TY - GEN A1 - Lehnen, Nadine A1 - Heuser, Fabian A1 - Sağlam, Murat A1 - Schulz, Christian M. A1 - Wagner, Klaus J. A1 - Taki, Masakatsu A1 - Kochs, Eberhard F. A1 - Jahn, Klaus A1 - Schneider, Erich T1 - Opioid-induced nausea involves a vestibular problem preventable by head-rest T2 - PLoS one Y1 - 2015 U6 - https://doi.org/10.1371/journal.pone.0135263 SN - 1932-6203 VL - 10 IS - 8 SP - e0135263 ER - TY - GEN A1 - Heuser, Fabian A1 - Schulz, Christian A1 - Sağlam, Murat A1 - Ramaioli, Cecilia A1 - Heuberger, Maria A1 - Wagner, Klaus J. A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Brandt, Thomas A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Preventing opioid-induced nausea and vomiting: Rest your head and close your eyes? T2 - PloS one Y1 - 2017 U6 - https://doi.org/10.1371/journal.pone.0173925 SN - 1932-6203 VL - 12 IS - 3 SP - e0173925 ER - TY - GEN A1 - Lehnen, Nadine A1 - Ramaioli, Cecilia A1 - Todd, Nicholas Sean A1 - Bartl, Klaus A1 - Kohlbecher, Stefan A1 - Jahn, Klaus A1 - Schneider, Erich T1 - Clinical and video head impulses: a simple bedside test in children T2 - Journal of Neurology KW - Head Velocity KW - Head Impulse KW - Head Impulse Testing KW - Rotational Chair KW - Vestibular Function Test Y1 - 2017 U6 - https://doi.org/10.1007/s00415-017-8450-y SN - 1432-1459 VL - 264 IS - 5 SP - 1002 EP - 1004 ER - TY - GEN A1 - Heuberger, Maria A1 - Sağlam, Murat A1 - Todd, Nicholas Sean A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Lehnen, Nadine T1 - Covert anti-compensatory quick eye movements during head impulses T2 - PLoS One Y1 - 2014 U6 - https://doi.org/10.1371/journal.pone.0093086 SN - 1932-6203 VL - 9 IS - 4 SP - e93086 ER - TY - GEN A1 - Helmchen, Christoph A1 - Machner, Björn A1 - Lehnen, Nadine A1 - Jahn, Klaus A1 - Schneider, Erich T1 - Current state of diagnostic management of acute vertigo: a survey of neurologists in Germany T2 - Journal of Neurology Y1 - 2014 U6 - https://doi.org/10.1007/s00415-014-7405-9 SN - 0340-5354 SN - 1432-1459 VL - 261 IS - 8 SP - 1638 EP - 1640 ER - TY - GEN A1 - Jahn, Klaus A1 - Schneider, Erich T1 - Untersuchung der vestibulären Funktion bei Schwindelpatienten T2 - Nervenheilkunde Y1 - 2012 SN - 0722-1541 VL - 31 IS - 5 SP - 370 EP - 377 ER - TY - GEN A1 - Schneider, Erich A1 - Jahn, Klaus A1 - Dieterich, Marianne A1 - Brandt, Thomas A1 - Strupp, Michael T1 - Gait deviations induced by visual stimulation in roll T2 - Experimental Brain Research Y1 - 2008 U6 - https://doi.org/10.1007/s00221-007-1134-6 SN - 0014-4819 SN - 1432-1106 VL - 185 IS - 1 SP - 21 EP - 26 ER - TY - GEN A1 - Lehnen, Nadine A1 - Schneider, Erich A1 - Jahn, Klaus T1 - Klinische Untersuchungen bei Schwindel: Kopfimpulstest und dynamische Sehschärfe T2 - Neurotransmitter Y1 - 2013 SN - 2196-6397 SN - 1436-123X VL - 24 IS - 4 SP - 39 EP - 43 ER - TY - GEN A1 - Lehnen, Nadine A1 - Schneider, Erich A1 - Jahn, Klaus T1 - Do neurologists need the head impulse test? T1 - Braucht der Neurologe den Kopfimpulstest? T2 - Nervenarzt Y1 - 2013 U6 - https://doi.org/10.1007/s00115-013-3822-8 SN - 0028-2804 SN - 1433-0407 VL - 84 IS - 8 SP - 973 EP - 974 ER - TY - GEN A1 - Jahn, Klaus A1 - Naeßl, Andrea A1 - Schneider, Erich A1 - Strupp, Michael A1 - Brandt, Thomas A1 - Dieterich, Marianne T1 - Inverse u-shaped curve for age dependency of torsional eye movement responses to galvanic vestibular stimulation T2 - Brain Y1 - 2003 U6 - https://doi.org/10.1093/brain/awg163 SN - 1460-2156 SN - 0006-8950 VL - 126 IS - 7 SP - 1579 EP - 1589 ER - TY - GEN A1 - Jahn, Klaus A1 - Naeßl, Andrea A1 - Strupp, Michael A1 - Schneider, Erich A1 - Brandt, Thomas A1 - Dieterich, Marianne T1 - Torsional eye movement responses to monaural and binaural galvanic vestibular stimulation: side-to-side asymmetries. T2 - Annals of the New York Academy of