TY - GEN A1 - Fless, Friederike A1 - Graf, Bernhard A1 - Dally, Ortwin A1 - Franke, Ute A1 - Gerbich, Christine A1 - Lengyel, Dominik A1 - Knaut, Matthias A1 - Näser, Claudia A1 - Savoy, Bénédicte A1 - Steinmüller, Laura Katharina A1 - Steudtner, Katharina A1 - Taschner, Moritz A1 - Toulouse, Catherine A1 - Weber, Stefan T1 - Authenticity and Communication T2 - eTOPOI Journal for Ancient Studies N2 - Authenticity is not an absolute and constant quality inherent in an object or an experience; it is constructed in the process of research. Actors inscribe and attribute it to both material objects and subjective processes like communication and consumption. This article from the research group seeks on the one hand to reflect on the historical scope of action and action patterns among actors from various disciplines between the conflicting priorities of authentication and communication, and on the other to find ways to visualize and operationalize attribution processes through joint reflection. When we look at both history and the discussions fifty years after the Venice Charter, its idea to hand on historic monuments “in the full richness of their authenticity” has turned into an abundance of vibrant action and decision-making. KW - Visualisation Y1 - 2016 UR - http://journal.topoi.org/index.php/etopoi/article/view/263 SN - 2192-2608 VL - 6 SP - 479 EP - 524 ER - TY - GEN A1 - Künzel, Stephan R. A1 - Hoffmann, Maximilian A1 - Weber, Silvio A1 - Künzel, Karolina A1 - Kämmerer, Susanne A1 - Günscht, Mario A1 - Klapproth, Erik A1 - Rausch, Johanna S. E. A1 - Sadek, Mirna S. A1 - Kolanowski, Tomasz A1 - Meyer-Roxlau, Stefanie A1 - Piorkowski, Christopher A1 - Tugtekin, Sems M. A1 - Rose-John, Stefan A1 - Yin, Xiaoke A1 - Mayr, Manuel A1 - Kuhlmann, Jan Dominik A1 - Wimberger, Pauline A1 - Grützmann, Konrad A1 - Herzog, Natalie A1 - Küpper, Jan-Heiner A1 - O’Reilly, Molly A1 - Kabir, S. Nashitha A1 - Sommerfeld, Laura C. A1 - Guan, Kaomei A1 - Wielockx, Ben A1 - Fabritz, Larissa A1 - Nattel, Stanley A1 - Ravens, Ursula A1 - Dobrev, Dobromir A1 - Wagner, Michael A1 - El-Armouche, Ali T1 - Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation T2 - Circulation Research N2 - Rationale: Fibrosis promotes the maintenance of atrial fibrillation (AF), making it resistant to therapy. Improved understanding of the molecular mechanisms leading to atrial fibrosis will open new pathways toward effective antifibrotic therapies. Objective: This study aims to decipher the mechanistic interplay between PLK2 (polo-like kinase 2) and the profibrotic cytokine OPN (osteopontin) in the pathogenesis of atrial fibrosis and AF. Methods and Results: Atrial PLK2 mRNA expression was 10-fold higher in human fibroblasts than in cardiomyocytes. Compared with sinus rhythm, right atrial appendages and isolated right atrial fibroblasts from patients with AF showed downregulation of PLK2 mRNA and protein, along with increased PLK2 promotor methylation. Genetic deletion as well as pharmacological inhibition of PLK2 induced profibrotic phenotype conversion in cardiac fibroblasts and led to a striking de novo secretion of OPN. Accordingly, PLK2-deficient (PLK2 knockout) mice showed cardiac fibrosis and were prone to experimentally induced AF. In line with these findings, OPN plasma levels were significantly higher only in patients with AF with atrial low-voltage zones (surrogates of fibrosis) compared with sinus rhythm controls. Mechanistically, we identified ERK1/2 as the relevant downstream mediator of PLK2 leading to increased OPN expression. Finally, oral treatment with the clinically available drug mesalazine, known to inhibit ERK1/2, prevented cardiac OPN overexpression and reversed the pathological PLK2 knockout phenotype in PLK2 knockout mice. Conclusions: Abnormal PLK2/ERK1/2/OPN axis function critically contributes to AF-related atrial fibrosis, suggesting reinforcing PLK2 activity and/or OPN inhibition as innovative targets to prevent fibrosis progression in AF. Mesalazine derivatives may be used as lead compounds for the development of novel anti-AF agents targeting fibrosis. KW - atrial fibrillation KW - fibroblasts KW - fibrosis KW - mesalamine KW - osteopontin Y1 - 2021 UR - https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.121.319425 U6 - https://doi.org/10.1161/CIRCRESAHA.121.319425 SN - 1524-4571 SN - 0009-7330 VL - 129 IS - 8 SP - 804 EP - 820 ER - TY - GEN A1 - Martre, Pierre A1 - Dueri, Sibylle A1 - Brown, Hamish A1 - Asseng, Senthold A1 - Ewert, Frank A1 - Webber, Heidi A1 - George, Mike A1 - Craigie, Rob A1 - Guarin, Jose Rafael A1 - Pequeno, Diego A1 - Stella, Tommaso A1 - Ahmed, Mukhtar A1 - Alderman, Phillip A1 - Basso, Bruno A1 - Berger, Andres A1 - Bracho Mujica, Gennady A1 - Cammarano, Davide A1 - Chen, Yi