TY - GEN A1 - Schöberl, Florian A1 - Irving, Stephanie A1 - Pradhan, Cauchy A1 - Bardins, Stanislav A1 - Trapp, Christoph A1 - Schneider, Erich A1 - Kugler, Günter A1 - Bartenstein, Peter A1 - Dietrich, Marianne A1 - Brandt, Thomas A1 - Zwergal, Andreas T1 - Prolonged allocentric navigation deficits indicate hippocampal damage in TGA T2 - Neurology : official journal of the American Academy of Neurology N2 - Objective To investigate long-term recovery of allocentric and egocentric spatial orientation as a sensitive marker for hippocampal and extrahippocampal network function in transient global amnesia (TGA). Methods A group of 18 patients with TGA performed an established real-space navigation paradigm, requiring allo- and egocentric spatial orientation abilities, 3 days (postacute stage) and 3 months (follow-up) after symptom onset. Visual exploration behavior and navigation strategy were documented by a gaze-controlled, head-fixed camera. Allo- and egocentric spatial orientation performance was compared to that of 12 age-matched healthy controls. Navigation-induced brain activations were measured using [18F]-fluorodeoxyglucose-PET in a subgroup of 8 patients in the postacute stage and compared to those of the controls. Results In the postacute stage, the patients navigated worse and had higher error rates than controls in allocentric (p = 0.002), but not in egocentric, route planning (p = 0.30), despite complete recovery of verbal (p = 0.58) and figural memory (p = 0.11). Until follow-up, allocentric navigation deficits improved, but higher error rates and reduced use of shortcuts persisted (p < 0.0001). Patients still exhibited relatively more fixations of unique landmarks during follow-up (p = 0.05). PET measurements during the postacute stage showed increased navigation-induced brain activations in the right hippocampus, bilateral retrosplenial, parietal, and mesiofrontal cortices, and cerebellar dentate nucleus in patients compared to controls (p < 0.005). Conclusions Patients with TGA show selective and prolonged deficits of allocentric spatial orientation. Activations in right hippocampal and extrahippocampal hubs of the cerebral navigation network functionally substitute for the deficit in creating and updating the internal cognitive map in TGA. Y1 - 2019 UR - https://n.neurology.org/content/92/3/e234/tab-article-info U6 - https://doi.org/10.1212/WNL.0000000000006779 SN - 0028-3878 SN - 1526-632X VL - 92 IS - 3 SP - e234 EP - e243 ER - TY - RPRT A1 - Feindt, Peter H. A1 - Wolters, Volkmar A1 - Backes, Gunter A1 - Bahrs, Enno A1 - Brandt, Horst A1 - Engels, Eve-Marie A1 - Engels, Johannes A1 - Graner, Andreas A1 - Hamm, Ulrich A1 - Herdegen, Matthias A1 - Isselstein, Johannes A1 - Schröder, Stefan A1 - Tholen, Ernst A1 - Wagner, Sven A1 - Wätzold, Frank A1 - Wedekind, Helmut A1 - Wolf, Heino T1 - Wege zu einem effizienten Waldnaturschutz in Deutschland: Stellungnahme Januar 2020 Y1 - 2020 UR - https://www.fnr.de/fileadmin/allgemein/pdf/Effizienter_Waldnaturschutz_in_Deutschland.pdf CY - Berlin ER - TY - RPRT A1 - Feindt, Peter H. A1 - Wolters, Volkmar A1 - Backes, Gunter A1 - Bahrs, Enno A1 - Brandt, Horst A1 - Engels, Eve-Marie A1 - Engels, Johannes A1 - Graner, Andreas A1 - Hamm, Ulrich A1 - Herdegen, Matthias A1 - Isselstein, Johannes A1 - Schröder, Stefan A1 - Tholen, Ernst A1 - Wagner, Sven A1 - Wätzold, Frank A1 - Wolf, Heino T1 - Schutz tiergenetischer Ressourcen im Tierseuchenfall - Vorschläge zum Schutz von Tierbeständen in Nukleus- bzw. Basiszuchtbetrieben und Besamungsstationen bei Auftreten der Afrikanischen Schweinepest Y1 - 2018 UR - https://www.genres.de/fileadmin/SITE_MASTER/content/SITE_GENRES/downloads/docs/Beirat-GR/Gutachten_Stellungnahmen/StellungnahmeWBBGR_Tierseuche_AfrikansicheSchweinepest_09_2018_web.pdf