TY - GEN A1 - Brandt, Thomas A1 - Glasauer, Stefan A1 - Schneider, Erich T1 - A third eye for the surgeon T2 - Journal of neurology, neurosurgery, and psychiatry Y1 - 2006 U6 - https://doi.org/10.1136/jnnp.2005.073734 SN - 0022-3050 SN - 1468-330X VL - 77 IS - 2 SP - 278 ER - TY - GEN A1 - Schneider, Erich A1 - Glasauer, Stefan A1 - Dieterich, Marianne A1 - Kalla, Roger A1 - Brandt, Thomas T1 - Diagnosis of vestibular imbalance in the blink of an eye T2 - Neurology Y1 - 2004 SN - 0028-3878 SN - 1526-632X VL - 63 IS - 7 SP - 1209 EP - 1216 ER - TY - GEN A1 - Schneider, Erich A1 - Glasauer, Stefan A1 - Brandt, Thomas A1 - Dieterich, Marianne T1 - Nonlinear nystagmus processing causes torsional vor nonlinearity T2 - Annals of the New York Academy of Sciences Y1 - 2003 SN - 1749-6632 VL - 1004 SP - 500 EP - 505 ER - TY - GEN A1 - Strupp, Michael A1 - Glasauer, Stefan A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Krafczyk, Siegbert A1 - Brandt, Thomas T1 - Eye movements and balance T2 - Annals of the New York Academy of Sciences Y1 - 2003 SN - 1749-6632 VL - 1004 SP - 352 EP - 358 ER - TY - GEN A1 - Heuser, Fabian A1 - Schulz, Christian A1 - Sağlam, Murat A1 - Ramaioli, Cecilia A1 - Heuberger, Maria A1 - Wagner, Klaus J. A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Brandt, Thomas A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Preventing opioid-induced nausea and vomiting: Rest your head and close your eyes? T2 - PloS one Y1 - 2017 U6 - https://doi.org/10.1371/journal.pone.0173925 SN - 1932-6203 VL - 12 IS - 3 SP - e0173925 ER - TY - GEN A1 - Glasauer, Stefan A1 - Dieterich, Marianne A1 - Brandt, Thomas T1 - Neuronal network-based mathematical modeling of perceived verticality in acute unilateral vestibular lesions: from nerve to thalamus and cortex T2 - Journal of Neurology Y1 - 2018 U6 - https://doi.org/10.1007/s00415-018-8909-5 SN - 1432-1459 SN - 0340-5354 VL - 265 IS - Supplement 1 SP - 112 ER - TY - GEN A1 - Dieterich, Marianne A1 - Glasauer, Stefan A1 - Brandt, Thomas T1 - Why acute unilateral vestibular midbrain lesions rarely manifest with rotational vertigo: a clinical and modelling approach to head direction cell function. T2 - Journal of Neurology Y1 - 2018 U6 - https://doi.org/10.1007/s00415-018-8828-5 SN - 0340-5354 SN - 1432-1459 VL - 265 IS - 5 SP - 1184 EP - 1198 ER - TY - GEN A1 - Glasauer, Stefan A1 - Dieterich, Marianne A1 - Brandt, Thomas T1 - Computational neurology of gravity perception involving semicircular canal dysfunction in unilateral vestibular lesions T2 - Progress in Brain Research N2 - Unilateral peripheral vestibular lesions not only lead to vertigo, nystagmus and imbalance, but also to a bias in the perception of verticality, which can be measured as tilt of the subjective visual vertical (SVV). Previously, this tilt has been assumed to be caused by a residual otolith bias, for example, because unequal numbers of active haircells on both sides of the utricular striola might result in an imbalance of the firing rates of central otolith neurons. Here we propose that a tilt of the subjective visual vertical might as well be caused by a vertical semicircular canal bias in the roll axis after unilateral peripheral lesions. The canal bias, acting similar to angular velocity stimuli, influences the SVV via the central gravity estimator, which under normal circumstances resolves a perceptual tilt-translation ambiguity. To illustrate our hypothesis, we compare model predictions to data on SVV measurements in patients with unilateral vestibular lesions while being tilted or