TY - GEN A1 - Lutter, Anne-Helen A1 - Hempel, Ute A1 - Dieter, Peter A1 - Anderer, Ursula T1 - Multinuclearity is not mandatory for Bone Resorption Mononuclear Osteoclasts are able to resorbe Extracellular Bone Matrix in vitro T2 - Bone-Tec, Munich, 2017 KW - mononuclear osteoclast Y1 - 2017 UR - https://www.researchgate.net/publication/327860900 ER - TY - GEN A1 - Lutter, Anne-Helen A1 - Hempel, Ute A1 - Dieter, Peter A1 - Anderer, Ursula T1 - The biomarker-based ODEM-assay affects cellular characteristics of osteoclasts in vitro Tissue culture polystyrene vs Osteoblast-Derived Extracellular Matrix T1 - 6th Munich Biomarker Conference, Munich, 2016 Y1 - 2016 U6 - https://doi.org/10.13140/RG.2.2.20195.96806 ER - TY - CHAP A1 - Lutter, Anne-Helen A1 - Hempel, Ute A1 - Dieter, Peter A1 - Anderer, Ursula T1 - Cost-efficient diagnostic platform to measure osteoclast activity T2 - 35. Jahrestagung der Deutschen Gesellschaft für Klinische Mikrozirkulation und Hämorheologie, Mainz, 2016 Y1 - 2016 U6 - https://doi.org/10.13140/RG.2.2.10550.19528 ER - TY - CHAP A1 - Kot, Małgorzata A1 - Kegelmann, Lukas A1 - Kus, Peter A1 - Tsud, Nataliya A1 - Matolínová, Iva A1 - Albrecht, Steve A1 - Matolin, Vladimir A1 - Schmeißer, Dieter T1 - Room temperature atomic layer deposition for perovskite solar cells T2 - Verhandlungen der Deutschen Physikalischen Gesellschaft, Reihe 6, Band 53,3 N2 - After few years of efficiency driven research on perovskite solar cells, the focus now is shifting to understand the underlying processes governing the high efficiency and also to obtain long-term stable devices. Among various deposition methods, atomic layer deposition (ALD) may represent one of the best options, being possible to coat substrates in a very efficient way and at very low temperatures. In our previous work [1] we reported that the efficiency of the solar cell containing aged perovskite film can be enhanced twice while covering the perovskite with a thin ALD alumina film at room temperature. In this work, the chemical, electronic and morphological properties of the fresh perovskite film treated by ALD pulses of the trimethylaluminium and water at room temperature investigated using X-ray Photoelectron Spectroscopy and Field Emission Scanning Electron Microscopy will be discused and correlated with the solar cells performance and stability. [1] M. Kot et al., ChemSusChem 2016, 9, 3401. KW - Perovskite solar cells KW - atomic layer deposition KW - X-Ray photoelectron spectroscopy (XPS) KW - atomic force microscopy KW - field emission scanning electron microscopy KW - photo-conversion efficiency Y1 - 2018 SN - 0420-0195 SP - S. 174 PB - Deutsche Physikalische Gesellschaft CY - Bad Honnef ER - TY - GEN A1 - Kammerer, Sarah A1 - Sokolowski, Armin Andreas A1 - Hackl, Hubert A1 - Platzer, Dieter A1 - Jahn, Stephan Wenzel A1 - El-Heliebi, Amin A1 - Schwarzenbacher, Daniela A1 - Stiegelbauer, Verena A1 - Pichler, Martin A1 - Rezania, Simin A1 - Fiegl, Heidelinde A1 - Peintinger, Florentia A1 - Regitnig, Peter A1 - Höfler, Gerald A1 - Schreibmayer, Wolfgang A1 - Bauernhofer, Thomas T1 - KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients T2 - OncoTarget : open access impact journal N2 - Numerous studies showed abnormal expression of ion channels in different cancer types. Amongst these, the potassium channel gene KCNJ3 (encoding for GIRK1 proteins) has been reported to be upregulated in tumors of patients with breast cancer and to correlate with positive lymph node status. We aimed to study KCNJ3 levels in different breast cancer subtypes using gene expression data from the TCGA, to validate our findings using RNA in situ hybridization in a validation cohort (GEO ID GSE17705), and to study the prognostic value of KCNJ3using survival analysis. In a total of > 1000 breast cancer patients of two independent data sets we showed a) that KCNJ3 expression is upregulated in tumor tissue compared to corresponding normal tissue (p < 0.001), b) that KCNJ3 expression is associated with estrogen receptor (ER) positive tumors (p < 0.001), but that KCNJ3 expression is variable within this group, and c) that ER positive patients with high KCNJ3 levels have worse overall (p < 0.05) and disease free survival probabilities (p < 0.01), whereby KCNJ3 is an independent prognostic factor (p <0.05). In conclusion, our data suggest that patients with ER positive breast cancer might be stratified into high risk and low risk groups based on the KCNJ3 levels in the tumor. Y1 - 2016 U6 - https://doi.org/10.18632/oncotarget.13224 VL - 7 IS - 51 SP - 84705 EP - 84717 ER - TY - CHAP A1 - Hendler, Marco A1 - Bestle, Dieter A1 - Flassig, Peter Michael T1 - Cloning Strategy for Aerodynamic Compressor Design based on Throughflow Analysis T2 - Proceedings of Montreal 2018, Global Power and Propulsion Forum, 7-9.05.2018 N2 - Due to their high complexity, aero engine development is a time-consuming and cost-intensive process. Therefore, pre-developed proven aerodynamic and geometric compressor information is often used as starting point and transferred to new compressor designs. In the present paper, a new approach for aerodynamic cloning of an already existing compressor flow to a new compressor geometry by use of a streamline curvature based Throughflow solver is presented. Parameterized compressor quantities are automatically modified with the help of optimization strategies, and the resulting compressor aerodynamics are compared to a reference design in each iteration step. The target is to minimize the discrepancy between reference design and new design regarding essential flow parameters like de Haller number, Mach number etc., and thereby to reproduce the aerodynamic image of the reference design. Thus, already collected experience from existing compressor flow fields can be used to reduce costs for developing as well as testing of new compressor configurations. Conducted investigations show a notable acceleration of the design process in comparison to former strategies starting from scratch while achieving an acceptable compliance of aerodynamic parameters. Y1 - 2018 UR - https://gpps.global/documents/events/montreal18/papers/design-modeling/GPPS-NA-2018-0144.pdf N1 - GPPS-NA-2018-0144 ER - TY - CHAP A1 - Extra, Simon A1 - Lockan, Michael A1 - Bestle, Dieter A1 - Flassig, Peter Michael T1 - A Comparison of Strategies for Efficient Core Engine Optimization with Coupled Subsystems T2 - Proceedings of Montreal 2018, Global Power and Propulsion Forum, 7-9.05.2018 N2 - The present paper compares four different optimization strategies for decoupled optimization in the context of preliminary core engine design for aero engines. An optimization with the AAO (All-At-Once) approach is performed as a baseline and compared against the performance and results of three cascaded optimization strategies: CO (Collaborative Optimization), BLISS 2000 (Bi-Level Integrated System Synthesis) and ISOC (Interface Segmentation Optimization Concept). The optimization problem is based on a thermodynamic core engine model representing an industrial application example. The results are assessed with respect to typical requirements for multidisciplinary core engine design. The impact of the used optimization strategy on the performance of the optimization concept is investigated and discussed. Y1 - 2018 UR - https://gpps.global/documents/events/montreal18/papers/design-modeling/GPPS-NA-2018-0097.pdf N1 - GPPS-NA-2018-0097 ER - TY - CHAP A1 - Extra, Simon A1 - Lockan, Michael A1 - Bestle, Dieter A1 - Flassig, Peter Michael T1 - Coupled Subsystem Optimization for Preliminary Core Engine Design T2 - Evolutionary and deterministic methods for design optimization and control with applications to industrial and societal problems, Sep. 13-15, 2017 in Madrid, Spain, EUROGEN 2017, Book of abstracts Y1 - 2017 SN - 978-84-697-5112-1 PB - Technical University CY - Madrid ER - TY - GEN A1 - Hendler, Marco A1 - Bestle, Dieter A1 - Flassig, Peter Michael T1 - Component-specific Engine Design Taking into Account Holistic Design Aspects T2 - International Journal of Turbomachinery, Propulsion and Power Y1 - 2018 U6 - https://doi.org/10.3390/ijtpp3020012 SN - 2504-186X N1 - This article belongs to the Special Issue Selected Papers from the 17th International Symposium on Transport Phenomena and Dynamics of Rotating Machinery VL - 3 IS - 2 SP - 1 EP - 16 ER - TY - CHAP A1 - Extra, Simon A1 - Lockan, Michael A1 - Bestle, Dieter A1 - Flassig, Peter Michael ED - Andrès-Pèrez, Esther ED - González, Leo M. ED - Periaux, Jacques ED - Gauger, Nicolas R. ED - Quagliarella, Domenico ED - Giannakoglou, Kyriakos C. T1 - Coupled Subsystem Optimiziation for Preliminary Core Engine Design T2 - Evolutionary and Deterministic Methods for Design Optimization and Control With Applications to Industrial and Societal Problems Y1 - 2018 SN - 978-3-319-89889-6 SN - 978-3-319-89890-2 U6 - https://doi.org/10.1007/978-3-319-89890-2_33 SP - 513 EP - 527 PB - Springer International Publishing CY - Cham ER -