TY - GEN A1 - Belyakova-Bodina, Alexandra A1 - Ratanov, Mikhail A1 - Schneider, Erich A1 - Seliverstov, Yury A1 - Nuzhnyi, Evgenii A1 - Klyushnikov, Sergey A1 - Broutian, Amayak T1 - Uncovering bilateral vestibulopathy in patients with SANDO syndrome caused by mutations in POLG gene: a case series T2 - Journal of Neurology N2 - The triad of sensory ataxic neuropathy, dysarthria, and ophthalmoparesis (SANDO) comprise a distinct phenotype of rare mitochondrial disease. It is caused mainly by mitochondrial DNA depletion and deletions due to mutations in the nuclear genes, with POLG being one of the most common ones [1]. In SANDO syndrome, balance and gait disturbances have traditionally been attributed to sensory ataxic neuropathy and, in some patients, to cerebellar ataxia and/or limb weakness [2, 3]. However, there has been a report of bilateral vestibulopathy (BV) in a patient with SANDO caused by mutations in the POLG gene [4]. We present five patients with SANDO due to POLG gene mutations, whose vestibular and oculomotor function were assessed with video-oculography (VOG) Y1 - 2021 U6 - https://doi.org/10.1007/s00415-021-10650-2 SN - 1432-1459 SN - 0340-5354 VL - 268 IS - 10 SP - 3909 EP - 3912 ER -