TY - GEN A1 - Jung, Ernst Michael A1 - Weber, Marc-André A1 - Jung, Friedrich A1 - Stroszczynski, Christian T1 - Super-resolution contrast-enhanced ultrasound (SR-CEUS) in solid organs T1 - Superhochauflösender kontrastverstärkter Ultraschall (SR-CEUS) in festen Organen T2 - RöFo : Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren N2 - It is becoming increasingly common for multimodal radiological imaging to use contrast-enhanced ultrasound (CEUS) because of its high-resolution ultrasound techniques. CEUS has several advantages. It can be used repeatedly without affecting renal function or the thyroid gland. It is also considered to be highly accurate with regard to the diagnosis and detection of small solid liver lesions. In addition, it can be used to characterize solid lesions in other abdominal organs. With additional perfusion imaging and its (semi)quantitative analysis using wash-in and wash-out kinetics, therapies can be monitored. It is also frequently used in the assessment of solid tumors in the near field, such as thyroid tumors and lymph nodes. Super-resolution CEUS (SR-CEUS) is a novel imaging method with dynamic evaluation of microflow changes to the level of capillary structures. SR-CEUS could also open up new possibilities regarding the dynamic assessment of the micro-vascularization of solid abdominal organs and interventional procedures. KW - CEUS KW - SR-CEUS KW - Microcirculation KW - Solid internal organs Y1 - 2026 U6 - https://doi.org/10.1055/a-2754-0219 SN - 1438-9029 VL - 90 IS - 2 PB - Georg Thieme Verlag KG CY - Stuttgart ER - TY - GEN A1 - Krüger-Genge, Anne A1 - Steinbrecht, Susanne A1 - Küpper, Jan-Heiner A1 - Lendlein, Andreas A1 - Jung, Friedrich T1 - Evidence for cytostatic effect of cyclophosphamide on human vein endothelial cells in cancer therapy: preliminary in vitro results. T2 - Clinical Hemorheology and Microcirculation Y1 - 2018 U6 - https://doi.org/10.3233/CH-189125 SN - 1875-8622 SN - 1386-0291 VL - 69 IS - 1-2 SP - 267 EP - 276 ER - TY - GEN A1 - Steinbrecht, Susanne A1 - König, Rosalie A1 - Schmidtke, Kai-Uwe A1 - Herzog, Natalie A1 - Scheibner, Katrin A1 - Krüger-Genge, Anne A1 - Jung, Friedrich A1 - Kammerer, Sarah A1 - Küpper, Jan-Heiner T1 - Metabolic activity testing can underestimate acute drug cytotoxicity as revealed by HepG2 cell clones overexpressing cytochrome P450 2C19 and 3A4 T2 - Toxicology Y1 - 2018 U6 - https://doi.org/10.1016/j.tox.2018.11.008 SN - 0300-483X VL - 412 SP - 37 EP - 47 ER - TY - GEN A1 - Krüger-Genge, Anne A1 - Braune, Steffen A1 - Walter, Maria A1 - Kratz, Karl A1 - Küpper, Jan-Heiner A1 - Krengel, M. A1 - Lendlein, Andreas A1 - Jung, Friedrich T1 - Influence of surface treatments of poly(n-butyl acrylate) networks on fibroblasts adhesion, morphology and viability T2 - Clinical Hemorheology and Microcirculation Y1 - 2018 U6 - https://doi.org/10.3233/CH-189130 SN - 1875-8622 SN - 1386-0291 VL - 69 IS - 1-2 SP - 305 EP - 316 ER - TY - GEN A1 - Nies, A. A1 - Proft, L. A1 - Nehring, M. E. A1 - Gruber, Cnristian A1 - Sievers, H. A1 - Hünigen, Hana A1 - Rodruigues, A. G. A1 - Gemeinhardt, Ole A1 - Mrowietz, Christof A1 - Jung, Friedrich A1 - Hiebl, Bernhard T1 - Growth-related micromorphological characteristics of the porcine femoral artery T2 - Clinical Hemorheology and Microcirculation Y1 - 2019 U6 - https://doi.org/10.3233/CH-199219 SN - 1875-8622 VL - 73 IS - 1 SP - 195 EP - 201 ER - TY - GEN A1 - Park, J. W. A1 - Matschke, K. A1 - Mrowietz, Christof A1 - Krüger-Genge, Anne A1 - Jung, Friedrich T1 - HELP-(Heparin-induced Extracorporeal LDL Precipitation)-apheresis in heart recipients with cardiac allograft vasculopathy and concomitant hypercholesterolemia: Influence of long-term treatment on the microcirculation T2 - Clinical Hemorheology and Microcirculation Y1 - 2019 U6 - https://doi.org/10.3233/CH-199216 SN - 1875-8622 VL - 73 IS - 1 SP - 19 EP - 27 ER - TY - GEN A1 - Haileka, Vanessa A1 - George, Sandra A1 - Steinbrecht, Susanne A1 - Jung, Friedrich A1 - Reinehr, R. A1 - Küpper, Jan-Heiner T1 - Colon cancer cells cultured under hyperosmotic conditions as in vitro model to investigate dehydration effects on cancer drug susceptibility T2 - Clinical Hemorheology and Microcirculation Y1 - 2019 U6 - https://doi.org/10.3233/CH-199210 