TY - GEN A1 - Yudice, Joshua A1 - Bayer, Johanna A1 - Bockisch, Christopher A1 - Glasauer, Stefan T1 - Inter-subject variability of visual-vestibular sensory fusion during angular rotation T2 - Bernstein Conference 2020 Y1 - 2020 U6 - https://doi.org/10.12751/nncn.bc2020.0250 ER - TY - GEN A1 - Yudice, Joshua A1 - Glasauer, Stefan T1 - Navigational frame of reference during idiothetic path integration in humans T2 - INAV 2020 Y1 - 2020 UR - https://inavsymposium.com/wp-content/uploads/2020/10/Data_Blitz_Booklet_2020.pdf VL - 2020 SP - 41 ER - TY - GEN A1 - Spiegel, Rainer A1 - Kalla, R. A1 - Rettinger, N. A1 - Schneider, Erich A1 - Straumann, D. A1 - Marti, S. A1 - Glasauer, Stefan T1 - Head position during resting modifies spontaneous daytime decrease of downbeat nystagmus T2 - Neurology Y1 - 2010 U6 - https://doi.org/10.1212/WNL.0b013e3181feb22f SN - 0028-3878 SN - 1526-632X VL - 75 IS - 21 SP - 1928 EP - 1932 ER - TY - GEN A1 - Wright, W. Geoffrey A1 - Schneider, Erich A1 - Glasauer, Stefan T1 - Compensatory manual motor responses while object wielding during combined linear visual and physical roll tilt stimulation T2 - Experimental Brain Research Y1 - 2009 U6 - https://doi.org/10.1007/s00221-008-1581-8 SN - 0014-4819 SN - 1432-1106 VL - 192 IS - 4 SP - 683 EP - 694 ER - TY - GEN A1 - Guenther, Anna L. A1 - Bartl, Klaus A1 - Nauderer, Josef A1 - Schneider, Erich A1 - Huesmann, Alexander A1 - Brandt, Thomas A1 - Glasauer, Stefan T1 - Modalitydependent indication of the subjective vertical during combined linear and rotational movements T2 - Annals of the New York Academy of Sciences Y1 - 2009 U6 - https://doi.org/10.1111/j.1749-6632.2009.03849.x SN - 1749-6632 VL - 1164 SP - 376 EP - 379 ER - TY - GEN A1 - Glasauer, Stefan A1 - Schneider, Erich A1 - Grasso, Renato A1 - Ivanenko, Yuri P. T1 - Space-time relativity in self-motion reproduction T2 - Journal of Neurophysiology Y1 - 2007 U6 - https://doi.org/10.1152/jn.01243.2005 SN - 0022-3077 SN - 1522-1598 VL - 97 IS - 1 SP - 451 EP - 461 ER - TY - GEN A1 - Zingler, Vera C. A1 - Kryvoshey, Dmytro A1 - Schneider, Erich A1 - Glasauer, Stefan A1 - Brandt, Thomas A1 - Strupp, Michael T1 - A clinical test of otolith function: static ocular counterroll with passive head tilt. T2 - Neuroreport Y1 - 2006 SN - 0959-4965 VL - 17 IS - 6 SP - 611 EP - 615 ER - TY - GEN A1 - Nowak, Dennis A. A1 - Hermsdörfer, Joachim A1 - Schneider, Erich A1 - Glasauer, Stefan T1 - Moving objects in a rotating environment rapid prediction of coriolis and centrifugal force perturbations T2 - Experimental Brain Research Y1 - 2004 U6 - https://doi.org/10.1007/s00221-004-1839-8 SN - 0014-4819 SN - 1432-1106 VL - 157 IS - 2 SP - 241 EP - 254 ER - TY - GEN A1 - Schneider, Erich A1 - Glasauer, Stefan A1 - Dieterich, Marianne A1 - Kalla, Roger A1 - Brandt, Thomas T1 - Diagnosis of vestibular imbalance in the blink of an eye T2 - Neurology Y1 - 2004 SN - 0028-3878 SN - 1526-632X VL - 63 IS - 7 SP - 1209 EP - 1216 ER - TY - GEN A1 - Schneider, Erich A1 - Glasauer, Stefan A1 - Dieterich, Marianne T1 - Comparison of human ocular torsion patterns during natural and galvanic vestibular stimulation T2 - Journal of Neurophysiology Y1 - 2002 U6 - https://doi.org/10.1152/jn.00558.2001 SN - 0022-3077 SN - 1522-1598 VL - 87 IS - 4 SP - 2064 EP - 2073 ER - TY - GEN A1 - Schröder, Lena A1 - Regnath, Franziska A1 - Glasauer, Stefan A1 - Hackenberg, Anna A1 - Hente, Juliane A1 - Weilenmann, Sonja A1 - Pohl, Daniel A1 - Känel, Roland von A1 - Lehnen, Nadine T1 - Altered sensorimotor processing in irritable bowel syndrome: Evidence for a transdiagnostic pathomechanism in functional somatic disorders T2 - Frontiers in Neuroscience N2 - Objective A recent hypothesis suggests that functional somatic symptoms are due to altered information processing in the brain, with rigid expectations biasing sensorimotor signal processing. First experimental results confirmed such altered processing within the affected symptom modality, e.g., deficient eye-head coordination in patients with functional dizziness. Studies in patients with functional somatic symptoms looking at general, trans-symptomatic processing deficits are sparse. Here, we investigate sensorimotor