TY - GEN A1 - Ruhe, Madeleine A1 - Rabe, Dominik A1 - Jurischka, Christoph A1 - Schröder, Julia A1 - Schierack, Peter A1 - Deckert, P. Markus A1 - Rödiger, Stefan T1 - Molecular biomarkers of DNA damage in diffuse large-cell lymphoma-a review T2 - Journal of Laboratory and Precision Medicine Y1 - 2019 U6 - https://doi.org/10.21037/jlpm.2019.01.01 SN - 2519-9005 VL - 4 ER - TY - GEN A1 - Lehnen, Nadine A1 - Schröder, Lena A1 - Henningsen, Peter A1 - Glasauer, Stefan A1 - Ramaioli, Cecilia T1 - Deficient head motor control in functional dizziness: Experimental evidence of central sensory-motor dysfunction in persistent physical symptoms T2 - Progress in Brain Research N2 - Understanding the mechanisms of symptoms that are insufficiently explained by organic dysfunction remains challenging. Recently, it has been proposed that such “functional symptoms” are based on erroneous sensory processing in the central nervous system (CNS), with internal expectations dominating sensory inputs. In a pilot study, we used a head motor control set-up to assess the interplay between sensory input and expectation on the example of patients with functional dizziness. Eight patients and 11 age-matched healthy controls performed large active eye-head gaze shifts towards visual targets in the natural situation and with the head moment of inertia 3.3-fold increased. The latter induces head oscillations and the expected sensory outcome of the movement, estimated in the CNS, does not match the actual sensory input. Head oscillations were assessed in patients and in healthy subjects and compared to prior results from patients with organic disease (vestibular loss and cerebellar ataxia). Head oscillations in patients with functional dizziness were different from those of healthy subjects (F(1,17) = 27.26, P < 0.001, partial η2 = 0.62), and similar to those of patients with cerebellar ataxia, and with vestibular loss (F(2,19) = 0.56, P = 0.58). Even in the natural, unweighted, condition, head oscillations were higher in functional dizziness patients than in healthy subjects (P = 0.001). Since an extensive work-up failed to demonstrate any explanatory peripheral vestibular, motor, or cerebellar organic dysfunction, these motor control deficits are a first indication of erroneous interplay between expectations and sensory input in the CNS that could account for persistent physical symptoms. Y1 - 2019 U6 - https://doi.org/10.1016/bs.pbr.2019.02.006 SN - 1875-7855 SN - 0079-6123 VL - 249 SP - 385 EP - 400 ER - TY - RPRT A1 - Feindt, Peter H. A1 - Wolters, Volkmar A1 - Backes, Gunter A1 - Bahrs, Enno A1 - Brandt, Horst A1 - Engels, Eve-Marie A1 - Engels, Johannes A1 - Graner, Andreas A1 - Hamm, Ulrich A1 - Herdegen, Matthias A1 - Isselstein, Johannes A1 - Schröder, Stefan A1 - Tholen, Ernst A1 - Wagner, Sven A1 - Wätzold, Frank A1 - Wedekind, Helmut A1 - Wolf, Heino T1 - Wege zu einem effizienten Waldnaturschutz in Deutschland: Stellungnahme Januar 2020 Y1 - 2020 UR - https://www.fnr.de/fileadmin/allgemein/pdf/Effizienter_Waldnaturschutz_in_Deutschland.pdf CY - Berlin ER - TY - GEN A1 - Schmidt, Carsten A1 - Schierack, Peter A1 - Gerber, Ulrike A1 - Schröder, Christian A1 - Choi, Youngeun A1 - Bald, Ilko A1 - Lehmann, Werner A1 - Rödiger, Stefan T1 - Streptavidin Homologues for Applications on Solid Surfaces at High Temperatures T2 - Langmuir Y1 - 2020 U6 - https://doi.org/10.1021/acs.langmuir.9b02339 SN - 1520-5827 SN - 0743-7463 VL - 36 IS - 2 SP - 628 EP - 636 ER - TY - GEN A1 - Wätzold, Frank A1 - Feindt, Peter H. A1 - Bahrs, Enno A1 - Hamm, Ulrich A1 - Isselstein, Johannes A1 - Schröder, Stefan A1 - Wagner, Sven A1 - Wedekind, Helmut A1 - Wolters, Volkmar T1 - Wie die Politik auf die Bedrohung der Biodiversität in Agrarlandschaften durch den Klimawandel reagieren kann. Stellungnahme des Wissenschaftlichen Beirats für Biodiversität und Genetische Ressourcen beim Bundesministerium für Ernährung und Landwirtschaft T2 - Berichte über Landwirtschaft : Zeitschrift für Agrarpolitik und Landwirtschaft. Sonderheft Y1 - 2020 U6 - https://doi.org/10.12767/buel.vi232.330 SN - 2196-5099 IS - 232 ER - TY - GEN A1 - Eichler, Christian A1 - Hofmeier, Henriette A1 - Reif, Stefan A1 - Hönig, Timo A1 - Nolte, Jörg A1 - Schröder-Preikschat, Wolfgang T1 - Neverlast: Towards the Design und Implementation of the NVM-based Everlasting Operating System T2 - Hawaii International Conference on System Sciences 2021 - HICSS-54 KW - operating systems KW - non-volatile memory KW - software development for mobile devices, the internet-of-things, and cyber physical systems energy Y1 - 2021 UR - https://scholarspace.manoa.hawaii.edu/handle/10125/71491 U6 - https://doi.org/10.24251/HICSS.2021.870 SP - 7227 EP - 7236 PB - Scholarspace ER - TY - GEN A1 - Liedtke, Victoria A1 - Schröder, Christian A1 - Roggenbuck, Dirk A1 - Weiss, Romano A1 - Stohwasser, Ralf A1 - Schierack, Peter A1 - Rödiger, Stefan A1 - Schenk, Lysann T1 - LEDGF/p75 is required