TY - GEN A1 - Berens, Eva-Maria A1 - Riedel, Jörg A1 - Reder, Maren A1 - Razum, Oliver A1 - Kolip, Petra A1 - Spallek, Jacob T1 - Postalische Befragung von Frauen mit türkischem Migrationshintergrund – Identifizierung, Stichprobenbereinigung und Response im Rahmen der InEMa-Studie T1 - Postal Survey Among Women With Turkish Migration Background in Germany – Identification, Sample Revision and Response in the InEMa Study T2 - Das Gesundheitswesen Y1 - 2017 U6 - https://doi.org/10.1055/s-0035-1564076 SN - 0941-3790 VL - 79 IS - 12 SP - 1000 EP - 1003 ER - TY - GEN A1 - Charissé, Daniel A1 - Erus, Guray A1 - Pomponio, Raymond A1 - Gorges, Martin A1 - Schmidt, Nele A1 - Schneider, Christine A1 - Liepelt-Scarfone, Inga A1 - Riedel, Oliver A1 - Reetz, Kathrin A1 - Schulz, Jörg B. A1 - Berg, Daniela A1 - Storch, Alexander A1 - Witt, Karsten A1 - Dodel, Richard A1 - Kalbe, Elke A1 - Kassubek, Jan A1 - Hilker-Roggendorf, Rüdiger A1 - Baudrexel, Simon T1 - Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease T2 - Neurobiology of Aging N2 - Recently, it was shown that patients with Parkinson's disease (PD) who exhibit an “Alzheimer's disease (AD)-like” pattern of brain atrophy are at greater risk for future cognitive decline. This study aimed to investigate whether this association is domain-specific and whether atrophy associated with brain aging also relates to cognitive impairment in PD. SPARE-AD, an MRI index capturing AD-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort. All patients underwent an extensive neuropsychological test battery. Patients diagnosed with mild cognitive impairment or dementia were found to have higher SPARE-AD scores as compared to patients with normal cognition and healthy controls. All patient groups showed increased brain age. SPARE-AD predicted impairment in memory, language and executive functions, whereas advanced brain age was associated with deficits in attention and working memory. Data suggest that SPARE-AD and brain age are differentially related to domain-specific cognitive decline in PD. The underlying pathomechanisms remain to be determined. KW - Alzheimer's disease KW - Brain Age KW - MRI KW - Parkinson's disease KW - Pattern classification Y1 - 2022 UR - https://www.sciencedirect.com/science/article/pii/S0197458021002748?via%3Dihub U6 - https://doi.org/10.1016/j.neurobiolaging.2021.08.020 SN - 0197-4580 VL - 109 SP - 31 EP - 42 ER -