TY - GEN A1 - Lehnen, Nadine A1 - Ramaioli, Cecilia A1 - Henningsen, Peter A1 - Glasauer, Stefan T1 - An experimental litmus test of the emerging hypothesis that persistent physical symptoms can be explained as perceptual dysregulation T2 - Journal of Psychosomatic Research Y1 - 2018 U6 - https://doi.org/10.1016/j.jpsychores.2018.08.007 SN - 1879-1360 SN - 0022-3999 VL - 114 SP - 15 EP - 17 ER - TY - GEN A1 - Salmasi, Mehrdad A1 - Loebel, Alex A1 - Glasauer, Stefan A1 - Stemmler, Martin T1 - Short-term synaptic depression can increase the rate of information transfer at a release site T2 - PLoS Computational Biology N2 - The release of neurotransmitters from synapses obeys complex and stochastic dynamics. Depending on the recent history of synaptic activation, many synapses depress the probability of releasing more neurotransmitter, which is known as synaptic depression. Our understanding of how synaptic depression affects the information efficacy, however, is limited. Here we propose a mathematically tractable model of both synchronous spike-evoked release and asynchronous release that permits us to quantify the information conveyed by a synapse. The model transits between discrete states of a communication channel, with the present state depending on many past time steps, emulating the gradual depression and exponential recovery of the synapse. Asynchronous and spontaneous releases play a critical role in shaping the information efficacy of the synapse. We prove that depression can enhance both the information rate and the information rate per unit energy expended, provided that synchronous spike-evoked release depresses less (or recovers faster) than asynchronous release. Furthermore, we explore the theoretical implications of short-term synaptic depression adapting on longer time scales, as part of the phenomenon of metaplasticity. In particular, we show that a synapse can adjust its energy expenditure by changing the dynamics of short-term synaptic depression without affecting the net information conveyed by each successful release. Moreover, the optimal input spike rate is independent of the amplitude or time constant of synaptic depression. We analyze the information efficacy of three types of synapses for which the short-term dynamics of both synchronous and asynchronous release have been experimentally measured. In hippocampal autaptic synapses, the persistence of asynchronous release during depression cannot compensate for the reduction of synchronous release, so that the rate of information transmission declines with synaptic depression. In the calyx of Held, the information rate per release remains constant despite large variations in the measured asynchronous release rate. Lastly, we show that dopamine, by controlling asynchronous release in corticostriatal synapses, increases the synaptic information efficacy in nucleus accumbens. Y1 - 2019 UR - https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006666 U6 - https://doi.org/10.1371/journal.pcbi.1006666 SN - 1553-7358 SN - 1553-734X VL - 15 ER - TY - GEN A1 - Kupferberg, Aleksandra A1 - Iacoboni, Marco A1 - Flanagin, Virginia A1 - Huber, Markus A1 - Kasparbauer, Anna A1 - Baumgartner, Thomas A1 - Hasler, Gregor A1 - Schmidt, Florian A1 - Borst, Christoph A1 - Glasauer, Stefan T1 - Fronto-parietal coding of goal-directed actions performed by artificial agents T2 - Human Brain Mapping Y1 - 2018 U6 - https://doi.org/10.1002/hbm.23905 SN - 1097-0193 SN - 1065-9471 VL - 39 IS - 3 SP - 1145 EP - 1162 ER - TY - GEN A1 - Dieterich, Marianne A1 - Glasauer, Stefan A1 - Brandt, Thomas T1 - Why acute unilateral vestibular midbrain lesions rarely manifest with rotational vertigo: a clinical and modelling approach to head direction cell function. T2 - Journal of Neurology Y1 - 2018 U6 - https://doi.org/10.1007/s00415-018-8828-5 SN - 0340-5354 SN - 1432-1459 VL - 265 IS - 5 SP - 1184 EP - 1198 ER - TY - GEN A1 - Oguz, Ozgur S. A1 - Zhou, Zhehua A1 - Glasauer, Stefan A1 - Wollherr, Dirk T1 - An Inverse Optimal Control Approach to Explain Human Arm Reaching Control Based on Multiple Internal Models T2 - Scientific Reports Y1 - 2018 U6 - https://doi.org/10.1038/s41598-018-23792-7 SN - 2045-2322 VL - 8 ER - TY - GEN A1 - Anggraini, Dian A1 - Glasauer, Stefan A1 - Wunderlich, Klaus T1 - Neural signatures of reinforcement learning correlate with strategy adoption during spatial navigation T2 - Scientific Reports Y1 - 2018 U6 - https://doi.org/10.1038/s41598-018-28241-z SN - 2045-2322 VL - 8 ER - TY - GEN A1 - MacNeilage, Paul R. A1 - Glasauer, Stefan T1 - Perceiving gravity: the role of the cerebellum T2 - Current Biology Y1 - 2018 U6 - https://doi.org/10.1016/j.cub.2018.09.053 SN - 1879-0445 SN - 0960-9822 VL - 28 IS - 22 SP - 1296 EP - 1298 ER - TY - JOUR A1 - Glasauer, Stefan T1 - Ferrè, Elisa Raffaella (Hrsg.): Vestibular Cognition. Leiden [u.a.] Boston : Brill, 2017 JF - Perception Y1 - 2018 SN - 1468-4233 VL - 47 IS - 7 SP - 799 EP - 801 ER - TY - GEN A1 - Hausmann, Peter A1 - Daumer, Martin A1 - MacNeilage, Paul R. A1 - Glasauer, Stefan T1 - Ecological momentary assessment of head motion: Towards normative data of head stabilization T2 - Frontiers in Human Neuroscience N2 - Head stabilization is fundamental for balance during locomotion but can be impaired in elderly or diseased populations. Previous studies have identified several parameters of head stability with possible diagnostic value in a laboratory setting. Recently, the ecological validity of measures obtained in such controlled contexts has been called into question. The aim of this study was to investigate the ecological validity of previously described parameters of head stabilization in a real-world setting. Ten healthy subjects participated in the study. Head and trunk movements of each subject were recorded with inertial measurement units (IMUs) for a period of at least 10 h. Periods of locomotion were extracted from the measurements and predominant frequencies, root mean squares (RMSs) and bout lengths were estimated. As parameters of head stabilization, attenuation coefficients (ACs), harmonic ratios (HRs), coherences, and phase differences were computed. Predominant frequencies were distributed tightly around 2 Hz and ACs, HRs, and coherences exhibited the highest values in this frequency