TY - GEN A1 - Stohwasser, Ralf A1 - Holzhütter, Hermann-Georg A1 - Lehmann, Undine A1 - Henklein, Peter A1 - Kloetzel, Peter-Michael T1 - Hepatitis B virus HBx peptide 116-138 and proteasome activator PA28 compete for binding to the proteasome alpha4/MC6 subunit. T2 - Biological Chemistry Y1 - 2003 U6 - https://doi.org/10.1515/BC.2003.005 SN - 1437-4315 SN - 1431-6730 VL - 384 IS - 1 SP - 39 EP - 49 ER - TY - GEN A1 - Rudolph, Matthias A1 - Heymann, Peter A1 - Boss, Hermann T1 - Impact of Receiver Bandwidth and Nonlinearity on Noise Measurement Methods Y1 - 2010 U6 - https://doi.org/http://dx.doi.org/10.1109/MMM.2010.937715 ER - TY - RPRT A1 - Feindt, Peter H. A1 - Wolters, Volkmar A1 - Backes, Gunter A1 - Bahrs, Enno A1 - Dempfle, Leo A1 - Engels, Eve-Marie A1 - Engels, Johannes A1 - Graner, Andreas A1 - Hamm, Ulrich A1 - Herdegen, Matthias A1 - Isselstein, Johannes A1 - Konnert, Monika A1 - Schröder, Stefan A1 - Schulte-Coerne, Hermann A1 - Wagner, Sven A1 - Wätzold, Frank A1 - Wedekind, Helmut T1 - Gründung der Deutschen Genbank landwirtschaftlicher Nutztiere : Kurzstellungnahme des Wissenschaftlichen Beirats für Biodiversität und Genetische Ressourcen beim Bundesministerium für Ernährung und Landwirtschaft Y1 - 2015 UR - https://beirat-gr.genres.de//fileadmin/SITE_GENRES/downloads/docs/Beirat-GR/Gutachten_Stellungnahmen/beirat_09_2015.pdf PB - BMEL CY - Bonn ER - TY - RPRT A1 - Wätzold, Frank A1 - Bahrs, Enno A1 - Feindt, Peter H. A1 - Hamm, Ulrich A1 - Isselstein, Johannes A1 - Schröder, Stefan A1 - Wolters, Volkmar A1 - Backes, Gunter A1 - Dempfle, Leo A1 - Engels, Eve-Marie A1 - Engels, Johannes A1 - Graner, Andreas A1 - Herdegen, Matthias A1 - Konnert, Monika A1 - Schulte-Coerne, Hermann A1 - Wagner, Sven A1 - Wedekind, Helmut T1 - Perspektiven für das artenreiche Grünland - Alternativen zur Belohnung einer Überschussproduktion bei Milch Y1 - 2015 CY - Bonn ER - TY - GEN A1 - Kolanek, Krzysztof A1 - Hermann, Peter A1 - Dudek, Piotr T. A1 - Gotszalk, Teodor A1 - Chumakov, Dmytro A1 - Weisheit, Martin A1 - Hecker, Michael A1 - Zschech, Ehrenfried T1 - Local anodic oxidation by atomic force microscopy for nano-Raman strain measurements on silicon-germanium thin films T2 - Thin Solid Films KW - oxidation KW - microscope KW - measurements KW - thin films Y1 - 2010 SN - 0040-6090 VL - 518 IS - 12 SP - 3267 EP - 3272 ER - TY - GEN A1 - Stohwasser, Ralf A1 - Salzmann, Ulrike A1 - Giesebrecht, Jan A1 - Kloetzel, Peter-Michael A1 - Holzhütter, Hermann-Georg T1 - Kinetic evidences for facilitation of peptide cannelling by the proteasome activator PA28 T2 - European Journal of Biochemistry Y1 - 2000 U6 - https://doi.org/10.1046/j.1432-1327.2000.01706.x SN - 1432-1033 SN - 0014-2956 VL - 267 SP - 6221 EP - 6230 ER - TY - CHAP A1 - Langendörfer, Peter A1 - Kornemann, Stephan A1 - Alsabbagh, Wael A1 - Hermann, Erik T1 - Information Security: The Cornerstone for Surviving the Digital Wild T2 - The Future of Smart Production for SMEs: A Methodological and Practical Approach Towards Digitalization in SMEs N2 - In this chapter we are discussing the very basics in the sense of how to prepare your company with respect to security. The essential issues are a proper information security governance framework that takes into account the managerial and organizational issues as well as proper technical means. For the latter we introduce network separation as this is one of the prime means to protect your production network from network based attacks. Y1 - 2023 SN - 978-3-031-15428-7 U6 - https://doi.org/10.1007/978-3-031-15428-7_29 SP - 335 EP - 341 PB - Springer International Publishing CY - Cham ER - TY - GEN A1 - Frömmel, Ulrike A1 - Lehmann, Werner A1 - Rödiger, Stefan A1 - Böhm, Alexander A1 - Nitschke, Jörg A1 - Weinreich, Jörg A1 - Groß, Julia A1 - Roggenbuck, Dirk A1 - Zinke, Olaf A1 - Ansorge, Hermann A1 - Vogel, Steffen A1 - Klemm, Per A1 - Wex, Thomas A1 - Schröder, Christian A1 - Wieler, Lothar H. A1 - Schierack, Peter T1 - Adhesion of human and animal Escherichia coli strains in association with their virulence-associated genes and phylogenetic origins T2 - Applied