TY - GEN A1 - Spiegel, Rainer A1 - Kalla, Roger A1 - Claassen, Jens A1 - Bardins, Stanislav A1 - Anciães da Silva, Fábio A1 - Farahmand, Parvis A1 - Hahn, Ales A1 - Schneider, Erich T1 - Aminopyridine treatment in a patient with bilateral vestibular failure and cryptogenic downbeat nystagmus T2 - Journal of Neuro-Ophthalmology Y1 - 2012 SN - 1536-5166 SN - 1070-8022 VL - 32 IS - 2 SP - 190 ER - TY - GEN A1 - Claassen, Jens A1 - Spiegel, Rainer A1 - Kalla, Roger A1 - Faldon, Mary A1 - Kennard, Christopher A1 - Schneider, Erich T1 - A randomised double-blind, cross-over trial of 4-aminopyridine for downbeat nystagmus–effects on slowphase eye velocity, postural stability, locomotion and symptoms T2 - Journal of neurology, neurosurgery, and psychiatry Y1 - 2013 U6 - https://doi.org/10.1136/jnnp-2012-304736 SN - 0022-3050 SN - 1468-330X VL - 84 IS - 12 SP - 1392 EP - 1399 ER - TY - GEN A1 - Claassen, Jens A1 - Feil, Katharina A1 - Bardins, Stanislav A1 - Teufel, Julian A1 - Spiegel, Rainer A1 - Kalla, Roger A1 - Schneider, Erich T1 - Dalfampridine in patients with downbeat nystagmus–an observational study T2 - Journal of Neurology Y1 - 2013 U6 - https://doi.org/10.1007/s00415-013-6911-5 SN - 0340-5354 SN - 1432-1459 VL - 260 IS - 8 SP - 1992 EP - 1996 ER - TY - GEN A1 - Spiegel, Rainer A1 - Claassen, Jens A1 - Teufel, Julian A1 - Bardins, Stanislav A1 - Schneider, Erich A1 - Lehrer, Nicole A1 - Jahn, Klaus A1 - Anciaes da Silva, Fábio A1 - Hahn, Ales A1 - Farahmand, Parvis A1 - Brandt, Thomas A1 - Strupp, Michael A1 - Kalla, Roger T1 - Resting in darkness improves downbeat nystagmus: evidence from an observational study T2 - Annals of the New York Academy of Sciences N2 - Resting in an upright position during daytime decreases downbeat nystagmus (DBN). When measured in brightness only, that is, without intermitting exposure to darkness, it does not make a significant difference whether patients have previously rested in brightness or in darkness. In real-world scenarios, people are often exposed to brightness and darkness intermittently. The aim of this study was to analyze whether resting in brightness or resting in darkness was associated with a lower post-resting DBN after intermitting exposures to brightness and darkness. Eight patients were recorded with three-dimensional video-oculography in brightness and darkness conditions, each following two 2-h resting intervals under either brightness or darkness resting conditions. The dependent variable was DBN intensity, measured in mean slow phase velocity. A repeated measures ANOVA with the factors measurement condition (brightness vs. darkness), resting condition (brightness vs. darkness), and time (after first vs. second resting interval) showed a significant effect for the factor resting condition, where previous resting in darkness was associated with a significantly lower DBN relative to previous resting in brightness (P < 0.01). The clinical relevance is to advise patients with DBN to rest in darkness. KW - downbeat nystagmus KW - symptom relief KW - resting KW - oscillopsia KW - video-oculographic measurement (VOG) Y1 - 2016 U6 - https://doi.org/10.1111/nyas.13172 SN - 1749-6632 SN - 0077-8923 VL - 1375 IS - 1 SP - 66 EP - 73 ER - TY - GEN A1 - Friedrich, Maximilian U. A1 - Schneider, Erich A1 - Buerklein, Miriam A1 - Taeger, Johannes A1 - Hartig, Johannes A1 - Volkmann, Jens A1 - Peach, Robert A1 - Zeller, Daniel T1 - Smartphone video nystagmography using convolutional neural networks: ConVNG T2 - Journal of Neurology N2 - Eye