range. All head stability parameters exhibited characteristics consistent with previous reports, although higher variances were observed. These results suggest that head stabilization is tuned to the 2 Hz fundamental frequency of locomotion and that previously described measures of head stability could generalize to a real-world setting. This is the first study to address the ecological validity of these measures, highlighting the potential use of head stability parameters as diagnostic tools or outcome measures for clinical trials. The low cost and ease of use of the IMU technology used in this study could additionally be of benefit for a clinical application. Y1 - 2019 U6 - https://doi.org/10.3389/fnhum.2019.00179 SN - 1662-5161 VL - 13 ER - TY - GEN A1 - Glasauer, Stefan A1 - Shi, Zhuanghua T1 - Central Tendency as Consequence of Experimental Protocol T2 - 2019 Conference on Cognitive Computational Neuroscience, 13-16 September 2019, Berlin, Germany N2 - Perceptual biases found experimentally are often taken to indicate that we should be cautious about the veridicality of our perception in everyday life. Here we show, to the contrary, that such biases may be a consequence of the experimental protocol that cannot be generalized to other situations. We show that the central tendency, an overestimation of small magnitudes and underestimation of large ones, strongly depends on stimulus order. If the same set of stimuli is, rather than being presented in the usual randomized order, is applied in an order that displays only small changes from one trial to the next, the central tendency decreases significantly. This decrease is predicted by a probabilistic model that assumes iterative trial-wise updating of a prior of the stimulus distribution. We conclude that the commonly used randomization of stimuli introduces systematic perceptual biases that may not relevant in everyday life. Y1 - 2019 U6 - https://doi.org/10.32470/CCN.2019.1148-0 SP - 268 EP - 271 CY - Berlin ER - TY - GEN A1 - Glasauer, Stefan T1 - Sequential Bayesian updating as a model for human perception T2 - Progress in Brain Research N2 - Sequential Bayesian updating has been proposed as model for explaining various systematic biases in human perception, such as the central tendency, range effects, and serial dependence. The present chapter introduces to the principal ideas behind Bayesian updating for the random-change model introduced previously and shows how to implement sequential updating using the exact method via probability distributions, the Kalman filter for Gaussian distributions, and a particle filter for approximate sequential updating. Finally, it is demonstrated how to couple perception to action by selecting an appropriate action based on the posterior distribution that results from sequential updating. Y1 - 2019 U6 - https://doi.org/10.1016/bs.pbr.2019.04.025 SN - 1875-7855 SN - 0079-6123 VL - 249 SP - 3 EP - 18 ER - TY - GEN A1 - Salmasi, Mehrdad A1 - Stemmler, Martin A1 - Glasauer, Stefan A1 - Loebel, Alex T1 - Synaptic Information Transmission in a Two-State Model of Short-Term Facilitation T2 - Entropy N2 - Action potentials (spikes) can trigger the release of a neurotransmitter at chemical synapses between neurons. Such release is uncertain, as it occurs only with a certain probability. Moreover, synaptic release can occur independently of an action potential (asynchronous release) and depends on the history of synaptic activity. We focus here on short-term synaptic facilitation, in which a sequence of action potentials can temporarily increase the release probability of the synapse. In contrast to the phenomenon of short-term depression, quantifying the information transmission in facilitating synapses remains to be done. We find rigorous lower and upper bounds for the rate of information transmission in a model of synaptic facilitation. We treat the synapse as a two-state binary asymmetric channel, in which the arrival of an action potential shifts the synapse to a facilitated state, while in the absence of a spike, the synapse returns to its baseline state. The information bounds are functions of both the asynchronous and synchronous release parameters. If synchronous release facilitates more than asynchronous release, the mutual information rate increases. In contrast, short-term facilitation degrades information transmission when the synchronous release probability is intrinsically high. As synaptic release is energetically expensive, we exploit the information bounds to determine the energy–information trade-off in facilitating synapses. We show that unlike information rate, the energy-normalized information rate is robust with respect to variations in the strength of facilitation. Y1 - 2019 U6 - https://doi.org/10.3390/e21080756 SN - 1099-4300 VL - 21 IS - 8 ER - TY - GEN A1 - Glasauer, Stefan A1 - Dieterich, Marianne A1 - Brandt, Thomas T1 - Computational neurology of gravity perception involving semicircular canal dysfunction in unilateral vestibular lesions T2 - Progress in Brain Research N2 - Unilateral peripheral vestibular lesions not only lead to vertigo, nystagmus and imbalance, but also to a bias in the perception of verticality, which can be measured as tilt of the subjective visual vertical (SVV). Previously, this tilt has been assumed to be caused by a residual otolith bias, for example, because unequal numbers of active haircells on both sides of the utricular striola might result in an imbalance of the firing rates of central otolith neurons. Here we propose that a tilt of the subjective visual vertical might as well be caused by a vertical semicircular canal bias in the roll axis after unilateral peripheral lesions. The canal bias, acting similar to angular velocity stimuli, influences the SVV via the central gravity estimator, which under normal circumstances resolves a perceptual tilt-translation ambiguity. To illustrate our hypothesis, we compare model predictions to data on SVV measurements in patients with unilateral vestibular lesions while being tilted or being rotated eccentrically. We further embed the model of peripheral processing in a neural network that implements the idiotropic bias and represents the direction of gravity as population code in a three dimensional spherical topography. Y1 - 2019 U6 - https://doi.org/10.1016/bs.pbr.2019.04.010 SN - 1875-7855 SN - 0079-6123 VL - 248 SP - 303 EP - 317 ER - TY - GEN A1 - Lehnen, Nadine A1 - Schröder, Lena A1 - Henningsen, Peter A1 - Glasauer, Stefan A1 - Ramaioli, Cecilia T1 - Deficient head motor control in functional dizziness: Experimental evidence of central sensory-motor dysfunction in persistent physical symptoms T2 - Progress in Brain Research N2 - Understanding the mechanisms of symptoms that are insufficiently explained by organic dysfunction remains challenging. Recently, it has been proposed that such “functional symptoms” are based on erroneous sensory processing in the central nervous system (CNS), with internal expectations dominating sensory inputs. In a pilot study, we used a head motor control set-up to assess the interplay between sensory input and expectation on the example of patients with functional dizziness. Eight patients and 11 age-matched healthy controls performed large active eye-head gaze shifts towards visual targets in the natural situation and with the head moment of inertia 3.3-fold increased. The latter induces head oscillations and the expected sensory outcome of the movement, estimated in the CNS, does not match the actual sensory input. Head oscillations were assessed in patients and in healthy subjects and compared to prior results from patients with organic disease (vestibular loss and cerebellar ataxia). Head oscillations in patients with functional dizziness were different from those of healthy subjects (F(1,17) = 27.26, P < 0.001, partial η2 = 0.62), and similar to those of patients with cerebellar ataxia, and with vestibular loss (F(2,19) = 0.56, P = 0.58). Even in the natural, unweighted, condition, head oscillations were higher in functional dizziness patients than in healthy subjects (P = 0.001). Since an extensive work-up failed to demonstrate any explanatory peripheral vestibular, motor, or cerebellar organic dysfunction, these motor control deficits are a first indication of erroneous interplay between expectations and sensory input in the CNS that could account for persistent physical symptoms. Y1 - 2019 U6 - https://doi.org/10.1016/bs.pbr.2019.02.006 SN - 1875-7855 SN - 0079-6123 VL - 249 SP - 385 EP - 400 ER - TY - GEN A1 - Dietrich, Haike A1 - Heidger, F. A1 - Schniepp, Roman A1 - MacNeilage, Paul R. A1 - Glasauer, Stefan A1 - Wühr, Max T1 - Head motion predictability explains activity-dependent suppression of vestibular balance control T2 - Scientific Reports N2 - Vestibular balance control is dynamically weighted during locomotion. this might result from a selective suppression of vestibular inputs in favor of a feed-forward balance regulation based on locomotor efference copies. The feasibility of such a feed-forward mechanism should however critically depend on the predictability of head movements (HMP) during locomotion. To test this, we studied in 10 healthy subjects the differential impact of a stochastic vestibular stimulation (SVS) on body sway (center-of-pressure, COP) during standing and walking at different speeds and compared it to activity-dependent changes in HMp. SVS-cop coupling was determined by correlation analysis in frequency and time domains. HMP was quantified as the proportion of head motion variance that can be explained by the average head trajectory across the locomotor cycle. SVS-COP coupling decreased from standing to walking and further dropped with faster locomotion. Correspondingly, HMP increased with faster locomotion. Furthermore, SVS-COP coupling depended on the gait-cycle-phase with peaks corresponding to periods of least HMP. These findings support the assumption that during stereotyped human self-motion, locomotor efference copies selectively replace vestibular cues, similar to what was previously observed in animal models. Y1 - 2020 U6 - https://doi.org/10.1038/s41598-019-57400-z SN - 2045-2322 VL - 10 ER - TY - GEN A1 - Salmasi, Mehrdad A1 - Glasauer, Stefan A1 - Stemmler, Martin T1 - Short-term facilitation and neurotransmitter spillover counteract each other in neuronal information transmission T2 - 28th Annual Computational Neuroscience Meeting: CNS*2019 Y1 - 2019 UR - https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-019-0538-0 U6 - https://doi.org/10.1186/s12868-019-0538-0 SN - 1471-2202 SP - 155 EP - 156 ER - TY - GEN A1 - Glasauer, Stefan T1 - Magnitude Estimation N2 - Data from the publication Petzschner FH, Glasauer S (2011) Iterative Bayesian Estimation as an Explanation for Range and Regression Effects: A Study on Human Path Integration. J Neurosci 31(47):17220 –17229. DOI:10.1523/JNEUROSCI.2028-11.2011 Data is stored in two Matlab files. AE_all.mat contains the raw angular estimation data, DE_all.mat the raw distance estimation data for all participants. Each structure in the cell array Data is for one participant and contains pdata (produced distance or angle, that’s the stimulus) and rdata (re-produced distance or angle, the response). There are 3x180 values, first dimension are the three ranges used, so Data{1}.pdata(1,:) contains the stimuli for participant 1 and the short range in the angular estimation experiment (given you loaded AE_all.mat). KW - psychophysics Y1 - 2020 ER - TY - GEN A1 - Kutz, Dieter F. A1 - Kolb, Florian P. A1 - Glasauer, Stefan A1 - Straka, Hans T1 - Somatosensory Influence on Platform-Induced Translational Vestibulo-Ocular Reflex in Vertical Direction in Humans T2 - Frontiers in Neurology N2 - The vestibulo-ocular reflex (VOR) consists of two components, the rotational VOR (rVOR) elicited by semicircular canal signals and the translational VOR (tVOR) elicited by otolith signals. Given the relevant role of the vertical tVOR in human walking, this study aimed at measuring the time delay of eye movements in relation to whole-body vertical translations in natural standing position. Twenty (13 females and 7 males) healthy, young subjects (mean 25 years) stood upright on a motor-driven platform and were exposed to sinusoidal movements while fixating a LED, positioned at a distance of 50 cm in front of the eyes. The platform motion induced a vertical translation of 2.6 cm that provoked counteracting eye movements similar to self-paced walking. The time differences between platform and eye movements indicated that the subject's timing