TY - GEN A1 - Smyth, Duncan A1 - Mossman, Stuart A1 - Weatherall, Mark A1 - Jolliffe, Evan A1 - Joshi, Purwa A1 - Taylor, Jennifer A1 - Thorne, Katie A1 - Watson, Eloise A1 - Leadbetter, Ruth A1 - Mossman, Benjamin A1 - Moss, Tawhai A1 - Todd, Nicholas Sean A1 - Schneider, Erich T1 - Gentamicin vestibulotoxicity with modern systemic dosing regimens : a prospective study using videooculography T2 - Acta Oto-Laryngologica N2 - Objectives: To determine the incidence of gentamicin vestibulotoxicity with current dosing regimens, and to evaluate the feasibility of routine video-oculography on all patients given gentamicin. Materials and methods: In this prospective incidence study serial horizontal vestibulo-ocular reflex (HVOR) gain measurements were recorded using video-oculography on adult inpatients receiving intravenous gentamicin. The primary outcome was the proportion of patients developing impairment of their HVOR gain. Results: After exclusions, 42 patients were included in the analysis. Three patients (7.1%) developed asymptomatic vestibulotoxicity, exact 95% confidence interval 1.5-19.5%. In two of these patients the deficit resolved within several hours. No patients developed symptomatic vestibulotoxicity. There was no evidence for a generalised reduction in group HVOR gain with time. HVOR gain was not associated with total gentamicin dose, dynamic visual acuity or subjective imbalance. Conclusions and significance: Gentamicin may cause reversible, asymptomatic vestibulotoxicity. Video-oculography may be useful to monitor for vestibulotoxicity in patients treated with gentamcin; however, testing all patients routinely may be challenging. Y1 - 2019 U6 - https://doi.org/10.1080/00016489.2019.1637935 VL - 139 IS - 9 SP - 759 EP - 768 ER -