TY - GEN A1 - Kordi, Negin A1 - Saydi, Ali A1 - Karami, Sajad A1 - Bagherzadeh-Rahmani, Behnam A1 - Marzetti, Emanuele A1 - Jung, Friedrich A1 - Stockwell, Brent R. T1 - Ferroptosis and aerobic training in ageing T2 - Clinical Hemorheology and Microcirculation N2 - Ferroptosis is a form of programmed cell death that plays a significant role in causing several diseases such as heart attack and heart failure, through alterations in fat, amino acid, and iron metabolism. Comprehending the regulatory mechanisms of ferroptosis signaling is critical because it has a considerable effect on the elderly’s mortality. Conversely, age-related changes in substrate metabolism and metabolite levels are recognized to give rise to obesity. Furthermore, research has proposed that aging and obesity-related changes in substrate metabolism may aggravate ferroptosis. The suppression of ferroptosis holds potential as a successful therapeutic approach for managing different diseases, including sarcopenia, cardiovascular diseases, and central nervous system diseases. However, the pathologic and biological mechanisms behind the function of ferroptosis are not fully comprehended yet. Physical activity could affect lipid, amino acid, and iron metabolism to modulate ferroptosis. The aim of this study is to showcase the current understanding of the molecular mechanisms leading to ferroptosis and discuss the role of aging and physical activity in this phenomenon. KW - Aerobic training KW - Elderly KW - Iron metabolism KW - Amino acid metabolism KW - Lipid metabolism Y1 - 2024 U6 - https://doi.org/10.3233/CH-232076 VL - 87 (2024) IS - 3 SP - 347 EP - 366 ER -