TY - GEN A1 - Bassereh, Hassan A1 - Fleuriet, Jérome A1 - Mustari, Michael J. A1 - Glasauer, Stefan T1 - Linear regression versus information-theoretic approach; efficiencies and deficiencies T2 - Bernstein Conference 2020, September, 29 - October, 1, 2020 Y1 - 2020 U6 - https://doi.org/10.12751/nncn.bc2020.0023 ER - TY - GEN A1 - Lutfi, Helana A1 - Glasauer, Stefan A1 - Spittler, Thomas T1 - The healthcare benefits and impact of artificial intelligence applications on behaviour of healthcare users: a structured review of primary literature T2 - Journal of the International Society for Telemedicine and EHealth N2 - Introduction: Artificial intelligence (AI) is one of the most considered topics of the current time. AI has the power to bring revolutionary improvements to the world of technology not only in the field of computer science but also in other fields like medical sciences. Objectives: This paper assumes the adoption of appropriate AI engineering principals in previous studies, and focusses on providing a structured review of the impact of AI on human society and the individual human being as a technology user. Additionally, it opens a window on how the future will look like in terms of AI and personalised medicine. Methods: The paper employed a qualitative research approach and data were collected through a structured literature review. Twenty-three peer reviewed papers were identified and analysed in relation to their relevance to the study. Results: Previous studies show a positive impact on users' behaviour is expected in supporting their healthcare needs especially in decision-making, personalised treatment and future diseases prediction, and that integrating users in studying AI impact is essential to test possible implications of the technology. Conclusion: Results indicate that without a clear understanding of why patients need AI, or how AI can support individuals with their healthcare needs, it is difficult to visualise the kinds of AI applications that have a meaningful and sustainable impact the daily lives of individuals. Therefore, there is an emerging need to understand the impact of AI technology on users' behaviour to maximise the potential benefits of AI technology. Y1 - 2020 UR - https://journals.ukzn.ac.za/index.php/JISfTeH/article/view/1876 U6 - https://doi.org/10.29086/JISfTeH.8.e10 SN - 2308-0310 VL - 8 SP - 1 EP - 5 ER - TY - GEN A1 - Glasauer, Stefan A1 - Hausmann, Peter A1 - MacNeilage, Paul R. T1 - Statistics of natural head motion suggest different head motion priors for rest and movement T2 - Bernstein Conference 2018 Y1 - 2018 U6 - https://doi.org/10.12751/nncn.bc2018.0132 ER - TY - GEN A1 - Glasauer, Stefan A1 - Salmasi, Mehrdad A1 - Stemmler, Martin T1 - The synergy between neurotransmitter spillover and asynchronous release in information transmission T2 - Bernstein Conference 2018 Y1 - 2018 U6 - https://doi.org/10.12751/nncn.bc2018.0209 ER - TY - GEN A1 - Bassereh, Hassan A1 - Rattay, Frank A1 - Glasauer, Stefan T1 - A mathematical framework for vesicle release from a retinal bipolar cell T2 - Bernstein Conference Y1 - 2019 U6 - https://doi.org/10.12751/nncn.bc2019.0209 ER - TY - GEN A1 - Glasauer, Stefan T1 - Sensorimotor control of smooth pursuit T2 - Neuroscience 2018 Home N2 - Interaction with the visual world critically depends on when and how we move our eyes. Eye movements, in turn, alter our experience of the world by selecting objects to foveate and tracking objects over time. The interaction between vision and eye movements continues indefinitely, one process modulating the strength and timing of the other. Despite this tight linkage, vision is often studied outside the context of eye movements, during stable fixation. Likewise, eye movements are often studied with sparse visual stimuli and under ideal viewing conditions. A more accurate understanding of vision requires studying perception in the context of eye movements. Different types of eye movements reveal different aspects of how the brain works. The continuous nature of tracking smooth pursuit eye movements, combined with its ubiquitous presence in natural vision, makes it an excellent system in which to analyze perception at fine spatial and temporal resolutions. For example, how does vision change during the transition from fixation to pursuit, and when does the brain allocate resources to account for these changes? In contrast, the ballistic nature of saccades requires analysis divided into discrete epochs, including well before the saccade during the planning stage, during saccade execution, and after the movement. At the neuronal level, how do heterogeneous populations of visual- and saccade-related cells come to represent a single saccade vector during these different epochs? What are the effects on visual perception when saccades and pursuit interact? This symposium will reveal how research incorporating both types of eye movements and visual perception can provide a more ecologically valid account of visual-motor integration and the intervening cognitive processes. This symposium will review innovative approaches and recent advances in understanding the interplay of eye movements and vision. We will take a multifaceted approach to understanding the effects of both exploratory (saccades) and tracking (smooth pursuit) eye movements on vision by using a range of methodologies and animal models (data-driven modeling, clinical populations, and simultaneous recordings of neuronal populations; humans, macaques, and marmosets). This symposium will appeal to vision scientists interested in selective attention, motion processing, neuronal modeling, motor control, neural circuits, and related topics. Our collective goal is to uncover the dynamics of visual perception and the candidate neuronal mechanisms that support eye movements. Y1 - 2018 UR - https://www.abstractsonline.com/pp8/#!