TY - GEN A1 - Regnath, Franziska A1 - Biersack, Katharina A1 - Schröder, Lena A1 - Stainer, Marie-Christin A1 - von Werder, Dina A1 - Pürner, Dominik A1 - Haslinger, Bernhard A1 - Lehnen, Nadine ED - Glasauer, Stefan T1 - Experimental evidence for a robust, transdiagnostic marker in functional disorders: Erroneous sensorimotor processing in functional dizziness and functional movement disorder T2 - Journal of Psychosomatic Research Y1 - 2024 U6 - https://doi.org/10.1016/j.jpsychores.2024.111694 SN - 0022-3999 VL - 183 PB - Elsevier BV ER - TY - GEN A1 - Regnath, Franziska A1 - Biersack, Katharina A1 - Jäger, Nina A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Not a general, symptom-unspecific, transdiagnostic marker for functional symptoms: sensorimotor processing of head control is intact in chronic pain T2 - Frontiers in Neurology N2 - Introduction: Functional disorders are prevalent in all medical fields and pose a tremendous public health problem, with pain being one of the most common functional symptoms. Understanding the underlying, potentially unifying mechanism in functional (pain) disorders is instrumental in facilitating timely diagnosis, stigma reduction, and adequate treatment options. Neuroscientific models of perception suggest that functional symptoms arise due to dysregulated sensorimotor processing in the central nervous system, with brain-based predictions dominating the eventual percept. Experimental evidence for this transdiagnostic mechanism has been established in various functional symptoms. The goal of the current study was to investigate whether erroneous sensorimotor processing is an underlying transdiagnostic mechanism in chronic (functional) pain. Method: A total of 13 patients with chronic (functional) pain [three patients with chronic (functional) pain disorder, F45.40, ICD-10; 10 patients with chronic pain disorder with somatic and psychological factors, F45.41, ICD-10]; and 15 healthy controls performed large combined eye-head gaze shifts toward visual targets, naturally and with increased head moment of inertia. We simultaneously measured participants’ eye and head movements to assess head oscillations at the end of the gaze shift, which are an established indicator of (transdiagnostic) sensorimotor processing deficits of head control. Results: Using a Bayesian analysis protocol, we found that patients with chronic (functional) pain and control participants stabilized their heads equally well (Bayes Factor 01 = 3.7, Bayes Factor exclusion = 5.23; corresponding to substantial evidence) during all sessions of the experiment. Conclusion: Our results suggest that patients with chronic (functional) pain do not show measurable symptom-unspecific sensorimotor processing deficits. Y1 - 2023 U6 - https://doi.org/10.3389/fneur.2023.1294702 SN - 1664-2295 VL - 14 ER - TY - GEN A1 - Aubele, Maria A1 - Grill, Eva A1 - Eggert, Thomas A1 - Schneider, Erich A1 - Strobl, Ralf A1 - Jahn, Klaus A1 - Müller, Martin A1 - Holle, Rolf A1 - Linkohr, Birgit A1 - Heier, Margit A1 - Ladwig, Karl-Heinz A1 - Lehnen, Nadine T1 - Symptoms in unilatral vestibular hypofunction are associated with number of catch-up saccades and retinal errors: results from the population-based KORA FF4study T2 - Frontiers in Neurology N2 - Objective: The presence and intensity of symptoms vary in patients with unilateral vestibular hypofunction. We aimed to determine which saccadic and vestibulo-ocular reflex parameters best predict the presence of symptoms in unilateral vestibular hypofunction in order to better understand vestibular compensation and its implications for rehabilitation therapy. Methods: Video head impulse test data were analyzed from a subpopulation of 23 symptomatic and 10 currently symptom-free participants with unilateral vestibular hypofunction, embedded in the KORA (Cooperative Health Research in the Region of Augsburg) FF4 study, the second follow-up of the KORA S4 population-based health survey (2,279 participants). Results: A higher number of catch-up saccades, a higher percentage of covert saccades, and a larger retinal error at 200 ms after the onset of the head impulse were associated with relevant symptoms in participants with unilateral vestibular hypofunction (p = 0.028, p = 0.046, and p = 0.038, respectively). After stepwise selection, the number of catch-up saccades and retinal error at 200 ms remained in the final logistic regression model, which was significantly better than a null model (p = 0.014). Age, gender, saccade amplitude, saccade latency, and VOR gain were not predictive of the presence of symptoms. Conclusion: The accuracy of saccadic compensation seems to be crucial for the presence of symptoms in unilateral vestibular hypofunction, highlighting the role of specific gaze stabilization exercises in rehabilitation. Early saccades, mainly triggered by the vestibular system, do not seem to compensate accurately enough, resulting in a relevant retinal error and the need for more as well as more accurate catch-up saccades, probably triggered by the visual system. KW - video head impulse test, vHIT, catch-up saccades, unilateral vestibular hypofunction, retinal error, vestibulo-ocular reflex, VOR, population-based survey Y1 - 2023 UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715252/ SN - 1664-2295 VL - 2023 IS - 14 ER - TY - GEN A1 - von Werder, Dina A1 - Aubele, Maria A1 - Regnath, Franziska A1 - Tebbe, Elisabeth A1 - Mladenov, Dejan A1 - von Rheinbaben, Victoria A1 - Hahn, Elisabeth A1 - Schäfer, Daniel A1 - Biersack, Katharina A1 - Adorjan, Kristina A1 - Stubbe, Hans C. A1 - Bogaerts, Katleen A1 - Jörres, Rudolf A. A1 - Nowak, Dennis A1 - Van den Bergh, Omer A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Increased breathlessness in post-COVID syndrome despite normal breathing patterns in a rebreathing challenge T2 - Scientific reports N2 - Severe symptoms in the absence of measurable body pathology are a frequent hallmark of post-COVID syndrome. From a Bayesian Brain perspective, such symptoms can be explained by incorrect internal models that the brain uses to interpret sensory signals. In this pre-registered study, we investigate whether induced breathlessness perception during a controlled CO2rebreathing challenge is reflected by altered respiratory measures (physiology and breathing patterns), and propose different computational mechanisms that could explain our findings in a Bayesian Brain framework. We analysed data from 40 patients with post-COVID syndrome and 40 healthy participants. Results from lung function, neurological and neurocognitive examination of all participants were within normal limits on the day of the experiment. Using a Bayesian repeated-measures ANOVA, we found that patients’ breathlessness was strongly increased (BF10,baseline =8.029, BF10,rebreathing =11636, BF10,recovery =43662) compared to controls. When excluding patients who hyperventilated (N = 8, 20%) during the experiment from the analysis, differences in breathlessness remained (BF10,baseline =1.283, BF10,rebreathing =126.812, BF10,recovery =751.282). For physiology and breathing patterns, all evidence pointed towards no difference between the two groups (0.307  BF10 < 0.704). In summary, we found intact breathing patterns and physiology but increased symptom perception in patients with post-COVID syndrome. Y1 - 2025 U6 - https://doi.org/10.1038/s41598-025-11728-x SN - 2045-2322 VL - 15 IS - 1 SP - 1 EP - 15 PB - Springer Nature CY - [London] ER -