TY - GEN A1 - Lehnen, Nadine A1 - Ramaioli, Cecilia A1 - Henningsen, Peter A1 - Glasauer, Stefan T1 - An experimental litmus test of the emerging hypothesis that persistent physical symptoms can be explained as perceptual dysregulation T2 - Journal of Psychosomatic Research Y1 - 2018 U6 - https://doi.org/10.1016/j.jpsychores.2018.08.007 SN - 1879-1360 SN - 0022-3999 VL - 114 SP - 15 EP - 17 ER - TY - GEN A1 - Lehnen, Nadine A1 - Schröder, Lena A1 - Henningsen, Peter A1 - Glasauer, Stefan A1 - Ramaioli, Cecilia T1 - Deficient head motor control in functional dizziness: Experimental evidence of central sensory-motor dysfunction in persistent physical symptoms T2 - Progress in Brain Research N2 - Understanding the mechanisms of symptoms that are insufficiently explained by organic dysfunction remains challenging. Recently, it has been proposed that such “functional symptoms” are based on erroneous sensory processing in the central nervous system (CNS), with internal expectations dominating sensory inputs. In a pilot study, we used a head motor control set-up to assess the interplay between sensory input and expectation on the example of patients with functional dizziness. Eight patients and 11 age-matched healthy controls performed large active eye-head gaze shifts towards visual targets in the natural situation and with the head moment of inertia 3.3-fold increased. The latter induces head oscillations and the expected sensory outcome of the movement, estimated in the CNS, does not match the actual sensory input. Head oscillations were assessed in patients and in healthy subjects and compared to prior results from patients with organic disease (vestibular loss and cerebellar ataxia). Head oscillations in patients with functional dizziness were different from those of healthy subjects (F(1,17) = 27.26, P < 0.001, partial η2 = 0.62), and similar to those of patients with cerebellar ataxia, and with vestibular loss (F(2,19) = 0.56, P = 0.58). Even in the natural, unweighted, condition, head oscillations were higher in functional dizziness patients than in healthy subjects (P = 0.001). Since an extensive work-up failed to demonstrate any explanatory peripheral vestibular, motor, or cerebellar organic dysfunction, these motor control deficits are a first indication of erroneous interplay between expectations and sensory input in the CNS that could account for persistent physical symptoms. Y1 - 2019 U6 - https://doi.org/10.1016/bs.pbr.2019.02.006 SN - 1875-7855 SN - 0079-6123 VL - 249 SP - 385 EP - 400 ER - TY - GEN A1 - Glasauer, Stefan A1 - Lehnen, Nadine A1 - Radziej, Katharina A1 - Weigel, Angelika A1 - Känel, Roland von A1 - Pitron, Victor A1 - Van den Bergh, Omer A1 - Löwe, Bernd A1 - Lehmann, Marco A1 - Henningsen, Peter T1 - Complementing conceptual models of persistent somatic symptoms with mathematical formalization T2 - Psychosomatic Medicine Y1 - 2020 U6 - https://doi.org/10.1097/PSY.0000000000000801 SN - 1534-7796 ER - TY - CHAP A1 - Kleber, Arno A1 - Terhorst, Birgit A1 - Hülle, Daniela A1 - Leopold, Matthias A1 - Müller, S. A1 - Raab, Thomas A1 - Sauer, Daniela A1 - Scholten, Thomas A1 - Dietze, Michael A1 - Felix-Henningsen, Peter A1 - Heinrich, J. A1 - Spies, E. D. A1 - Thiemeyer, H. ED - Kleber, Arno ED - Terhorst, Birgit T1 - Subdued Mountains of Central Europe T2 - Mid-Latitude Slope Deposits (Cover Beds) N2 - Slope deposits, which veil entire slopes or large parts of them in a rather uniform manner (cover beds), are ubiquitous in the subdued mountains of Central Europe. Here we provide an overview of the current state of knowledge on these deposits. The Central European cover beds are divided into (1) the upper layer that is ubiquitously distributed and displays a relatively constant thickness; (2) the intermediate layer the distribution of which is mainly restricted to flat relief, to slope depressions, and to lee-ward facing slopes; and (3) the basal layer, which is rather widespread again. Both the upper and intermediate layer contain intermixed loess, whereas the basal layer is free of loess and typically has a high bulk density. Aside from the loess content, the composition of the layers differs, reflecting varying portions of crushed and chemically weathered rock allocated from up-slope. This causes notable diversity depending on bedrock and, thus, induces remarkable regional differences. Cover beds were mainly formed by periglacial gelifluction. The upper layer formed in the Late Glacial possibly during several short episodes of activity. In contrast, the underlying layers may be diachronous; nevertheless, they display recurring vertical sequences. This is probably due to the fact that loess-free layers usually could not deposit as long as there was loess in the environs, which may have been inherited from older deposits. Thus, the last phase of surface wash, during which older loess was removed, determines the age of the lower layers. Y1 - 2013 SN - 978-0-444-53118-6 U6 - https://doi.org/10.1016/B978-0-444-53118-6.00002-7 SP - 9 EP - 93 PB - Elsevier CY - Oxford ER - TY - GEN A1 - Schröder, Lena A1 - Werder, Dina von A1 - Ramaioli, Cecilia A1 - Wachtler, Thomas A1 - Henningsen, Peter A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Unstable Gaze in Functional Dizziness: A Contribution to Understanding the Pathophysiology of Functional Disorders T2 - Frontiers in Neuroscience N2 - Objective: We are still lacking a pathophysiological mechanism for functional disorders explaining the emergence and manifestation of characteristic, severely impairing bodily symptoms like chest pain or dizziness. A recent hypothesis based on the predictive coding theory of brain function suggests that in functional disorders, internal expectations do not match the actual sensory body states, leading to perceptual dysregulation and symptom perception. To test this hypothesis, we investigated the account of internal expectations and sensory input on gaze stabilization, a physiologically relevant parameter of gaze shifts, in functional dizziness. Methods: We assessed gaze stabilization in eight functional dizziness patients and 11 healthy controls during two distinct epochs of large gaze shifts: during a counter- rotation epoch (CR epoch), where the brain can use internal models, motor planning, and resulting internal expectations to achieve internally driven gaze stabilization; and during an oscillation epoch (OSC epoch), where, due to terminated motor planning, no movement expectations are present, and gaze is stabilized by sensory input alone. Results: Gaze stabilization differed between functional patients and healthy controls only when internal movement expectations were involved [F(1,17) = 14.63, p = 0.001, and partial η2 = 0.463]: functional dizziness patients showed reduced gaze stabilization during the CR (p = 0.036) but not OSC epoch (p = 0.26). Conclusion: While sensory-driven gaze stabilization is intact, there are marked, well- measurable deficits in internally-driven gaze stabilization in functional dizziness pointing at internal expectations that do not match actual body states. This experimental evidence supports the perceptual dysregulation hypothesis of functional disorders and is an important step toward understanding the underlying pathophysiology. Y1 - 2021 U6 - https://doi.org/10.3389/fnins.2021.685590 SN - 1662-453X SN - 1662-4548 VL - 15 ER - TY - CHAP A1 - Bens, Oliver A1 - Felix-Henningsen, Peter T1 - Variability of litter decomposition and nitrogen turnover in different Scots pine (Pinus sylvestris) ecosystems in Northwest Germany under the influence of groundwater lowering Y1 - 2001 ER -