/4649/presentation/40985 ER - TY - GEN A1 - Salmasi, Mehrdad A1 - Glasauer, Stefan A1 - Stemmler, Martin T1 - Neurotransmitter spillover redresses the information loss caused by synaptic depression T2 - Lisboa 2019, Conference Lisbon, Portugal, 28 feb - 3 mar Y1 - 2019 UR - http://cosyne.org/cosyne19/Cosyne2019_program_book.pdf SP - 154 ER - TY - GEN A1 - Kostorz, Kathrin A1 - Flanagin, Virginia A1 - Glasauer, Stefan T1 - Instructor-observer synchronization of BOLD activity mediated by instructive origami videos T2 - Neuroscience 2018 Y1 - 2018 UR - https://www.abstractsonline.com/pp8/#!/4649/presentation/5751 ER - TY - GEN A1 - Glasauer, Stefan A1 - Shi, Z. T1 - 150 years of Vierordt’s law: The role of experimental protocol T2 - CA: Society for Neuroscience, 2018 Y1 - 2018 UR - https://www.abstractsonline.com/pp8/#!/4649/presentation/4957 UR - https://www.sfn.org/-/media/SfN/Documents/NEW-SfN/Meetings/Neuroscience-2018/Abstracts/Neuroscience-2018-Abstracts/SFN18_Abstract-PDFs---Theme-J.pdf CY - San Diego ER - TY - GEN A1 - Glasauer, Stefan A1 - Shi, Zhuanghua T1 - The origin of Vierordt's law: The experimental protocol matters T2 - PsyCH Journal N2 - In 1868, Karl Vierordt discovered one type of errors in time perception—an overestimation of short duration and underestimation of long durations, known as Vierordt's law. Here we reviewed the original study in its historical context and asked whether Vierordt's law is a result of an unnatural experimental randomization protocol. Using iterative Bayesian updating, we simulated the original results with high accuracy. Importantly, the model also predicted that a slowly changing random-walk sequence produces less central tendency than a random sequence with the same durations. This was validated by a duration reproduction experiment from two sequences (random and random walk) with the same sampled distribution. The results showed that trial-wise variation influenced the magnitude of Vierordt's law. We concluded that Vierordt's law is caused by an unnatural yet widely used experimental protocol. Y1 - 2021 UR - https://onlinelibrary.wiley.com/doi/10.1002/pchj.464 U6 - https://doi.org/10.1002/pchj.464 SN - 2046-0260 SN - 2046-0252 VL - 10 IS - 5 SP - 732 EP - 741 ER - TY - GEN A1 - Glasauer, Stefan A1 - Shi, Zhuanghua T1 - Differences in beliefs about stimulus generation explain individual perceptual biases T2 - Bernstein Conference 2021, September 21 - 23, 2021 Y1 - 2021 U6 - https://doi.org/10.12751/nncn.bc2021.p052 VL - 2021 ER - TY - GEN A1 - Kostorz, Kathrin A1 - Flanagin, Virginia A1 - Glasauer, Stefan T1 - Intersubject synchrony of viewers during naturalistic observational learning of a complex bimanual task T2 - Neuroimage: Reports N2 - Watching an instructional video has become a common way to learn a new task. However, we have but a sparse understanding of the neural processes involved during observational learning in naturalistic settings. Recently developed data driven methods for analyzing brain activity provide an opportunity for further investigation. Here, we evaluate intersubject synchrony during fMRI to understand common brain processes during naturalistic observational learning. Participants solitarily watched an instructional video and learned how to fold a paper figure. Three learning runs were sufficient to successfully solve the task. To assess interbrain synchrony, we extended previous principal component (PCA)-based methods to an intersubject principal component analysis (PCA), which offers multiple measures for additional insights into the nature of the synchrony. Using the different metrics of this method, we show a robust synchronous involvement of the action observation execution network (AOEN) in observational learning, between subjects as well as within subjects, regardless of the task or video content. Importantly, additional areas such as the cerebellum, primary motor cortex, control, and sensory integration areas also showed robust synchrony in observational learning. Complimentary to this robust general synchrony, individual regions of the AOEN exhibited task-related differences. Synchrony decreased during the learning process, likely reflecting task state and individual learning strategies. To test the stimulus as a possible source of synchrony, we quantified the temporal structure as the optic flow of the instructional video. Optic flow was strongly related to common activation of the somatomotor areas of the AOEN well beyond visual areas, but could not completely explain synchrony. Thus, although visual motion provides a proxy for meaningful hand actions, our results suggest that intersubject synchrony reflects common cognitive processing during observa- tional learning beyond sensory input. Y1 - 2022 U6 - https://doi.org/10.1016/j.ynirp.2022.100084 SN - 2666-9560 VL - 2 IS - 2 ER - TY - GEN A1 - Glasauer, Stefan A1 - Shi, Zhuanghua T1 - Individual beliefs about temporal continuity explain variation of perceptual biases T2 - Scientific Reports N2 - Perception of magnitudes such as duration or distance is often found to be systematically biased. The biases, which result from incorporating prior knowledge in the perceptual process, can vary considerably between individuals. The variations are commonly attributed to differences in sensory precision and reliance on priors. However, another factor not considered so far is the implicit belief about how successive sensory stimuli are generated: independently from each other or with certain temporal continuity. The main types of explanatory models proposed so far—static or iterative—mirror this distinction but cannot adequately explain individual biases. Here we propose a new unifying model that explains individual variation as combination of sensory precision and beliefs about temporal continuity and predicts the experimentally found changes in biases when altering temporal continuity. Thus, according to the model, individual differences in perception depend on beliefs about how stimuli are generated in the world. Y1 - 2022 U6 - https://doi.org/10.1038/s41598-022-14939-8 SN - 2045-2322 VL - 12 ER - TY - GEN A1 - Glasauer, Stefan A1 - Straka, Hans T1 - Low Gain Values of the Vestibulo-Ocular Reflex Can Optimize Retinal Image Slip T2 - Frontiers in Neurology N2 - The angular vestibulo-ocular reflex (aVOR) stabilizes retinal images by counter-rotating the eyes during head rotations. Perfect compensatory movements would thus rotate the eyes exactly opposite to the head, that is, eyes vs. head would exhibit a unity gain. However, in many species, but also in elderly humans or patients with a history of vestibular damage, the aVOR is far from compensatory with gains that are in part considerably lower than unity. The reason for this apparent suboptimality is unknown. Here, we propose that low VOR gain values reflect an optimal adaptation to sensory and motor signal variability. According to this hypothesis, gaze stabilization mechanisms that aim at minimizing the overall retinal image slip must consider the effects of (1) sensory and motor noise and (2) dynamic constraints of peripheral and central nervous processing. We demonstrate that a computational model for optimizing retinal image slip in the presence of such constraints of signal processing in fact predicts gain values smaller than unity. We further show specifically for tadpoles of the clawed toad, Xenopus laevis with particularly low gain values that previously reported VOR gains quantitatively correspond to the observed variability of eye movements and thus constitute an optimal adaptation mechanism. We thus hypothesize that lower VOR gain values in elderly human subjects or recovered patients with a history of vestibular damage may be the sign of an optimization given higher noise levels rather than a direct consequence of the damage, such as an inability of executing fast compensatory eye movements. Y1 - 2022 U6 - https://doi.org/10.3389/fneur.2022.897293 SN - 1664-2295 VL - 13 ER - TY - GEN A1 - Glasauer, Stefan A1 - Straka, Hans T1 - Ear pins down evolution of thermoregulation T2 - Nature N2 - An analysis of fossil specimens of the inner ear helps to refine the timeframe of a key transition in vertebrate evolution — when our mammal-like ancestors began to regulate and maintain a high body temperature. Y1 - 2022 U6 - https://doi.org/10.1038/d41586-022-01943-1 IS - 607 SP - 661 EP - 662 ER - TY - GEN A1 - Kremmyda, Olympia A1 - Rettinger, Nicole A1 - Strupp, Michael A1 - Büttner, Ulrich A1 - Glasauer, Stefan T1 - Teaching Video NeuroImages: Unilateral RIMLF lesion. Pathologic eye movement torsion indicates lesion side and site T2 - Neurology Y1 - 2023 U6 - https://doi.org/10.1212/WNL.0000000000207003 SN - 0028-3878 VL - 100 IS - 16, Supplement 1 SP - S182 EP - S183 ER - TY - GEN A1 - Cheng, Si A1 - Chen, Siyi A1 - Glasauer, Stefan A1 - Keeser, Daniel A1 - Shi, Zhuanghua T1 - Neural mechanisms of sequential dependence in time perception: the impact of prior task and memory processing T2 - Cerebral Cortex N2 - Our perception and decision-making are susceptible to prior context. Such sequential dependence has been extensively studied in the visual domain, but less is known about its impact on time perception. Moreover, there are ongoing debates about whether these sequential biases occur at the perceptual stage or during subsequent post-perceptual processing. Using functional magnetic resonance imaging, we investigated neural mechanisms underlying temporal sequential dependence and the role of action in time judgments across trials. Participants performed a timing task where they had to remember the duration of green coherent motion and were cued to either actively reproduce its duration or simply view it passively. We found that sequential biases in time perception were only evident when the preceding task involved active duration reproduction. Merely encoding a prior duration without reproduction failed to induce such biases. Neurally, we observed activation in networks associated with timing, such as striato-thalamo-cortical circuits, and performance monitoring networks, particularly when a “Response” trial was anticipated. Importantly, the hippocampus showed sensitivity to these sequential biases, and its activation negatively correlated with the individual’s sequential bias following active reproduction trials. These findings highlight the significant role of memory networks in shaping time-related