movement abnormalities are commonplace in neurological disorders. However, unaided eye movement assessments lack granularity. Although videooculography (VOG) improves diagnostic accuracy, resource intensiveness precludes its broad use. To bridge this care gap, we here validate a framework for smartphone video-based nystagmography capitalizing on recent computer vision advances. Methods A convolutional neural network was fine-tuned for pupil tracking using > 550 annotated frames: ConVNG. In a cross-sectional approach, slow-phase velocity of optokinetic nystagmus was calculated in 10 subjects using ConVNG and VOG. Equivalence of accuracy and precision was assessed using the “two one-sample t-test” (TOST) and Bayesian interval-null approaches. ConVNG was systematically compared to OpenFace and MediaPipe as computer vision (CV) benchmarks for gaze estimation. Results ConVNG tracking accuracy reached 9–15% of an average pupil diameter. In a fully independent clinical video dataset, ConVNG robustly detected pupil keypoints (median prediction confidence 0.85). SPV measurement accuracy was equivalent to VOG (TOST p < 0.017; Bayes factors (BF) > 24). ConVNG, but not MediaPipe, achieved equivalence to VOG in all SPV calculations. Median precision was 0.30°/s for ConVNG, 0.7°/s for MediaPipe and 0.12°/s for VOG. ConVNG precision was significantly higher than MediaPipe in vertical planes, but both algorithms’ precision was inferior to VOG. Conclusions ConVNG enables offline smartphone video nystagmography with an accuracy comparable to VOG and significantly higher precision than MediaPipe, a benchmark computer vision application for gaze estimation. This serves as a blueprint for highly accessible tools with potential to accelerate progress toward precise and personalized Medicine. KW - Digital medicine KW - Nystagmus KW - Eye movement disorders KW - Videooculography KW - Computer vision KW - Telemedicine KW - Precision medicine Y1 - 2022 U6 - https://doi.org/10.1007/s00415-022-11493-1 SN - 1432-1459 VL - 270 SP - 2518 EP - 2530 ER - TY - GEN A1 - Feil, Katharina A1 - Claassen, Jens A1 - Brandins, Stanislavs A1 - Teufel, Julian A1 - Krafczyk, Siegbert A1 - Schneider, Erich T1 - Effect of chlorzoxazone in patients with downbeat nystagmus: a pilot trial T2 - Neurology Y1 - 2013 U6 - https://doi.org/10.1212/WNL.0b013e3182a55f6d SN - 0028-3878 SN - 1526-632X VL - 81 IS - 13 SP - 1152 EP - 1158 ER - TY - GEN A1 - Kalla, Roger A1 - Spiegel, Rainer A1 - Claassen, Jens A1 - Bardins, Stanislav A1 - Hahn, Ales A1 - Schneider, Erich A1 - Lehrer, Nicole A1 - Glasauer, Stefan A1 - Brandt, Thomas A1 - Strupp, Michael T1 - Comparison of 10-mg doses of 4-aminopyridine and 3,4-diaminopyridine for the treatment of downbeat nystagmus T2 - Journal of neuro-ophthalmology Y1 - 2011 U6 - https://doi.org/10.1097/WNO.0b013e3182258086 SN - 1536-5166 SN - 1070-8022 VL - 32 IS - 2 SP - 320 EP - 325 ER - TY - GEN A1 - Quinkenstein, Ansgar A1 - Böhm, Christian A1 - Freese, Dirk A1 - Wöllecke, Jens A1 - Grünewald, Holger A1 - Schneider, Bernd Uwe A1 - Hüttl, Reinhard F. T1 - Alley-Cropping - Ein klima-adaptierbares Landnutzungssystem zur nachhaltigen Biomasseproduktion T2 - Forum der Forschung Y1 - 2008 SN - 0947-6989 VL - 12 IS - 21 SP - 131 EP - 138 ER - TY - GEN A1 - Schneider, Jens A1 - Weiss, Romano A1 - Ruhe, Madeleine A1 - Jung, Tobias A1 - Roggenbuck, Dirk A1 - Stohwasser, Ralf A1 - Schierack, Peter A1 - Rödiger, Stefan T1 - Open source bioimage informatic tools for the analysis of DNA damage and associated biomarkers T2 - Journal of Laboratory and Precision Medicine KW - bioimage informatics KW - DNA damage response (DDR) KW - double-strand break (DSB) KW - immunofluorescence microscopy KW - open source software KW - proteasome activator PA28gamma Y1 - 2019 U6 - https://doi.org/10.21037/jlpm.2019.04.05 SN - 2519-9005 VL - 4 ER - TY - GEN A1 - Rödiger, Stefan A1 - Schneider, Jens A1 - Sauer, Lysann A1 - Reddig, Annika A1 - Schierack, Peter A1 - Roggenbuck, Dirk A1 - Schröder, Christian T1 - A Multiparameter Platform for The Analysis of DNA Double-strand Breaks and Associated Biomarkers after genome Editing Austrian Biomarker Symposium (ASBD) 2016, 10.-11.03.2016, Wien, Österreich Y1 - 2016 UR - https://f1000research.com/posters/5-350 ER - TY - GEN A1 - Sauer, Lysann A1 - Rödiger, Stefan A1 - Schneider, Jens A1 - Schierack, Peter A1 - Roggenbuck, Dirk A1 - Schröder, Christian T1 - Functional Multiparameter Analy sis of Double-Strand Breaks and Associate Biomarkers during Genome Editing, Genome Editing and Gene Modulation Congress 2016, 6.–8.04.2016, Oxford, United Kingdom Y1 - 2016 UR - https://f1000research.com/posters/5-706 ER - TY - GEN A1 - Quinkenstein, Ansgar A1 - Wöllecke, Jens A1 - Böhm, Christian A1 - Grünewald, Holger A1 - Freese, Dirk A1 - Schneider, Bernd Uwe A1 - Hüttl, Reinhard F. T1 - Ecological benefits of the alley cropping agroforestry system in sensitive regions of Europe T2 - Environmental Science & Policy Y1 - 2009 U6 - https://doi.org/10.1016/j.envsci.2009.08.008 SN - 1462-9011 VL - 12 IS - 8 SP - 1112 EP - 1121 ER - TY - CHAP A1 - Böhm, Christian A1 - Etterer, Florian A1 - Kempa, Daniela A1 - König, Bettina A1 - Matthes, Gesa A1 - Schaffrin, André A1 - Schindele, Stephan A1 - Schneider, Jens A1 - Streit, Anne von ED - Schön, Susanne ED - Eismann, Christian ED - Wendt-Schwarzburg, Helke ED - Ansmann, Till T1 - Land nachhaltig nutzen T2 - Nachhaltige Landnutzung managen : Akteure beteiligen – Ideen entwickeln – Konflikte lösen Y1 - 2019 SN - 978-3-7639-6027-9 SP - 12 EP - 24 PB - wbv Media GmbH & Co KG CY - Bielefeld ER - TY - CHAP A1 - Quinkenstein, Ansgar A1 - Schultze, Bernd A1 - Grünewald, Holger A1 - Wöllecke, Jens A1 - Schneider, Bernd Uwe A1 - Jochheim, Hubert A1 - Hüttl, Reinhard F. ED - Murach, Dieter ED - Knur, Lisa ED - Schultze, Mareike T1 - Landschaftsökologische Aspekte der Dendromasseproduktion - Analyse und Bewertung von Risiken und Vorteilswirkungen T2 - DENROM - Zukunftsrohstoff Dendromasse : systemische Analyse, Leitbilder und Szenarien für die nachhaltige energetische und stoffliche Verwertung von Dendromasse aus Wald- und Agrarholz Y1 - 2009 SN - 978-3-941300-05-7 SP - 193 EP - 204 PB - Verlag Kessel CY - Remagen-Oberwinter ER - TY - CHAP A1 - Wöllecke, Jens A1 - Böllmann, Jörg A1 - Schneider, Bernd Uwe A1 - Hüttl, Reinhard F. ED - Hüttl, Reinhard F. ED - Schneider, Bernd Uwe T1 - Vergleichende Untersuchungen zur Durchwurzelbarkeit und Mykorrhizierung auf forstlich rekultivierten Kippsubstraten T2 - Neue Ansätze in der land- und forstwirtschaftlichen Rekultivierung Y1 - 2009 SN - 978-3-937728-06-3 SN - 3-937728-06-6 SP - 207 EP - 224 PB - BTU CY - Cottbus ER - TY - CHAP A1 - Wöllecke, Jens A1 - Grünewald, Holger A1 - Schneider, Bernd Uwe A1 - Hüttl, Reinhard F. T1 - Alley-Cropping - Eine Möglichkeit der Etablierung von Biotopverbundstrukturen in der Agrarlandschaft? T2 - Naturschutz und Ökologie, ausgewählte Beiträge zur GfÖ-Jahrestagung 2007 in Marburg Y1 - 2008 SN - 978-3-7843-3960-3 SP - 73 EP - 78 PB - Bundesamt für Naturschutz CY - Bonn-Bad Godesberg ER -