A1 - Dumont, Benjamin A1 - Rezaei, Ehsan Eyshi A1 - Fereres, Elias A1 - Ferrise, Roberto A1 - Gaiser, Thomas A1 - Gao, Yujing A1 - Garcia-Vila, Margarita A1 - Gayler, Sebastian A1 - Hochman, Zvi A1 - Hoogenboom, Gerrit A1 - Kersebaum, Kurt C. A1 - Nendel, Claas A1 - Olesen, Jørgen A1 - Padovan, Gloria A1 - Palosuo, Taru A1 - Priesack, Eckart A1 - Pullens, Johannes A1 - Rodríguez, Alfredo A1 - Rötter, Reimund P. A1 - Ruiz Ramos, Margarita A1 - Semenov, Mikhail A1 - Senapati, Nimai A1 - Siebert, Stefan A1 - Srivastava, Amit Kumar A1 - Stöckle, Claudio A1 - Supit, Iwan A1 - Tao, Fulu A1 - Thorburn, Peter A1 - Wang, Enli A1 - Weber, Tobias A1 - Xiao, Liujun A1 - Zhao, Chuang A1 - Zhao, Jin A1 - Zhao, Zhigan A1 - Zhu, Yan T1 - Winter wheat experiments to optimize sowing dates and densities in a high-yielding environment in New Zealand: field experiments and AgMIP-Wheat multi-model simulations T2 - Open Data Journal for Agricultural Research N2 - This paper describes the data set that was used to test the accuracy of twenty-nine crop models in simulating the effect of changing sowing dates and sowing densities on wheat productivity for a high-yielding environment in New Zealand. The data includes one winter wheat cultivar (Wakanui) grown during six consecutive years, from 2012-2013 to 2017-2018, at two farms located in Leeston and Wakanui in Canterbury, New Zealand. The simulations were carried out in the framework of the Agricultural Model Intercomparison and Improvement Project for wheat (AgMIP-Wheat). Data include local daily weather data, soil profile characteristics and initial conditions, crop measurements at maturity (grain, stem, chaff and leaf dry weight, ear number and grain number, grain unit dry weight), and at stem elongation and anthesis (total above ground dry biomass, leaf number per stem and leaf area index). Several in-season measurements of the normalized difference vegetation index (NDVI) and the fraction of intercepted photosynthetically active radiation (FIPAR) are also available. The crop model simulations include both daily in-season and end-of-season results from twenty-nine wheat models. KW - field experimental data KW - multi-crop model ensemble KW - sowing date KW - sowing density KW - winter wheat KW - yield potential Y1 - 2024 U6 - https://doi.org/10.18174/odjar.v10i0.18442 SN - 2352-6378 VL - 10 SP - 14 EP - 21 PB - Wageningen University and Research ER - TY - GEN A1 - Kedia, Mayank A1 - Das, Chittaranjan A1 - Kot, Malgorzata A1 - Yalcinkaya, Yenal A1 - Zuo, Weiwei A1 - Tabah Tanko, Kenedy A1 - Matvija, Peter A1 - Ezquer, Mikel A1 - Cornago, Iñaki A1 - Hempel, Wolfram A1 - Kauffmann, Florian A1 - Plate, Paul A1 - Lira-Cantu, Monica A1 - Weber, Stefan A.L. A1 - Saliba, Michael T1 - Mitigating the amorphization of perovskite layers by using atomic layer deposition of alumina T2 - Energy & environmental science N2 - Atomic layer deposition of aluminum oxide (ALD-Al2O3) layers has recently been studied for stabilizing perovskite solar cells (PSCs) against environmental stressors, such as humidity and oxygen. In addition, the ALD-Al2O3 layer acts as a protective barrier, mitigating pernicious halide ion migration from the perovskite towards the hole transport interface. However, its effectiveness in preventing the infiltration of ions and additives from the hole-transport layer into perovskites remains insufficiently understood. Herein, we demonstrate the deposition of a compact ultrathin (∼0.75 nm) ALD-Al2O3 layer that conformally coats the morphology of a triple-cation perovskite layer. This promotes an effective contact of the hole transporter layer on top of the perovskite, thereby improving the charge carrier collection between these two layers. Upon systematically investigating the layer-by-layer structure of the PSC, we discovered that ALD-Al2O3 also acts as a diffusion barrier for the degraded species from the adjacent transport layer into the perovskite. In addition to these protective considerations, ALD-Al2O3 impedes the transition of crystalline perovskites to an undesired amorphous phase. Consequently, the dual functionality (i.e., enhanced contact and diffusion barrier) of the ALD-Al2O3 protection enhanced the device performance from 19.1% to 20.5%, while retaining 98% of its initial performance compared to <10% for pristine devices after 1500 h of outdoor testing under ambient conditions. Finally, this study deepens our understanding of the mechanism of ALD-Al2O3 as a two-way diffusion barrier, highlighting the multifaceted role of buffer layers in interfacial engineering for the long-term stability of PSCs. Y1 - 2025 U6 - https://doi.org/10.1039/D4EE05703A SN - 1754-5692 VL - 18 IS - 11 SP - 5250 EP - 5263 PB - Royal Society of Chemistry (RSC) CY - London ER -