TY - CHAP A1 - Ulrich, Rainer G. A1 - Schlegel, Matthias A1 - Mertens, Marc A1 - Groschup, Martin H. A1 - Schmidt-Chanasit, Jonas A1 - Plenge-Bönig, Anita A1 - Jacob, Jens A1 - Pelz, Hans-Joachim A1 - Freise, Jona A1 - Wenk, Matthias A1 - Thiel, Jörg A1 - Triebenbacher, Cornelia A1 - Schmolz, Eric A1 - Kurth, Andreas A1 - Krüger, Frank A1 - Rühe, Ferdinand A1 - Kiffner, Christian A1 - Ansorge, Hermann A1 - Gerwin, Werner A1 - Wegener, Wolfgang A1 - Müller, Jörg A1 - Bemmann, Margit A1 - Wolf, Ronny A1 - Otto, Lutz-Florian A1 - Oehme, Rainer A1 - Pfeffer, Martin A1 - Heckel, Gerald A1 - Schex, Susanne A1 - Essbauer, Sandra S. T1 - Netzwerk Nagetier-übertragene Pathogene: Monitoring von Hantavirus-Infektionen in Deutschland T2 - Wildhygiene, Wildtierkrankheiten, Parasiten, Epidemiologie Y1 - 2009 SN - 978-378-88131-2-3 SN - 1436-3895 SP - 229 EP - 250 PB - Ges. für Wildtier- und Jagdforschung CY - Halle/Saale ER - TY - GEN A1 - Werner, Jens Martin A1 - Zidek, Martin A1 - Kammerer, Sylvia A1 - Platz Batista da Silva, Natascha A1 - Jung, Friedrich A1 - Schlitt, Hans Jürgen A1 - Hornung, Matthias A1 - Jung, Ernst Michael T1 - Intraoperative contrast-enhanced ultrasound can have a crucial role in surgical decision-making during hepato-pancreatico-biliary surgery –Analysis of impact and input T2 - Clinical Hemorheology and Microcirculation N2 - OBJECTIVE: To assess the impact and procedural input of intraoperative ultrasound (IOUS) with contrast-enhanced ultrasound (CEUS) and ultrasound elastography on surgical decision making during the procedure and consequently the out-come after hepato-pancreatico-biliary (HPB) surgery. MATERIALS AND METHODS: Data of 50 consecutive patients, who underwent HPB surgery from 04/2018 to 07/2018 were prospectively collected for this study. During surgery, IOUS with a high-resolution ultrasound device using CEUS after bolus injection of 2.4–5 ml Sulphur hexafluoride microbubbles using a 6–9 MHz probe and a share wave and strain elastography was performed by an experienced examiner. Process and time analysis were carried out using mobile phone timer. RESULTS: The IOUS with CEUS and elastography correctly identified 42 malignant tumors and 4 benign lesions. In 3 cases, the examination provided false positive result (identifying 3 benign lesions as malignant) and in 1 case a malignant lesion was incorrectly assessed as benign (sensitivity 97,7%, specificity 57,1%, PPV 93,3% and NPV 80%). The specific question by the surgeon could be answered successfully in 98% of the cases. In 76% of the cases, there was a modification (42%) or a fundamental change (34%) of the planned surgical approach due to the information provided by the IOUS. Within the last group, the IOUS had a major impact on therapy outcome. In 7 patients an additional tumor resection was required, in 5 patients the tumor was assessed as inoperable, and in total in 5 patients an intraoperative RFA (4/5) or postoperative RITA (1/5) was required. Regarding procedural input, there was only a slight, but significant difference between the transport and set-up times before the intraoperative use (mean: 14 min 22 s) and the return transport (mean 13 min 6 s), (p = 0,038). The average examination time was 14 minutes, which makes only one third of the overall time demand. CONCLUSION: Combination of IOUS with CEUS and elastography in oncological HPB surgery provides valuable information that affects surgical decision-making. The procedural input of about 45 minutes seems to be a good investment considering the improvement of the surgical procedure and a significant modification of the therapy approach in the majority of the cases. KW - Surgical decision-making KW - hepato-pancreatico-biliary surgery KW - CEUS KW - elastography Y1 - 2021 UR - https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch201031 U6 - https://doi.org/10.3233/CH-201031 VL - 78 IS - 1 SP - 1 EP - 14 ER - TY - GEN A1 - Gäbler, Jan A1 - Klauck, Ronny A1 - Schöpke, Sebastian A1 - König, Hartmut A1 - Werner, Martin A1 - Roth, Jörg T1 - Lemon Tree - Flexible Deichüberwachung mit XMPP und Cloud-Diensten T2 - 8. GI/ITG KuVS-Fachgespräch Ortsbezogene Anwendungen und Dienst Y1 - 2011 SN - 978-3-8325-3041-9 SP - 137 EP - 148 PB - Logos-Verlag CY - Berlin ER - TY - GEN A1 - Rauch, Georg