TY - GEN A1 - Panasyuk-Delaney, Tanya A1 - Mirsky, Vladimir M. A1 - Wolfbeis, Otto S. T1 - Capacitive sensors based on photografted molecularly imprinted polymers T2 - Biocybernetics and Biomedical Engineering N2 - The reversible chemosensors to creatinine and desmetryn based on artificial chemoreceptors are described. A grafted photopolymerization combined with a technique of molecular imprinting was used for the receptor layer preparation. After polymer deposition and intensive washing from templates, the electrodes were investigated by impedance spectrometry. Creatinine and desmetryn binding were detected as a decrease in the electrode capacitance. Sensor response to creatining was highly selective. No response to the addition of sodium chloride, creatine, urea or glucose were observed. The electrodes coated with the molecularly imprinted polymers selective to desmetryn displayed specific binding of this herbicide: only small capacitive effects were observed to addition of terbumeton or atrazine, while metribuzine displayed capacitance decrease similar to desmetryn. KW - capacitive sensor KW - creatinine KW - atrazine KW - chemical sensor KW - photografted polymerization Y1 - 2001 SN - 0208-5216 VL - 21 IS - 3 SP - 43 EP - 54 ER - TY - GEN A1 - Panasyuk-Delaney, Tanya A1 - Mirsky, Vladimir M. A1 - Ulbricht, Mathias A1 - Wolfbeis, Otto S. T1 - Impedometric herbicide chemosensors based on molecularly imprinted polymers T2 - Analytica Chimica Acta N2 - The technique of grafting polymerization has been used for preparation of thin films of molecularly imprinting polymers on the surface of polypropylene membranes and on hydrophobized gold electrodes. The herbicide desmetryn was used as a template. The solid supports used were hydrophobic, while the polymer was hydrophilic. The adsorbed layer of benzophenone, irradiated by UV-light, initiated a radical polymerization near the surface. Polymer films were characterized by weighing, contact angle measurements and impedance spectroscopy. The electrodes coated with the molecularly imprinted polymers displayed fairly specific binding of desmetryn, as detected by the decrease in the capacitance of the electrode. Only small capacitive effects were observed on addition of terbumeton or atrazine, while metribuzine displayed capacitance decrease similar to desmetryn. KW - Molecular imprinting KW - Capacitive sensor KW - Chemical sensor KW - Grafting polymerization KW - Photopolymerization Y1 - 2001 U6 - https://doi.org/10.1016/S0003-2670(00)01280-0 SN - 0003-2670 VL - 435 IS - 1 SP - 157 EP - 162 ER - TY - GEN A1 - Panasyuk-Delaney, Tanya A1 - Mirsky, Vladimir M. A1 - Piletsky, Sergey A. A1 - Wolfbeis, Otto S. T1 - Electropolymerized molecularly imprinted polymers as receptor layers in capacitive chemical sensors T2 - Analytical Chemistry N2 - The first application of molecularly imprinted polymers to chemical sensors with capacitive detection is described. The sensitive layer was prepared by electropolymerization of phenol on gold electrodes in the presence of the template (phenylalanine). The insulating properties of the polymer layer were studied by electrochemical impedance spectroscopy. Electrical leakages through the polymer layer were suppressed by deposition of a self-assembled monolayer of mercaptophenol before polymerization and of alkanethiol after polymerization. At the final stage of sensor preparation, the template was removed. The multilayer system obtained displayed a decrease in electrical capacitance on addition of phenylalanine. Only a low response was observed toward other amino acids and phenol. Y1 - 1999 U6 - https://doi.org/10.1021/ac9903196 SN - 0003-2700 SN - 1520-6882 VL - 71 IS - 20 SP - 4609 EP - 4613 ER - TY - GEN A1 - Panasyuk-Delaney, Tanya A1 - Mirsky, Vladimir M. A1 - Wolfbeis, Otto S. T1 - Capacitive creatinine sensor based on molecularly imprinted polymer T2 - Electroanalysis N2 - The first reversible chemosensor to creatinine based on artificial chemoreceptors is described. The receptor layer was prepared by molecularly imprinted photopolymerization of acrylamidomethylpropanesulfonic acid and methylenediacrylamide. The polymer layer was grafted onto the surface of gold electrodes coated with an alkanethiol monolayer. Creatinine binding was detected by a decrease in the electrode capacitance. The sensor response is reversible and highly selective: no response to addition of sodium chloride, creatine, urea or glucose were observed. The detection limit for creatinine is 10 μM which is optimal for medical applications. KW - Capacitive sensor KW - Creatinine KW - Molecularly imprinted polymer KW - Chemical sensor KW - Photografted polymerization Y1 - 2002 U6 - https://doi.org/10.1002/1521-4109(200202)14:3<221::AID-ELAN221>3.0.CO;2-Y SN - 1521-4109 VL - 14 IS - 3 SP - 221 EP - 224 ER - TY - GEN A1 - Mirsky, Vladimir M. A1 - Panasyuk-Delaney, Tanya A1 - Wolfbeis, Otto S. T1 - Chemical sensors based on ultrathin membranes from molecularly imprinted polymers T2 - Membrane & cell biology Y1 - 2001 VL - 18 IS - 6 SP - 496 EP - 501 ER -