TY - GEN A1 - MacNeilage, Paul R. A1 - Glasauer, Stefan T1 - Perceiving gravity: the role of the cerebellum T2 - Current Biology Y1 - 2018 U6 - https://doi.org/10.1016/j.cub.2018.09.053 SN - 1879-0445 SN - 0960-9822 VL - 28 IS - 22 SP - 1296 EP - 1298 ER - TY - GEN A1 - Hausmann, Peter A1 - Daumer, Martin A1 - MacNeilage, Paul R. A1 - Glasauer, Stefan T1 - Ecological momentary assessment of head motion: Towards normative data of head stabilization T2 - Frontiers in Human Neuroscience N2 - Head stabilization is fundamental for balance during locomotion but can be impaired in elderly or diseased populations. Previous studies have identified several parameters of head stability with possible diagnostic value in a laboratory setting. Recently, the ecological validity of measures obtained in such controlled contexts has been called into question. The aim of this study was to investigate the ecological validity of previously described parameters of head stabilization in a real-world setting. Ten healthy subjects participated in the study. Head and trunk movements of each subject were recorded with inertial measurement units (IMUs) for a period of at least 10 h. Periods of locomotion were extracted from the measurements and predominant frequencies, root mean squares (RMSs) and bout lengths were estimated. As parameters of head stabilization, attenuation coefficients (ACs), harmonic ratios (HRs), coherences, and phase differences were computed. Predominant frequencies were distributed tightly around 2 Hz and ACs, HRs, and coherences exhibited the highest values in this frequency range. All head stability parameters exhibited characteristics consistent with previous reports, although higher variances were observed. These results suggest that head stabilization is tuned to the 2 Hz fundamental frequency of locomotion and that previously described measures of head stability could generalize to a real-world setting. This is the first study to address the ecological validity of these measures, highlighting the potential use of head stability parameters as diagnostic tools or outcome measures for clinical trials. The low cost and ease of use of the IMU technology used in this study could additionally be of benefit for a clinical application. Y1 - 2019 U6 - https://doi.org/10.3389/fnhum.2019.00179 SN - 1662-5161 VL - 13 ER - TY - GEN A1 - Dietrich, Haike A1 - Heidger, F. A1 - Schniepp, Roman A1 - MacNeilage, Paul R. A1 - Glasauer, Stefan A1 - Wühr, Max T1 - Head motion predictability explains activity-dependent suppression of vestibular balance control T2 - Scientific Reports N2 - Vestibular balance control is dynamically weighted during locomotion. this might result from a selective suppression of vestibular inputs in favor of a feed-forward balance regulation based on locomotor efference copies. The feasibility of such a feed-forward mechanism should however critically depend on the predictability of head movements (HMP) during locomotion. To test this, we studied in 10 healthy subjects the differential impact of a stochastic vestibular stimulation (SVS) on body sway (center-of-pressure, COP) during standing and walking at different speeds and compared it to activity-dependent changes in HMp. SVS-cop coupling was determined by correlation analysis in frequency and time domains. HMP was quantified as the proportion of head motion variance that can be explained by the average head trajectory across the locomotor cycle. SVS-COP coupling decreased from standing to walking and further dropped with faster locomotion. Correspondingly, HMP increased with faster locomotion. Furthermore, SVS-COP coupling depended on the gait-cycle-phase with peaks corresponding to periods of least HMP. These findings support the assumption that during stereotyped human self-motion, locomotor efference copies selectively replace vestibular cues, similar to what was previously observed in animal models. Y1 - 2020 U6 - https://doi.org/10.1038/s41598-019-57400-z SN - 2045-2322 VL - 10 ER - TY - GEN A1 - Glasauer, Stefan A1 - Hausmann, Peter A1 - MacNeilage, Paul R. T1 - Statistics of natural head motion suggest different head motion priors for rest and movement T2 - Bernstein Conference 2018 Y1 - 2018 U6 - https://doi.org/10.12751/nncn.bc2018.0132 ER - TY - CHAP A1 - Glasauer, Stefan A1 - MacNeilage, Paul R. ED - Fritzsch, Bernd ED - Straka, Hans T1 - Computational Rules for Integrating Vestibular and Multi-Modal Motion Signals in the Central Nervous System T2 - The Senses: A Comprehensive Reference; Volume 6: Vestibular System and Balance N2 - Integration of multi-sensory signals is normally required to infer the properties and states of the external world and of the own body. This applies also to vestibular signals, which, when activated are naturally accompanied by other sensory or self-generated signals. Here, we review computational schemes and normative principles that have been proposed to achieve meaningful signal fusion that allows perception and action in the face of uncertain information. Y1 - 2020 U6 - https://doi.org/10.1016/B978-0-12-809324-5.24262-4 SP - 445 EP - 457 PB - Elsevier CY - Amsterdam ET - 2. Edition ER - TY - GEN A1 - Dietrich, Haike A1 - Heidger, F. A1 - Schniepp, Roman A1 - MacNeilage, Paul R. A1 - Glasauer, Stefan A1 - Wühr, Max T1 - Head motion predictability explains phase-and speed-dependent suppression of vestibular balance control during walking T2 - Elsevier N2 - Methods: Body sway was analyzed by measuring the center of pressure (CoP) in 10 healthy participants on a pressure-sensitive treadmill during standing and walking at 0.4 or 0.8 m/s. Continuous SVS (0–25 Hz; peak amplitude at±4.5 mA) was delivered by a bipolar binaural electrode configuration over the mastoid processes to evoke postural responses in the roll plane. Time-dependent coherence between SVS and medio-lateral body sway was analyzed to examine the dynamic impact of vestibular cues during locomotion. HMP was estimated using a previously established model (MacNeilage and Glasauer, 2017). Results: SVS-CoP coherence decreased from standing to slow walking and further decreased with increasing locomotor speed (p< 0.001). Correspondingly, HMP increased with faster locomotion (p= 0.001). SVS-CoP coherence depended on the gait cycle phase with two distinct peaks occurring at 25 … Y1 - 2020 U6 - https://doi.org/10.1016/j.clinph.2019.12.083 VL - 131 IS - 4 SP - e219 EP - e220 PB - Elsevier ET - 1. ER -