sequential biases at the post-perceptual stages. Y1 - 2023 U6 - https://doi.org/10.1093/cercor/bhad453 SN - 1460-2199 VL - 34(2024) IS - 1 SP - 1 EP - 14 ER - TY - GEN A1 - Regnath, Franziska A1 - Biersack, Katharina A1 - Jäger, Nina A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Not a general, symptom-unspecific, transdiagnostic marker for functional symptoms: sensorimotor processing of head control is intact in chronic pain T2 - Frontiers in Neurology N2 - Introduction: Functional disorders are prevalent in all medical fields and pose a tremendous public health problem, with pain being one of the most common functional symptoms. Understanding the underlying, potentially unifying mechanism in functional (pain) disorders is instrumental in facilitating timely diagnosis, stigma reduction, and adequate treatment options. Neuroscientific models of perception suggest that functional symptoms arise due to dysregulated sensorimotor processing in the central nervous system, with brain-based predictions dominating the eventual percept. Experimental evidence for this transdiagnostic mechanism has been established in various functional symptoms. The goal of the current study was to investigate whether erroneous sensorimotor processing is an underlying transdiagnostic mechanism in chronic (functional) pain. Method: A total of 13 patients with chronic (functional) pain [three patients with chronic (functional) pain disorder, F45.40, ICD-10; 10 patients with chronic pain disorder with somatic and psychological factors, F45.41, ICD-10]; and 15 healthy controls performed large combined eye-head gaze shifts toward visual targets, naturally and with increased head moment of inertia. We simultaneously measured participants’ eye and head movements to assess head oscillations at the end of the gaze shift, which are an established indicator of (transdiagnostic) sensorimotor processing deficits of head control. Results: Using a Bayesian analysis protocol, we found that patients with chronic (functional) pain and control participants stabilized their heads equally well (Bayes Factor 01 = 3.7, Bayes Factor exclusion = 5.23; corresponding to substantial evidence) during all sessions of the experiment. Conclusion: Our results suggest that patients with chronic (functional) pain do not show measurable symptom-unspecific sensorimotor processing deficits. Y1 - 2023 U6 - https://doi.org/10.3389/fneur.2023.1294702 SN - 1664-2295 VL - 14 ER - TY - GEN A1 - Shirzhiyan, Zahra A1 - Glasauer, Stefan T1 - Late CNV-P2 amplitude as neural index of time interval perception T2 - Bernstein Conference 2021, September 21 - 23, 2021 Y1 - 2021 U6 - https://doi.org/10.12751/nncn.bc2021.p153 VL - 2021 ER - TY - GEN A1 - Glasauer, Stefan A1 - Straka, Hans T1 - Optimality of the vestibulo-ocular reflex T2 - Abstracts NWG Meeting Göttingen 2021 Y1 - 2021 UR - https://www.nwg-goettingen.de/2021/module/posterliste/supMat.asp?nr=T17-11 VL - 2021 ER - TY - GEN A1 - Hoxha, Isabelle A1 - Chevallier, Sylvain A1 - Ciarchi, Matteo A1 - Glasauer, Stefan A1 - Delorme, Arnaud A1 - Amorim, Michel‐Ange T1 - Accounting for endogenous effects in decision‐making with a non‐linear diffusion decision model T2 - Scientific Reports N2 - The Drift‐Diffusion Model (DDM) is widely accepted for two‐alternative forced‐choice decision paradigms thanks to its simple formalism and close fit to behavioral and neurophysiological data. However, this formalism presents strong limitations in capturing inter‐trial dynamics at the single‐ trial level and endogenous influences. We propose a novel model, the non‐linear Drift‐Diffusion Model (nl‐DDM), that addresses these issues by allowing the existence of several trajectories to the decision boundary. We show that the non‐linear model performs better than the drift‐diffusion model for an equivalent complexity. To give better intuition on the meaning of nl‐DDM parameters, we compare the DDM and the nl‐DDM through correlation analysis. This paper provides evidence of the functioning of our model as an extension of the DDM. Moreover, we show that the nl‐DDM captures time effects better than the DDM. Our model paves the way toward more accurately analyzing across‐trial variability for perceptual decisions and accounts for peri‐stimulus influences. Y1 - 2023 U6 - https://doi.org/10.1038/s41598-023-32841-9 SN - 2045-2322 VL - 13 ER - TY - GEN A1 - Glasauer, Stefan A1 - Straka, Hans T1 - Der Beginn der Warmblütigkeit T2 - Spektrum der Wissenschaft Y1 - 2023 UR - https://www.spektrum.de/magazin/evolution-der-beginn-der-warmbluetigkeit/2085762 SN - 0170-2971 IS - 2 SP - 30 EP - 31 ER - TY - GEN A1 - Glasauer, Stefan T1 - Individual differences do matter T2 - Behavioral and Brain Sciences N2 - The integrative experiment design proposal currently only relates to group results, but downplays individual differences between participants, which may nevertheless be substantial enough to constitute a relevant dimension in the design space. Excluding the individual participant in the integrative design will not solve all problems mentioned in the target article, because averaging results may obscure the underlying mechanisms. KW - Behavioral Neuroscience KW - Physiology KW - Neuropsychology and Physiological Psychology Y1 - 2024 U6 - https://doi.org/10.1017/S0140525X2300242X SN - 0140-525X VL - 47 ER - TY - GEN A1 - Shi, Zhuanghua A1 - Gu, Bon-Mi A1 - Glasauer, Stefan A1 - Meck, Warren H. T1 - Beyond Scalar