TY - GEN A1 - Schneider, Erich A1 - Villgrattner, Thomas A1 - Vockeroth, Johannes A1 - Bartl, Klaus A1 - Kohlbecher, Stefan A1 - Bardins, Stanislav A1 - Ulbrich, Heinz A1 - Brandt, Thomas T1 - Eyeseecam: an eye movement-driven head camera for the examination of natural visual exploration T2 - Annals of the New York Academy of Sciences Y1 - 2009 U6 - https://doi.org/10.1111/j.1749-6632.2009.03858.x SN - 1749-6632 VL - 1164 SP - 461 EP - 467 ER - TY - GEN A1 - Spiegel, Rainer A1 - Kalla, Roger A1 - Claassen, Jens A1 - Bardins, Stanislav A1 - Anciães da Silva, Fábio A1 - Farahmand, Parvis A1 - Hahn, Ales A1 - Schneider, Erich T1 - Aminopyridine treatment in a patient with bilateral vestibular failure and cryptogenic downbeat nystagmus T2 - Journal of Neuro-Ophthalmology Y1 - 2012 SN - 1536-5166 SN - 1070-8022 VL - 32 IS - 2 SP - 190 ER - TY - GEN A1 - Claassen, Jens A1 - Feil, Katharina A1 - Bardins, Stanislav A1 - Teufel, Julian A1 - Spiegel, Rainer A1 - Kalla, Roger A1 - Schneider, Erich T1 - Dalfampridine in patients with downbeat nystagmus–an observational study T2 - Journal of Neurology Y1 - 2013 U6 - https://doi.org/10.1007/s00415-013-6911-5 SN - 0340-5354 SN - 1432-1459 VL - 260 IS - 8 SP - 1992 EP - 1996 ER - TY - CHAP A1 - Kohlbecher, Stefan A1 - Bartl, Klaus A1 - Bardins, Stanislav A1 - Schneider, Erich T1 - Low-latency combined eye and head tracking system for teleoperating a robotic head in real-time T2 - Proceedings of the 2010 Symposium on EyeTracking Research & Applications T2 - ETRA '10, Proceedings of the 2010 Symposium on Eye-Tracking Research & Applications, Austin, Texas — March 22 - 24 Y1 - 2010 SN - 978-1-60558-994-7 U6 - https://doi.org/10.1145/1743666.1743695 SP - 117 EP - 120 PB - ACM Press CY - New York ER - TY - GEN A1 - Schöberl, Florian A1 - Irving, Stephanie A1 - Pradhan, Cauchy A1 - Bardins, Stanislav A1 - Trapp, Christoph A1 - Schneider, Erich A1 - Kugler, Günter A1 - Bartenstein, Peter A1 - Dietrich, Marianne A1 - Brandt, Thomas A1 - Zwergal, Andreas T1 - Prolonged allocentric navigation deficits indicate hippocampal damage in TGA T2 - Neurology : official journal of the American Academy of Neurology N2 - Objective To investigate long-term recovery of allocentric and egocentric spatial orientation as a sensitive marker for hippocampal and extrahippocampal network function in transient global amnesia (TGA). Methods A group of 18 patients with TGA performed an established real-space navigation paradigm, requiring allo- and egocentric spatial orientation abilities, 3 days (postacute stage) and 3 months (follow-up) after symptom onset. Visual exploration behavior and navigation strategy were documented by a gaze-controlled, head-fixed camera. Allo- and egocentric spatial orientation performance was compared to that of 12 age-matched healthy controls. Navigation-induced brain activations were measured using [18F]-fluorodeoxyglucose-PET in a subgroup of 8 patients in the postacute stage and compared to those of the controls. Results In the postacute stage, the patients navigated worse and had higher error rates than controls in allocentric (p = 0.002), but not in egocentric, route planning (p = 0.30), despite complete recovery of verbal (p = 0.58) and figural memory (p = 0.11). Until follow-up, allocentric navigation deficits improved, but higher error rates and reduced use of shortcuts persisted (p < 0.0001). Patients still exhibited relatively more fixations of unique landmarks during follow-up (p = 0.05). PET measurements during the postacute stage showed increased navigation-induced brain activations in the right hippocampus, bilateral retrosplenial, parietal, and mesiofrontal cortices, and cerebellar dentate nucleus in patients compared to