood. In this study, the possible relationship between different plastic-related compounds and CYP3A4 as one of the most important CYPs was analyzed using hepatic cells overexpressing this enzyme. Beginning with virtual compound screening and molecular docking of more than 1000 plastic-related compounds, several candidates were identified to interact with CYP3A4. In a second step, RNA-sequencing was used to study in detail the transcriptome-wide gene expression levels affected by the selected compounds. Three candidate molecules ((2,2′-methylenebis(6- tert -butyl-4-methylphenol), 1,1-bis(3,5-di- tert -butyl-2-hydroxyphenyl)ethane, and 2,2′-methylenebis(6-cyclohexyl-4-methylphenol)) had an excellent binding affinity to CYP3A4 in-silico as well as cytotoxic effects and interactions with several metabolic pathways in-vitro. We identified common pathways influenced by all three selected plastic-related compounds. In particular, the suppression of pathways related to mitosis and ‘DNA-templated DNA replication’ which were confirmed by cell cycle analysis and single-cell gel electrophoresis. Furthermore, several mis-regulated metabolic and inflammation-related pathways were identified, suggesting the induction of hepatotoxicity at different levels. These findings imply that these compounds may cause liver problems subsequently affecting the entire organism. KW - Cytotoxicity KW - Ecotoxicity KW - Environmental pollution KW - Hepatotoxicity KW - Marine pollution KW - Microplastic KW - RNA-sequencing KW - Biological Sciences Y1 - 2024 U6 - https://doi.org/10.1007/s00204-023-03648-4 SN - 0340-5761 SN - 1432-0738 VL - 98 IS - 2 SP - 525 EP - 536 PB - Springer Berlin Heidelberg ER -