of the extraocular motor reaction depended on stimulus frequency and number of repetitions. At low stimulus frequencies (<0.8 Hz) and small numbers of repetitions (<3), eye movements were phase advanced or in synchrony with platform movements. At higher stimulus frequencies or continuous stimulation, eye movements were phase lagged by ~40 ms. Interestingly, the timing of eye movements depended on the initial platform inclination. Starting with both feet in dorsiflexion, eye movements preceded platform movements by 137 ms, whereas starting with both feet in plantar flexion eye movement precession was only 19 ms. This suggests a remarkable influence of foot proprioceptive signals on the timing of eye movements, indicating that the dynamics of the vertical tVOR is controlled by somatosensory signals. Y1 - 2020 U6 - https://doi.org/10.3389/fneur.2020.00332 SN - 1664-2295 VL - 11 SP - 1 EP - 10 ER - TY - GEN A1 - Glasauer, Stefan A1 - Lehnen, Nadine A1 - Radziej, Katharina A1 - Weigel, Angelika A1 - Känel, Roland von A1 - Pitron, Victor A1 - Van den Bergh, Omer A1 - Löwe, Bernd A1 - Lehmann, Marco A1 - Henningsen, Peter T1 - Complementing conceptual models of persistent somatic symptoms with mathematical formalization T2 - Psychosomatic Medicine Y1 - 2020 U6 - https://doi.org/10.1097/PSY.0000000000000801 SN - 1534-7796 ER - TY - GEN A1 - Kostorz, Kathrin A1 - Flanagin, Virginia A1 - Glasauer, Stefan T1 - Synchronization between instructor and observer when learning a complex bimanual skill T2 - Neuroimage N2 - While learning from an instructor by watching a ‘how-to’ video has become common practice, we know sur- prisingly little about the relation between brain activities in instructor and observers. In this fMRI study we investigated the temporal synchronization between instructor and observers using intersubject correlation in the naturalistic setting of learning to fold origami. Brain activity of the blindfolded instructor during action pro- duction was compared to the observers while they viewed the instructor’s video-taped actions. We demonstrate for the first time that the BOLD activity in the instructor’s and observer’s brain are synchronized while observing and learning a manual complex task with the goal of reproducing it. We can rule out that this synchrony originates from visual feedback. Observers exhibiting higher synchrony with the instructor in the ventral premotor cortex, while viewing the video for the first time, were more successful in reproducing the origami afterwards. Furthermore, changes in instructor-observer synchrony across observational learning sessions occur in cerebellar areas, as well as differences in instructor-observer synchrony between learning and the counting folds, our non- learning control. Not only known cerebellar motor production areas show synchrony, shedding new light on the involvement of the cerebellum in action observation and learning. Y1 - 2020 U6 - https://doi.org/10.1016/j.neuroimage.2020.116659 SN - 1053-8119 ER - TY - GEN A1 - Bassereh, Hassan A1 - Fleuriet, Jérome A1 - Mustari, Michael J. A1 - Glasauer, Stefan T1 - Linear regression versus information-theoretic approach; efficiencies and deficiencies T2 - Bernstein Conference 2020, September, 29 - October, 1, 2020 Y1 - 2020 U6 - https://doi.org/10.12751/nncn.bc2020.0023 ER - TY - GEN A1 - Lutfi, Helana A1 - Glasauer, Stefan A1 - Spittler, Thomas T1 - The healthcare benefits and impact of artificial intelligence applications on behaviour of healthcare users: a structured review of primary literature T2 - Journal of the International Society for Telemedicine and EHealth N2 - Introduction: Artificial intelligence (AI) is one of the most considered topics of the current time. AI has the power to bring revolutionary improvements to the world of technology not only in the field of computer science but also in other fields like medical sciences. Objectives: This paper assumes the adoption of appropriate AI engineering principals in previous studies, and focusses on providing a structured review of the impact of AI on human society and the individual human being as a technology user. Additionally, it opens a window on how the future will look like in terms of AI and personalised medicine. Methods: The paper employed a qualitative research approach and data were collected through a structured literature review. Twenty-three peer reviewed papers were identified and analysed in relation to their relevance to the study. Results: Previous studies show a positive impact on users' behaviour is expected in supporting their healthcare needs especially in decision-making, personalised treatment and future diseases prediction, and that integrating users in studying AI impact is essential to test possible implications of the technology. Conclusion: Results indicate that without a clear understanding of why patients need AI, or how AI can support individuals with their healthcare needs, it is difficult to visualise the kinds of AI applications that have a meaningful and sustainable impact the daily lives of individuals. Therefore, there is an emerging need to understand the impact of AI technology on users' behaviour to maximise the potential benefits of AI technology. Y1 - 2020 UR - https://journals.ukzn.ac.za/index.php/JISfTeH/article/view/1876 U6 - https://doi.org/10.29086/JISfTeH.8.e10 SN - 2308-0310 VL - 8 SP - 1 EP - 5 ER - TY - GEN A1 - Glasauer, Stefan A1 - Hausmann, Peter A1 - MacNeilage, Paul R. T1 - Statistics of natural head motion suggest different head motion priors for rest and movement T2 - Bernstein Conference 2018 Y1 - 2018 U6 - https://doi.org/10.12751/nncn.bc2018.0132 ER - TY - GEN A1 - Glasauer, Stefan A1 - Salmasi, Mehrdad A1 - Stemmler, Martin T1 - The synergy between neurotransmitter spillover and asynchronous release in information transmission T2 - Bernstein Conference 2018 Y1 - 2018 U6 - https://doi.org/10.12751/nncn.bc2018.0209 ER - TY - GEN A1 - Bassereh, Hassan A1 - Rattay, Frank A1 - Glasauer, Stefan T1 - A mathematical framework for vesicle release from a retinal bipolar cell T2 - Bernstein Conference Y1 - 2019 U6 - https://doi.org/10.12751/nncn.bc2019.0209 ER - TY - GEN A1 - Glasauer, Stefan T1 - Sensorimotor control of smooth pursuit T2 - Neuroscience 2018 Home N2 - Interaction with the visual world critically