controls (p < 0.005). Conclusions Patients with TGA show selective and prolonged deficits of allocentric spatial orientation. Activations in right hippocampal and extrahippocampal hubs of the cerebral navigation network functionally substitute for the deficit in creating and updating the internal cognitive map in TGA. Y1 - 2019 UR - https://n.neurology.org/content/92/3/e234/tab-article-info U6 - https://doi.org/10.1212/WNL.0000000000006779 SN - 0028-3878 SN - 1526-632X VL - 92 IS - 3 SP - e234 EP - e243 ER - TY - GEN A1 - Donald, Aimee A1 - Tan, Chong Y. A1 - Chakrapani, Anupam A1 - Hughes, Derralyn A. A1 - Sharma, Reena A1 - Cole, Duncan A1 - Bardins, Stanislav A1 - Gorges, Martin A1 - Jones, Simon A. A1 - Schneider, Erich T1 - Eye movement biomarkers allow for the definition of phenotypes in Gaucher Disease T2 - Orphanet journal of rare diseases : OJRD N2 - Background: Neurological forms of Gaucher disease, the inherited disorder of β-Glucosylceramidase caused by bi-allelic variants in GBA1, is a progressive disorder which lacks a disease-modifying therapy. Systemic manifestations of disease are effectively treated with enzyme replacement therapy, however, molecules which cross the blood-brain barrier are still under investigation. Clinical trials of such therapeutics require robust, reproducible clinical endpoints to demonstrate efficacy and clear phenotypic definitions to identify suitable patients for inclusion in trials. The single consistent clinical feature in all patients with neuronopathic disease is the presence of a supranuclear saccadic gaze palsy, in the presence of Gaucher disease this finding serves as diagnostic of 'type 3' Gaucher disease. Y1 - 2020 UR - https://ojrd.biomedcentral.com/articles/10.1186/s13023-020-01637-9 U6 - https://doi.org/10.1186/s13023-020-01637-9 SN - 1750-1172 VL - 15 ER - TY - GEN A1 - Spiegel, Rainer A1 - Claassen, Jens A1 - Teufel, Julian A1 - Bardins, Stanislav A1 - Schneider, Erich A1 - Lehrer, Nicole A1 - Jahn, Klaus A1 - Anciaes da Silva, Fábio A1 - Hahn, Ales A1 - Farahmand, Parvis A1 - Brandt, Thomas A1 - Strupp, Michael A1 - Kalla, Roger T1 - Resting in darkness improves downbeat nystagmus: evidence from an observational study T2 - Annals of the New York Academy of Sciences N2 - Resting in an upright position during daytime decreases downbeat nystagmus (DBN). When measured in brightness only, that is, without intermitting exposure to darkness, it does not make a significant difference whether patients have previously rested in brightness or in darkness. In real-world scenarios, people are often exposed to brightness and darkness intermittently. The aim of this study was to analyze whether resting in brightness or resting in darkness was associated with a lower post-resting DBN after intermitting exposures to brightness and darkness. Eight patients were recorded with three-dimensional video-oculography in brightness and darkness conditions, each following two 2-h resting intervals under either brightness or darkness resting conditions. The dependent variable was DBN intensity, measured in mean slow phase velocity. A repeated measures ANOVA with the factors measurement condition (brightness vs. darkness), resting condition (brightness vs. darkness), and time (after first vs. second resting interval) showed a significant effect for the factor resting condition, where previous resting in darkness was associated with a significantly lower DBN relative to previous resting in brightness (P < 0.01). The clinical relevance is to advise patients with DBN to rest in darkness. KW - downbeat nystagmus KW - symptom relief KW - resting KW - oscillopsia KW - video-oculographic measurement (VOG) Y1 - 2016 U6 - https://doi.org/10.1111/nyas.13172 