A1 - Lutz, Johannes A1 - Werner, Martin A1 - Gurwara, Sagar A1 - Steinberg, Peter T1 - Synergetic 1D-3D-Coupling in Engine Development Part 1: Verification of Concept T2 - SAE Technical Paper N2 - This paper introduces an innovative approach, named synergetic 1D-3D-Coupling, by using synergy effects of 1D and 3D simulation in order to bring down modeling and simulation efforts. At the same time the methodology sustains the spatial resolution of a 3D model. This goal is reached by reducing the 3D fluid side with its time consuming continuity, momentum, energy and turbulence equations to a simple but precise 1D model. Because of the solid structure staying three dimensional, heat flux direction and spatial resolution have 3D accuracy but short calculation times due to the simple heat diffusion equation to be solved. The 1D model is represented by an automatically generated equation system which is capable of considering transient effects. The energy transfer between 1D fluid model and 3D structure model is realized through a neutral 1D-3D-coupling program and the application of the fluid element specific Nusselt correlations. The following approach is not only applicable for engine development but for any field where fast transient CHT simulations of internal flows are needed. The theretical background and the newly developed approach are presented in this paper. For this purpose an abstract pipe system is used to generate a hydraulic and thermal network. This network is coupled with a 3D structure in order to show the potential velocity benefit and the possible loss in accuray compared to the conventional full 3D modeling approach. Y1 - 2015 SN - 0148-7191 ER - TY - GEN A1 - Böhm, Uwe A1 - Kücken, Martin A1 - Hauffe, Detlef A1 - Gerstengarbe, F.-W. A1 - Werner, P. C. A1 - Flechsig, Michael A1 - Keuler, Klaus A1 - Block, Alexander A1 - Ahrens, Wilfried A1 - Nocke, Th. T1 - Reliability of regional climate model simulations of extremes and of long-term climate T2 - Natural Hazards and Earth System Sciences N2 - We present two case studies that demonstrate how a common evaluation methodology can be used to assess the reliability of regional climate model simulations from different fields of research. In Case I, we focused on the agricultural yield loss risk for maize in Northeastern Brazil during a drought linked to an El-Niño event. In Case II, the present-day regional climatic conditions in Europe for a 10-year period are simulated. To comprehensively evaluate the model results for both kinds of investigations, we developed a general methodology. On its basis, we elaborated and implemented modules to assess the quality of model results using both advanced visualization techniques and statistical algorithms. Besides univariate approaches for individual near-surface parameters, we used multivariate statistics to investigate multiple near-surface parameters of interest together. For the latter case, we defined generalized quality measures to quantify the model's accuracy. Furthermore, we elaborated a diagnosis tool applicable for atmospheric variables to assess the model's accuracy in representing the physical processes above the surface under various aspects. By means of this evaluation approach, it could be demonstrated in Case Study I that the accuracy of the applied regional climate model resides at the same level as that we found for another regional model and a global model. Excessive precipitation during the rainy season in coastal regions could be identified as a major contribution leading to this result. In Case Study II, we also identified the accuracy of the investigated mean characteristics for near-surface temperature and precipitation to be comparable to another regional model. In this case, an artificial modulation of the used initial and boundary data during preprocessing could be identified as the major source of error in the simulation. Altogether, the achieved results for the presented investigations indicate the potential of our methodology to be applied as a common test bed to different fields of research in regional climate modeling. Y1 - 2004 U6 - https://doi.org/10.5194/nhess-4-417-2004 VL - 4 IS - 3 SP - 417 EP - 431 ER - TY - GEN A1 - Bönte, Werner A1 - Procher, Vivien D. A1 - Urbig, Diemo A1 - Voracek, Martin