TY - GEN A1 - Teufel, Julian A1 - Bardins, Stanislav A1 - Spiegel, Rainer A1 - Kremmyda, O. A1 - Schneider, Erich A1 - Strupp, Michael A1 - Kalla, R. T1 - Real time computerbased visual feedback improves visual acuity in downbeat nystagmus, a pilot study T2 - Journal of NeuroEngineering and Rehabilitation Y1 - 2016 SN - 1743-0003 VL - 13 IS - 1 ER - TY - GEN A1 - Feil, Katharina A1 - Claassen, Jens A1 - Brandins, Stanislavs A1 - Teufel, Julian A1 - Krafczyk, Siegbert A1 - Schneider, Erich T1 - Effect of chlorzoxazone in patients with downbeat nystagmus: a pilot trial T2 - Neurology Y1 - 2013 U6 - https://doi.org/10.1212/WNL.0b013e3182a55f6d SN - 0028-3878 SN - 1526-632X VL - 81 IS - 13 SP - 1152 EP - 1158 ER - TY - GEN A1 - Claassen, Jens A1 - Feil, Katharina A1 - Bardins, Stanislav A1 - Teufel, Julian A1 - Spiegel, Rainer A1 - Kalla, Roger A1 - Schneider, Erich T1 - Dalfampridine in patients with downbeat nystagmus–an observational study T2 - Journal of Neurology Y1 - 2013 U6 - https://doi.org/10.1007/s00415-013-6911-5 SN - 0340-5354 SN - 1432-1459 VL - 260 IS - 8 SP - 1992 EP - 1996 ER - TY - GEN A1 - Spiegel, Rainer A1 - Claassen, Jens A1 - Teufel, Julian A1 - Bardins, Stanislav A1 - Schneider, Erich A1 - Lehrer, Nicole A1 - Jahn, Klaus A1 - Anciaes da Silva, Fábio A1 - Hahn, Ales A1 - Farahmand, Parvis A1 - Brandt, Thomas A1 - Strupp, Michael A1 - Kalla, Roger T1 - Resting in darkness improves downbeat nystagmus: evidence from an observational study T2 - Annals of the New York Academy of Sciences N2 - Resting in an upright position during daytime decreases downbeat nystagmus (DBN). When measured in brightness only, that is, without intermitting exposure to darkness, it does not make a significant difference whether patients have previously rested in brightness or in darkness. In real-world scenarios, people are often exposed to brightness and darkness intermittently. The aim of this study was to analyze whether resting in brightness or resting in darkness was associated with a lower post-resting DBN after intermitting exposures to brightness and darkness. Eight patients were recorded with three-dimensional video-oculography in brightness and darkness conditions, each following two 2-h resting intervals under either brightness or darkness resting conditions. The dependent variable was DBN intensity, measured in mean slow phase velocity. A repeated measures ANOVA with the factors measurement condition (brightness vs. darkness), resting condition (brightness vs. darkness), and time (after first vs. second resting interval) showed a significant effect for the factor resting condition, where previous resting in darkness was associated with a significantly lower DBN relative to previous resting in brightness (P < 0.01). The clinical relevance is to advise patients with DBN to rest in darkness. KW - downbeat nystagmus KW - symptom relief KW - resting KW - oscillopsia KW - video-oculographic measurement (VOG) Y1 - 2016 U6 - https://doi.org/10.1111/nyas.13172 SN - 1749-6632 SN - 0077-8923 VL - 1375 IS - 1 SP - 66 EP - 73 ER -