SN - 1875-8622 VL - 73 IS - 1 SP - 169 EP - 176 ER - TY - GEN A1 - Krüger-Genge, Anne A1 - Blocki, Anna A1 - Franke, Ralf-Peter A1 - Jung, Friedrich T1 - Vascular Endothelial Cell Biology: An Update T2 - International Journal of Molecular Sciences Y1 - 2019 U6 - https://doi.org/10.3390/ijms20184411 SN - 1422-0067 SN - 1661-6596 VL - 20 IS - 18 ER - TY - GEN A1 - Jung, Friedrich A1 - Connes, Philippe A1 - Lehmann, Christian T1 - A.L. Copley Best Paper Prize 2018 T2 - Clinical Hemorheology and Microcirculation Y1 - 2019 U6 - https://doi.org/10.3233/CH-199008 SN - 1386-0291 VL - 72 IS - 2 SP - 117 EP - 118 ER - TY - GEN A1 - Lau, S. A1 - Rangarajan, R. A1 - Krüger-Genge, Anne A1 - Braune, Steffen A1 - Kammerer, Sarah A1 - Küpper, Jan-Heiner A1 - Lendlein, Andreas A1 - Jung, Friedrich T1 - Effects of acrolein in comparison to its prodrug cyclophosphamide on human primary endothelial cells in vitro T2 - Toxicology in Vitro N2 - Cyclophosphamide (CPA) is one of the most successful anticancer prodrugs that becomes effective after biotransformation in the liver resulting in the toxic metabolite acrolein. Cancer is often accompanied by thromboembolic events, which might be a result of dysfunctional endothelial cells due to CPA treatment. Here, the effect of 1 mM CPA or acrolein (10/50/100/500 μM) on human umbilical vein endothelial cells (HUVECs) was analyzed after two days of treatment. The addition of CPA or 10 μM acrolein did not affect HUVECs. However, concentrations of 100 μM and 500 μM acrolein significantly reduced the number of adherent cells by 86 ± 13% and 99 ± 1% and cell viability by 51 ± 29% and 93 ± 8% compared to the control. Moreover, pronounced stress fibers as well as multiple nuclei were observed and von Willebrand factor (vWF) was completely released. Lactate dehydrogenase was 8.5 ± 7.0-fold and 252.9 ± 42.9-fold increased showing a loss of cell membrane integrity. The prostacyclin and thromboxane secretion was significantly increased by the addition of 500 μM acrolein (43.1 ± 17.6-fold and 246.4 ± 106.3-fold) indicating cell activation/pertubation. High doses of acrolein led to HUVEC death and loss of vWF production. This effect might be associated with the increased incidence of thromboembolic events in cancer patients treated with high doses of CPA. KW - Human umbilical venous endothelial cells KW - Acrolein KW - Aneuploidy KW - von Willebrand factor KW - in vitro study Y1 - 2020 U6 - https://doi.org/10.1016/j.tiv.2019.104685 SN - 0887-2333 VL - 62 ER - TY - GEN A1 - Jung, Friedrich A1 - Krüger-Genge, Anne A1 - Waldeck, Peter A1 - Küpper, Jan-Heiner T1 - Spirulina platensis, a super food? T2 - Journal of Cellular Biotechnology N2 - Spirulina platensis, a multicelluar, photosynthetic prokaryote (algae) contains a high amount of proteins, vitamins and minerals superior to many foods as e.g. soybeans. Thus, Spirulina platensis was recognized as nutritious food by the United Nations World Food Conference. Due to the high amount of nutritive ingredients Spirulina has a long history as dietary supplement. In addition, spirulina platensis is also efficiently used as forage with known effects on flesh, egg and plumage color, milk yield and fertility. The versatile utilization of the alga can be explained on the one hand with the nutrient levels and on the other hand with recognized effects as anti-viral, anti-bacterial, anti-oxidant, anti-diabetic, anti-cancer and anti-inflammatory substance. Therefore, this alga is named as “superfood”. Beyond, these algae convert carbon dioxide into organic substances and produce oxygen during their growth in alkaline and saline water thereby not wasting fresh water allowing the production in barren areas. Despite this diverse use of Spirulina platensis due to its beneficial properties, many basic mechanisms on a molecular and cellular level are not well understood and should be explored in future studies. KW - Spirulina KW - health effects KW - dietary supplements KW - liver protection KW - virus infection KW - HIV KW - nutrition KW - animal feeding Y1 - 2019 UR - https://content.iospress.com/articles/journal-of-cellular-biotechnology/jcb189012 U6 - https://doi.org/10.3233/JCB-189012 SN - 2352-3689 SN - 2352-3697 VL - 5 IS - 1 SP - 43 EP - 54 ER -