T1 - Digit Ratio (2D:4D) predicts self-reported measures of general competitiveness, but not behavior in economic experiments T2 - Frontiers in Behavioral Neuroscience N2 - The ratio of index finger length to ring finger length (2D:4D) is considered to be a putative biomarker of prenatal androgen exposure (PAE), with previous research suggesting that 2D:4D is associated with human behaviors, especially sex-typical behaviors. This study empirically examines the relationship between 2D:4D and individual competitiveness, a behavioral trait that is found to be sexually dimorphic. We employ two related, but distinct, measures of competitiveness, namely behavioral measures obtained from economic experiments and psychometric self-reported measures. Our analyses are based on two independent data sets obtained from surveys and economic experiments with 461 visitors of a shopping mall (Study I) and 617 university students (Study II). The correlation between behavior in the economic experiment and digit ratios of both hands is not statistically significant in either study. In contrast, we find a negative and statistically significant relationship between psychometric self-reported measures of competitiveness and right hand digit ratios (R2D:4D) in both studies. This relationship is especially strong for younger people. Hence, this study provides some robust empirical evidence for a negative association between R2D:4D and self-reported competitiveness. We discuss potential reasons why digit ratio may relate differently to behaviors in specific economics experiments and to self-reported general competitiveness. Y1 - 2017 U6 - https://doi.org/10.3389/fnbeh.2017.00238 SN - 1662-5153 VL - 11 ER - TY - GEN A1 - Kenda, Andreas A1 - Kraft, Martin A1 - Tortschanoff, Andreas A1 - Scherf, Werner A1 - Sandner, Thilo A1 - Schenk, Harald A1 - Luettjohann, Stephan A1 - Simon, Apolline T1 - Development, characterization and application of compact spectrometers based on MEMS with in-plane capacitive drives T2 - Next-generation spectroscopic technologies VII, 5 - 6 May 2014, Baltimore, Maryland, United States Y1 - 2014 SN - 978-1-62841-038-9 SP - 910102-1 EP - 910102-10 PB - SPIE CY - Bellingham, Wash. ER - TY - GEN A1 - Röder, Martin A1 - Urbig, Diemo A1 - Stöckmann, Christoph A1 - Bönte, Werner A1 - Procher, Vivien D. T1 - There's no fox like an old fox: Dimensions of entrepreneurial orientation and venture closure T2 - 26th Annual Interdisciplinary Conference on Entrepreneurship, Innovation and SMEs, 2023 N2 - Only a few scholars examined downsides of EO and suggest it may negatively affect survival. Previous research, which mainly focuses on mature companies, assumes that the relationship between EO and survival is constant. However, because firm characteristics and causal mechanisms change as young venture survive and grow into mature firms, the relationships between EO and survival could also change over time. We extend the EO literature by considering changing EO effects when venture grow into mature firms and by employing a multidimensional view on EO and identify isolating independent mechanisms for the influence of each dimension (i.e. innovativeness, proactiveness and risk-taking) on the survival of young ventures. While the nature of proactiveness on performance is rathe positive, risk-taking and innovativeness increases the variance of firm performance and thus the chances of failure. However, the latter can be separated according to whether the increase in variance occurs at a single point in time (risk-taking) or over time (innovation) and whether the survivors have more money or more innovations. For young firms, innovativeness and risk-taking inhibit survival, while proactiveness promotes it, so the dimensions have divergent effects. As a consequence of the attrition of young ventures, the associations of innovativeness and risk-taking reverse when they grow older. Our empirical analyses are based on panel data of 8,518 young firms. KW - Entrepreneurship KW - Survival KW - Failure KW - Entrepreneurial orientation KW - time-varying Cox proportional hazard model Y1 - 2023 UR - https://www.researchgate.net/publication/379155763 UR - https://www.fgf-ev.de/wp-content/uploads/2023/09/G-Forum-2023-Programmgeruest_18-09-2023_Internet.pdf ER -