depends on when and how we move our eyes. Eye movements, in turn, alter our experience of the world by selecting objects to foveate and tracking objects over time. The interaction between vision and eye movements continues indefinitely, one process modulating the strength and timing of the other. Despite this tight linkage, vision is often studied outside the context of eye movements, during stable fixation. Likewise, eye movements are often studied with sparse visual stimuli and under ideal viewing conditions. A more accurate understanding of vision requires studying perception in the context of eye movements. Different types of eye movements reveal different aspects of how the brain works. The continuous nature of tracking smooth pursuit eye movements, combined with its ubiquitous presence in natural vision, makes it an excellent system in which to analyze perception at fine spatial and temporal resolutions. For example, how does vision change during the transition from fixation to pursuit, and when does the brain allocate resources to account for these changes? In contrast, the ballistic nature of saccades requires analysis divided into discrete epochs, including well before the saccade during the planning stage, during saccade execution, and after the movement. At the neuronal level, how do heterogeneous populations of visual- and saccade-related cells come to represent a single saccade vector during these different epochs? What are the effects on visual perception when saccades and pursuit interact? This symposium will reveal how research incorporating both types of eye movements and visual perception can provide a more ecologically valid account of visual-motor integration and the intervening cognitive processes. This symposium will review innovative approaches and recent advances in understanding the interplay of eye movements and vision. We will take a multifaceted approach to understanding the effects of both exploratory (saccades) and tracking (smooth pursuit) eye movements on vision by using a range of methodologies and animal models (data-driven modeling, clinical populations, and simultaneous recordings of neuronal populations; humans, macaques, and marmosets). This symposium will appeal to vision scientists interested in selective attention, motion processing, neuronal modeling, motor control, neural circuits, and related topics. Our collective goal is to uncover the dynamics of visual perception and the candidate neuronal mechanisms that support eye movements. Y1 - 2018 UR - https://www.abstractsonline.com/pp8/#!/4649/presentation/40985 ER - TY - GEN A1 - Salmasi, Mehrdad A1 - Glasauer, Stefan A1 - Stemmler, Martin T1 - Neurotransmitter spillover redresses the information loss caused by synaptic depression T2 - Lisboa 2019, Conference Lisbon, Portugal, 28 feb - 3 mar Y1 - 2019 UR - http://cosyne.org/cosyne19/Cosyne2019_program_book.pdf SP - 154 ER - TY - GEN A1 - Kostorz, Kathrin A1 - Flanagin, Virginia A1 - Glasauer, Stefan T1 - Instructor-observer synchronization of BOLD activity mediated by instructive origami videos T2 - Neuroscience 2018 Y1 - 2018 UR - https://www.abstractsonline.com/pp8/#!/4649/presentation/5751 ER - TY - GEN A1 - Glasauer, Stefan A1 - Shi, Z. T1 - 150 years of Vierordt’s law: The role of experimental protocol T2 - CA: Society for Neuroscience, 2018 Y1 - 2018 UR - https://www.abstractsonline.com/pp8/#!/4649/presentation/4957 UR - https://www.sfn.org/-/media/SfN/Documents/NEW-SfN/Meetings/Neuroscience-2018/Abstracts/Neuroscience-2018-Abstracts/SFN18_Abstract-PDFs---Theme-J.pdf CY - San Diego ER - TY - GEN A1 - Glasauer, Stefan A1 - Shi, Zhuanghua T1 - The origin of Vierordt's law: The experimental protocol matters T2 - PsyCH Journal N2 - In 1868, Karl Vierordt discovered one type of errors in time perception—an overestimation of short duration and underestimation of long durations, known as Vierordt's law. Here we reviewed the original study in its historical context and asked whether Vierordt's law is a result of an unnatural experimental randomization protocol. Using iterative Bayesian updating, we simulated the original results with high accuracy. Importantly, the model also predicted that a slowly changing random-walk sequence produces less central tendency than a random sequence with the same durations. This was validated by a duration reproduction experiment from two sequences (random and random walk) with the same sampled distribution. The results showed that trial-wise variation influenced the magnitude of Vierordt's law. We concluded that Vierordt's law is caused by an unnatural yet widely used experimental protocol. Y1 - 2021 UR - https://onlinelibrary.wiley.com/doi/10.1002/pchj.464 U6 - https://doi.org/10.1002/pchj.464 SN - 2046-0260 SN - 2046-0252 VL - 10 IS - 5 SP - 732 EP - 741 ER - TY - GEN A1 - Glasauer, Stefan A1 - Shi, Zhuanghua T1 - Differences in beliefs about stimulus generation explain individual perceptual biases T2 - Bernstein Conference 2021, September 21 - 23, 2021 Y1 - 2021 U6 - https://doi.org/10.12751/nncn.bc2021.p052 VL - 2021 ER - TY - GEN A1 - Kostorz, Kathrin A1 - Flanagin, Virginia A1 - Glasauer, Stefan T1 - Intersubject synchrony of viewers during naturalistic observational learning of a complex bimanual task T2 - Neuroimage: Reports N2 - Watching an instructional video has become a common way to learn a new task. However, we have but a sparse understanding of the neural processes involved during observational learning in naturalistic settings. Recently developed data driven methods for analyzing brain activity provide an opportunity for further investigation. Here, we evaluate intersubject synchrony during fMRI to understand common brain processes during naturalistic observational learning. Participants solitarily watched an instructional video and learned how to fold a paper figure. Three learning runs were sufficient to successfully solve the task. To assess interbrain synchrony, we extended previous principal component (PCA)-based methods to an intersubject principal component analysis (PCA), which offers multiple measures for additional insights into the nature of the synchrony. Using the different metrics of this method, we show a robust synchronous involvement of the action observation execution network (AOEN) in observational