TY - GEN A1 - Jung, E.M. A1 - Kaiser, U. A1 - Herr, W. A1 - Stroszczynski, C. A1 - Jung, F. T1 - Novel high-resolution contrast agent ultrasound techniques HiFR CEUS and SR CEUSin combination with shear wave elastography, fat assessment and viscosity of liver parenchymal changes and tumors T2 - Clinical Hemorheology and Microcirculation N2 - Abstract. BACKGROUND: The continuous development of ultrasound techniques increasingly enables better description and visu alization of unclear lesions. New ultrasound systems must be evaluated with regard to all these diagnostic possibilities. METHODS:Amultifrequency C1-7 convex probe (SC7-1M) with the new high-end system Resona A20 Series was used moderntechnologies, includingHiFRCEUS, SRCEUSandmultimodaltissueimaging withs hearwaveelastography(SWE), fat evaluation and viscosity measurements (M-Ref) were applied. RESULTS:Ofn=70(meanvalue 48,3 years±20,3 years, range 18–84 years) cases examined, a definitive diagnosis could be made in n=67 cases, confirmed by reference imaging and/or follow-up. Of these, n=22 cases were malignant changes (HCC (hepatocellular carcinoma) n=9, CCC (cholangiocellular carcinoma) n=3, metastases of colorectal carcinomas or recurrences of HCC n=10). In all 12 cases of HCC or CCC, the elastography measurements using the shear wave technique (with values >2m/s to 3.7m/s) showed mean values of 2.3±0.31m/s and a degree of fibrosis of F2 to F4. In n=14 cases, changes in the fat measurement (range 0.51 to 0.72dB/cm/MHz, mean values 0.58±0.12dB/cm/MHz) in the sense of proportional fatty changes in the liver were detected. In the 4 cases of localized fat distribution disorders, the values were >0.7dB/cm/MHz in the sense of significant fatty deposits in the remaining liver tissue. Relevant changes in the viscosity measurements with values >1.8kPa were found in n=31 cases, in n=5 cases of cystic lesions with partially sclerosing cholangitis, in n=13 cases of malignant lesions and in n=9 cases post-interventionally, but also in n=4 cases of benign foci with additional systemic inflammation. CONCLUSIONS:The results are promising and show a new quality of ultrasound-based liver diagnostics. However, there is a need for further investigations with regard to the individual aspects, preferably on a multi-center basis. KW - Multimodal liver tissue imaging (M-Ref) KW - UMA KW - HiFR CEUS KW - SR CEUS KW - Elastography KW - Fat evaluation KW - Viscosity Y1 - 2024 UR - https://content.iospress.com/download/clinical-hemorheology-and-microcirculation/ch249103?id=clinical-hemorheology-and-microcirculation%2Fch249103 U6 - https://doi.org/10.3233/CH-249103 VL - 86 (2024) SP - 263 EP - 273 ER - TY - GEN A1 - Jung, EM A1 - Pleyer, L A1 - Dropco, I A1 - Kaiser, U A1 - Yi, D A1 - Stroszczynski, C A1 - Jung, F T1 - Dynamic Contrast Ultrasound Diagnostics (CEUS) of Liver Lesions and Post-treatment Control with A New High-resolution Examination Technique (HiFR) and Perfusion T2 - Journal of Gastrointestinal & Liver Diseases N2 - Background & Aims: To evaluate, if high frame rate (HiFR) contrast-enhanced ultrasound (CEUS) and external perfusion analysis (VueBox®)can give answers on liver tumour diagnostics. Methods: A multifrequency probe (C1-6 /Resona R9) and 1-2.4 ml ultrasound contrast medium were used for CEUS up to 5-6 min. Independent analysis of DICOM-CINE files was performed, correlated to follow-up, computed tomography, magnetic resonance imaging, or histopathology. Results: In 110 patients the difference between marginal peak enhancement (PE) of malignant and benign leasions was significant. In the peripheral area, the AUCs were lower in malignant lesions (144.8±139.3) than in benign lesions (123.6±119.8). The mean transit time (mTT) was shorter in malignant lesions in the center. In the liver parenchyma, however, the mTT was significantly longer in malignant lesions (141.6±107.9s) than in benign lesions (128.8±138.6 s). The rise time (RT) was significantly shorter central (66.5±30.9s) and peripheral (72.8±35.1s) in malignant lesions than in benign lesions (114.33±159.58s). The wash in rate (WiR) in benign lesions was 848.3±2,563.7 rU in the center. Wash-out rate (WoR) in the center, peripheral and in the liver parenchyma showed a significantly lower wash-out in the malignant lesions. Conclusions: HiFR CEUS with perfusion analysis enables the assessment of focal, diffuse and postinterventional liver changes. KW - Ultrasound contrast media KW - Magnetic resonance imaging KW - Contrast-enhanced ultrasound KW - Liver analysis KW - Perfusion Y1 - 2024 U6 - https://doi.org/10.15403/jgld-5589 VL - 33 IS - 3 SP - 362 EP - 371 ER -