PB - Bundesanstalt für Landwirtschaft und Ernährung (BLE), Informations- und Koordinationszentrum für Biologische Vielfalt (IBV) CY - Bonn ER - TY - RPRT A1 - Feindt, Peter H. A1 - Wolters, Volkmar A1 - Backes, Gunter A1 - Bahrs, Enno A1 - Brandt, Horst A1 - Dempfle, Leo A1 - Engels, Eve-Marie A1 - Engels, Johannes A1 - Graner, Andreas A1 - Hamm, Ulrich A1 - Herdegen, Matthias A1 - Isselstein, Johannes A1 - Konnert, Monika A1 - Schröder, Stefan A1 - Wagner, Sven A1 - Wätzold, Frank A1 - Wedekind, Helmut T1 - Verbraucher für die Erhaltung der biologischen Vielfalt in der Landwirtschaft aktivieren! Y1 - 2016 UR - http://www.schafzuchtverband-berlin-brandenburg.de/wp-content/uploads/Stellungnahme_Beirat.pdf PB - Bundesanstalt für Landwirtschaft und Ernährung (BLE) Informations- und Koordinationszentrum für Biologische Vielfalt (IBV) CY - Bonn ER - TY - GEN A1 - Schöberl, Florian A1 - Pradhan, Cauchy A1 - Irving, Stephanie A1 - Buerger, Katharina A1 - Xiong, Guoming A1 - Kugler, Günter A1 - Kohlbecher, Stefan A1 - Engmann, Julia A1 - Werner, Philipp A1 - Brendel, Matthias A1 - Schneider, Erich A1 - Perneczky, Robert A1 - Jahn, Klaus A1 - Fougère, Christian la A1 - Bartenstein, Peter A1 - Brandt, Thomas A1 - Dietrich, Marianne A1 - Zwergal, Andreas T1 - Real-space navigation testing differentiates between amyloid-positive and -negative aMCI T2 - Neurology : official journal of the American Academy of Neurology Y1 - 2020 UR - https://n.neurology.org/content/94/8/e861 U6 - https://doi.org/10.1212/WNL.0000000000008758 SN - 1526-632X VL - 94 IS - 8 SP - e861 EP - e873 ER - TY - CHAP A1 - Maltitz, Graham P. von A1 - Midgley, Guy F. A1 - Veitch, Jennifer A1 - Brümmer, Christian A1 - Rötter, Reimund P. A1 - Rixen, Tim A1 - Brandt, Peter A1 - Veste, Maik ED - Maltitz, Graham P. von ED - Midgley, Guy F. ED - Veitch, Jennifer ED - Brümmer, Christian ED - Rötter, Reimund P. ED - Viehberg, Finn A. ED - Veste, Maik T1 - Synthesis and Outlook on Future Research and Scientific Education in Southern Africa T2 - Sustainability of Southern African Ecosystems under Global Change N2 - The sustainability of southern Africa’s natural and managed marine and terrestrial ecosystems is threatened by overuse, mismanagement, population pressures, degradation, and climate change. Counteracting unsustainable development requires a deep understanding of earth system processes and how these are affected by ongoing and anticipated global changes. This information must be translated into practical policy and management interventions. Climate models project that the rate of terrestrial warming in southern Africa is above the global terrestrial average. Moreover, most of the region will become drier. Already there is evidence that climate change is disrupting ecosystem functioning and the provision of ecosystem services. This is likely to continue in the foreseeable future, but impacts can be partly mitigated through urgent implementation of appropriate policy and management interventions to enhance resilience and sustainability of the ecosystems. The recommendations presented in the previous chapters are informed by a deepened scientific understanding of the relevant earth system processes, but also identify research and knowledge gaps. Ongoing disciplinary research remains critical, but needs to be complemented with cross-disciplinary and transdisciplinary research that can integrate across temporal and spatial scales to give a fuller understanding of not only individual components of the complex earth-system, but how they interact. KW - Southern Africa KW - Marine Ecosystems KW - Biomes KW - BMBF KW - SPACES II Y1 - 2024 SN - 978-3-031-10947-8 SN - 978-3-031-10948-5 U6 - https://doi.org/10.1007/978-3-031-10948-5_32 SP - 933 EP - 964 PB - Springer CY - Cham ER -