Timing Theory: Integrating Neural Oscillators with Computational Accessibility in Memory T2 - Timing & Time Perception N2 - One of the major challenges for computational models of timing and time perception is to identify a neurobiological plausible implementation that predicts various behavioral properties, including the scalar property and retrospective timing. The available timing models primarily focus on the scalar property and prospective timing, while virtually ignoring the computational accessibility. Here, we first selectively review timing models based on ramping activity, oscillatory pattern, and time cells, and discuss potential challenges for the existing models. We then propose a multifrequency oscilla- tory model that offers computational accessibility, which could account for a much broader range of timing features, including both retrospective and prospective timing. Y1 - 2022 U6 - https://doi.org/10.1163/22134468-bja10059 SN - 2213-4468 SP - 1 EP - 22 ER - TY - PAT A1 - Brandt, Thomas A1 - Glasauer, Stefan A1 - Schneider, Erich T1 - Aufnahmevorrichtung für die kopfgestützte Bilderfassung und Verfahren zur Steuerung der Aufnahmevorrichtung Y1 - 2004 UR - http://google.com/patents/DE10251933A1?cl=no. ER - TY - GEN A1 - Shirzhiyan, Zahra A1 - Glasauer, Stefan T1 - Dual-task modulation of neural activity related to perception of time T2 - Abstract NWG Meeting Göttingen 2021 Y1 - 2021 UR - https://www.nwg-goettingen.de/2021/module/posterliste/supMat.asp?nr=T26-7 VL - 2021 CY - Göttingen ER - TY - GEN A1 - Choi, Jeong-Yoon A1 - Glasauer, Stefan A1 - Zee, David S. A1 - Kim, Ji-Soo T1 - Characteristics and Mechanism of Apogeotropic Central Positional Nystagmus T2 - Brain Y1 - 2018 U6 - https://doi.org/10.1093/brain/awx381 SN - 1460-2156 SN - 0006-8950 VL - 141 IS - 3 SP - 762 EP - 775 ER - TY - CHAP A1 - Glasauer, Stefan A1 - MacNeilage, Paul R. ED - Fritzsch, Bernd ED - Straka, Hans T1 - Computational Rules for Integrating Vestibular and Multi-Modal Motion Signals in the Central Nervous System T2 - The Senses: A Comprehensive Reference; Volume 6: Vestibular System and Balance N2 - Integration of multi-sensory signals is normally required to infer the properties and states of the external world and of the own body. This applies also to vestibular signals, which, when activated are naturally accompanied by other sensory or self-generated signals. Here, we review computational schemes and normative principles that have been proposed to achieve meaningful signal fusion that allows perception and action in the face of uncertain information. Y1 - 2020 U6 - https://doi.org/10.1016/B978-0-12-809324-5.24262-4 SP - 445 EP - 457 PB - Elsevier CY - Amsterdam ET - 2. Edition ER - TY - GEN A1 - Schröder, Lena A1 - Werder, Dina von A1 - Ramaioli, Cecilia A1 - Wachtler, Thomas A1 - Henningsen, Peter A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Unstable Gaze in Functional Dizziness: A Contribution to Understanding the Pathophysiology of Functional Disorders T2 - Frontiers in Neuroscience N2 - Objective: We are still lacking a pathophysiological mechanism for functional disorders explaining the emergence and manifestation of characteristic, severely impairing bodily symptoms like chest pain or dizziness. A recent hypothesis based on the predictive coding theory of brain function suggests that in functional disorders, internal expectations do not match the actual sensory body states, leading to perceptual dysregulation and symptom perception. To test this hypothesis, we investigated the account of internal expectations and sensory input on gaze stabilization, a physiologically relevant parameter of gaze shifts, in functional dizziness. Methods: We assessed gaze stabilization in eight functional dizziness patients and 11 healthy controls during two distinct epochs of large gaze shifts: during a counter- rotation epoch (CR epoch), where the brain can use internal models, motor planning, and resulting internal expectations to achieve internally driven gaze stabilization; and during an oscillation epoch (OSC epoch), where, due to terminated motor planning, no movement expectations are present, and gaze is stabilized by sensory input alone. Results: Gaze stabilization differed between functional patients and healthy controls only when internal movement expectations were involved [F(1,17) = 14.63, p = 0.001, and partial η2 = 0.463]: functional dizziness patients showed reduced gaze stabilization during the CR (p = 0.036) but not OSC epoch (p = 0.26). Conclusion: While sensory-driven gaze stabilization is intact, there are marked, well- measurable deficits in internally-driven gaze stabilization in functional dizziness pointing at internal expectations that do not match actual body states. This experimental evidence supports the perceptual dysregulation hypothesis of functional disorders and is an important step toward understanding the underlying pathophysiology. Y1 - 2021 U6 - https://doi.org/10.3389/fnins.2021.685590 SN - 1662-453X SN - 1662-4548 VL - 15 ER - TY - GEN A1 - Knorr, Alexander G. A1 - Gravot, Céline M. A1 - Glasauer, Stefan A1 - Straka, Hans T1 - Image motion with color contrast suffices to elicit an optokinetic reflex in Xenopus laevis tadpoles T2 - Scientific Reports N2 - The optokinetic reflex is a closed-loop gaze-stabilizing ocular motor reaction that minimizes residual retinal image slip during vestibulo-ocular reflexes. In experimental isolation, the