TY - RPRT A1 - Zundel, Stefan A1 - Krahl, Susanne A1 - Schröder, Wolfgang A1 - Schuster, Helmut T1 - Oberspreewald Lausitz Strukturentwicklungskonzept : Endbericht Y1 - 2008 UR - http://daten2.verwaltungsportal.de/dateien/seitengenerator/strukturentwicklungskonzept.pdf PB - Eigenverlag CY - Senftenberg ER - TY - RPRT A1 - Feindt, Peter H. A1 - Wolters, Volkmar A1 - Backes, Gunter A1 - Bahrs, Enno A1 - Dempfle, Leo A1 - Engels, Eve-Marie A1 - Engels, Johannes A1 - Graner, Andreas A1 - Hamm, Ulrich A1 - Herdegen, Matthias A1 - Isselstein, Johannes A1 - Konnert, Monika A1 - Schröder, Stefan A1 - Schulte-Coerne, Hermann A1 - Wagner, Sven A1 - Wätzold, Frank A1 - Wedekind, Helmut T1 - Gründung der Deutschen Genbank landwirtschaftlicher Nutztiere : Kurzstellungnahme des Wissenschaftlichen Beirats für Biodiversität und Genetische Ressourcen beim Bundesministerium für Ernährung und Landwirtschaft Y1 - 2015 UR - https://beirat-gr.genres.de//fileadmin/SITE_GENRES/downloads/docs/Beirat-GR/Gutachten_Stellungnahmen/beirat_09_2015.pdf PB - BMEL CY - Bonn ER - TY - RPRT A1 - Wätzold, Frank A1 - Bahrs, Enno A1 - Feindt, Peter H. A1 - Hamm, Ulrich A1 - Isselstein, Johannes A1 - Schröder, Stefan A1 - Wolters, Volkmar A1 - Backes, Gunter A1 - Dempfle, Leo A1 - Engels, Eve-Marie A1 - Engels, Johannes A1 - Graner, Andreas A1 - Herdegen, Matthias A1 - Konnert, Monika A1 - Schulte-Coerne, Hermann A1 - Wagner, Sven A1 - Wedekind, Helmut T1 - Perspektiven für das artenreiche Grünland - Alternativen zur Belohnung einer Überschussproduktion bei Milch Y1 - 2015 CY - Bonn ER - TY - GEN A1 - Nürnberger, Stefan A1 - Drescher, Gabor A1 - Rotta, Randolf A1 - Nolte, Jörg A1 - Schröder-Preikschat, Wolfgang T1 - Shared Memory in the Many-Core Age T2 - Euro-Par 2014: Parallel Processing Workshops, Porto, 2014 N2 - With the evolution toward fast networks of many-core processors, the design assumptions at the basis of software-level distributed shared memory (DSM) systems change considerably. But efficient DSMs are needed because they can significantly simplify the implementation of complex distributed algorithms. This paper discusses implications of the many-core evolution and derives a set of reusable elementary operations for future software DSMs. These elementary operations will help in exploring and evaluating new memory models and consistency protocols. Y1 - 2014 UR - http://link.springer.com/chapter/10.1007%2F978-3-319-14313-2_30 SN - 978-3-319-14312-5 U6 - https://doi.org/10.1007/978-3-319-14313-2_30 SP - 351 EP - 362 PB - Springer International Publishing CY - Cham ER - TY - RPRT A1 - Feindt, Peter H. A1 - Wolters, Volkmar A1 - Backes, Gunter A1 - Bahrs, Enno A1 - Brandt, Horst A1 - Dempfle, Leo A1 - Engels, Eve-Marie A1 - Engels, Johannes A1 - Graner, Andreas A1 - Hamm, Ulrich A1 - Herdegen, Matthias A1 - Isselstein, Johannes A1 - Konnert, Monika A1 - Schröder, Stefan A1 - Wagner, Sven A1 - Wätzold, Frank A1 - Wedekind, Helmut T1 - Verbraucher für die Erhaltung der biologischen Vielfalt in der Landwirtschaft aktivieren! Y1 - 2016 UR - http://www.schafzuchtverband-berlin-brandenburg.de/wp-content/uploads/Stellungnahme_Beirat.pdf PB - Bundesanstalt für Landwirtschaft und Ernährung (BLE) Informations- und Koordinationszentrum für Biologische Vielfalt (IBV) CY - Bonn ER - TY - GEN A1 - Sharat, S. U. A1 - Joseph, Merin A1 - Vogel, Stefan A1 - Hildebrandt, E. A1 - Komissinskiy, P. A1 - Kurian, J. A1 - Schröder, Thomas