for an efficient DNA damage response T2 - International Journal of Molecular Sciences KW - LEDGF KW - CRISPR/Cas9 KW - DNA damage signaling KW - gH2AX KW - ubiquitination Y1 - 2021 U6 - https://doi.org/10.3390/ijms22115866 VL - 22 IS - 11 SP - 1 EP - 16 ER - TY - GEN A1 - Schröder, Lena A1 - Werder, Dina von A1 - Ramaioli, Cecilia A1 - Wachtler, Thomas A1 - Henningsen, Peter A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Unstable Gaze in Functional Dizziness: A Contribution to Understanding the Pathophysiology of Functional Disorders T2 - Frontiers in Neuroscience N2 - Objective: We are still lacking a pathophysiological mechanism for functional disorders explaining the emergence and manifestation of characteristic, severely impairing bodily symptoms like chest pain or dizziness. A recent hypothesis based on the predictive coding theory of brain function suggests that in functional disorders, internal expectations do not match the actual sensory body states, leading to perceptual dysregulation and symptom perception. To test this hypothesis, we investigated the account of internal expectations and sensory input on gaze stabilization, a physiologically relevant parameter of gaze shifts, in functional dizziness. Methods: We assessed gaze stabilization in eight functional dizziness patients and 11 healthy controls during two distinct epochs of large gaze shifts: during a counter- rotation epoch (CR epoch), where the brain can use internal models, motor planning, and resulting internal expectations to achieve internally driven gaze stabilization; and during an oscillation epoch (OSC epoch), where, due to terminated motor planning, no movement expectations are present, and gaze is stabilized by sensory input alone. Results: Gaze stabilization differed between functional patients and healthy controls only when internal movement expectations were involved [F(1,17) = 14.63, p = 0.001, and partial η2 = 0.463]: functional dizziness patients showed reduced gaze stabilization during the CR (p = 0.036) but not OSC epoch (p = 0.26). Conclusion: While sensory-driven gaze stabilization is intact, there are marked, well- measurable deficits in internally-driven gaze stabilization in functional dizziness pointing at internal expectations that do not match actual body states. This experimental evidence supports the perceptual dysregulation hypothesis of functional disorders and is an important step toward understanding the underlying pathophysiology. Y1 - 2021 U6 - https://doi.org/10.3389/fnins.2021.685590 SN - 1662-453X SN - 1662-4548 VL - 15 ER - TY - GEN A1 - Schröder, Lena A1 - Regnath, Franziska A1 - Glasauer, Stefan A1 - Hackenberg, Anna A1 - Hente, Juliane A1 - Weilenmann, Sonja A1 - Pohl, Daniel A1 - Känel, Roland von A1 - Lehnen, Nadine T1 - Altered sensorimotor processing in irritable bowel syndrome: Evidence for a transdiagnostic pathomechanism in functional somatic disorders T2 - Frontiers in Neuroscience N2 - Objective A recent hypothesis suggests that functional somatic symptoms are due to altered information processing in the brain, with rigid expectations biasing sensorimotor signal processing. First experimental results confirmed such altered processing within the affected symptom modality, e.g., deficient eye-head coordination in patients with functional dizziness. Studies in patients with functional somatic symptoms looking at general, trans-symptomatic processing deficits are sparse. Here, we investigate sensorimotor processing during eye-head gaze shifts in irritable bowel syndrome (IBS) to test whether processing deficits exist across symptom modalities. Methods Study participants were seven patients suffering from IBS and seven age- and gender-matched healthy controls who performed large gaze shifts toward visual targets. Participants performed combined eye-head gaze shifts in the natural condition and with experimentally increased head moment of inertia. Head oscillations as a marker for sensorimotor processing deficits were assessed. Bayes statistics was used to assess evidence for the presence or absence of processing differences between IBS patients and healthy controls. Results With the head moment of inertia increased, IBS patients displayed more pronounced head oscillations than healthy controls (Bayes Factor 10 = 56.4, corresponding to strong evidence). Conclusion Patients with IBS show sensorimotor processing deficits, reflected by increased head oscillations during large gaze shifts to visual targets. In particular, patients with IBS have difficulties to adapt to the context of altered head moment of inertia. Our results suggest general transdiagnostic processing deficits in functional somatic disorders. KW - irritable bowel syndrome (IBS) KW - functional somatic disorders KW - somatoform disorders KW - predictive processing KW - transdiagnostic mechanism KW - gaze shift Y1 - 2022 U6 - https://doi.org/10.3389/fnins.2022.1029126 SN - 1662-453X VL - 16 ER -