being rotated eccentrically. We further embed the model of peripheral processing in a neural network that implements the idiotropic bias and represents the direction of gravity as population code in a three dimensional spherical topography. Y1 - 2019 U6 - https://doi.org/10.1016/bs.pbr.2019.04.010 SN - 1875-7855 SN - 0079-6123 VL - 248 SP - 303 EP - 317 ER - TY - GEN A1 - Schöberl, Florian A1 - Pradhan, Cauchy A1 - Irving, Stephanie A1 - Buerger, Katharina A1 - Xiong, Guoming A1 - Kugler, Günter A1 - Kohlbecher, Stefan A1 - Engmann, Julia A1 - Werner, Philipp A1 - Brendel, Matthias A1 - Schneider, Erich A1 - Perneczky, Robert A1 - Jahn, Klaus A1 - Fougère, Christian la A1 - Bartenstein, Peter A1 - Brandt, Thomas A1 - Dietrich, Marianne A1 - Zwergal, Andreas T1 - Real-space navigation testing differentiates between amyloid-positive and -negative aMCI T2 - Neurology : official journal of the American Academy of Neurology Y1 - 2020 UR - https://n.neurology.org/content/94/8/e861 U6 - https://doi.org/10.1212/WNL.0000000000008758 SN - 1526-632X VL - 94 IS - 8 SP - e861 EP - e873 ER - TY - GEN A1 - Schöberl, Florian A1 - Irving, Stephanie A1 - Pradhan, Cauchy A1 - Bardins, Stanislav A1 - Trapp, Christoph A1 - Schneider, Erich A1 - Kugler, Günter A1 - Bartenstein, Peter A1 - Dietrich, Marianne A1 - Brandt, Thomas A1 - Zwergal, Andreas T1 - Prolonged allocentric navigation deficits indicate hippocampal damage in TGA T2 - Neurology : official journal of the American Academy of Neurology N2 - Objective To investigate long-term recovery of allocentric and egocentric spatial orientation as a sensitive marker for hippocampal and extrahippocampal network function in transient global amnesia (TGA). Methods A group of 18 patients with TGA performed an established real-space navigation paradigm, requiring allo- and egocentric spatial orientation abilities, 3 days (postacute stage) and 3 months (follow-up) after symptom onset. Visual exploration behavior and navigation strategy were documented by a gaze-controlled, head-fixed camera. Allo- and egocentric spatial orientation performance was compared to that of 12 age-matched healthy controls. Navigation-induced brain activations were measured using [18F]-fluorodeoxyglucose-PET in a subgroup of 8 patients in the postacute stage and compared to those of the controls. Results In the postacute stage, the patients navigated worse and had higher error rates than controls in allocentric (p = 0.002), but not in egocentric, route planning (p = 0.30), despite complete recovery of verbal (p = 0.58) and figural memory (p = 0.11). Until follow-up, allocentric navigation deficits improved, but higher error rates and reduced use of shortcuts persisted (p < 0.0001). Patients still exhibited relatively more fixations of unique landmarks during follow-up (p = 0.05). PET measurements during the postacute stage showed increased navigation-induced brain activations in the right hippocampus, bilateral retrosplenial, parietal, and mesiofrontal cortices, and cerebellar dentate nucleus in patients compared to controls (p < 0.005). Conclusions Patients with TGA show selective and prolonged deficits of allocentric spatial orientation. Activations in right hippocampal and extrahippocampal hubs of the cerebral navigation network functionally substitute for the deficit in creating and updating the internal cognitive map in TGA. Y1 - 2019 UR - https://n.neurology.org/content/92/3/e234/tab-article-info U6 - https://doi.org/10.1212/WNL.0000000000006779 SN - 0028-3878 SN - 1526-632X VL - 92 IS - 3 SP - e234 EP - e243 ER -