processing during eye-head gaze shifts in irritable bowel syndrome (IBS) to test whether processing deficits exist across symptom modalities. Methods Study participants were seven patients suffering from IBS and seven age- and gender-matched healthy controls who performed large gaze shifts toward visual targets. Participants performed combined eye-head gaze shifts in the natural condition and with experimentally increased head moment of inertia. Head oscillations as a marker for sensorimotor processing deficits were assessed. Bayes statistics was used to assess evidence for the presence or absence of processing differences between IBS patients and healthy controls. Results With the head moment of inertia increased, IBS patients displayed more pronounced head oscillations than healthy controls (Bayes Factor 10 = 56.4, corresponding to strong evidence). Conclusion Patients with IBS show sensorimotor processing deficits, reflected by increased head oscillations during large gaze shifts to visual targets. In particular, patients with IBS have difficulties to adapt to the context of altered head moment of inertia. Our results suggest general transdiagnostic processing deficits in functional somatic disorders. KW - irritable bowel syndrome (IBS) KW - functional somatic disorders KW - somatoform disorders KW - predictive processing KW - transdiagnostic mechanism KW - gaze shift Y1 - 2022 U6 - https://doi.org/10.3389/fnins.2022.1029126 SN - 1662-453X VL - 16 ER - TY - GEN A1 - Werder, Dina von A1 - Regnath, Franziska A1 - Schäfer, Daniel A1 - Jörres, Rudolf A1 - Lehnen, Nadine A1 - Glasauer, Stefan T1 - Post-COVID breathlessness: a mathematical model of respiratory processing in the brain T2 - European Archives of Psychiatry and Clinical Neuroscience N2 - Breathlessness is among the most common post-COVID symptoms. In a considerable number of patients, severe breathlessness cannot be explained by peripheral organ impairment. Recent concepts have described how such persistent breathlessness could arise from dysfunctional processing of respiratory information in the brain. In this paper, we present a first quantitative and testable mathematical model of how processing of respiratory-related signals could lead to breathlessness perception. The model is based on recent theories that the brain holds an adaptive and dynamic internal representation of a respiratory state that is based on previous experiences and comprises gas exchange between environment, lung and tissue cells. Perceived breathlessness reflects the brain’s estimate of this respiratory state signaling a potentially hazardous disequilibrium in gas exchange. The internal respiratory state evolves from the respiratory state of the last breath, is updated by a sensory measurement of CO2 concentration, and is dependent on the current activity context. To evaluate our model and thus test the assumed mechanism, we used data from an ongoing rebreathing experiment investigating breathlessness in patients with post-COVID without peripheral organ dysfunction (N = 5) and healthy control participants without complaints after COVID-19 (N = 5). Although the observed breathlessness patterns varied extensively between individual participants in the rebreathing experiment, our model shows good performance in replicating these individual, heterogeneous time courses. The model assumes the same underlying processes in the central nervous system in all individuals, i.e., also between patients and healthy control participants, and we hypothesize that differences in breathlessness are explained by different weighting and thus influence of these processes on the final percept. Our model could thus be applied in future studies to provide insight into where in the processing cascade of respiratory signals a deficit is located that leads to (post-COVID) breathlessness. A potential clinical application could be, e.g., the monitoring of effects of pulmonary rehabilitation on respiratory processing in the brain to improve the therapeutic strategies. KW - Pharmacology (medical) KW - Biological Psychiatry KW - Psychiatry and Mental health KW - General Medicine Y1 - 2024 U6 - https://doi.org/10.1007/s00406-023-01739-y SN - 0940-1334 ER -