reflex is usually activated by motion of an achromatic large-field visual background with strong influence of radiance contrast on visual motion estimation and behavioral performance. The presence of color in natural environments, however, suggests that chromatic cues of visual scenes provide additional parameters for image motion detection. Here, we employed Xenopus laevis tadpoles to study the influence of color cues on the performance of the optokinetic reflex and multi-unit optic nerve discharge during motion of a large-field visual scene. Even though the amplitude of the optokinetic reflex decreases with smaller radiance contrast, considerable residual eye movements persist at the ‘point of equiluminance’ of the colored stimuli. Given the color motion preferences of individual optic nerve fibers, the underlying computation potentially originates in retinal circuits. Differential retinal ganglion cell projections and associated ocular motor signal transformation might further reinforce the color dependency in conceptual correspondence with head/body optomotor signaling. Optokinetic reflex performance under natural light conditions is accordingly influenced by radiance contrast as well as by the color composition of the moving visual scene. Y1 - 2021 U6 - https://doi.org/10.1038/s41598-021-87835-2 SN - 2045-2322 VL - 11 ER - TY - GEN A1 - Dietrich, Haike A1 - Heidger, F. A1 - Schniepp, Roman A1 - MacNeilage, Paul R. A1 - Glasauer, Stefan A1 - Wühr, Max T1 - Head motion predictability explains phase-and speed-dependent suppression of vestibular balance control during walking T2 - Elsevier N2 - Methods: Body sway was analyzed by measuring the center of pressure (CoP) in 10 healthy participants on a pressure-sensitive treadmill during standing and walking at 0.4 or 0.8 m/s. Continuous SVS (0–25 Hz; peak amplitude at±4.5 mA) was delivered by a bipolar binaural electrode configuration over the mastoid processes to evoke postural responses in the roll plane. Time-dependent coherence between SVS and medio-lateral body sway was analyzed to examine the dynamic impact of vestibular cues during locomotion. HMP was estimated using a previously established model (MacNeilage and Glasauer, 2017). Results: SVS-CoP coherence decreased from standing to slow walking and further decreased with increasing locomotor speed (p< 0.001). Correspondingly, HMP increased with faster locomotion (p= 0.001). SVS-CoP coherence depended on the gait cycle phase with two distinct peaks occurring at 25 … Y1 - 2020 U6 - https://doi.org/10.1016/j.clinph.2019.12.083 VL - 131 IS - 4 SP - e219 EP - e220 PB - Elsevier ET - 1. ER - TY - GEN A1 - Chen, Siyi A1 - Glasauer, Stefan A1 - Müller, Hermann J. A1 - Conci, Markus T1 - Surface filling-in and contour interpolation contribute independently to Kanizsa figure formation T2 - Journal of Experimental Psychology Y1 - 2018 U6 - https://doi.org/10.1037/xhp0000540 SN - 1939-1277 SN - 0096-1523 VL - 44 IS - 9 SP - 1399 EP - 1413 ER - TY - GEN A1 - Kalla, Roger A1 - Spiegel, Rainer A1 - Claassen, Jens A1 - Bardins, Stanislav A1 - Hahn, Ales A1 - Schneider, Erich A1 - Lehrer, Nicole A1 - Glasauer, Stefan A1 - Brandt, Thomas A1 - Strupp, Michael T1 - Comparison of 10-mg doses of 4-aminopyridine and 3,4-diaminopyridine for the treatment of downbeat nystagmus T2 - Journal of neuro-ophthalmology Y1 - 2011 U6 - https://doi.org/10.1097/WNO.0b013e3182258086 SN - 1536-5166 SN - 1070-8022 VL - 32 IS - 2 SP - 320 EP - 325 ER - TY - GEN A1 - Flanagin, Virginia A1 - Klinkowski, Svenja A1 - Brodt, Svenja A1 - Graetsch, Melanie A1 - Roselli, Carolina A1 - Glasauer, Stefan A1 - Gais, Steffen T1 - The precuneus as a central node in declarative memory retrieval T2 - Cerebral Cortex N2 - Both, the hippocampal formation and the neocortex are contributing to declarative memory, but their functional specialization remains unclear. We investigated the differential contribution of both memory systems during free recall of word lists. In total, 21 women and 17 men studied the same list but with the help of different encoding associations. Participants associated the words either sequentially with the previous word on the list, with spatial locations on a well-known path, or with unique autobiographical events. After intensive rehearsal, subjects recalled the words during functional magnetic resonance imaging (fMRI). Common activity to all three types of encoding associations was identified in the posterior parietal cortex, in particular in the precuneus. Additionally, when associating spatial or autobiographical material, retrosplenial cortex activity was elicited during word list recall, while hippocampal activity emerged only for autobiographically associated words. These findings support a general, critical function of the precuneus in episodic memory storage and retrieval. The encoding-retrieval repetitions during learning seem to have accelerated hippocampus-independence and lead to direct neocortical integration in the sequentially associated and spatially associated word list tasks. During recall of words associated with autobiographical memories, the hippocampus might add spatiotemporal information supporting detailed scenic and contextual memories. Y1 - 2023 U6 - https://doi.org/10.1093/cercor/bhac476 SN - 1460-2199 VL - 33 IS - 10 SP - 5981 EP - 5990 ER - TY - CHAP A1 - Glasauer, Stefan A1 - Knorr, Alexander G. ED - Fritzsch, Bernd ED - Straka, Hans T1 - Physical