SN - 1749-6632 SN - 0077-8923 VL - 1375 IS - 1 SP - 66 EP - 73 ER - TY - GEN A1 - Michailidou, Efterpi A1 - Korda, Athanasia A1 - Wyss, Thomas A1 - Bardins, Stanislav A1 - Schneider, Erich A1 - Morrison, Miranda A1 - Wagner, Franca A1 - Caversaccio, Marco A1 - Mantokoudis, Georgios T1 - The value of saccade metrics and VOR gain in detecting a vestibular stroke T2 - Journal of Vestibular Research N2 - Objective: A normal video Head Impulse Test is the gold standard in the emergency department to rule-in patients with an acute vestibular syndrome and a stroke. We aimed to compare the diagnostic accuracy of vHIT metrics regarding the vestibulo-ocular reflex gain and the corrective saccades in detecting vestibular strokes. Methods: Prospective cross-sectional study (convenience sample) of patients presenting with acute vestibular syndrome in the emergency department of a tertiary referral centre between February 2015 and May 2020. We screened 1677 patients and enrolled 76 patients fulfilling the inclusion criteria of acute vestibular syndrome. All patients underwent video head impulse test with automated and manual data analysis. A delayed MRI served as a gold standard for vestibular stroke confirmation. Results: Out of 76 patients, 52 were diagnosed with acute unilateral vestibulopathy and 24 with vestibular strokes. The overall accuracy of detecting stroke with an automated vestibulo-ocular reflex gain was 86.8%, compared to 77.6% for cumulative saccade amplitude and automatic saccade mean peak velocity measured by an expert and 71% for cumulative saccade amplitude and saccade mean peak velocity measured automatically. Gain misclassified 13.1% of the patients as false positive or false negative, manual cumulative saccade amplitude and saccade mean peak velocity 22.3%, and automated cumulative saccade amplitude and saccade mean peak velocity 28.9% respectively. Conclusions: We found a better accuracy of video head impulse test for the diagnosis of vestibular strokes when using the vestibulo-ocular reflex gain than using saccade metrics. Nevertheless, saccades provide an additional and important information for video head impulse test evaluation. The automated saccade detection algorithm is not yet perfect compared to expert analysis, but it may become a valuable tool for future non-expert video head impulse test evaluations. KW - Head impulse test saccades KW - vestibular stroke KW - saccades Y1 - 2024 U6 - https://doi.org/10.3233/VES-230083 SN - 1878-6464 VL - 34 IS - 1 SP - 49 EP - 61 ER - TY - GEN A1 - Kalla, Roger A1 - Spiegel, Rainer A1 - Claassen, Jens A1 - Bardins, Stanislav A1 - Hahn, Ales A1 - Schneider, Erich A1 - Lehrer, Nicole A1 - Glasauer, Stefan A1 - Brandt, Thomas A1 - Strupp, Michael T1 - Comparison of 10-mg doses of 4-aminopyridine and 3,4-diaminopyridine for the treatment of downbeat nystagmus T2 - Journal of neuro-ophthalmology Y1 - 2011 U6 - https://doi.org/10.1097/WNO.0b013e3182258086 SN - 1536-5166 SN - 1070-8022 VL - 32 IS - 2 SP - 320 EP - 325 ER - TY - GEN A1 - Teufel, Julian A1 - Bardins, Stanislav A1 - Spiegel, Rainer A1 - Kremmyda, O. A1 - Schneider, Erich A1 - Strupp, Michael A1 - Kalla, R. T1 - Real time computerbased visual feedback improves visual acuity in downbeat nystagmus, a pilot study T2 - Journal of NeuroEngineering and Rehabilitation Y1 - 2016 SN - 1743-0003 VL - 13 IS - 1 ER - TY - GEN A1 - Einhäuser, Wolfgang A1 - Schumann, Frank A1 - Bardins, Stanislav A1 - Bartl, Klaus A1 - Böning, Guido A1 - Schneider, Erich A1 - König, Peter T1 - Human eyehead co-ordination in natural exploration T2 - Network Y1 - 2007 U6 - https://doi.org/10.1080/09548980701671094 SN - 0954-898X SN - 1361-6536 VL - 18 IS - 3 SP - 267 EP - 297 ER -