Sciences Y1 - 2003 U6 - https://doi.org/10.1111/j.1749-6632.2003.tb00265.x SN - 0077-8923 SN - 1749-6632 VL - 1004 SP - 485 EP - 489 ER - TY - GEN A1 - Jahn, Klaus A1 - Strupp, Michael A1 - Schneider, Erich A1 - Dieterich, Marianne A1 - Brandt, Thomas T1 - Visually induced gait deviations during different locomotion speeds T2 - Experimental Brain Research Y1 - 2001 U6 - https://doi.org/10.1007/s002210100884 SN - 0014-4819 SN - 1432-1106 VL - 141 IS - 3 SP - 370 EP - 374 ER - TY - GEN A1 - Jahn, Klaus A1 - Strupp, Michael A1 - Schneider, Erich A1 - Dieterich, Marianne A1 - Brandt, Thomas T1 - Differential effects of vestibular stimulation on walking and running T2 - Neuroreport Y1 - 2000 SN - 1473-558X SN - 0959-4965 VL - 11 IS - 8 SP - 1745 EP - 1748 ER - TY - GEN A1 - Glasauer, Stefan A1 - Schneider, Erich A1 - Jahn, Klaus A1 - Strupp, Michael T1 - How the eyes move the body T2 - Neurology Y1 - 2005 U6 - https://doi.org/10.1212/01.wnl.0000175132.01370.fc SN - 0028-3878 SN - 1526-632X VL - 65 IS - 8 SP - 1291 EP - 1293 ER - TY - GEN A1 - Strupp, Michael A1 - Glasauer, Stefan A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Krafczyk, Siegbert A1 - Brandt, Thomas T1 - Eye movements and balance T2 - Annals of the New York Academy of Sciences Y1 - 2003 SN - 1749-6632 VL - 1004 SP - 352 EP - 358 ER - TY - GEN A1 - Li, Chouyang A1 - Rezania, Simin A1 - Kammerer, Sarah A1 - Sokolowski, Armin Andreas A1 - Devaney, Trevor Thomas Joseph A1 - Gorischek, Astrid A1 - Jahn, Stephan Wenzel A1 - Hackl, Hubert A1 - Groschner, Klaus A1 - Windpassinger, Christian A1 - Malle, Ernst A1 - Bauernhofer, Thomas A1 - Schreibmayer, Wolfgang T1 - Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line T2 - Scientific Reports N2 - Mechanical interaction between cells - specifically distortion of tensional homeostasis-emerged as an important aspect of breast cancer genesis and progression. We investigated the biophysical characteristics of mechanosensitive ion channels (MSCs) in the malignant MCF-7 breast cancer cell line. MSCs turned out to be the most abundant ion channel species and could be activated by negative pressure at the outer side of the cell membrane in a saturable manner. Assessing single channel conductance (GΛ) for different monovalent cations revealed an increase in the succession: Li⁺ < Na⁺ < K⁺ ≈Rb⁺ ≈ Cs⁺. Divalent cations permeated also with the order: Ca²⁺ < Ba²⁺. Comparison of biophysical properties enabled us to identify MSCs in MCF-7 as ion channels formed by the Piezo1 protein. Using patch clamp technique no functional MSCs were observed in the benign MCF-10A mammary epithelial cell line. Blocking of MSCs by GsMTx-4 resulted in decreased motility of MCF-7, but not of MCF-10A cells, underscoring a possible role of Piezo1 in invasion and metastatic propagation. The role of Piezo1 in biology and progression of breast cancer is further substantiated by markedly reduced overall survival in patients with increased Piezo1 mRNA levels in the primary tumor. Y1 - 2015 U6 - https://doi.org/10.1038/srep08364 SN - 2045-2322 VL - 5 ER - TY - GEN A1 - Lehnen, Nadine A1 - Kellerer, Silvy A1 - Knorr, Alexander G. A1 - Schlick, Cornelia A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Heuberger, Maria A1 - Ramaioli, Cecilia T1 - Head-Movement-Emphasized Rehabilitation in Bilateral Vestibulopathy T2 - Frontiers in Neurology Y1 - 2018 U6 - https://doi.org/10.3389/fneur.2018.00562 SN - 1664-2295 VL - 9 ER - TY - GEN A1 - Schöberl, Florian A1 - Pradhan, Cauchy A1 - Irving, Stephanie A1 - Buerger, Katharina A1 - Xiong, Guoming A1 - Kugler, Günter A1 - Kohlbecher, Stefan A1 - Engmann, Julia A1 - Werner, Philipp A1 - Brendel, Matthias A1 - Schneider, Erich A1 - Perneczky, Robert A1 - Jahn, Klaus A1 - Fougère, Christian la A1 - Bartenstein, Peter A1 - Brandt, Thomas A1 - Dietrich, Marianne A1 - Zwergal, Andreas T1 - Real-space navigation testing differentiates between amyloid-positive and -negative aMCI T2 - Neurology : official journal of the American Academy of Neurology Y1 - 2020 UR - https://n.neurology.org/content/94/8/e861 U6 - https://doi.org/10.1212/WNL.0000000000008758 SN - 1526-632X VL - 94 IS - 8 SP - e861 EP - e873 ER - TY - GEN A1 - Grill, Eva A1 - Heuberger, Maria A1 - Strobl, Ralf A1 - Saglam, Murat A1 - Holle, Rolf A1 - Linkohr, Birgit A1 - Ladwig, Karl-Heinz A1 - Peters, Annette A1 - Schneider, Erich A1 - Jahn, Klaus A1 - Lehnen, Nadine T1 - Prevalence, determinants, and consequences of vestibular hypofunction. results from the kora-ff4 survey T2 - Frontiers in Neurology N2 - Objective: Uni- or bilateral vestibular hypofunction (VH) impairs balance and mobility, and may specifically lead to injury from falls and to disability. The extent of this problem in the general population is still unknown and most likely to be underestimated. Objective of this study was to determine the prevalence, determinants, and consequences of VH in the general population. Methods: Data originates from the cross-sectional second follow-up (FF4) in 2013/14 of the KORA (Cooperative Health Research in the Region of Augsburg)-S4 study (1999–2001) from Southern Germany. This was a random sample of the target population consisting of all residents of the region aged 25–74 years in 1999. We included all participants who reported moderate or severe vertigo or dizziness during the last 12 months and a random sub-sample of participants representative for the general population without vertigo or dizziness during the last 12 months were tested. VH was assessed with the Video-Head Impulse Test (vHIT). Trained examiners applied high-acceleration, small-amplitude passive head rotations (“head impulses”) to the left and right in the plane of the horizontal semicircular canals while participants fixated a target straight ahead. During head impulses, head movements were measured with inertial sensors, eye movements with video-oculography (EyeSeeCam vHIT). Results: A total of 2,279 participants were included (mean age 60.8 years, 51.6% female), 570 (25.0%) with moderate or severe vertigo or dizziness during the last 12 months. Of these, 450 were assessed with vHIT where 26 (5.8%) had unilateral VH, and 16 (3.6%) had bilateral VH. Likewise, 190 asymptomatic participants were tested. Of these 5 (2.6%) had unilateral VH, and 2 (1.1%) had bilateral VH. Prevalence of uni- or bilateral VH among tested symptomatic participants was 2.4% in those < 48 years, and 32.1% in individuals aged 79 and over. Age-adjusted prevalence was 6.7% (95% CI 4.8%; 8.6%). VH was associated with worse health, falls, hearing loss, hearing impairment, and ear pressure. Conclusion: VH may affect between 53 and 95 million adults in Europe and the US. While not all affected persons will experience the full spectrum of symptoms and consequences, adequate diagnostic and therapeutic measures should become standard of care to decrease the burden of disease. Y1 - 2018 U6 - https://doi.org/10.3389/fneur.2018.01076 SN - 1664-2295 VL - 9 ER - TY - GEN A1 - Spiegel, Rainer A1 - Claassen, Jens A1 - Teufel, Julian A1 - Bardins, Stanislav A1 - Schneider, Erich A1 - Lehrer, Nicole A1 - Jahn, Klaus A1 - Anciaes da Silva, Fábio A1 - Hahn, Ales A1 - Farahmand, Parvis A1 - Brandt, Thomas A1 - Strupp, Michael A1 - Kalla, Roger T1 - Resting in darkness improves downbeat nystagmus: evidence from an observational study T2 - Annals of the New York Academy of Sciences N2 - Resting in an upright position during daytime decreases downbeat nystagmus (DBN). When measured in brightness only, that is, without intermitting exposure to darkness, it does not make a significant difference whether patients have