learning, between subjects as well as within subjects, regardless of the task or video content. Importantly, additional areas such as the cerebellum, primary motor cortex, control, and sensory integration areas also showed robust synchrony in observational learning. Complimentary to this robust general synchrony, individual regions of the AOEN exhibited task-related differences. Synchrony decreased during the learning process, likely reflecting task state and individual learning strategies. To test the stimulus as a possible source of synchrony, we quantified the temporal structure as the optic flow of the instructional video. Optic flow was strongly related to common activation of the somatomotor areas of the AOEN well beyond visual areas, but could not completely explain synchrony. Thus, although visual motion provides a proxy for meaningful hand actions, our results suggest that intersubject synchrony reflects common cognitive processing during observa- tional learning beyond sensory input. Y1 - 2022 U6 - https://doi.org/10.1016/j.ynirp.2022.100084 SN - 2666-9560 VL - 2 IS - 2 ER - TY - GEN A1 - Glasauer, Stefan A1 - Shi, Zhuanghua T1 - Individual beliefs about temporal continuity explain variation of perceptual biases T2 - Scientific Reports N2 - Perception of magnitudes such as duration or distance is often found to be systematically biased. The biases, which result from incorporating prior knowledge in the perceptual process, can vary considerably between individuals. The variations are commonly attributed to differences in sensory precision and reliance on priors. However, another factor not considered so far is the implicit belief about how successive sensory stimuli are generated: independently from each other or with certain temporal continuity. The main types of explanatory models proposed so far—static or iterative—mirror this distinction but cannot adequately explain individual biases. Here we propose a new unifying model that explains individual variation as combination of sensory precision and beliefs about temporal continuity and predicts the experimentally found changes in biases when altering temporal continuity. Thus, according to the model, individual differences in perception depend on beliefs about how stimuli are generated in the world. Y1 - 2022 U6 - https://doi.org/10.1038/s41598-022-14939-8 SN - 2045-2322 VL - 12 ER - TY - GEN A1 - Glasauer, Stefan A1 - Straka, Hans T1 - Low Gain Values of the Vestibulo-Ocular Reflex Can Optimize Retinal Image Slip T2 - Frontiers in Neurology N2 - The angular vestibulo-ocular reflex (aVOR) stabilizes retinal images by counter-rotating the eyes during head rotations. Perfect compensatory movements would thus rotate the eyes exactly opposite to the head, that is, eyes vs. head would exhibit a unity gain. However, in many species, but also in elderly humans or patients with a history of vestibular damage, the aVOR is far from compensatory with gains that are in part considerably lower than unity. The reason for this apparent suboptimality is unknown. Here, we propose that low VOR gain values reflect an optimal adaptation to sensory and motor signal variability. According to this hypothesis, gaze stabilization mechanisms that aim at minimizing the overall retinal image slip must consider the effects of (1) sensory and motor noise and (2) dynamic constraints of peripheral and central nervous processing. We demonstrate that a computational model for optimizing retinal image slip in the presence of such constraints of signal processing in fact predicts gain values smaller than unity. We further show specifically for tadpoles of the clawed toad, Xenopus laevis with particularly low gain values that previously reported VOR gains quantitatively correspond to the observed variability of eye movements and thus constitute an optimal adaptation mechanism. We thus hypothesize that lower VOR gain values in elderly human subjects or recovered patients with a history of vestibular damage may be the sign of an optimization given higher noise levels rather than a direct consequence of the damage, such as an inability of executing fast compensatory eye movements. Y1 - 2022 U6 - https://doi.org/10.3389/fneur.2022.897293 SN - 1664-2295 VL - 13 ER - TY - GEN A1 - Glasauer, Stefan A1 - Straka, Hans T1 - Ear pins down evolution of thermoregulation T2 - Nature N2 - An analysis of fossil specimens of the inner ear helps to refine the timeframe of a key transition in vertebrate evolution — when our mammal-like ancestors began to regulate and maintain a high body temperature. Y1 - 2022 U6 - https://doi.org/10.1038/d41586-022-01943-1 IS - 607 SP - 661 EP - 662 ER - TY - GEN A1 - Kremmyda, Olympia A1 - Rettinger, Nicole A1 - Strupp, Michael A1 - Büttner, Ulrich A1 - Glasauer, Stefan T1 - Teaching Video NeuroImages: Unilateral RIMLF lesion. Pathologic eye movement torsion indicates lesion side and site T2 - Neurology Y1 - 2023 U6 - https://doi.org/10.1212/WNL.0000000000207003 SN - 0028-3878 VL - 100 IS - 16, Supplement 1 SP - S182 EP - S183 ER - TY - GEN A1 - Cheng, Si A1 - Chen, Siyi A1 - Glasauer, Stefan A1 - Keeser, Daniel A1 - Shi, Zhuanghua T1 - Neural mechanisms of sequential dependence in time perception: the impact of prior task and memory processing T2 - Cerebral Cortex N2 - Our perception and decision-making are susceptible to prior context. Such sequential dependence has been extensively studied in the visual domain, but less is known about its impact on time perception. Moreover, there are ongoing debates about whether these sequential biases occur at the perceptual stage or during subsequent post-perceptual processing. Using functional magnetic resonance imaging, we investigated neural mechanisms underlying temporal sequential dependence and the role of action in time judgments across trials. Participants performed a timing task where they had to remember the duration of green coherent motion and were cued to either actively reproduce its duration or simply view it passively. We found that sequential biases in time perception were only evident when the preceding task involved active duration reproduction. Merely encoding a prior duration without reproduction failed to induce such biases. Neurally, we observed activation in networks associated with timing, such as striato-thalamo-cortical