A1 - Alff, Lambert T1 - Impact of Oxygen stoichiometry on electroforming and multiple switching modes in TiN/TaOₓ/Pt based ReRAM T2 - Applied Physics Letters Y1 - 2016 U6 - https://doi.org/10.1063/1.4965872 SN - 1077-3118 SN - 0003-6951 VL - 109 IS - 17 SP - 173503 ER - TY - GEN A1 - George, Sandra A1 - Rödiger, Stefan A1 - Schröder, Christian A1 - Knaut, Michael A1 - Küpper, Jan-Heiner T1 - Development of multiplex PCR systems for expression profiling of human cardiomyocytes induced to profilerate by lentivirus transduction of upcyte genes T2 - Journal of Cellular Biotechnology Y1 - 2016 U6 - https://doi.org/10.3233/JCB-15025 SN - 2352-3697 SN - 2352-3689 VL - 2 IS - 1 SP - 35 EP - 55 ER - TY - RPRT A1 - Feindt, Peter H. A1 - Bahrs, Enno A1 - Engels, Eve-Marie A1 - Hamm, Ulrich A1 - Herdegen, Matthias A1 - Isselstein, Johannes A1 - Schröder, Stefan A1 - Wätzold, Frank A1 - Wolters, Volkmar T1 - Für eine Gemeinsame Agrarpolitik, die konsequent zum Erhalt der biologischen Vielfalt beiträgt Y1 - 2018 UR - https://www.bmel.de/SharedDocs/Downloads/Ministerium/Beiraete/Biodiversitaet/StellungnahmeAgrarpolitikErhaltbioVielfalt.pdf?__blob=publicationFile PB - Bundesanstalt für Landwirtschaft und Ernährung (BLE), Informations- und Koordinationszentrum für Biologische Vielfalt (IBV) CY - Bonn ER - TY - GEN A1 - Schierack, Peter A1 - Rödiger, Stefan A1 - Kuhl, Christoph A1 - Hiemann, Rico A1 - Roggenbuck, Dirk A1 - Li, Ganwu A1 - Weinreich, Jörg A1 - Berger, Enrico A1 - Nolan, Lisa K. A1 - Nicholson, Bryon A1 - Römer, Antje A1 - Frömmel, Ulrike A1 - Wieler, Lothar H. A1 - Schröder, Christian T1 - Porcine E. coli: Virulence-Associated Genes, Resistance Genes and Adhesion and Probiotic Activity Tested by a New Screening Method T2 - PLoS One N2 - We established an automated screening method to characterize adhesion of Escherichia coli to intestinal porcine epithelial cells (IPEC-J2) and their probiotic activity against infection by enteropathogenic E. coli (EPEC). 104 intestinal E. coli isolates from domestic pigs were tested by PCR for the occurrence of virulence-associated genes, genes coding for resistances to antimicrobial agents and metals, and for phylogenetic origin by PCR. Adhesion rates and probiotic activity were examined for correlation with the presence of these genes. Finally, data were compared with those from 93 E. coli isolates from wild boars. Isolates from domestic pigs carried a broad variety of all tested genes and showed great diversity in gene patterns. Adhesions varied with a maximum of 18.3 or 24.2 mean bacteria adherence per epithelial cell after 2 or 6 hours respectively. Most isolates from domestic pigs and wild boars showed low adherence, with no correlation between adhesion/probiotic activity and E. coli genes or gene clusters. The gene sfa/foc, encoding for a subunit of F1C fimbriae did show a positive correlative association with adherence and probiotic activity; however E. coli isolates from wild boars with the sfa/foc gene showed less adhesion and probiotic activity than E. coli with the sfa/foc gene isolated from domestic pigs after 6 hour incubation. In conclusion, screening porcine E. coli for virulence associated genes genes, adhesion to intestinal epithelial cells, and probiotic activity revealed a single important adhesion factor, several probiotic candidates, and showed important differences between E. coli of domestic pigs and wild boars. Y1 - 2013 U6 - https://doi.org/10.1371/journal.pone.0059242 VL - 8 IS - 4 ER - TY - GEN A1 - Frömmel, Ulrike A1 - Lehmann, Werner A1 - Rödiger, Stefan A1 - Böhm, Alexander A1 - Nitschke, Jörg A1 - Weinreich, Jörg A1 - Groß, Julia A1 - Roggenbuck, Dirk A1 - Zinke, Olaf A1 - Ansorge, Hermann A1 - Vogel, Steffen A1 - Klemm, Per A1 - Wex, Thomas A1 - Schröder, Christian A1 - Wieler, Lothar H. A1 - Schierack, Peter T1 - Adhesion of human and animal Escherichia coli strains in association with their virulence-associated genes and phylogenetic origins T2 - Applied and environmental microbiology N2 - Intestinal colonization is influenced by the ability of the bacterium to inhabit a niche, which is based on the expression of colonization factors. Escherichia coli carries a broad range of virulence-associated genes (VAGs) which contribute to intestinal (inVAGs) and extraintestinal (exVAGs) infection. Moreover, initial evidence indicates that inVAGs and exVAGs support intestinal colonization. We developed new screening tools to genotypically and phenotypically characterize E. coli isolates originating in humans, domestic pigs, and 17 wild mammal and avian species. We analyzed 317 isolates for the occurrence of 44 VAGs using a novel multiplex PCR microbead assay (MPMA) and for adhesion to four epithelial cell lines using a new adhesion assay. We correlated data for the definition of new adhesion genes. inVAGs were identified only sporadically, particularly in roe deer (Capreolus capreolus) and the European hedgehog ( Erinaceus europaeus). The prevalence of exVAGs depended on isolation from a specific host. Human uropathogenic E. coli isolates carried exVAGs with the highest prevalence, followed by badger (Meles meles) and roe deer isolates. Adhesion was found to be very diverse. Adhesion was specific to cells, host, and tissue, though it was also unspecific. Occurrence of the following VAGs was associated with a higher rate of adhesion to one or more cell lines: afa-dra, daaD, tsh, vat, ibeA, fyuA, mat, sfa-foc, malX, pic, irp2, and papC. In summary, we established new screening methods which enabled us to characterize large numbers of E. coli isolates. We defined reservoirs for potential pathogenic E. coli. We also identified a very broad range of colonization strategies and defined potential new adhesion genes. Y1 - 2013 U6 - https://doi.org/10.1128/AEM.01384-13 SN - 1098-5336 SN - 0099-2240 VL - 79 IS - 19 SP - 5814 EP - 5829 ER - TY - GEN A1 - Frömmel, Ulrike A1 - Böhm, Alexander A1 - Nitschke, Jörg A1 - Weinreich, Jörg A1 - Groß, Julia A1 - Rödiger, Stefan A1 - Wex, Thomas A1 - Ansorge, Hermann A1 - Zinke, Olaf A1 - Schröder, Christian A1 - Roggenbuck, Dirk A1 - Schierack, Peter T1 - Adhesion patterns of commensal and pathogenic Escherichia coli from humans and wild animals on human and porcine epithelial cell lines T2 - Gut Pathogens N2 - Abstract BACKGROUND: Different strategies of colonization or infection by E. coli result in formation of certain adhesion patterns which help also in classifying intestinal E. coli into pathotypes. Little is known about adhesion patterns and host- and tissue adaption of commensal E. coli and about E. coli originating in clinically healthy hosts carrying pathotype-specific virulence-associated genes. FINDINGS: Adhesion pattern of E. coli (n = 282) from humans and from 18 animal species were verified on intestinal human Caco-2 and porcine IPEC-J2 cells