previously rested in brightness or in darkness. In real-world scenarios, people are often exposed to brightness and darkness intermittently. The aim of this study was to analyze whether resting in brightness or resting in darkness was associated with a lower post-resting DBN after intermitting exposures to brightness and darkness. Eight patients were recorded with three-dimensional video-oculography in brightness and darkness conditions, each following two 2-h resting intervals under either brightness or darkness resting conditions. The dependent variable was DBN intensity, measured in mean slow phase velocity. A repeated measures ANOVA with the factors measurement condition (brightness vs. darkness), resting condition (brightness vs. darkness), and time (after first vs. second resting interval) showed a significant effect for the factor resting condition, where previous resting in darkness was associated with a significantly lower DBN relative to previous resting in brightness (P < 0.01). The clinical relevance is to advise patients with DBN to rest in darkness. KW - downbeat nystagmus KW - symptom relief KW - resting KW - oscillopsia KW - video-oculographic measurement (VOG) Y1 - 2016 U6 - https://doi.org/10.1111/nyas.13172 SN - 1749-6632 SN - 0077-8923 VL - 1375 IS - 1 SP - 66 EP - 73 ER - TY - GEN A1 - Aubele, Maria A1 - Grill, Eva A1 - Eggert, Thomas A1 - Schneider, Erich A1 - Strobl, Ralf A1 - Jahn, Klaus A1 - Müller, Martin A1 - Holle, Rolf A1 - Linkohr, Birgit A1 - Heier, Margit A1 - Ladwig, Karl-Heinz A1 - Lehnen, Nadine T1 - Symptoms in unilatral vestibular hypofunction are associated with number of catch-up saccades and retinal errors: results from the population-based KORA FF4study T2 - Frontiers in Neurology N2 - Objective: The presence and intensity of symptoms vary in patients with unilateral vestibular hypofunction. We aimed to determine which saccadic and vestibulo-ocular reflex parameters best predict the presence of symptoms in unilateral vestibular hypofunction in order to better understand vestibular compensation and its implications for rehabilitation therapy. Methods: Video head impulse test data were analyzed from a subpopulation of 23 symptomatic and 10 currently symptom-free participants with unilateral vestibular hypofunction, embedded in the KORA (Cooperative Health Research in the Region of Augsburg) FF4 study, the second follow-up of the KORA S4 population-based health survey (2,279 participants). Results: A higher number of catch-up saccades, a higher percentage of covert saccades, and a larger retinal error at 200 ms after the onset of the head impulse were associated with relevant symptoms in participants with unilateral vestibular hypofunction (p = 0.028, p = 0.046, and p = 0.038, respectively). After stepwise selection, the number of catch-up saccades and retinal error at 200 ms remained in the final logistic regression model, which was significantly better than a null model (p = 0.014). Age, gender, saccade amplitude, saccade latency, and VOR gain were not predictive of the presence of symptoms. Conclusion: The accuracy of saccadic compensation seems to be crucial for the presence of symptoms in unilateral vestibular hypofunction, highlighting the role of specific gaze stabilization exercises in rehabilitation. Early saccades, mainly triggered by the vestibular system, do not seem to compensate accurately enough, resulting in a relevant retinal error and the need for more as well as more accurate catch-up saccades, probably triggered by the visual system. KW - video head impulse test, vHIT, catch-up saccades, unilateral vestibular hypofunction, retinal error, vestibulo-ocular reflex, VOR, population-based survey Y1 - 2023 UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715252/ SN - 1664-2295 VL - 2023 IS - 14 ER -