TY - GEN A1 - Berens, Eva-Maria A1 - Riedel, Jörg A1 - Reder, Maren A1 - Razum, Oliver A1 - Kolip, Petra A1 - Spallek, Jacob T1 - Postalische Befragung von Frauen mit türkischem Migrationshintergrund – Identifizierung, Stichprobenbereinigung und Response im Rahmen der InEMa-Studie T1 - Postal Survey Among Women With Turkish Migration Background in Germany – Identification, Sample Revision and Response in the InEMa Study T2 - Das Gesundheitswesen Y1 - 2017 U6 - https://doi.org/10.1055/s-0035-1564076 SN - 0941-3790 VL - 79 IS - 12 SP - 1000 EP - 1003 ER - TY - GEN A1 - Charissé, Daniel A1 - Erus, Guray A1 - Pomponio, Raymond A1 - Gorges, Martin A1 - Schmidt, Nele A1 - Schneider, Christine A1 - Liepelt-Scarfone, Inga A1 - Riedel, Oliver A1 - Reetz, Kathrin A1 - Schulz, Jörg B. A1 - Berg, Daniela A1 - Storch, Alexander A1 - Witt, Karsten A1 - Dodel, Richard A1 - Kalbe, Elke A1 - Kassubek, Jan A1 - Hilker-Roggendorf, Rüdiger A1 - Baudrexel, Simon T1 - Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease T2 - Neurobiology of Aging N2 - Recently, it was shown that patients with Parkinson's disease (PD) who exhibit an “Alzheimer's disease (AD)-like” pattern of brain atrophy are at greater risk for future cognitive decline. This study aimed to investigate whether this association is domain-specific and whether atrophy associated with brain aging also relates to cognitive impairment in PD. SPARE-AD, an MRI index capturing AD-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort. All patients underwent an extensive neuropsychological test battery. Patients diagnosed with mild cognitive impairment or dementia were found to have higher SPARE-AD scores as compared to patients with normal cognition and healthy controls. All patient groups showed increased brain age. SPARE-AD predicted impairment in memory, language and executive functions, whereas advanced brain age was associated with deficits in attention and working memory. Data suggest that SPARE-AD and brain age are differentially related to domain-specific cognitive decline in PD. The underlying pathomechanisms remain to be determined. KW - Alzheimer's disease KW - Brain Age KW - MRI KW - Parkinson's disease KW - Pattern classification Y1 - 2022 UR - https://www.sciencedirect.com/science/article/pii/S0197458021002748?via%3Dihub U6 - https://doi.org/10.1016/j.neurobiolaging.2021.08.020 SN - 0197-4580 VL - 109 SP - 31 EP - 42 ER - TY - GEN A1 - Riedel, Ramona A1 - Braun, Burga A1 - Böllmann, Jörg A1 - Martienssen, Marion T1 - Neuer Standard-Abbautests für synthetische Phosphonate T2 - BIOspektrum : Das Magazin für Biowissenschaften N2 - The evaluation of the ready biodegradation of organic substances is usually carried out using the standardised OECD test methods 301 (A–F). However, this can become a great challenge for substances such as aminophosphonates which are chemically imbalanced and do not automatically promote microbial growth in standardized tests. Here, we report on the development of a standardized batch test that is suitable for phosphonates and overcomes important obstacles of the test methods above-mentioned. Y1 - 2024 U6 - https://doi.org/10.1007/s12268-024-2194-x SN - 1868-6249 SN - 0947-0867 VL - 30 SP - 345 EP - 347 ER - TY - GEN A1 - Riedel, Ramona A1 - Krahl, Kathrin A1 - Buder, Kai A1 - Böllmann, Jörg A1 - Braun, Burga A1 - Martienssen, Marion T1 - Novel standard biodegradation test for synthetic phosphonates T2 - Journal of Microbiological Methods N2 - Determination of biodegradation of synthetic phosphonates such as aminotris(methylenephosphonic acid) (ATMP), ethylenediamine tetra(methylenephosphonic acid) (EDTMP), or diethylenetriamine penta(methylenephosphonic acid) (DTPMP) is a great challenge. Commonly, ready biodegradability of organic substances is assessed by OECD 301 standard tests. However, due to the chemical imbalance of carbon to phosphorus synthetic phosphonates do not promote microbial growth and, thus, limiting its biodegradation. Therefore, standard OECD test methods are not always reliable to predict the real biodegradability of phosphonates. In the presented study, we report the development of a standardized batch system suitable to synthetic phosphonates such as ATMP, EDTMP, DTPMP and others. The novel standard batch test is applicable with pure strains, activated sludge from different wastewater treatment plants (i.e., municipal and industrial), and with tap water as inoculum. We optimized the required calcium and magnesium exposure levels as well as the amount of the start inoculum biomass. We demonstrated that our test also allows to determine several parameters including ortho-phosphate (o-PO43􀀀 ), total phosphorus (TP), ammonium (NH4+) and total organic carbon (TOC). In addition, also LC/MS analyses of cell-free medium is applicable for determining the mother compounds and metabolites. We applied our optimized standardized batch with selected phosphonates and evidenced that the chemical structure has a major influence of the microbial growth rates. Thus, our novel batch test overcomes drawbacks of the OECD 301 test series for determination of easy biodegradability for stoichiometric imbalanced organic compounds such as phosphonates. Y1 - 2023 U6 - https://doi.org/10.1016/j.mimet.2023.106793 SN - 1872-8359 SN - 0167-7012 VL - Vol. 212 SP - 1 EP - 13 ER - TY - GEN A1 - Böllmann, Jörg A1 - Riedel, Ramona A1 - Martienssen, Marion T1 - Inhibition of Pseudomonas aeruginosa with silver in a new synthetic medium : investigation on the MIC, growth rate and lag-phase at the lower limit T2 - Journal of microbiological methods N2 - The antimicrobial properties of silver are well-known and widely applied. Although it is known, that silver interacts and binds on complex organic substances like proteins, many experiments on the sterilisation efficiency and inhibiting properties are still carried out in complex culture media. Given, that silver is often applied in environments with no or few organic substrates, like cooling circuits or in the treatment of tap and process water, further insight on the minimum inhibition concentration and lethal concentration at those conditions is of interest. We have developed a defined medium for the standard bacterium Pseudomonas aeruginosa that is free of complex organic carbon with equal cultivation properties like commonly used nutrient solutions. With this medium we could narrow the range of the MIC between 2.5 μg to 10 μg∙L−1, which very much overlaps with the bactericidic concentration depending on the initial concentration of bacteria cells. These results might help to optimise the technical application of silver. We further observed a delayed growth of bacterial cultures of up to three days compared to silver free controls, which is caused either by a partial sterilisation down to theoretical one surviving cell or by a prolonged lag phase. Based on these observations we recommend a prolonged incubation for experiments on sterilisation with silver and the use of defined media, which do not interact with the disinfecting agent. KW - Silver KW - Minimum inhibition concentration KW - Disinfection KW - Defined medium KW - Lag-phase Y1 - 2025 U6 - https://doi.org/https://doi.org/10.1016/j.mimet.2025.107095 SN - 1872-8359 VL - 230-231 SP - 1 EP - 9 PB - Elsevier Bv CY - Amsterdam ER -