and, furthermore, for comparison on human urinary bladder 5637, porcine kidney PK-15 epithelial and HEp-2 cells. The analysis was carried out on 150,000 images of adhesion assays.Adhesion patterns were very diverse; 88 isolates were completely non-adherent, whereas 194 adhered to at least one cell line with the dominant adhesion patterns "diffusely distributed" and "microcolony formation". Adhesion patterns "chains" and "clumps" were also visible. Chain formation was mediated by the presence of epithelial cells. Clump formation was very specific on only the 5637 cell line. All enteropathogenic (eae+) E. coli (EPEC; n = 14) were able to form microcolonies which was cell line specific for each isolate. Most EPEC formed microcolonies on intestinal IPEC-J2 and Caco-2 but several also on urinary tract cells. Shigatoxin-producing (stx+) E. coli (n = 10) showed no specific adhesion patterns. CONCLUSIONS: E. coli isolates were highly diverse. Commensal and pathogenic isolates can adhere in various forms, including diffuse distribution, microcolonies, chains and clumps. Microcolony formation seems to be a global adhesion strategy also for commensal E. coli. Y1 - 2013 U6 - https://doi.org/10.1186/1757-4749-5-31 SN - 1757-4749 VL - 5 IS - 31 ER - TY - GEN A1 - Rödiger, Stefan A1 - Ruhland, Mirko A1 - Schröder, Christian A1 - Großmann, Kai A1 - Böhm, Alexander A1 - Nitschke, Jörg A1 - Berger, Ingo A1 - Schimke, Ingolf A1 - Schierack, Peter T1 - Fluorescence dye adsorption assay to quantify carboxyl groups on the surface of poly(methyl methacrylate) microbeads T2 - Analytical Chemistry Y1 - 2011 U6 - https://doi.org/10.1021/ac103277s SN - 0003-2700 SN - 1520-6882 VL - 83 IS - 9 SP - 3379 EP - 3385 ER - TY - CHAP A1 - Rödiger, Stefan A1 - Schierack, Peter A1 - Böhm, Alexander A1 - Nitschke, Jörg A1 - Berger, Ingo A1 - Frömmel, Ulrike A1 - Schmidt, Carsten A1 - Ruhland, Mirko A1 - Schimke, Ingolf A1 - Roggenbuck, Dirk A1 - Lehmann, Werner A1 - Schröder, Christian ED - Seitz, Harald ED - Berger, Ingo T1 - A highly versatile microscope imaging technology platform for the multiplex real-time detection of biomolecules and autoimmune antibodies T2 - Molecular diagnostics Y1 - 2013 SN - 978-3-642-37690-0 SN - 978-3-642-37691-7 SP - 35 EP - 74 PB - Springer CY - Berlin [u.a.] ER - TY - GEN A1 - Schmidt, Carsten A1 - Rödiger, Stefan A1 - Gruner, Melanie A1 - Moncsek, Anja A1 - Stohwasser, Ralf A1 - Hanack, Katja A1 - Schierack, Peter A1 - Schröder, Christian T1 - Multiplex localization of sequential peptide epitopes by use of a planar microbead chip T2 - Analytica Chimica Acta Y1 - 2016 U6 - https://doi.org/10.1016/j.aca.2015.12.030 SN - 0003-2670 VL - 908 SP - 150 EP - 160 ER - TY - GEN A1 - Rödiger, Stefan A1 - Kramer, Toni A1 - Frömmel, Ulrike A1 - Weinreich, Jörg A1 - Roggenbuck, Dirk A1 - Guenther, Sebastian A1 - Schaufler, Katharina A1 - Schröder, Christian A1 - Schierack, Peter T1 - Intestinal Escherichia coli colonization in a mallard duck population over four consecutive winter season T2 - Environmental Microbiology Y1 - 2015 U6 - https://doi.org/10.1111/1462-2920.12807 SN - 1462-2920 SN - 1462-2912 VL - 17 IS - 9 SP - 3352 EP - 3361 ER - TY - CHAP A1 - Rödiger, Stefan A1 - Böhm, Alexander A1 - Nitschke, Jörg A1 - Stavitskaya, Luba A1 - Gruner, Melanie A1 - Kundzer, Alena V. A1 - Volkova, Margarita V. A1 - Generalov, I. A1 - Schmidt, Carsten A1 - Schröder, Christian A1 - Roggenbuck, Dirk A1 - Schierack, Peter T1 - Development of a Method for Multiplex Real-Time Analysis of Enzymatic Activity on a Microbead-Chip T2 - Infection, tumors and autoimmunity, report on the 11th Dresden Symposium on Autoantibodies held in Dresden on September 1-4, 2013 Y1 - 2013 SN - 978-3-89967-881-9 SP - 275 EP - 280 PB - Pabst Science Publ. CY - Lengerich [u.a.] ER - TY - GEN A1 - Rödiger, Stefan A1 - Lehmann, Werner A1 - Frömmel, Ulrike A1 - Böhm, Alexander A1 - Nitschke, Jörg A1 - Burdukiewicz, Michał A1 - Schröder, Christian A1 - Dangla, Rémi A1 - Droniou, Magali A1 - Schierack, Peter T1 - The Modi Operandi of the VideoScan Platform for the Detection and Analysis of Nucleic Acids. Life Science Day 2013 & 17. Leibniz Conference of Advanced Science, Freie Universität Berlin, 24.10.2013 Y1 - 2013 UR - https://leibniz-institut.de/Konferenzen/lsd2013/roediger_the_modi_operandi_of_the_videoscan_platform.pdf ER - TY - GEN A1 - Rödiger, Stefan A1 - Schneider, Jens A1 - Sauer, Lysann A1 - Reddig, Annika A1 - Schierack, Peter A1 - Roggenbuck, Dirk A1 - Schröder, Christian T1 - A Multiparameter Platform for The Analysis of DNA Double-strand Breaks and Associated Biomarkers after genome Editing Austrian Biomarker Symposium (ASBD) 2016, 10.-11.03.2016, Wien, Österreich Y1 - 2016 UR - https://f1000research.com/posters/5-350 ER - TY - GEN A1 - Sauer, Lysann A1 - Rödiger, Stefan A1 - Schneider, Jens A1 - Schierack, Peter A1 - Roggenbuck, Dirk A1 - Schröder, Christian T1 - Functional Multiparameter Analy sis of Double-Strand Breaks and Associate Biomarkers during Genome Editing, Genome Editing and Gene Modulation Congress 2016, 6.–8.04.2016, Oxford, United Kingdom Y1 - 2016 UR - https://f1000research.com/posters/5-706 ER - TY - CHAP A1 - Rödiger, Stefan A1 - Böhm, Alexander A1 - Nitschke, Jörg A1 - Stavitskaya, Luba A1 - Gruner, Melanie A1 - Kundzer, Alena V. A1 - Volkova, Margarita V. A1 - Generalov, I. A1 - Schmidt, Carsten A1 - Schröder, Christian A1 - Roggenbuck, Dirk A1 - Schierack, Peter T1 - Development of a Method for Multiplex Real-Time Analysis of Enzymati c Activity on a Microbead-Chip. T2 - Infections, Tumors and Autoimmunity, Report on the 11th Dresden Symposium on Autoantibodies held in Dresden on September 01. - 04., 2013 Y1 - 2013 SN - 978-3-89967-881-9 SP - 280 PB - Pabst Science Publ. CY - Lengerich ER - TY - CHAP A1 - Rödiger, Stefan A1 - Hanschmann, Henning A1 - Steidle, Michael A1 - Schröder, Christian A1 - Schierack, Peter A1 - Lehmann, Werner T1 - Detection of Borrelia, Bordetella and HPV with the LoopTag Real-Time PCR Probe System T2 - International journal of medical microbiology Y1 - 2013 SN - 1618-0607 SN - 1438-4221 N1 - 65. Jahrestagung der Deutschen Gesellschaft für Hygiene und Mikrobiologie e.V. und der Jahrestagung der Deutschen Gesellschaft für Infektiologie (DGI) e.V., Universität Rostock, 22.09. – 25.09.20 13, Rostock VL - 303 IS - Supplement 1 SP - 12 EP - 13 ER - TY - RPRT A1 - Feindt, Peter H. A1 - Wolters, Volkmar A1 - Backes, Gunter A1 - Bahrs, Enno A1 - Brandt, Horst A1 - Engels, Eve-Marie A1 - Engels, Johannes A1 - Graner, Andreas A1 - Hamm, Ulrich A1 - Herdegen, Matthias A1 - Isselstein, Johannes A1 - Schröder, Stefan A1 - Tholen, Ernst A1 - Wagner, Sven A1 - Wätzold, Frank A1 - Wolf, Heino T1 - Schutz tiergenetischer Ressourcen im Tierseuchenfall - Vorschläge zum Schutz von Tierbeständen in Nukleus- bzw. Basiszuchtbetrieben und Besamungsstationen bei Auftreten