circuits, and performance monitoring networks, particularly when a “Response” trial was anticipated. Importantly, the hippocampus showed sensitivity to these sequential biases, and its activation negatively correlated with the individual’s sequential bias following active reproduction trials. These findings highlight the significant role of memory networks in shaping time-related sequential biases at the post-perceptual stages. Y1 - 2023 U6 - https://doi.org/10.1093/cercor/bhad453 SN - 1460-2199 VL - 34(2024) IS - 1 SP - 1 EP - 14 ER - TY - GEN A1 - Regnath, Franziska A1 - Biersack, Katharina A1 - Jäger, Nina A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Not a general, symptom-unspecific, transdiagnostic marker for functional symptoms: sensorimotor processing of head control is intact in chronic pain T2 - Frontiers in Neurology N2 - Introduction: Functional disorders are prevalent in all medical fields and pose a tremendous public health problem, with pain being one of the most common functional symptoms. Understanding the underlying, potentially unifying mechanism in functional (pain) disorders is instrumental in facilitating timely diagnosis, stigma reduction, and adequate treatment options. Neuroscientific models of perception suggest that functional symptoms arise due to dysregulated sensorimotor processing in the central nervous system, with brain-based predictions dominating the eventual percept. Experimental evidence for this transdiagnostic mechanism has been established in various functional symptoms. The goal of the current study was to investigate whether erroneous sensorimotor processing is an underlying transdiagnostic mechanism in chronic (functional) pain. Method: A total of 13 patients with chronic (functional) pain [three patients with chronic (functional) pain disorder, F45.40, ICD-10; 10 patients with chronic pain disorder with somatic and psychological factors, F45.41, ICD-10]; and 15 healthy controls performed large combined eye-head gaze shifts toward visual targets, naturally and with increased head moment of inertia. We simultaneously measured participants’ eye and head movements to assess head oscillations at the end of the gaze shift, which are an established indicator of (transdiagnostic) sensorimotor processing deficits of head control. Results: Using a Bayesian analysis protocol, we found that patients with chronic (functional) pain and control participants stabilized their heads equally well (Bayes Factor 01 = 3.7, Bayes Factor exclusion = 5.23; corresponding to substantial evidence) during all sessions of the experiment. Conclusion: Our results suggest that patients with chronic (functional) pain do not show measurable symptom-unspecific sensorimotor processing deficits. Y1 - 2023 U6 - https://doi.org/10.3389/fneur.2023.1294702 SN - 1664-2295 VL - 14 ER - TY - GEN A1 - Shirzhiyan, Zahra A1 - Glasauer, Stefan T1 - Late CNV-P2 amplitude as neural index of time interval perception T2 - Bernstein Conference 2021, September 21 - 23, 2021 Y1 - 2021 U6 - https://doi.org/10.12751/nncn.bc2021.p153 VL - 2021 ER - TY - GEN A1 - Glasauer, Stefan A1 - Straka, Hans T1 - Optimality of the vestibulo-ocular reflex T2 - Abstracts NWG Meeting Göttingen 2021 Y1 - 2021 UR - https://www.nwg-goettingen.de/2021/module/posterliste/supMat.asp?nr=T17-11 VL - 2021 ER - TY - GEN A1 - Hoxha, Isabelle A1 - Chevallier, Sylvain A1 - Ciarchi, Matteo A1 - Glasauer, Stefan A1 - Delorme, Arnaud A1 - Amorim, Michel‐Ange T1 - Accounting for endogenous effects in decision‐making with a non‐linear diffusion decision model T2 - Scientific Reports N2 - The Drift‐Diffusion Model (DDM) is widely accepted for two‐alternative forced‐choice decision paradigms thanks to its simple formalism and close fit to behavioral and neurophysiological data. However, this formalism presents strong limitations in capturing inter‐trial dynamics at the single‐ trial level and endogenous influences. We propose a novel model, the non‐linear Drift‐Diffusion Model (nl‐DDM), that addresses these issues by allowing the existence of several trajectories to the decision boundary. We show that the non‐linear model performs better than the drift‐diffusion model for an equivalent complexity. To give better intuition on the meaning of nl‐DDM parameters, we compare the DDM and the nl‐DDM through correlation analysis. This paper provides evidence of the functioning of our model as an extension of the DDM. Moreover, we show that the nl‐DDM captures time effects better than the DDM. Our model paves the way toward more accurately analyzing across‐trial variability for perceptual decisions and accounts for peri‐stimulus influences. Y1 - 2023 U6 - https://doi.org/10.1038/s41598-023-32841-9 SN - 2045-2322 VL - 13 ER - TY - GEN A1 - Glasauer, Stefan A1 - Straka, Hans T1 - Der Beginn der Warmblütigkeit T2 - Spektrum der Wissenschaft Y1 - 2023 UR - https://www.spektrum.de/magazin/evolution-der-beginn-der-warmbluetigkeit/2085762 SN - 0170-2971 IS - 2 SP - 30 EP - 31 ER - TY - GEN A1 - Glasauer, Stefan T1 - Individual differences do matter T2 - Behavioral and Brain Sciences N2 - The integrative experiment design proposal currently only relates to group results, but downplays individual differences between participants, which may nevertheless be substantial enough to constitute a relevant dimension in the design space. Excluding the individual participant in the integrative design will not solve all problems mentioned in the target article, because averaging results may obscure the underlying mechanisms. KW - Behavioral Neuroscience KW - Physiology KW - Neuropsychology and Physiological Psychology Y1 - 2024 U6 - https://doi.org/10.1017/S0140525X2300242X SN - 0140-525X VL - 47 ER - TY - GEN A1 - Shi, Zhuanghua A1 - Gu, Bon-Mi A1 - Glasauer, Stefan A1 - Meck, Warren H. T1 - Beyond Scalar Timing Theory: Integrating Neural Oscillators with Computational Accessibility in Memory T2 - Timing & Time Perception N2 - One of the major challenges for computational models of timing and time perception is to identify a neurobiological plausible implementation that predicts various behavioral properties, including the scalar property and retrospective timing. The available timing models primarily focus on the scalar property and prospective timing, while virtually ignoring