Nature of Vestibular Stimuli T2 - The Senses: A Comprehensive Reference, Volume 6: Vestibular System and Balance N2 - The vestibular sensors in the inner ear measure head movement with respect to an inertial frame of reference. The chapter describes the principles of measurement of the vestibular sensors, the physical stimuli that are measured, and specific issues that require central processing. An overview about so-called artificial vestibular stimuli that mimic the effect of natural head movement is provided. Y1 - 2020 U6 - https://doi.org/10.1016/B978-0-12-809324-5.23909-6 SP - 6 EP - 11 PB - Elsevier CY - Amsterdam ET - 2. Edition ER - TY - GEN A1 - Costalago Meruelo, Alicia A1 - Fleuriet, Jérome A1 - Bakst, Leah A1 - Mustari, Michael J. A1 - Glasauer, Stefan T1 - Modeling and Prediction of Sinusoidal Smooth Pursuit using Artificial Neural Networks T2 - 40th Annual International Conference of the IEEE, Engineering in Medicine and Biology Society, 2018 Y1 - 2018 UR - http://embc.embs.org/2018/wp-content/uploads/sites/35/2018/08/99118-EMBC-Final-Program.pdf UR - https://embs.papercept.net/conferences/conferences/EMBC18/program/EMBC18_ContentListWeb_3.html#thpos-23_09 PB - IEEE EMBC Hawaii ER - TY - GEN A1 - Glasauer, Stefan A1 - Dieterich, Marianne A1 - Brandt, Thomas T1 - Neuronal network-based mathematical modeling of perceived verticality in acute unilateral vestibular lesions: from nerve to thalamus and cortex T2 - Journal of Neurology Y1 - 2018 U6 - https://doi.org/10.1007/s00415-018-8909-5 SN - 1432-1459 SN - 0340-5354 VL - 265 IS - Supplement 1 SP - 112 ER - TY - GEN A1 - Xiang, Min A1 - Seemungal, Barry M. A1 - Glasauer, Stefan T1 - Quantitative postural models as biomarkers of balance in Parkinson’s disease T2 - Brain Y1 - 2018 U6 - https://doi.org/10.1093/brain/awy250 SN - 0006-8950 SN - 1460-2156 VL - 141 IS - 10 SP - 2824 EP - 2827 ER - TY - GEN A1 - Salmasi, Mehrdad A1 - Glasauer, Stefan A1 - Stemmler, Martin T1 - The optimal number of release sites in synapses with neurotransmitter spillover T2 - Bernstein Conference 2019 Y1 - 2019 U6 - https://doi.org/10.12751/nncn.bc2019.0264 ER - TY - GEN A1 - Glasauer, Stefan A1 - Shi, Z. T1 - Another dead salmon? The measurement flaw of serial dependence in human perception T2 - Abstract for SfN Global Connectome Y1 - 2020 UR - https://www.sfn.org/-/media/SfN/Documents/NEW-SfN/Meetings/SfN-Global-Connectome/SFN21_Connectome_Abstracts_PDFs.pdf SP - 1891 EP - 11892 ER - TY - GEN A1 - Yudice, Joshua A1 - Bayer, Johanna A1 - Bockisch, Christopher A1 - Glasauer, Stefan T1 - Inter-subject variability of visual-vestibular sensory fusion during angular rotation T2 - Bernstein Conference 2020 Y1 - 2020 U6 - https://doi.org/10.12751/nncn.bc2020.0250 ER - TY - GEN A1 - Yudice, Joshua A1 - Glasauer, Stefan T1 - Navigational frame of reference during idiothetic path integration in humans T2 - INAV 2020 Y1 - 2020 UR - https://inavsymposium.com/wp-content/uploads/2020/10/Data_Blitz_Booklet_2020.pdf VL - 2020 SP - 41 ER - TY - GEN A1 - Spiegel, Rainer A1 - Kalla, R. A1 - Rettinger, N. A1 - Schneider, Erich A1 - Straumann, D. A1 - Marti, S. A1 - Glasauer, Stefan T1 - Head position during resting modifies spontaneous daytime decrease of downbeat nystagmus T2 - Neurology Y1 - 2010 U6 - https://doi.org/10.1212/WNL.0b013e3181feb22f SN - 0028-3878 SN - 1526-632X VL - 75 IS - 21 SP - 1928 EP - 1932 ER - TY - GEN A1 - Wright, W. Geoffrey A1 - Schneider, Erich A1 - Glasauer, Stefan T1 - Compensatory manual motor responses while object wielding during combined linear visual and physical roll tilt stimulation T2 - Experimental Brain Research Y1 - 2009 U6 - https://doi.org/10.1007/s00221-008-1581-8 SN - 0014-4819 SN - 1432-1106 VL - 192 IS - 4 SP - 683 EP - 694 ER - TY - GEN A1 - Guenther, Anna L. A1 - Bartl, Klaus A1 - Nauderer, Josef A1 - Schneider, Erich A1 - Huesmann, Alexander A1 - Brandt, Thomas A1 - Glasauer, Stefan T1 - Modalitydependent indication of the subjective vertical during combined linear and rotational movements T2 - Annals of the New York Academy of Sciences Y1 - 2009 U6 - https://doi.org/10.1111/j.1749-6632.2009.03849.x SN - 1749-6632 VL - 1164 SP - 376 EP - 379 ER - TY - GEN A1 - Glasauer, Stefan A1 - Schneider, Erich A1 - Grasso, Renato A1 - Ivanenko, Yuri P. T1 - Space-time relativity in self-motion reproduction T2 - Journal of Neurophysiology Y1 - 2007 U6 - https://doi.org/10.1152/jn.01243.2005 SN - 0022-3077 SN - 1522-1598 VL - 97 IS - 1 SP - 451 EP - 461 ER - TY - GEN A1 - Zingler, Vera C. A1 - Kryvoshey, Dmytro A1 - Schneider, Erich A1 - Glasauer, Stefan A1 - Brandt, Thomas A1 - Strupp, Michael T1 - A clinical test of otolith function: static ocular counterroll with passive head tilt. T2 - Neuroreport Y1 - 2006 SN - 0959-4965 VL - 17 IS - 6 SP - 611 EP - 615 ER - TY - GEN A1 - Nowak, Dennis A. A1 - Hermsdörfer, Joachim A1 - Schneider, Erich A1 - Glasauer, Stefan T1 - Moving objects in a rotating environment rapid prediction of coriolis and centrifugal force perturbations T2 - Experimental Brain Research Y1 - 2004 U6 - https://doi.org/10.1007/s00221-004-1839-8 SN - 0014-4819 SN - 1432-1106 VL - 157 IS - 2 SP - 241 EP - 254 ER - TY - GEN A1 - Schneider, Erich A1 - Glasauer, Stefan A1 - Dieterich, Marianne A1 - Kalla, Roger A1 - Brandt, Thomas T1 - Diagnosis of vestibular imbalance in the blink of an eye T2 - Neurology Y1 - 2004 SN - 0028-3878 SN - 1526-632X VL - 63 IS - 7 SP - 1209 EP - 1216 ER - TY - GEN A1 - Schneider, Erich A1 - Glasauer, Stefan A1 - Dieterich, Marianne T1 - Comparison of human ocular torsion patterns during natural and galvanic vestibular stimulation T2 - Journal of Neurophysiology Y1 - 2002 U6 - https://doi.org/10.1152/jn.00558.2001 SN - 0022-3077 SN - 1522-1598 VL - 87 IS - 4 SP - 2064 EP - 2073 ER - TY - GEN A1 - Schröder, Lena A1 - Regnath, Franziska A1 - Glasauer, Stefan A1 - Hackenberg, Anna A1 - Hente, Juliane A1 - Weilenmann, Sonja A1 - Pohl, Daniel A1 - Känel, Roland von A1 - Lehnen, Nadine T1 - Altered sensorimotor processing in irritable bowel syndrome: Evidence for a transdiagnostic pathomechanism in functional somatic disorders T2 - Frontiers in Neuroscience N2 - Objective A recent hypothesis suggests that functional somatic symptoms are due to altered information processing in the brain, with rigid expectations biasing sensorimotor signal processing. First experimental results confirmed such altered processing within the affected symptom modality, e.g., deficient eye-head coordination in patients with functional dizziness. Studies in patients with functional somatic symptoms looking at general, trans-symptomatic processing deficits are sparse. Here, we investigate sensorimotor processing during eye-head gaze shifts in irritable bowel syndrome (IBS) to test whether processing deficits exist across symptom modalities. Methods Study participants were seven patients suffering from IBS and seven age- and gender-matched healthy controls who performed large gaze shifts toward visual targets. Participants performed combined eye-head gaze shifts in the natural condition and with experimentally increased head moment of inertia. Head oscillations as a marker for sensorimotor processing deficits were assessed. Bayes statistics was used to assess evidence for the presence or absence of processing differences between IBS patients and healthy controls. Results With the head moment of inertia increased, IBS patients displayed more pronounced head oscillations than healthy controls (Bayes Factor 10 = 56.4, corresponding to strong evidence). Conclusion Patients with IBS show sensorimotor processing deficits, reflected by increased head oscillations during large gaze shifts to visual targets. In particular, patients with IBS have difficulties to adapt to the context of altered head moment of inertia. Our results suggest general transdiagnostic processing deficits in functional somatic disorders. KW - irritable bowel syndrome (IBS) KW - functional somatic disorders KW - somatoform disorders KW - predictive processing KW - transdiagnostic mechanism KW - gaze shift Y1 - 2022 U6 - https://doi.org/10.3389/fnins.2022.1029126 SN - 1662-453X VL - 16 ER - TY - GEN A1 - Werder, Dina von A1 - Regnath, Franziska A1 - Schäfer, Daniel A1 - Jörres, Rudolf A1 - Lehnen, Nadine A1 - Glasauer, Stefan T1 - Post-COVID breathlessness: a mathematical model of respiratory processing in the brain T2 - European Archives of Psychiatry and Clinical Neuroscience N2 - Breathlessness is among the most common post-COVID symptoms. In a considerable number of patients, severe breathlessness cannot be explained by peripheral organ impairment. Recent concepts have described how such persistent breathlessness could arise from dysfunctional processing of respiratory information in the brain. In this paper, we present a first quantitative and testable mathematical model of how processing of respiratory-related signals could lead to breathlessness perception. The model is based on recent theories that the brain holds an adaptive and dynamic internal representation of a respiratory state that is based on previous experiences and comprises gas exchange between environment, lung and tissue cells. Perceived breathlessness reflects the brain’s estimate of this respiratory state signaling a potentially hazardous disequilibrium in gas exchange. The internal respiratory state evolves from the respiratory state of the last breath, is updated by a sensory measurement of CO2 concentration, and is dependent on the current activity context. To evaluate our model and thus test the assumed mechanism, we used data from an ongoing rebreathing experiment investigating breathlessness in patients with post-COVID without peripheral organ dysfunction (N = 5) and healthy control participants without complaints after COVID-19 (N = 5). Although the observed breathlessness patterns varied extensively between individual participants in the rebreathing experiment, our model shows good performance in replicating these individual, heterogeneous time courses. The model assumes the same underlying processes in the central nervous system in all individuals, i.e., also between patients and healthy control participants, and we hypothesize that differences in breathlessness are explained by different weighting and thus influence of these processes on the final percept. Our model could thus be applied in future studies to provide insight into where in the processing cascade of respiratory signals a deficit is located that leads to (post-COVID) breathlessness. A potential clinical application could be, e.g., the monitoring of effects of pulmonary rehabilitation on respiratory processing in the brain to improve the therapeutic strategies. KW - Pharmacology (medical) KW - Biological Psychiatry KW - Psychiatry and Mental health KW - General Medicine Y1 - 2024 U6 - https://doi.org/10.1007/s00406-023-01739-y SN - 0940-1334 ER -