and environmental microbiology N2 - Intestinal colonization is influenced by the ability of the bacterium to inhabit a niche, which is based on the expression of colonization factors. Escherichia coli carries a broad range of virulence-associated genes (VAGs) which contribute to intestinal (inVAGs) and extraintestinal (exVAGs) infection. Moreover, initial evidence indicates that inVAGs and exVAGs support intestinal colonization. We developed new screening tools to genotypically and phenotypically characterize E. coli isolates originating in humans, domestic pigs, and 17 wild mammal and avian species. We analyzed 317 isolates for the occurrence of 44 VAGs using a novel multiplex PCR microbead assay (MPMA) and for adhesion to four epithelial cell lines using a new adhesion assay. We correlated data for the definition of new adhesion genes. inVAGs were identified only sporadically, particularly in roe deer (Capreolus capreolus) and the European hedgehog ( Erinaceus europaeus). The prevalence of exVAGs depended on isolation from a specific host. Human uropathogenic E. coli isolates carried exVAGs with the highest prevalence, followed by badger (Meles meles) and roe deer isolates. Adhesion was found to be very diverse. Adhesion was specific to cells, host, and tissue, though it was also unspecific. Occurrence of the following VAGs was associated with a higher rate of adhesion to one or more cell lines: afa-dra, daaD, tsh, vat, ibeA, fyuA, mat, sfa-foc, malX, pic, irp2, and papC. In summary, we established new screening methods which enabled us to characterize large numbers of E. coli isolates. We defined reservoirs for potential pathogenic E. coli. We also identified a very broad range of colonization strategies and defined potential new adhesion genes. Y1 - 2013 U6 - https://doi.org/10.1128/AEM.01384-13 SN - 1098-5336 SN - 0099-2240 VL - 79 IS - 19 SP - 5814 EP - 5829 ER - TY - GEN A1 - Frömmel, Ulrike A1 - Böhm, Alexander A1 - Nitschke, Jörg A1 - Weinreich, Jörg A1 - Groß, Julia A1 - Rödiger, Stefan A1 - Wex, Thomas A1 - Ansorge, Hermann A1 - Zinke, Olaf A1 - Schröder, Christian A1 - Roggenbuck, Dirk A1 - Schierack, Peter T1 - Adhesion patterns of commensal and pathogenic Escherichia coli from humans and wild animals on human and porcine epithelial cell lines T2 - Gut Pathogens N2 - Abstract BACKGROUND: Different strategies of colonization or infection by E. coli result in formation of certain adhesion patterns which help also in classifying intestinal E. coli into pathotypes. Little is known about adhesion patterns and host- and tissue adaption of commensal E. coli and about E. coli originating in clinically healthy hosts carrying pathotype-specific virulence-associated genes. FINDINGS: Adhesion pattern of E. coli (n = 282) from humans and from 18 animal species were verified on intestinal human Caco-2 and porcine IPEC-J2 cells and, furthermore, for comparison on human urinary bladder 5637, porcine kidney PK-15 epithelial and HEp-2 cells. The analysis was carried out on 150,000 images of adhesion assays.Adhesion patterns were very diverse; 88 isolates were completely non-adherent, whereas 194 adhered to at least one cell line with the dominant adhesion patterns "diffusely distributed" and "microcolony formation". Adhesion patterns "chains" and "clumps" were also visible. Chain formation was mediated by the presence of epithelial cells. Clump formation was very specific on only the 5637 cell line. All enteropathogenic (eae+) E. coli (EPEC; n = 14) were able to form microcolonies which was cell line specific for each isolate. Most EPEC formed microcolonies on intestinal IPEC-J2 and Caco-2 but several also on urinary tract cells. Shigatoxin-producing (stx+) E. coli (n = 10) showed no specific adhesion patterns. CONCLUSIONS: E. coli isolates were highly diverse. Commensal and pathogenic isolates can adhere in various forms, including diffuse distribution, microcolonies, chains and clumps. Microcolony formation seems to be a global adhesion strategy also for commensal E. coli. Y1 - 2013 U6 - https://doi.org/10.1186/1757-4749-5-31 SN - 1757-4749 VL - 5 IS - 31 ER -