der Afrikanischen Schweinepest Y1 - 2018 UR - https://www.genres.de/fileadmin/SITE_MASTER/content/SITE_GENRES/downloads/docs/Beirat-GR/Gutachten_Stellungnahmen/StellungnahmeWBBGR_Tierseuche_AfrikansicheSchweinepest_09_2018_web.pdf PB - Bundesanstalt für Landwirtschaft und Ernährung (BLE), Informations- und Koordinationszentrum für Biologische Vielfalt (IBV) CY - Bonn ER - TY - GEN A1 - Ruhe, Madeleine A1 - Rabe, Dominik A1 - Jurischka, Christoph A1 - Schröder, Julia A1 - Schierack, Peter A1 - Deckert, P. Markus A1 - Rödiger, Stefan T1 - Molecular biomarkers of DNA damage in diffuse large-cell lymphoma-a review T2 - Journal of Laboratory and Precision Medicine Y1 - 2019 U6 - https://doi.org/10.21037/jlpm.2019.01.01 SN - 2519-9005 VL - 4 ER - TY - GEN A1 - Lehnen, Nadine A1 - Schröder, Lena A1 - Henningsen, Peter A1 - Glasauer, Stefan A1 - Ramaioli, Cecilia T1 - Deficient head motor control in functional dizziness: Experimental evidence of central sensory-motor dysfunction in persistent physical symptoms T2 - Progress in Brain Research N2 - Understanding the mechanisms of symptoms that are insufficiently explained by organic dysfunction remains challenging. Recently, it has been proposed that such “functional symptoms” are based on erroneous sensory processing in the central nervous system (CNS), with internal expectations dominating sensory inputs. In a pilot study, we used a head motor control set-up to assess the interplay between sensory input and expectation on the example of patients with functional dizziness. Eight patients and 11 age-matched healthy controls performed large active eye-head gaze shifts towards visual targets in the natural situation and with the head moment of inertia 3.3-fold increased. The latter induces head oscillations and the expected sensory outcome of the movement, estimated in the CNS, does not match the actual sensory input. Head oscillations were assessed in patients and in healthy subjects and compared to prior results from patients with organic disease (vestibular loss and cerebellar ataxia). Head oscillations in patients with functional dizziness were different from those of healthy subjects (F(1,17) = 27.26, P < 0.001, partial η2 = 0.62), and similar to those of patients with cerebellar ataxia, and with vestibular loss (F(2,19) = 0.56, P = 0.58). Even in the natural, unweighted, condition, head oscillations were higher in functional dizziness patients than in healthy subjects (P = 0.001). Since an extensive work-up failed to demonstrate any explanatory peripheral vestibular, motor, or cerebellar organic dysfunction, these motor control deficits are a first indication of erroneous interplay between expectations and sensory input in the CNS that could account for persistent physical symptoms. Y1 - 2019 U6 - https://doi.org/10.1016/bs.pbr.2019.02.006 SN - 1875-7855 SN - 0079-6123 VL - 249 SP - 385 EP - 400 ER - TY - RPRT A1 - Feindt, Peter H. A1 - Wolters, Volkmar A1 - Backes, Gunter A1 - Bahrs, Enno A1 - Brandt, Horst A1 - Engels, Eve-Marie A1 - Engels, Johannes A1 - Graner, Andreas A1 - Hamm, Ulrich A1 - Herdegen, Matthias A1 - Isselstein, Johannes A1 - Schröder, Stefan A1 - Tholen, Ernst A1 - Wagner, Sven A1 - Wätzold, Frank A1 - Wedekind, Helmut A1 - Wolf, Heino T1 - Wege zu einem effizienten Waldnaturschutz in Deutschland: Stellungnahme Januar 2020 Y1 - 2020 UR - https://www.fnr.de/fileadmin/allgemein/pdf/Effizienter_Waldnaturschutz_in_Deutschland.pdf