the computational accessibility. Here, we first selectively review timing models based on ramping activity, oscillatory pattern, and time cells, and discuss potential challenges for the existing models. We then propose a multifrequency oscilla- tory model that offers computational accessibility, which could account for a much broader range of timing features, including both retrospective and prospective timing. Y1 - 2022 U6 - https://doi.org/10.1163/22134468-bja10059 SN - 2213-4468 SP - 1 EP - 22 ER - TY - PAT A1 - Brandt, Thomas A1 - Glasauer, Stefan A1 - Schneider, Erich T1 - Aufnahmevorrichtung für die kopfgestützte Bilderfassung und Verfahren zur Steuerung der Aufnahmevorrichtung Y1 - 2004 UR - http://google.com/patents/DE10251933A1?cl=no. ER - TY - GEN A1 - Shirzhiyan, Zahra A1 - Glasauer, Stefan T1 - Dual-task modulation of neural activity related to perception of time T2 - Abstract NWG Meeting Göttingen 2021 Y1 - 2021 UR - https://www.nwg-goettingen.de/2021/module/posterliste/supMat.asp?nr=T26-7 VL - 2021 CY - Göttingen ER - TY - GEN A1 - Choi, Jeong-Yoon A1 - Glasauer, Stefan A1 - Zee, David S. A1 - Kim, Ji-Soo T1 - Characteristics and Mechanism of Apogeotropic Central Positional Nystagmus T2 - Brain Y1 - 2018 U6 - https://doi.org/10.1093/brain/awx381 SN - 1460-2156 SN - 0006-8950 VL - 141 IS - 3 SP - 762 EP - 775 ER - TY - CHAP A1 - Glasauer, Stefan A1 - MacNeilage, Paul R. ED - Fritzsch, Bernd ED - Straka, Hans T1 - Computational Rules for Integrating Vestibular and Multi-Modal Motion Signals in the Central Nervous System T2 - The Senses: A Comprehensive Reference; Volume 6: Vestibular System and Balance N2 - Integration of multi-sensory signals is normally required to infer the properties and states of the external world and of the own body. This applies also to vestibular signals, which, when activated are naturally accompanied by other sensory or self-generated signals. Here, we review computational schemes and normative principles that have been proposed to achieve meaningful signal fusion that allows perception and action in the face of uncertain information. Y1 - 2020 U6 - https://doi.org/10.1016/B978-0-12-809324-5.24262-4 SP - 445 EP - 457 PB - Elsevier CY - Amsterdam ET - 2. Edition ER - TY - GEN A1 - Schröder, Lena A1 - Werder, Dina von A1 - Ramaioli, Cecilia A1 - Wachtler, Thomas A1 - Henningsen, Peter A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Unstable Gaze in Functional Dizziness: A Contribution to Understanding the Pathophysiology of Functional Disorders T2 - Frontiers in Neuroscience N2 - Objective: We are still lacking a pathophysiological mechanism for functional disorders explaining the emergence and manifestation of characteristic, severely impairing bodily symptoms like chest pain or dizziness. A recent hypothesis based on the predictive coding theory of brain function suggests that in functional disorders, internal expectations do not match the actual sensory body states, leading to perceptual dysregulation and symptom perception. To test this hypothesis, we investigated the account of internal expectations and sensory input on gaze stabilization, a physiologically relevant parameter of gaze shifts, in functional dizziness. Methods: We assessed gaze stabilization in eight functional dizziness patients and 11 healthy controls during two distinct epochs of large gaze shifts: during a counter- rotation epoch (CR epoch), where the brain can use internal models, motor planning, and resulting internal expectations to achieve internally driven gaze stabilization; and during an oscillation epoch (OSC epoch), where, due to terminated motor planning, no movement expectations are present, and gaze is stabilized by sensory input alone. Results: Gaze stabilization differed between functional patients and healthy controls only when internal movement expectations were involved [F(1,17) = 14.63, p = 0.001, and partial η2 = 0.463]: functional dizziness patients showed reduced gaze stabilization during the CR (p = 0.036) but not OSC epoch (p = 0.26). Conclusion: While sensory-driven gaze stabilization is intact, there are marked, well- measurable deficits in internally-driven gaze stabilization in functional dizziness pointing at internal expectations that do not match actual body states. This experimental evidence supports the perceptual dysregulation hypothesis of functional disorders and is an important step toward understanding the underlying pathophysiology. Y1 - 2021 U6 - https://doi.org/10.3389/fnins.2021.685590 SN - 1662-453X SN - 1662-4548 VL - 15 ER - TY - GEN A1 - Knorr, Alexander G. A1 - Gravot, Céline M. A1 - Glasauer, Stefan A1 - Straka, Hans T1 - Image motion with color contrast suffices to elicit an optokinetic reflex in Xenopus laevis tadpoles T2 - Scientific Reports N2 - The optokinetic reflex is a closed-loop gaze-stabilizing ocular motor reaction that minimizes residual retinal image slip during vestibulo-ocular reflexes. In experimental isolation, the reflex is usually activated by motion of an achromatic large-field visual background with strong influence of radiance contrast on visual motion estimation and behavioral performance. The presence of color in natural environments, however, suggests that chromatic cues of visual scenes provide additional parameters for image motion detection. Here, we employed Xenopus laevis tadpoles to study the influence of color cues on the performance of the optokinetic reflex and multi-unit optic nerve discharge during motion of a large-field visual scene. Even though the amplitude of the optokinetic reflex decreases with smaller radiance contrast, considerable residual eye movements persist at the ‘point of equiluminance’ of the colored stimuli. Given the color motion preferences of individual optic nerve fibers, the underlying computation potentially originates in retinal circuits. Differential retinal ganglion cell projections and associated ocular motor signal transformation might further reinforce the color dependency in conceptual correspondence with head/body optomotor signaling. Optokinetic reflex performance under natural light conditions is accordingly influenced by radiance contrast as well as by the color composition of the moving visual scene. Y1 - 2021 U6 - https://doi.org/10.1038/s41598-021-87835-2 SN - 2045-2322 VL - 11 ER -