TY - GEN A1 - Kupke, Laura S. A1 - Dropco, Ivor A1 - Götz, Markus A1 - Kupke, Paul A1 - Jung, Friedrich A1 - Stroszczynski, Christian A1 - Jung, Ernst Michael ED - Miraglia, Roberto T1 - Contrast-enhanced intraoperative ultrasound shows excellent performance in improving intraoperative decision-making T2 - Life N2 - Background: The aim of this study was to evaluate the performance and the impact of contrast-enhanced intraoperative ultrasound (CE-IOUS) on intraoperative decision-making, as there is still no standardized protocol for its use. Therefore, we retrospectively analyzed multiple CE-IOUS performed in hepato-pancreatic-biliary surgery with respect to pre- and postoperative imaging and histopathological findings. Methods: Data of 50 patients who underwent hepato-pancreatic-biliary surgery between 03/2022 and 03/2024 were retrospectively collected. CE-IOUS was performed with a linear 6–9 MHz multifrequency probe connected to a high-resolution device. The ultrasound contrast agent used was a stabilized aqueous suspension of sulphur hexafluoride microbubbles. Results: In total, all 50 lesions indicated for surgery were correctly identified. In 30 cases, CE-IOUS was used to localize the primary lesion and to define the resection margins. In the remaining 20 cases, CE-IOUS identified an additional lesion. Fifteen of these findings were identified as malignant. In eight of these cases, the additional malignant lesion was subsequently resected. In the remaining seven cases, CE-IOUS again revealed an inoperable situation. In summary, CE-IOUS diagnostics resulted in a high correct classification rate of 95.7%, with positive and negative predictive values of 95.2% and 100.0%, respectively. Conclusions: CE-IOUS shows excellent performance in describing intraoperative findings in hepato-pancreatic-biliary surgery, leading to a substantial impact on intraoperative decision-making. KW - ultrasound KW - contrast-enhanced ultrasound KW - CEUS KW - micro-vascularization KW - intraoperative ultrasound KW - IOUS KW - intraoperative decision-making Y1 - 2024 U6 - https://doi.org/10.3390/life14091199 SN - 2075-1729 VL - 14 IS - 9 PB - MDPI ER -