CY - Berlin ER - TY - GEN A1 - Schmidt, Carsten A1 - Schierack, Peter A1 - Gerber, Ulrike A1 - Schröder, Christian A1 - Choi, Youngeun A1 - Bald, Ilko A1 - Lehmann, Werner A1 - Rödiger, Stefan T1 - Streptavidin Homologues for Applications on Solid Surfaces at High Temperatures T2 - Langmuir Y1 - 2020 U6 - https://doi.org/10.1021/acs.langmuir.9b02339 SN - 1520-5827 SN - 0743-7463 VL - 36 IS - 2 SP - 628 EP - 636 ER - TY - GEN A1 - Wätzold, Frank A1 - Feindt, Peter H. A1 - Bahrs, Enno A1 - Hamm, Ulrich A1 - Isselstein, Johannes A1 - Schröder, Stefan A1 - Wagner, Sven A1 - Wedekind, Helmut A1 - Wolters, Volkmar T1 - Wie die Politik auf die Bedrohung der Biodiversität in Agrarlandschaften durch den Klimawandel reagieren kann. Stellungnahme des Wissenschaftlichen Beirats für Biodiversität und Genetische Ressourcen beim Bundesministerium für Ernährung und Landwirtschaft T2 - Berichte über Landwirtschaft : Zeitschrift für Agrarpolitik und Landwirtschaft. Sonderheft Y1 - 2020 U6 - https://doi.org/10.12767/buel.vi232.330 SN - 2196-5099 IS - 232 ER - TY - GEN A1 - Eichler, Christian A1 - Hofmeier, Henriette A1 - Reif, Stefan A1 - Hönig, Timo A1 - Nolte, Jörg A1 - Schröder-Preikschat, Wolfgang T1 - Neverlast: Towards the Design und Implementation of the NVM-based Everlasting Operating System T2 - Hawaii International Conference on System Sciences 2021 - HICSS-54 KW - operating systems KW - non-volatile memory KW - software development for mobile devices, the internet-of-things, and cyber physical systems energy Y1 - 2021 UR - https://scholarspace.manoa.hawaii.edu/handle/10125/71491 U6 - https://doi.org/10.24251/HICSS.2021.870 SP - 7227 EP - 7236 PB - Scholarspace ER - TY - GEN A1 - Liedtke, Victoria A1 - Schröder, Christian A1 - Roggenbuck, Dirk A1 - Weiss, Romano A1 - Stohwasser, Ralf A1 - Schierack, Peter A1 - Rödiger, Stefan A1 - Schenk, Lysann T1 - LEDGF/p75 is required for an efficient DNA damage response T2 - International Journal of Molecular Sciences KW - LEDGF KW - CRISPR/Cas9 KW - DNA damage signaling KW - gH2AX KW - ubiquitination Y1 - 2021 U6 - https://doi.org/10.3390/ijms22115866 VL - 22 IS - 11 SP - 1 EP - 16 ER - TY - GEN A1 - Schröder, Lena A1 - Werder, Dina von A1 - Ramaioli, Cecilia A1 - Wachtler, Thomas A1 - Henningsen, Peter A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Unstable Gaze in Functional Dizziness: A Contribution to Understanding the Pathophysiology of Functional Disorders T2 - Frontiers in Neuroscience N2 - Objective: We are still lacking a pathophysiological mechanism for functional disorders explaining the emergence and manifestation of characteristic, severely impairing bodily symptoms like chest pain or dizziness. A recent hypothesis based on the predictive coding theory of brain function suggests that in functional disorders, internal expectations do not match the actual sensory body states, leading to perceptual dysregulation and symptom perception. To test this hypothesis, we investigated the account of internal expectations and sensory input on gaze stabilization, a physiologically relevant parameter of gaze shifts, in functional dizziness. Methods: We assessed gaze stabilization in eight functional dizziness patients and 11 healthy controls during two distinct epochs of large gaze shifts: during a counter- rotation epoch (CR epoch), where the brain can use internal models, motor planning, and resulting internal expectations to achieve internally driven gaze stabilization; and during an oscillation epoch (OSC epoch), where, due to terminated motor planning, no movement expectations are present, and gaze is stabilized by sensory input alone. Results: Gaze stabilization differed between functional patients and healthy controls only when internal movement expectations were involved [F(1,17) = 14.63, p = 0.001, and partial η2 = 0.463]: functional dizziness patients showed reduced gaze stabilization during the CR (p = 0.036) but not OSC epoch (p = 0.26). Conclusion: While sensory-driven gaze stabilization is intact, there are marked, well- measurable deficits in internally-driven gaze stabilization in functional dizziness pointing at internal expectations that do not match actual body states. This experimental evidence supports the perceptual dysregulation hypothesis of functional disorders and is an important step toward understanding the underlying pathophysiology. Y1 - 2021 U6 - https://doi.org/10.3389/fnins.2021.685590 SN - 1662-453X SN - 1662-4548 VL - 15 ER - TY - GEN A1 - Schröder, Lena A1 - Regnath, Franziska A1 - Glasauer, Stefan A1 - Hackenberg, Anna A1 - Hente, Juliane A1 - Weilenmann, Sonja A1 - Pohl, Daniel A1 - Känel, Roland von A1 - Lehnen, Nadine T1 - Altered sensorimotor processing in irritable bowel syndrome: Evidence for a transdiagnostic pathomechanism in functional somatic disorders T2 - Frontiers in Neuroscience N2 - Objective A recent hypothesis suggests that functional somatic symptoms are due to altered information processing in the brain, with rigid expectations biasing sensorimotor signal processing. First experimental results confirmed such altered processing within the affected symptom modality, e.g., deficient eye-head coordination in patients with functional dizziness. Studies in patients with functional somatic symptoms looking at general, trans-symptomatic processing deficits are sparse. Here, we investigate sensorimotor processing during eye-head gaze shifts in irritable bowel syndrome (IBS) to test whether processing deficits exist across symptom modalities. Methods Study participants were seven patients suffering from IBS and seven age- and gender-matched healthy controls who performed large gaze shifts toward visual targets. Participants performed combined eye-head gaze shifts in the natural condition and with experimentally increased head moment of inertia. Head oscillations as a marker for sensorimotor processing deficits were assessed. Bayes statistics was used to assess evidence for the presence or absence of processing differences between IBS patients and healthy controls. Results With the head moment of inertia increased, IBS patients displayed more pronounced head oscillations than healthy controls (Bayes Factor 10 = 56.4, corresponding to strong evidence). Conclusion Patients with IBS show sensorimotor processing deficits, reflected by increased head oscillations during large gaze shifts to visual targets. In particular, patients with IBS have difficulties to adapt to the context of altered head moment of inertia. Our results suggest general transdiagnostic processing deficits in functional somatic disorders. KW - irritable bowel syndrome (IBS) KW - functional somatic disorders KW - somatoform disorders KW - predictive processing KW - transdiagnostic mechanism KW - gaze shift Y1 - 2022 U6 - https://doi.org/10.3389/fnins.2022.1029126 SN - 1662-453X VL - 16 ER -